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There's a statement about the possibility that acetaminophen is a larger risk factor than aspirin. Normally, I would add a "citation needed" but there is a citation -- to an article that does not make that claim in the first place. I'm not sure what the right way is to clean this up.
The article claims that 1% of cases are correlated with aspirin consumption, only 1% of aspirin sales are for pediatric use, acetaminophen is the predominant pediatric medicine, and 6% of cases correlate with acetaminophen use. Although the article doesn't say what percentage of patients use acetaminophen overall, and the implication is that it's well over 6% (thus making the correlation with acetaminophen lower than with aspirin), it simply doesn't say one way or the other. I'm not trying to debate whether there's a link between either or neither of these, but there's no citation here. The article says nothing and implies nothing about the percentage of patients with and without the syndrome who use aspirin vs acetaminophen. Hagrinas ( talk) 15:51, 21 March 2012 (UTC)
During my recovery from the flu, I've been applying salicylic acid topically as an acne medication. Yesterday, I had nausea, and two days ago, I threw up. At first I thought that these were only symptoms of the flu, but now that I've learned the link between sal. acid and Reye's syndrome, I think I might have it. Is there a 100% certainty? I mean, if you take salicylic acid while recovering from the flu, you WILL get Reye's syndrome?
First of all, there are five stages, not two. Also, the symptoms are vague and nonspecific. I'll get this section cleaned up in a jiffity when I have time. Right now is not a good time, at least not for me. Freddie 00:00, 17 March 2006 (UTC)
When I was a student at a tertiary neuroological centre, I was taught that Reye's syndrome is one of a family of mitochondrial diseases (mitochondropathies), which explains its multi-system nature and its predominant effects on liver and brain. Unfortunately this now lies well outside my field of expertise. Anyone elucidate? Thanks. Preacherdoc 13:57, 26 July 2006 (UTC)
I've noticed that bottles of Pepto and its generic versions contain a warning about possibly causing Reye's Syndrome. Shouldn't this get a mention as well? BioTube 18:27, 9 September 2006 (UTC)
Although I agree that there's no need to mention Pepto Bismol specifically, the article mentions aspirin as a possible cause rather than listing salicylates as a possible cause with aspirin as an example. Mentioning Pepto Bismol doesn't seem to be the appropriate way to rectify anything, but if there's a possible link to salicylates in general, mentioning Pepto Bismol makes no less sense than mentioning fruit. Before the era of perfect looking fruit in the supermarkets, bruised, irregular, or fruit with scars was a more regular part of the human diet. Salicylates were consumed at a higher level and are still consumed to a degree by those who never take medicine because plants form salicylates naturally as a reaction to that sort of damage. I don't see any reason to mention anything with salicylates aside from aspirin unless there's a citation somebody can give showing a possible link rather than a warning label. Warning labels exist due to the correlation between lawsuits and the lack of warning labels. Hagrinas ( talk) 16:11, 21 March 2012 (UTC)
Currently, this symptom has links to fat and liver. Would it not be more logical for it to have a link to fatty liver, or is the fat in the liver caused by Reye's Syndrome not the same as fatty liver? -- PBurns 22:17, 9 October 2006 (UTC)
The current wikipedia entry for Reye syndrome is biased against aspirin as a potential risk factor, and this view seems to contradict the prevailing consensus of the scientific community on the subject. As a result, the entry has poor credibility, and should be edited.
How is the disease treated? Is the coma reversible? Jack Daw 18:45, 3 December 2006 (UTC)
I'm also curious as to how this is treated. This article doesn't even address it. Can this disease be treated? If so, what is most effective in treating it? -- T H L 07:56, 21 December 2006 (UTC)
Agreed - the intro paragraph states that early diagnosis is critical, and that "with support" the prognosis is good. This begs the question, what "support" or other treatment is given to so vitally impact the outcome? — Preceding unsigned comment added by 76.88.95.56 ( talk) 22:17, 3 November 2012 (UTC)
This page is partially a copyvio, but much content is original (e.g. by myself). Would not support deletion. JFW | T@lk 14:48, 20 February 2007 (UTC)
- Someone please use these facts (as taught to us in medical biochemistry) to update the page - See 1983 study on this subject - Marked by dicarboxylic aciduria - During viral illness, stress hormones cause release of FA. - Salicylic acid (aspirin) binds carriers for these FA's (carnitine/CoA) - Build up of FA in mitochondria due to lack of carriers can lead to the dissolution of mitochondrial membranes and can even lead to cell destruction - Hexanoyglycine is the big marker for detection of this disease - Hexanogylcine results from glycine conjugation in an amide conjugation with the free fatty acid - Any questions, please ask I will try to check this later. —Preceding unsigned comment added by 66.49.47.34 ( talk) 20:22, 23 November 2009 (UTC)
For those that know the history, this passage fails to mention that around 300 children died unnecessarily in the U.S. because industry lobby groups fought long and hard for years against a warning label. This needs to be added to the article. Viriditas ( talk) 11:25, 13 August 2010 (UTC)
Starko submitted her paper to Lancet. It was rejected....Her results were subsequently tacked onto an MMWR summary article in July 1980...Four months later the MMWR followed up with verification...The following month, Starko's study was finally published in Pediatrics...In June the surgeon general issued an advisory and the FDA proposed a warning label on aspirin. The aspirin industry demanded more studies and successfully delayed a warning label on medication containing salicylates until 1986. From 1981 through 1985, more than 1,000 U.S. children contracted Reye's syndrome, with 291 deaths. Up to a third of the survivors probably suffered permanent brain damage...Reye's cases in the United States fell from a peak of 555 in 1980 to 36 in 1987, and finally to just 2 cases in 1997, by which time most children's medication no longer contained aspirin. [1]
{{
cite journal}}
: Unknown parameter |month=
ignored (
help)
Viriditas (
talk) 20:01, 13 August 2010 (UTC)
These External links are no more:
I tried searching the sites for displacement addresses, but just couldn't find them. I don't know what the editors had in mind when choosing these links, but perhaps one of these sites could stand as a substitution:
National Institute of Neurological Disorders and Stroke
http://www.ninds.nih.gov/disorders/reyes_syndrome/reyes_syndrome.htm
MedlinePlus, U.S. National Library of Medicine, National Institutes of Health
http://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v%3Aproject=medlineplus&query=reye+syndrome
NIH Consensus Development Program, U.S. Department of Health and Human Services, National Institutes of Health
http://consensus.nih.gov/1981/1981ReyesSyndrome030html.htm
Yours, Wordreader ( talk) 03:40, 16 June 2012 (UTC)
Formally, in the USA in professional research circles, it's Reye-Johnson Syndrome.
However, the popular name has three variations across the 'Net and two can even occur within a single site. Creditable sites, too.
REYE Syndrome: FDA, PubMed Health, American Journal of Public Health article, Western Journal of Medicine article, American Liver Foundation, National Institutes of Health, Medline Plus, Centers for Disease Control, Department of Health & Human Services, American Medial Association
REYES Syndrome: Medline Plus
REYE'S Syndrome: National Reye's Syndrome Foundation, National Institute of Neurological Disorders and Stroke, Mayo Clinic, Western Journal of Medicine article, National Institutes of Health, Medline Plus, Centers for Disease Control, American Medial Association
For further information, these items give a history of the discovery and naming of the condition:
"Tale of Triumph on Every Aspirin Bottle", The New York Times http://partners.nytimes.com/library/national/science/051199sci-doctor-reyes.html
"Reye's Syndrome; Because You Need to Know" National Reye's Syndrome Foundation, Inc. http://nrsfpublishing.org/sampler/sampler_RS_BYNTK.pdf
"REYE SYNDROME: The Decline of a Disease", Department of Health and Human Services, Public Health Service, Food and Drug Administration http://www.web-pub.com/library/brochure/reye-syd.html
All the best, Wordreader ( talk) 05:25, 16 June 2012 (UTC)
The page mentions treatment, but says nothing about what it is... TREKphiler any time you're ready, Uhura 20:36, 7 October 2015 (UTC)
The first para states it is a rapidly progressing encephalopathy - through 5 stages to death - yet only 30% prove fatal - says early diagnosis is helpful but gives no treatment - so what stops the progression? -- Iztwoz ( talk) 08:48, 27 January 2017 (UTC)
Bibliography
{{
cite news}}
: CS1 maint: multiple names: authors list (
link){{
citation}}
: |author=
has generic name (
help)Please explain? Doc James ( talk · contribs · email) 13:14, 9 May 2018 (UTC)
This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||
|
Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Reye syndrome.
|
There's a statement about the possibility that acetaminophen is a larger risk factor than aspirin. Normally, I would add a "citation needed" but there is a citation -- to an article that does not make that claim in the first place. I'm not sure what the right way is to clean this up.
The article claims that 1% of cases are correlated with aspirin consumption, only 1% of aspirin sales are for pediatric use, acetaminophen is the predominant pediatric medicine, and 6% of cases correlate with acetaminophen use. Although the article doesn't say what percentage of patients use acetaminophen overall, and the implication is that it's well over 6% (thus making the correlation with acetaminophen lower than with aspirin), it simply doesn't say one way or the other. I'm not trying to debate whether there's a link between either or neither of these, but there's no citation here. The article says nothing and implies nothing about the percentage of patients with and without the syndrome who use aspirin vs acetaminophen. Hagrinas ( talk) 15:51, 21 March 2012 (UTC)
During my recovery from the flu, I've been applying salicylic acid topically as an acne medication. Yesterday, I had nausea, and two days ago, I threw up. At first I thought that these were only symptoms of the flu, but now that I've learned the link between sal. acid and Reye's syndrome, I think I might have it. Is there a 100% certainty? I mean, if you take salicylic acid while recovering from the flu, you WILL get Reye's syndrome?
First of all, there are five stages, not two. Also, the symptoms are vague and nonspecific. I'll get this section cleaned up in a jiffity when I have time. Right now is not a good time, at least not for me. Freddie 00:00, 17 March 2006 (UTC)
When I was a student at a tertiary neuroological centre, I was taught that Reye's syndrome is one of a family of mitochondrial diseases (mitochondropathies), which explains its multi-system nature and its predominant effects on liver and brain. Unfortunately this now lies well outside my field of expertise. Anyone elucidate? Thanks. Preacherdoc 13:57, 26 July 2006 (UTC)
I've noticed that bottles of Pepto and its generic versions contain a warning about possibly causing Reye's Syndrome. Shouldn't this get a mention as well? BioTube 18:27, 9 September 2006 (UTC)
Although I agree that there's no need to mention Pepto Bismol specifically, the article mentions aspirin as a possible cause rather than listing salicylates as a possible cause with aspirin as an example. Mentioning Pepto Bismol doesn't seem to be the appropriate way to rectify anything, but if there's a possible link to salicylates in general, mentioning Pepto Bismol makes no less sense than mentioning fruit. Before the era of perfect looking fruit in the supermarkets, bruised, irregular, or fruit with scars was a more regular part of the human diet. Salicylates were consumed at a higher level and are still consumed to a degree by those who never take medicine because plants form salicylates naturally as a reaction to that sort of damage. I don't see any reason to mention anything with salicylates aside from aspirin unless there's a citation somebody can give showing a possible link rather than a warning label. Warning labels exist due to the correlation between lawsuits and the lack of warning labels. Hagrinas ( talk) 16:11, 21 March 2012 (UTC)
Currently, this symptom has links to fat and liver. Would it not be more logical for it to have a link to fatty liver, or is the fat in the liver caused by Reye's Syndrome not the same as fatty liver? -- PBurns 22:17, 9 October 2006 (UTC)
The current wikipedia entry for Reye syndrome is biased against aspirin as a potential risk factor, and this view seems to contradict the prevailing consensus of the scientific community on the subject. As a result, the entry has poor credibility, and should be edited.
How is the disease treated? Is the coma reversible? Jack Daw 18:45, 3 December 2006 (UTC)
I'm also curious as to how this is treated. This article doesn't even address it. Can this disease be treated? If so, what is most effective in treating it? -- T H L 07:56, 21 December 2006 (UTC)
Agreed - the intro paragraph states that early diagnosis is critical, and that "with support" the prognosis is good. This begs the question, what "support" or other treatment is given to so vitally impact the outcome? — Preceding unsigned comment added by 76.88.95.56 ( talk) 22:17, 3 November 2012 (UTC)
This page is partially a copyvio, but much content is original (e.g. by myself). Would not support deletion. JFW | T@lk 14:48, 20 February 2007 (UTC)
- Someone please use these facts (as taught to us in medical biochemistry) to update the page - See 1983 study on this subject - Marked by dicarboxylic aciduria - During viral illness, stress hormones cause release of FA. - Salicylic acid (aspirin) binds carriers for these FA's (carnitine/CoA) - Build up of FA in mitochondria due to lack of carriers can lead to the dissolution of mitochondrial membranes and can even lead to cell destruction - Hexanoyglycine is the big marker for detection of this disease - Hexanogylcine results from glycine conjugation in an amide conjugation with the free fatty acid - Any questions, please ask I will try to check this later. —Preceding unsigned comment added by 66.49.47.34 ( talk) 20:22, 23 November 2009 (UTC)
For those that know the history, this passage fails to mention that around 300 children died unnecessarily in the U.S. because industry lobby groups fought long and hard for years against a warning label. This needs to be added to the article. Viriditas ( talk) 11:25, 13 August 2010 (UTC)
Starko submitted her paper to Lancet. It was rejected....Her results were subsequently tacked onto an MMWR summary article in July 1980...Four months later the MMWR followed up with verification...The following month, Starko's study was finally published in Pediatrics...In June the surgeon general issued an advisory and the FDA proposed a warning label on aspirin. The aspirin industry demanded more studies and successfully delayed a warning label on medication containing salicylates until 1986. From 1981 through 1985, more than 1,000 U.S. children contracted Reye's syndrome, with 291 deaths. Up to a third of the survivors probably suffered permanent brain damage...Reye's cases in the United States fell from a peak of 555 in 1980 to 36 in 1987, and finally to just 2 cases in 1997, by which time most children's medication no longer contained aspirin. [1]
{{
cite journal}}
: Unknown parameter |month=
ignored (
help)
Viriditas (
talk) 20:01, 13 August 2010 (UTC)
These External links are no more:
I tried searching the sites for displacement addresses, but just couldn't find them. I don't know what the editors had in mind when choosing these links, but perhaps one of these sites could stand as a substitution:
National Institute of Neurological Disorders and Stroke
http://www.ninds.nih.gov/disorders/reyes_syndrome/reyes_syndrome.htm
MedlinePlus, U.S. National Library of Medicine, National Institutes of Health
http://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v%3Aproject=medlineplus&query=reye+syndrome
NIH Consensus Development Program, U.S. Department of Health and Human Services, National Institutes of Health
http://consensus.nih.gov/1981/1981ReyesSyndrome030html.htm
Yours, Wordreader ( talk) 03:40, 16 June 2012 (UTC)
Formally, in the USA in professional research circles, it's Reye-Johnson Syndrome.
However, the popular name has three variations across the 'Net and two can even occur within a single site. Creditable sites, too.
REYE Syndrome: FDA, PubMed Health, American Journal of Public Health article, Western Journal of Medicine article, American Liver Foundation, National Institutes of Health, Medline Plus, Centers for Disease Control, Department of Health & Human Services, American Medial Association
REYES Syndrome: Medline Plus
REYE'S Syndrome: National Reye's Syndrome Foundation, National Institute of Neurological Disorders and Stroke, Mayo Clinic, Western Journal of Medicine article, National Institutes of Health, Medline Plus, Centers for Disease Control, American Medial Association
For further information, these items give a history of the discovery and naming of the condition:
"Tale of Triumph on Every Aspirin Bottle", The New York Times http://partners.nytimes.com/library/national/science/051199sci-doctor-reyes.html
"Reye's Syndrome; Because You Need to Know" National Reye's Syndrome Foundation, Inc. http://nrsfpublishing.org/sampler/sampler_RS_BYNTK.pdf
"REYE SYNDROME: The Decline of a Disease", Department of Health and Human Services, Public Health Service, Food and Drug Administration http://www.web-pub.com/library/brochure/reye-syd.html
All the best, Wordreader ( talk) 05:25, 16 June 2012 (UTC)
The page mentions treatment, but says nothing about what it is... TREKphiler any time you're ready, Uhura 20:36, 7 October 2015 (UTC)
The first para states it is a rapidly progressing encephalopathy - through 5 stages to death - yet only 30% prove fatal - says early diagnosis is helpful but gives no treatment - so what stops the progression? -- Iztwoz ( talk) 08:48, 27 January 2017 (UTC)
Bibliography
{{
cite news}}
: CS1 maint: multiple names: authors list (
link){{
citation}}
: |author=
has generic name (
help)Please explain? Doc James ( talk · contribs · email) 13:14, 9 May 2018 (UTC)