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The interstitium of individual organs has been discussed as a fluid space or extracellular compartment since the 1950s-70s, with numerous reviews included among these abstracts and titles. The 2018 report here is not a "discovery" of a new organ, but discusses a microscopic subcompartment that is part of the general interstitium. The news reports reflect public ignorance of what physiologists and medical students have known for > 50 years. Reverting the current article description as misleading per WP:BRD and WP:RECENTISM -- Zefr ( talk) 20:19, 2 April 2018 (UTC)
In sum, we describe the anatomy and histology of a previously unrecognized, though widespread, macroscopic, fluid-filled space within and between tissues, a novel expansion and specification of the concept of the human interstitium.
Removed from the article until WP:CON merits it to be included in the article.
:In 2018, new research claimed to have found evidence that the interstitium was a previously-undiscovered organ, and that it had not been previously recognised due to sample-preparation techniques which are now known to collapse the structure of the interstitium. [1] [2] [3]
- However, while these claims did receive much attention from the scientific community, some scientists expressed doubt about the accuracy of these claims, while still acknowledging the claims as significant. [4] [5] In the words of one scientist at University of Texas:
"It is fair to say that histologists [and] pathologists have long known that there is an interstitial space and that it contains fluid. The claim that it is a hitherto undiscovered organ, and the largest one ever at that, seems a stretch.” [6]
- Similarly, a scientist from Yale School of Medicine said:
"I would think of this as a new component that is common among a variety of organs, rather than a new organ in and of itself. It would be analogous to discovering blood vessels for the first time, in that they are in every organ but they aren't an organ themselves." [7]
- The interstitium was identified using confocal laser endomicroscopy and fluroscein injection of bile duct tissue. [1] A microscopic subcompartment of the interstitial space, having a depth of 60–70 micrometres (0.0024–0.0028 in) and filled with lymph, was reported as draining into lymph nodes, and was structurally supported by a network of collagen. [2]
References
- ^ Interstitium: New organ discovered in human body after it was previously missed by scientists,by Josh Gabbatiss, March 28, 2018.
- ^ Overlooked 'organ' could play role in cancer spread, March 31, 2018 .
- ^ Meet Your Interstitium, a Newfound "Organ", By Rachael Rettner, LiveScience on March 27, 2018.
- ^ The Interstitium Is Important, But Don't Call It An Organ (Yet), by Nathaniel Scharping | March 28, 2018
- ^ Newfound 'organ' could be the biggest in your body, Jacqueline Howard, CNN March 31, 2018.
- ^ Is the Interstitium Really a New Organ?, By Abby Olena, The Scientist, March 28, 2018.
- ^ [ https://newatlas.com/interstitium-new-organ-discovery/53981/ Did scientists really just discover a new organ in the human body? by Rich Haridy, March 27th, 2018
'Deleted' at 17:32, 26 April 2018 by Zefr (talk | contribs) . . (5,830 bytes) (-908) . . (→Research: theory, conjecture; not a WP:MEDRS source). On investigation I could not find peer-reviewed publication either, however this has been newsworthy in early 2018, so, for the (non orthodox medical) record here is the offending sub-paragraph (but with relevant emphasis added):
Dr. Neil Theise, a professor of pathology working with the departments of pathology and of medicine at the Beth Israel Medical Center of the Albert Einstein College of Medicine, in New York 'proposes the interstitum be considered an organ in its own right'. [1]
This [hypothesis] is based on the 'rejection of the conventional cell-based medical model' in favour of a mathematical principle of self-organizing complexity. He cites several ancient medical concepts in support of this perspective. [2]
'Note:' While orthodoxy does provide stability, new ideas are appropriate to human evolution and so also Wikipedia (if it is to be of any use to future generations). After all, it took orthodox medicine two millennial to accept that Bloodletting was a bad idea.
So maybe WP:MEDRS source should not rigorously eliminate controversial ideas from decent (if not actually peer reviewed) sources, as it appears to do now? Timpo ( talk) 07:55, 28 April 2018 (UTC)
References
Not all interstitiums fit the definition in the introduction. For instance, the interstitium of the testis is not a "fluid-filled space existing between the skin and the body organs." Skingski ( talk) 18:47, 19 July 2018 (UTC)
This article was the subject of a Wiki Education Foundation-supported course assignment, between 9 January 2024 and 17 April 2024. Further details are available on the course page. Student editor(s): EnvrSci ( article contribs).
— Assignment last updated by EnvrSci ( talk) 18:11, 15 March 2024 (UTC)
In response to Morganfitzp ( talk) 05:43, 19 November 2023 (UTC) and Curran919 ( talk) 13:06, 21 December 2023 (UTC) following WP:GF and WP:BOLD, I added the History section to address the Theise discovery in 2018 now that it has been six years since publication while still conveying uncertainty surrounding the findings. Hoping this is a start to moving this topic out of the talk page, and open to feedback & changes. EnvrSci ( talk) 20:55, 22 April 2024 (UTC)
This article is rated Start-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||||||
|
The interstitium of individual organs has been discussed as a fluid space or extracellular compartment since the 1950s-70s, with numerous reviews included among these abstracts and titles. The 2018 report here is not a "discovery" of a new organ, but discusses a microscopic subcompartment that is part of the general interstitium. The news reports reflect public ignorance of what physiologists and medical students have known for > 50 years. Reverting the current article description as misleading per WP:BRD and WP:RECENTISM -- Zefr ( talk) 20:19, 2 April 2018 (UTC)
In sum, we describe the anatomy and histology of a previously unrecognized, though widespread, macroscopic, fluid-filled space within and between tissues, a novel expansion and specification of the concept of the human interstitium.
Removed from the article until WP:CON merits it to be included in the article.
:In 2018, new research claimed to have found evidence that the interstitium was a previously-undiscovered organ, and that it had not been previously recognised due to sample-preparation techniques which are now known to collapse the structure of the interstitium. [1] [2] [3]
- However, while these claims did receive much attention from the scientific community, some scientists expressed doubt about the accuracy of these claims, while still acknowledging the claims as significant. [4] [5] In the words of one scientist at University of Texas:
"It is fair to say that histologists [and] pathologists have long known that there is an interstitial space and that it contains fluid. The claim that it is a hitherto undiscovered organ, and the largest one ever at that, seems a stretch.” [6]
- Similarly, a scientist from Yale School of Medicine said:
"I would think of this as a new component that is common among a variety of organs, rather than a new organ in and of itself. It would be analogous to discovering blood vessels for the first time, in that they are in every organ but they aren't an organ themselves." [7]
- The interstitium was identified using confocal laser endomicroscopy and fluroscein injection of bile duct tissue. [1] A microscopic subcompartment of the interstitial space, having a depth of 60–70 micrometres (0.0024–0.0028 in) and filled with lymph, was reported as draining into lymph nodes, and was structurally supported by a network of collagen. [2]
References
- ^ Interstitium: New organ discovered in human body after it was previously missed by scientists,by Josh Gabbatiss, March 28, 2018.
- ^ Overlooked 'organ' could play role in cancer spread, March 31, 2018 .
- ^ Meet Your Interstitium, a Newfound "Organ", By Rachael Rettner, LiveScience on March 27, 2018.
- ^ The Interstitium Is Important, But Don't Call It An Organ (Yet), by Nathaniel Scharping | March 28, 2018
- ^ Newfound 'organ' could be the biggest in your body, Jacqueline Howard, CNN March 31, 2018.
- ^ Is the Interstitium Really a New Organ?, By Abby Olena, The Scientist, March 28, 2018.
- ^ [ https://newatlas.com/interstitium-new-organ-discovery/53981/ Did scientists really just discover a new organ in the human body? by Rich Haridy, March 27th, 2018
'Deleted' at 17:32, 26 April 2018 by Zefr (talk | contribs) . . (5,830 bytes) (-908) . . (→Research: theory, conjecture; not a WP:MEDRS source). On investigation I could not find peer-reviewed publication either, however this has been newsworthy in early 2018, so, for the (non orthodox medical) record here is the offending sub-paragraph (but with relevant emphasis added):
Dr. Neil Theise, a professor of pathology working with the departments of pathology and of medicine at the Beth Israel Medical Center of the Albert Einstein College of Medicine, in New York 'proposes the interstitum be considered an organ in its own right'. [1]
This [hypothesis] is based on the 'rejection of the conventional cell-based medical model' in favour of a mathematical principle of self-organizing complexity. He cites several ancient medical concepts in support of this perspective. [2]
'Note:' While orthodoxy does provide stability, new ideas are appropriate to human evolution and so also Wikipedia (if it is to be of any use to future generations). After all, it took orthodox medicine two millennial to accept that Bloodletting was a bad idea.
So maybe WP:MEDRS source should not rigorously eliminate controversial ideas from decent (if not actually peer reviewed) sources, as it appears to do now? Timpo ( talk) 07:55, 28 April 2018 (UTC)
References
Not all interstitiums fit the definition in the introduction. For instance, the interstitium of the testis is not a "fluid-filled space existing between the skin and the body organs." Skingski ( talk) 18:47, 19 July 2018 (UTC)
This article was the subject of a Wiki Education Foundation-supported course assignment, between 9 January 2024 and 17 April 2024. Further details are available on the course page. Student editor(s): EnvrSci ( article contribs).
— Assignment last updated by EnvrSci ( talk) 18:11, 15 March 2024 (UTC)
In response to Morganfitzp ( talk) 05:43, 19 November 2023 (UTC) and Curran919 ( talk) 13:06, 21 December 2023 (UTC) following WP:GF and WP:BOLD, I added the History section to address the Theise discovery in 2018 now that it has been six years since publication while still conveying uncertainty surrounding the findings. Hoping this is a start to moving this topic out of the talk page, and open to feedback & changes. EnvrSci ( talk) 20:55, 22 April 2024 (UTC)