Histamine N-methyltransferase was nominated as a Natural sciences good article, but it did not meet the good article criteria at the time (April 15, 2021). There are suggestions on the review page for improving the article. If you can improve it, please do; it may then be renominated. |
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Histamine N-methyltransferase has been listed as one of the
Natural sciences good articles under the
good article criteria. If you can improve it further,
please do so. If it no longer meets these criteria, you can
reassess it. Review: March 26, 2024. ( Reviewed version). |
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Reviewer: Esculenta ( talk · contribs) 15:29, 9 April 2021 (UTC)
Hi, I'll review this article. I'll need a day (or few) to post a full review, but on first glance I notice that the article is missing historical background, i.e., who discovered the enzyme, when, why, etc. Also missing is any information about the enzyme structure. How big is it? Is it made of subunits? What is the nature of its active site, etc., etc. These aspects will have to be added to the article for it to meet WIAGA criteria 3a ("it addresses the main aspects of the topic"). There's 1000's of hits for this topic on Google Scholar, including several review articles published in the past years that haven't been used as sources, so it shouldn't be difficult to find this kind of information. I see the article is listed as A-class, but I can't find a link to an A-class review ... could you kindly point me to that? Esculenta ( talk) 15:29, 9 April 2021 (UTC)
Ok, I read through the article and it seems to me like it is quite a ways from GA-standard.
For these reasons, I think the article needs quite a bit of work to meet the GA criteria, specifically criteria 1a, 3a, and 3b. I think this would be best worked on outside of the time contraints of the GA review, so I am closing this review, but hope to see it back at GAN after the issues above have been addressed. Esculenta ( talk) 16:34, 15 April 2021 (UTC)
@ Esculenta:Thank you very much! I will edit the page to address all the issues that you have described, and will then apply again. Thank you for your time and your carefully made, valuable observations! Maxim Masiutin ( talk) 20:37, 15 April 2021 (UTC)
the lead is too short and does not adequately summarize the article’s contents
the lead should briefly explain what histamine is and why it is important, which would help give context for the reader about the importance of the enzyme
the lead says MNMT is involved in histamine metabolism, which is of course true, but I get few hints from the article that it inactivates histamine - this should be more explicit
should link gene, chromosome 2
could we have a reaction equation somewhere in the article? see here for an example
first paragraph of “Function” needs a citation
”In brain of mammals histamine neurotransmitter activity is controlled by Nτ-methylation” please explain how neurotransmission is “controlled” by methylation
”As about the biologic species” not sure what this phrase adds, can it be left out?
”Whereas DAO metabolizes extracellular free histamine, be it either exogenous came with food or mostly endogenous released from granules of mast cells and basophils[8] as a result of allergic reactions, in view of the fact that DAO is mainly expressed in the cells of intestinal epithelium, HNMT is involved in metabolism of the persistently present intracellular primarily endogenous histamine, mainly in kidneys and liver, but also in bronchi, large intestine, ovary, prostate, spinal cord, spleen, trachea[9] and peripheral tissues.” This is a really long sentence that’s hard to parse and would benefit by being broken up.
”The most studied genetic variant is T allele at rs11558538 (c.314C>T, p.Thr105Ile),” where in the two cited sources does it support the assertion that it is “the most studied genetic variant”? The first source says it “has been the matter of several case–control association studies”, while I cannot find any such assertion in the second cited article.
The shorthand jargon (c.314C>T, p.Thr105Ile) is incomprehensible for the average reader and should be explained.
Also, the frequency of this allele should be mentioned (“occurring in an estimated 5 to 10% of the healthy Caucasian population” according to PMC5058861)
why is the website for the diagnostic testing company IMD Labor Berlin used as a source? Surely a neutral secondary source could be used to cite these basic facts.
”In a study of 48 adults, median enzyme activity was significantly lower in subjects with the CT or TT genotype than in those with the wild-type CC genotype (485 versus 631 U/mL of red blood cells).[13] In another study of 195 subjects, the C314T variant also showed an association with serum Interleukin-8 (IL-8) levels — individuals with the CT or TT genotype had lower levels of IL-8 (1.2 ± 0.7 versus 2.1) and higher levels of histamine (107.0 ± 53.9 versus 85.6 ± 45.7 ng/mL) in comparison with individuals with the CC genotype.” This is far too detailed for a Wikipedia article – the average reader doesn’t need to know the number of study participants, nor the experimentally determined concentrations (complete with standard deviations). Additionally, reference 13 is a pilot study (i.e. a primary study) from 2006, and shouldn’t even be used in an overview article like this (see WP:SCIRS)
per WP:SEEALSO, links already in the article shouldn’t be repeated here, so this could just be removed
any rationale for inclusion into the lengthy “Further reading” section? Some are older primary studies
Missing stuff:
Kinetic data comparing the standard form of the enzyme with the common Thr105 variant? (e.g. what is the difference in activities between standard and Thr105 variant?)
mention of the association with defective HNMT (i.e. SNPs) and Parkinson’s disease, ADHD, mood disorders, or decreased intellectual ability
mention of HNMT’s role in regulating the airway response (e.g. doi:10.1152/ajplung.1994.267.3.L342
research into use of HNMT as treatment for meth overdose doi:10.4137/DTI.S38342
there’s an image of HNMT’s structure in the infobox, so presumably this enzyme has been crystallized. When and by whom? Are there interesting aspects of its structure that have been revealed by this work? Does it have a structure consistent with other S-adenosyl-methionine-dependent methyltransferases (e.g. a standard AdoMet binding domain)?
only human HNMT is discussed in the article. Any info on this enzyme from other animals? Is it highly conserved? % amino acid identities?
has there been any work done with HMNT knockout mice?
methylhistamine is one of the products of the enzyme reaction; perhaps a few words could be said about its resulting pharmacologic activity … is it active at histamine receptors?
The GA feedback - not sure every point was covered nor if every point was ever super relevant - against the GA guidance.
Dr. BeingObjective ( talk) 01:06, 28 November 2023 (UTC)
I looked at the structure of the S21H article, I understood this likely follows a prescribed format? Perhaps I am mistaken - logically, I can see a flow that would be.
Lede/Overview - I think it is LEDE oddly -- Gene -- Protein -- Activity -- Pathologies -- History -- etc. I think the species/distribution are oddly placed -- IMHO -- the function/mechanism - is low in the article - clinical sig. -- but if this maps to some guidance - I understand it is a requirement.
I noted a lot of data in the infobox structure - I assume it is a template - and I stated - my molecular biology skills are like a decade or more out of date.
It might seem irrelevant but left to my own professional devices - I'd likely have gone for:
Lede/Summary -- History -- Gene Info. -- Protein Data -- Chemical Functionality/mechanism -- Distribution -- Clinical Sig.
About the degree of detail and target audience:
Just a few late night mumblings - BeingObjective ( talk) 07:22, 28 November 2023 (UTC)
In a monomodular structure, all of the genes are functional i.e. protein-coding, but if a module count is two or more, there is only one copy of each functional gene rest being non-coding pseudogenes with the exception of the C4 gene which always has active copies.
I think you stated you might have materials that express this section in a more diagrammatic way - it is text dense, an is arguably a very important section - I looked at the S21H activity area - and a lot of work was done to represent this schematically.
I need to understand the ways other articles work this section - the S21H is especially detailed, I am not totally convinced one has to be that intricate in every article about an enzyme - I guess it depends on the source materials available.
BeingObjective ( talk) 14:28, 28 November 2023 (UTC)
There seems a little concern on what should be in the lede of this article based on the aforementioned GA review.
I think it worth capturing on the article talk page - the original dialog was on my talk page and will get lost in time.
Guidance states 'most' content - I think there is merit in not be too literal, in the following circumstance.
Cheers -
BeingObjective ( talk) 16:56, 28 November 2023 (UTC)
HNMT inactivates histamine by transferring a methyl group from S-adenosyl-L-methionine (AdoMet) to the Nε2 atom of the imidazole ring, yielding methylhistamine and S-adenosyl-L-homocysteine (AdoHcy).
According to
Wikipedia:Image use policy: Wikipedia encourages users to upload their own images.
The providence of images uploaded to Wikimedia commons is clear when the "created myself" option is used. Using figures downloaded from the web would require a Wikipedia compatible license which is often difficult to find. Also a lot of what is available on the web is low quality. At the same time, it is important to include a source (preferably secondary or tertiary) that confirms what is in the image is accurate. For the reaction catalyzed by histamine N-methyltransferase, one could use
KEGG whose layout closely resembles
File:HNMT-methylation-of-histamine.svg.
[1]
Boghog (
talk) 04:36, 29 November 2023 (UTC)
References
@ BeingObjective, @ Boghog Can you help me with chemistry? There is a ting that I don't fully understand. In chemistry, a curved (curly) single-headed arrow is used to depict the movement of a single electron from one place to another, either in resonance or in a mechanism. However, in a hystamine methylation, curly arrow on the sources I given (via PMIDs) is from SAMe to SAH. There also a hydrogen atom relesed, but it is not shown on reaction. However, I couldn't find any specific information about the use of a curved arrow to distinguish a cosubstrate transformation from the main substrate transformation. Does the electron move from SAMe to SAH in this reaction? Maxim Masiutin ( talk) 15:15, 29 November 2023 (UTC)
The following discussion is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.
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Nominator: Maxim Masiutin ( talk · contribs)
Reviewer: Sammi Brie ( talk · contribs) 22:25, 23 March 2024 (UTC)
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Some reference issues. Britannica needs to be excised, and I need some explanation on the blood serum line. I also want to see Esculenta's comments if they materialize soon. Ping me when done; I may still hold for Esculenta to determine if the issues from GA1 still linger. Sammi Brie (she/her • t • c) 02:26, 24 March 2024 (UTC)
Did you know? If you fancy doing so, I always have plenty of GA nominees to review. Just look for the all-uppercase titles in the Television section. Reviews always appreciated.
I also saw that Esculenta was previously requested to provide feedback on this article at some point. Feel free to join in. Sammi Brie (she/her • t • c) 01:53, 24 March 2024 (UTC)
The DAO protein is stored in plasma membrane-associated vesicular structures in epithelial cells of kidney and intestine and is secreted into the circulation upon stimulation ... The highest expression of DAO has been observed in the intestine, kidney and placenta
Since the key metaboliteNτ-methylhistamine, like all other metabolites, is inactive at the different members of the histamine receptor family
The visualization is published under CC-BY license, as is the methylation diagram. Encouragement: Consider alt text, probably "Refer to caption", for the latter.
User:Sammi Brie, there is a convention for the molecular biology articles ( Wikipedia:WikiProject_Molecular_Biology/Style_guide_(gene_and_protein_articles)) that human genes should have all characters capitalized whereas other species genes should only have the first letter capitalized, referring to gene nomenclature that is followed by peer-reviewed articles. Maxim Masiutin ( talk) 14:04, 24 March 2024 (UTC)
User:Sammi Brie, on December 1st, 2023, I asked User:Esculenta to review the article again, just for your information. [1] Maxim Masiutin ( talk) 17:56, 24 March 2024 (UTC)
Maxim Masiutin ( talk) 17:56, 24 March 2024 (UTC)
Maxim Masiutin ( talk) 17:56, 24 March 2024 (UTC)
Maxim Masiutin ( talk) 17:56, 24 March 2024 (UTC)
Maxim Masiutin ( talk) 17:56, 24 March 2024 (UTC)
Maxim Masiutin ( talk) 22:14, 24 March 2024 (UTC)
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.; P50135-2
Note Has no histamine-methylating activity.; P50135-3 Nothing is mentioned about histamine-methylating activity. My understanding is that only the P50135-1 has histamine-methylating activity, while P50135-2 and P50135-3 have no histamine-methylating activity. UniProt is vague, but at least it does not contradict to the information presented in the article, because UniProt mentions that at least one isoform does not have histamine-methylating activity, while the article mentions that only one isoform has histamine-methylating activity citing a source that explicitly mentions that.
Extracellular fluid is distributed in two major sub-compartments: interstitial fluid and plasmaand I also found specific articles that mention that DAO exists in specifically interstitial fluid and specifically in plasma, I added those references.
Maxim Masiutin ( talk) 22:14, 24 March 2024 (UTC)
TBD
No issues with images: no need to reply. Sammi Brie (she/her • t • c) 18:27, 24 March 2024 (UTC)
<img alt="Histamine inactivation by HNMT" src=
.@ Sammi Brie - I have a follow-up question. You wrote that Britannica is not a good source. Can you please provide the reasoning for that? Thank you! Maxim Masiutin ( talk) 16:10, 28 March 2024 (UTC)
This subsection is transcluded from Template:Did you know nominations/Histamine N-methyltransferase.
The result was: promoted by
AirshipJungleman29
talk 21:13, 21 April 2024 (UTC)
Number of QPQs required: 0. Nominator has less than 5 past nominations.
Post-promotion hook changes will be logged on the talk page; consider watching the nomination until the hook appears on the Main Page.Maxim Masiutin ( talk) 21:15, 28 March 2024 (UTC).
ALT1 could perhaps be streamlined a bit more to "... plays a crucial role in sleep-wake cycles as the only histamine-metabolizing enzyme in the human central nervous system?" JoelleJay ( talk) 06:05, 7 April 2024 (UTC)
Regarding the new sources, I would definitely advise against citing Scientific Reports or Frontiers for this, especially the former as it is also a primary source. Per MEDRS we should reflect what secondary review sources say on a topic, and I think for statements made in wikivoice in a high-profile venue we need much more reputable sources than Sci Rep and Frontiers. They can still be used in the article, but ought to be accompanied by additional supporting sources. This Physiological Reviews article could serve as a replacement for the claim that it's the only neuronal enzyme degrading histamine, while this Sleep review touches on HNMT's role in aggression and indirectly on sleep. The Handbook cited in ALT4 also works for all of these claims (though a lot of the HNMT info is just the authors reviewing their own work; not necessarily a problem, but something to keep in mind). Note that the first two state it is acting in the extracellular space, which is in contrast to the mechanism put forth in the last. Regarding ALT4, this could easily be read as "HNMT is the only enzyme in the brain that maintains arousal and sleep functions, which it does by degrading histamine", which is incorrect, rather than "HNMT is the only histamine-metabolizing enzyme in the brain, AND its activity helps maintain arousal and sleep functions". JoelleJay ( talk) 16:46, 7 April 2024 (UTC)
Please give me one day to address current issue raised. I wanted to resolve them yesterday, but didn't manage to do that, sorry for the delayed answer, just give me one day please. Maxim Masiutin ( talk) 07:16, 16 April 2024 (UTC)
There are no articles in predatory journals cited in
HNMT. If you could point a particular cite, please let me know ASAP. By predatory journals I mean journals listed at least one of the following: (1)
Template:Predatory open access source list; (2)
Wikipedia:Potentially unreliable sources. The script
User:Headbomb/unreliable.js uses yellow background for the sources that this script considers "borderline", i.e. as defined by
[2] is "situated at or near a border", but in a good set, i.e. is compliant to
WP:MEDRS. Still, if there are a few source that raise your concern, I can address them one-by-one, but I don't think that finding alternative sources for all MDPI articles is appropriate just because the script considers them "borderline". The Wikipedia article
MDPI mentions: MDPI was included on Jeffrey Beall's list of predatory open access publishing companies in 2014[25][26] but was removed in 2015 following a successful appeal[23][25] while applying pressure on Beall's employer.[27] Some journals published by MDPI have also been noted by the Chinese Academy of Sciences and Norwegian Scientific Index for lack of rigor and possible predatory practices.[28][29][30]
This Wikipedia article has a detailed discussion on what MDPI is, but it is in no way currently predatory.
Maxim Masiutin (
talk) 20:35, 18 April 2024 (UTC)
Hello, User:AstonishingTunesAdmirer, User:AryKun, User:David Eppstein, I followed your suggestions at https://en.wikipedia.org/?title=Wikipedia_talk:Good_article_nominations&oldid=1217067219#Hard-to-understand_terms_in_the_lead and replaced uncommon terms in the lead and in the body that you pointed out. Can you please provide your feedback on the following changes:
See https://en.wikipedia.org/?title=Histamine_N-methyltransferase&diff=1217089317&oldid=1215724083
Maxim Masiutin ( talk) 18:59, 3 April 2024 (UTC)
Hello, @ Boghog! Can you please help with editing this article by replacing all instances first#/last# to vauthors? Thank you in advance! Maxim Masiutin ( talk) 08:06, 20 April 2024 (UTC)
Histamine N-methyltransferase was nominated as a Natural sciences good article, but it did not meet the good article criteria at the time (April 15, 2021). There are suggestions on the review page for improving the article. If you can improve it, please do; it may then be renominated. |
This article is rated GA-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||||
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This is the
talk page for discussing improvements to the
Histamine N-methyltransferase article. This is not a forum for general discussion of the article's subject. |
Article policies
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Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL |
Histamine N-methyltransferase has been listed as one of the
Natural sciences good articles under the
good article criteria. If you can improve it further,
please do so. If it no longer meets these criteria, you can
reassess it. Review: March 26, 2024. ( Reviewed version). |
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Reviewing |
Reviewer: Esculenta ( talk · contribs) 15:29, 9 April 2021 (UTC)
Hi, I'll review this article. I'll need a day (or few) to post a full review, but on first glance I notice that the article is missing historical background, i.e., who discovered the enzyme, when, why, etc. Also missing is any information about the enzyme structure. How big is it? Is it made of subunits? What is the nature of its active site, etc., etc. These aspects will have to be added to the article for it to meet WIAGA criteria 3a ("it addresses the main aspects of the topic"). There's 1000's of hits for this topic on Google Scholar, including several review articles published in the past years that haven't been used as sources, so it shouldn't be difficult to find this kind of information. I see the article is listed as A-class, but I can't find a link to an A-class review ... could you kindly point me to that? Esculenta ( talk) 15:29, 9 April 2021 (UTC)
Ok, I read through the article and it seems to me like it is quite a ways from GA-standard.
For these reasons, I think the article needs quite a bit of work to meet the GA criteria, specifically criteria 1a, 3a, and 3b. I think this would be best worked on outside of the time contraints of the GA review, so I am closing this review, but hope to see it back at GAN after the issues above have been addressed. Esculenta ( talk) 16:34, 15 April 2021 (UTC)
@ Esculenta:Thank you very much! I will edit the page to address all the issues that you have described, and will then apply again. Thank you for your time and your carefully made, valuable observations! Maxim Masiutin ( talk) 20:37, 15 April 2021 (UTC)
the lead is too short and does not adequately summarize the article’s contents
the lead should briefly explain what histamine is and why it is important, which would help give context for the reader about the importance of the enzyme
the lead says MNMT is involved in histamine metabolism, which is of course true, but I get few hints from the article that it inactivates histamine - this should be more explicit
should link gene, chromosome 2
could we have a reaction equation somewhere in the article? see here for an example
first paragraph of “Function” needs a citation
”In brain of mammals histamine neurotransmitter activity is controlled by Nτ-methylation” please explain how neurotransmission is “controlled” by methylation
”As about the biologic species” not sure what this phrase adds, can it be left out?
”Whereas DAO metabolizes extracellular free histamine, be it either exogenous came with food or mostly endogenous released from granules of mast cells and basophils[8] as a result of allergic reactions, in view of the fact that DAO is mainly expressed in the cells of intestinal epithelium, HNMT is involved in metabolism of the persistently present intracellular primarily endogenous histamine, mainly in kidneys and liver, but also in bronchi, large intestine, ovary, prostate, spinal cord, spleen, trachea[9] and peripheral tissues.” This is a really long sentence that’s hard to parse and would benefit by being broken up.
”The most studied genetic variant is T allele at rs11558538 (c.314C>T, p.Thr105Ile),” where in the two cited sources does it support the assertion that it is “the most studied genetic variant”? The first source says it “has been the matter of several case–control association studies”, while I cannot find any such assertion in the second cited article.
The shorthand jargon (c.314C>T, p.Thr105Ile) is incomprehensible for the average reader and should be explained.
Also, the frequency of this allele should be mentioned (“occurring in an estimated 5 to 10% of the healthy Caucasian population” according to PMC5058861)
why is the website for the diagnostic testing company IMD Labor Berlin used as a source? Surely a neutral secondary source could be used to cite these basic facts.
”In a study of 48 adults, median enzyme activity was significantly lower in subjects with the CT or TT genotype than in those with the wild-type CC genotype (485 versus 631 U/mL of red blood cells).[13] In another study of 195 subjects, the C314T variant also showed an association with serum Interleukin-8 (IL-8) levels — individuals with the CT or TT genotype had lower levels of IL-8 (1.2 ± 0.7 versus 2.1) and higher levels of histamine (107.0 ± 53.9 versus 85.6 ± 45.7 ng/mL) in comparison with individuals with the CC genotype.” This is far too detailed for a Wikipedia article – the average reader doesn’t need to know the number of study participants, nor the experimentally determined concentrations (complete with standard deviations). Additionally, reference 13 is a pilot study (i.e. a primary study) from 2006, and shouldn’t even be used in an overview article like this (see WP:SCIRS)
per WP:SEEALSO, links already in the article shouldn’t be repeated here, so this could just be removed
any rationale for inclusion into the lengthy “Further reading” section? Some are older primary studies
Missing stuff:
Kinetic data comparing the standard form of the enzyme with the common Thr105 variant? (e.g. what is the difference in activities between standard and Thr105 variant?)
mention of the association with defective HNMT (i.e. SNPs) and Parkinson’s disease, ADHD, mood disorders, or decreased intellectual ability
mention of HNMT’s role in regulating the airway response (e.g. doi:10.1152/ajplung.1994.267.3.L342
research into use of HNMT as treatment for meth overdose doi:10.4137/DTI.S38342
there’s an image of HNMT’s structure in the infobox, so presumably this enzyme has been crystallized. When and by whom? Are there interesting aspects of its structure that have been revealed by this work? Does it have a structure consistent with other S-adenosyl-methionine-dependent methyltransferases (e.g. a standard AdoMet binding domain)?
only human HNMT is discussed in the article. Any info on this enzyme from other animals? Is it highly conserved? % amino acid identities?
has there been any work done with HMNT knockout mice?
methylhistamine is one of the products of the enzyme reaction; perhaps a few words could be said about its resulting pharmacologic activity … is it active at histamine receptors?
The GA feedback - not sure every point was covered nor if every point was ever super relevant - against the GA guidance.
Dr. BeingObjective ( talk) 01:06, 28 November 2023 (UTC)
I looked at the structure of the S21H article, I understood this likely follows a prescribed format? Perhaps I am mistaken - logically, I can see a flow that would be.
Lede/Overview - I think it is LEDE oddly -- Gene -- Protein -- Activity -- Pathologies -- History -- etc. I think the species/distribution are oddly placed -- IMHO -- the function/mechanism - is low in the article - clinical sig. -- but if this maps to some guidance - I understand it is a requirement.
I noted a lot of data in the infobox structure - I assume it is a template - and I stated - my molecular biology skills are like a decade or more out of date.
It might seem irrelevant but left to my own professional devices - I'd likely have gone for:
Lede/Summary -- History -- Gene Info. -- Protein Data -- Chemical Functionality/mechanism -- Distribution -- Clinical Sig.
About the degree of detail and target audience:
Just a few late night mumblings - BeingObjective ( talk) 07:22, 28 November 2023 (UTC)
In a monomodular structure, all of the genes are functional i.e. protein-coding, but if a module count is two or more, there is only one copy of each functional gene rest being non-coding pseudogenes with the exception of the C4 gene which always has active copies.
I think you stated you might have materials that express this section in a more diagrammatic way - it is text dense, an is arguably a very important section - I looked at the S21H activity area - and a lot of work was done to represent this schematically.
I need to understand the ways other articles work this section - the S21H is especially detailed, I am not totally convinced one has to be that intricate in every article about an enzyme - I guess it depends on the source materials available.
BeingObjective ( talk) 14:28, 28 November 2023 (UTC)
There seems a little concern on what should be in the lede of this article based on the aforementioned GA review.
I think it worth capturing on the article talk page - the original dialog was on my talk page and will get lost in time.
Guidance states 'most' content - I think there is merit in not be too literal, in the following circumstance.
Cheers -
BeingObjective ( talk) 16:56, 28 November 2023 (UTC)
HNMT inactivates histamine by transferring a methyl group from S-adenosyl-L-methionine (AdoMet) to the Nε2 atom of the imidazole ring, yielding methylhistamine and S-adenosyl-L-homocysteine (AdoHcy).
According to
Wikipedia:Image use policy: Wikipedia encourages users to upload their own images.
The providence of images uploaded to Wikimedia commons is clear when the "created myself" option is used. Using figures downloaded from the web would require a Wikipedia compatible license which is often difficult to find. Also a lot of what is available on the web is low quality. At the same time, it is important to include a source (preferably secondary or tertiary) that confirms what is in the image is accurate. For the reaction catalyzed by histamine N-methyltransferase, one could use
KEGG whose layout closely resembles
File:HNMT-methylation-of-histamine.svg.
[1]
Boghog (
talk) 04:36, 29 November 2023 (UTC)
References
@ BeingObjective, @ Boghog Can you help me with chemistry? There is a ting that I don't fully understand. In chemistry, a curved (curly) single-headed arrow is used to depict the movement of a single electron from one place to another, either in resonance or in a mechanism. However, in a hystamine methylation, curly arrow on the sources I given (via PMIDs) is from SAMe to SAH. There also a hydrogen atom relesed, but it is not shown on reaction. However, I couldn't find any specific information about the use of a curved arrow to distinguish a cosubstrate transformation from the main substrate transformation. Does the electron move from SAMe to SAH in this reaction? Maxim Masiutin ( talk) 15:15, 29 November 2023 (UTC)
The following discussion is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.
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Reviewing |
Nominator: Maxim Masiutin ( talk · contribs)
Reviewer: Sammi Brie ( talk · contribs) 22:25, 23 March 2024 (UTC)
GA review (see here for what the criteria are, and here for what they are not) |
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Overall: |
· · · |
Some reference issues. Britannica needs to be excised, and I need some explanation on the blood serum line. I also want to see Esculenta's comments if they materialize soon. Ping me when done; I may still hold for Esculenta to determine if the issues from GA1 still linger. Sammi Brie (she/her • t • c) 02:26, 24 March 2024 (UTC)
Did you know? If you fancy doing so, I always have plenty of GA nominees to review. Just look for the all-uppercase titles in the Television section. Reviews always appreciated.
I also saw that Esculenta was previously requested to provide feedback on this article at some point. Feel free to join in. Sammi Brie (she/her • t • c) 01:53, 24 March 2024 (UTC)
The DAO protein is stored in plasma membrane-associated vesicular structures in epithelial cells of kidney and intestine and is secreted into the circulation upon stimulation ... The highest expression of DAO has been observed in the intestine, kidney and placenta
Since the key metaboliteNτ-methylhistamine, like all other metabolites, is inactive at the different members of the histamine receptor family
The visualization is published under CC-BY license, as is the methylation diagram. Encouragement: Consider alt text, probably "Refer to caption", for the latter.
User:Sammi Brie, there is a convention for the molecular biology articles ( Wikipedia:WikiProject_Molecular_Biology/Style_guide_(gene_and_protein_articles)) that human genes should have all characters capitalized whereas other species genes should only have the first letter capitalized, referring to gene nomenclature that is followed by peer-reviewed articles. Maxim Masiutin ( talk) 14:04, 24 March 2024 (UTC)
User:Sammi Brie, on December 1st, 2023, I asked User:Esculenta to review the article again, just for your information. [1] Maxim Masiutin ( talk) 17:56, 24 March 2024 (UTC)
Maxim Masiutin ( talk) 17:56, 24 March 2024 (UTC)
Maxim Masiutin ( talk) 17:56, 24 March 2024 (UTC)
Maxim Masiutin ( talk) 17:56, 24 March 2024 (UTC)
Maxim Masiutin ( talk) 17:56, 24 March 2024 (UTC)
Maxim Masiutin ( talk) 22:14, 24 March 2024 (UTC)
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.; P50135-2
Note Has no histamine-methylating activity.; P50135-3 Nothing is mentioned about histamine-methylating activity. My understanding is that only the P50135-1 has histamine-methylating activity, while P50135-2 and P50135-3 have no histamine-methylating activity. UniProt is vague, but at least it does not contradict to the information presented in the article, because UniProt mentions that at least one isoform does not have histamine-methylating activity, while the article mentions that only one isoform has histamine-methylating activity citing a source that explicitly mentions that.
Extracellular fluid is distributed in two major sub-compartments: interstitial fluid and plasmaand I also found specific articles that mention that DAO exists in specifically interstitial fluid and specifically in plasma, I added those references.
Maxim Masiutin ( talk) 22:14, 24 March 2024 (UTC)
TBD
No issues with images: no need to reply. Sammi Brie (she/her • t • c) 18:27, 24 March 2024 (UTC)
<img alt="Histamine inactivation by HNMT" src=
.@ Sammi Brie - I have a follow-up question. You wrote that Britannica is not a good source. Can you please provide the reasoning for that? Thank you! Maxim Masiutin ( talk) 16:10, 28 March 2024 (UTC)
This subsection is transcluded from Template:Did you know nominations/Histamine N-methyltransferase.
The result was: promoted by
AirshipJungleman29
talk 21:13, 21 April 2024 (UTC)
Number of QPQs required: 0. Nominator has less than 5 past nominations.
Post-promotion hook changes will be logged on the talk page; consider watching the nomination until the hook appears on the Main Page.Maxim Masiutin ( talk) 21:15, 28 March 2024 (UTC).
ALT1 could perhaps be streamlined a bit more to "... plays a crucial role in sleep-wake cycles as the only histamine-metabolizing enzyme in the human central nervous system?" JoelleJay ( talk) 06:05, 7 April 2024 (UTC)
Regarding the new sources, I would definitely advise against citing Scientific Reports or Frontiers for this, especially the former as it is also a primary source. Per MEDRS we should reflect what secondary review sources say on a topic, and I think for statements made in wikivoice in a high-profile venue we need much more reputable sources than Sci Rep and Frontiers. They can still be used in the article, but ought to be accompanied by additional supporting sources. This Physiological Reviews article could serve as a replacement for the claim that it's the only neuronal enzyme degrading histamine, while this Sleep review touches on HNMT's role in aggression and indirectly on sleep. The Handbook cited in ALT4 also works for all of these claims (though a lot of the HNMT info is just the authors reviewing their own work; not necessarily a problem, but something to keep in mind). Note that the first two state it is acting in the extracellular space, which is in contrast to the mechanism put forth in the last. Regarding ALT4, this could easily be read as "HNMT is the only enzyme in the brain that maintains arousal and sleep functions, which it does by degrading histamine", which is incorrect, rather than "HNMT is the only histamine-metabolizing enzyme in the brain, AND its activity helps maintain arousal and sleep functions". JoelleJay ( talk) 16:46, 7 April 2024 (UTC)
Please give me one day to address current issue raised. I wanted to resolve them yesterday, but didn't manage to do that, sorry for the delayed answer, just give me one day please. Maxim Masiutin ( talk) 07:16, 16 April 2024 (UTC)
There are no articles in predatory journals cited in
HNMT. If you could point a particular cite, please let me know ASAP. By predatory journals I mean journals listed at least one of the following: (1)
Template:Predatory open access source list; (2)
Wikipedia:Potentially unreliable sources. The script
User:Headbomb/unreliable.js uses yellow background for the sources that this script considers "borderline", i.e. as defined by
[2] is "situated at or near a border", but in a good set, i.e. is compliant to
WP:MEDRS. Still, if there are a few source that raise your concern, I can address them one-by-one, but I don't think that finding alternative sources for all MDPI articles is appropriate just because the script considers them "borderline". The Wikipedia article
MDPI mentions: MDPI was included on Jeffrey Beall's list of predatory open access publishing companies in 2014[25][26] but was removed in 2015 following a successful appeal[23][25] while applying pressure on Beall's employer.[27] Some journals published by MDPI have also been noted by the Chinese Academy of Sciences and Norwegian Scientific Index for lack of rigor and possible predatory practices.[28][29][30]
This Wikipedia article has a detailed discussion on what MDPI is, but it is in no way currently predatory.
Maxim Masiutin (
talk) 20:35, 18 April 2024 (UTC)
Hello, User:AstonishingTunesAdmirer, User:AryKun, User:David Eppstein, I followed your suggestions at https://en.wikipedia.org/?title=Wikipedia_talk:Good_article_nominations&oldid=1217067219#Hard-to-understand_terms_in_the_lead and replaced uncommon terms in the lead and in the body that you pointed out. Can you please provide your feedback on the following changes:
See https://en.wikipedia.org/?title=Histamine_N-methyltransferase&diff=1217089317&oldid=1215724083
Maxim Masiutin ( talk) 18:59, 3 April 2024 (UTC)
Hello, @ Boghog! Can you please help with editing this article by replacing all instances first#/last# to vauthors? Thank you in advance! Maxim Masiutin ( talk) 08:06, 20 April 2024 (UTC)