This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||
|
Am I the only one who would prefer for this article to focus on specific medical effects instead of aimless ramblings about how this is such a great example of evolution in humans? 198,269.189.327 29:73, 13 May 2013
There are other articles on medical effects of altitude such as Altitude sickness. This article is devoted to a great evolution in humans, though I agree it may be edited to reduce ramblings...
Goulu ( talk • contribs) 09:58, 17 August 2014 (UTC)
Someone should probably update this to show that the Tibetan mutation is tens of thousands of years old. Demigord ( talk) 15:52, 1 September 2014 (UTC)
Two phrases seem incompatible to me :
Explanation ?
Goulu ( talk • contribs) 09:58, 17 August 2014 (UTC)
I agree that the two patterns of response - Tibetan and Andean - are different. And I agree that they are an elegant example of evolution in humans. However, the paragraph above requires some editing for accuracy. Here's a try.
BEGIN DRAFT Andean highlanders have elevated Hb concentration compared with lowland populations at low altitude. Andean highlanders' hemoglobin concentrations fall to low-altitude levels when they spend weeks or more at low altitude. That is, Andean highlanders exemplify reversible acclimatization for hemoglobin concentration.
Tibetan highlanders have significantly lower Hb than their Andean counterparts at similar altitudes. (see this cited paper) (& see this 17494744) Tibetan highlanders show little or no altitude related increase in hemoglobin concentration up to altitudes as high at 4200m . Alleles at the EPAS1 and EGLN1 loci that have uniquely high frequency in Tibetan highland populations associate with ~ 0.8 - 1.0m gm/dL lower hemoglobin concentration than that associated with the alleles common in lowland populations around the world 20534544, 21030426
Thus, the same stress of high-altitude hypoxia resulted in natural selection for different hematological adaptive responses in the two indigenous highland populations. END DRAFT
Sanetti ( talk) 21:34, 20 August 2014 (UTC)
Under the paragraph on Ethiopians it states "...are known to play a role in the HIF-1 pathway, a pathway implicated in previous work reported in Tibetan and Andean studies. This supports the concept that adaptation to high altitude arose independently among different highlanders as a result of convergent evolution." However, table 1 of this paper clearly shows that more haemoglobin is produced in the Andean populations and the epidemiology section of the wikipedia page for Chronic mountain sickness shows that Andeans are significantly more likely to have CMS. Both of these mean Andeans have a significantly more active HIF pathway, so there could not have been convergent evolution to have a less active HIF pathway amongst all groups as stated. If someone can explain to the contrary please do. -- Bliptuned ( talk) 19:18, 18 July 2020 (UTC)
This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||
|
Am I the only one who would prefer for this article to focus on specific medical effects instead of aimless ramblings about how this is such a great example of evolution in humans? 198,269.189.327 29:73, 13 May 2013
There are other articles on medical effects of altitude such as Altitude sickness. This article is devoted to a great evolution in humans, though I agree it may be edited to reduce ramblings...
Goulu ( talk • contribs) 09:58, 17 August 2014 (UTC)
Someone should probably update this to show that the Tibetan mutation is tens of thousands of years old. Demigord ( talk) 15:52, 1 September 2014 (UTC)
Two phrases seem incompatible to me :
Explanation ?
Goulu ( talk • contribs) 09:58, 17 August 2014 (UTC)
I agree that the two patterns of response - Tibetan and Andean - are different. And I agree that they are an elegant example of evolution in humans. However, the paragraph above requires some editing for accuracy. Here's a try.
BEGIN DRAFT Andean highlanders have elevated Hb concentration compared with lowland populations at low altitude. Andean highlanders' hemoglobin concentrations fall to low-altitude levels when they spend weeks or more at low altitude. That is, Andean highlanders exemplify reversible acclimatization for hemoglobin concentration.
Tibetan highlanders have significantly lower Hb than their Andean counterparts at similar altitudes. (see this cited paper) (& see this 17494744) Tibetan highlanders show little or no altitude related increase in hemoglobin concentration up to altitudes as high at 4200m . Alleles at the EPAS1 and EGLN1 loci that have uniquely high frequency in Tibetan highland populations associate with ~ 0.8 - 1.0m gm/dL lower hemoglobin concentration than that associated with the alleles common in lowland populations around the world 20534544, 21030426
Thus, the same stress of high-altitude hypoxia resulted in natural selection for different hematological adaptive responses in the two indigenous highland populations. END DRAFT
Sanetti ( talk) 21:34, 20 August 2014 (UTC)
Under the paragraph on Ethiopians it states "...are known to play a role in the HIF-1 pathway, a pathway implicated in previous work reported in Tibetan and Andean studies. This supports the concept that adaptation to high altitude arose independently among different highlanders as a result of convergent evolution." However, table 1 of this paper clearly shows that more haemoglobin is produced in the Andean populations and the epidemiology section of the wikipedia page for Chronic mountain sickness shows that Andeans are significantly more likely to have CMS. Both of these mean Andeans have a significantly more active HIF pathway, so there could not have been convergent evolution to have a less active HIF pathway amongst all groups as stated. If someone can explain to the contrary please do. -- Bliptuned ( talk) 19:18, 18 July 2020 (UTC)