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Joszi et. al have discussed (and it seems more likely) that FHR-1 isn't necessary for preventing aHUS so much as it is for developing FH tolerance. 50% of Nigerians lacks FHR3 and FHR1. Also, 21/24 IgG from that paper that are anti-FH will bind FHR1. Thus, it's likely they protect in mechanisms distinct from "Anti C5-convertase activity". — Preceding unsigned comment added by 129.96.87.45 ( talk) 07:46, 6 February 2020 (UTC) reply