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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901381/#:~:text=Vaccine-associated%20enhanced%20diseases%20(VAED,vaccination%20for%20the%20same%20pathogen. "1.4.3. Vaccine platforms Numerous vaccines are under evaluation for SARS-CoV-2 and other emerging pathogens [83]. These include well established vaccine constructs used in existing licensed vaccines (protein subunit, inactivated, virus-like particle, and replicating viral vectored vaccines), and new technologies (nucleic acid, DNA or mRNA-based vaccines) that allow for the rapid development of vaccine candidates [84]. Certain vaccines may be more appropriate for specific populations, such as the elderly, children and pregnant women, compared with healthy adults. The safety, immunogenicity and efficacy of SARS-CoV-2 vaccines must be carefully evaluated prior to their use in the general population, particularly given concerns for disease enhancement and the global need for effective vaccines to control the COVID-19 pandemic."

is the only caution the paper seems to have and the paper seems to say that this "Vaccine-associated enhanced disease" has not been found in humans re covid-19

It seems like the responses to the first RSV vaccines could be ADE. /info/en/?search=Respiratory_syncytial_virus_vaccine How much clarity about that would be required before it could be included here? 222.152.28.14 ( talk) 07:42, 18 December 2021 (UTC) reply

This following sentence in italics from the current version online needs a capital "A" if it is to remain. However, this study of Cleveland Clinic health care workers from February 2022, makes the information below outdated (although technically correct, since the date below is before this study).

I believe it is better to delete the inaccurate information. However I am NOT suggesting to replace it with the study information, as more studies would provide further clarification.

Please delete this sentence or fix the starting "a" to "A":

as of 27 January 2022, there have been no observed incidents with vaccines for COVID-19 in trials with nonhuman primates, in clinical trials with humans, or following the widespread use of approved vaccines.

An alternative approach, for those concerned about ADE would be to explain why the 2023 XBB vaccines are monovalent-only - and therefore safer in the context of ADE. The strategy behind eliminating earlier strains is to prevent the possibility of ADE by not including off-target non-neutralizing antibodies from earlier strains - based on that Cleveland Clinic study data above, as well as others.

Perhaps a better second sentence is:

The updated 2023 monovalent COVID vaccines produce antibodies specific to the current XBB variants. Vaccines targeting only the currently circulating variants would minimize the hypothetical risk of ADE by excluding off-target antibodies from prior strains. LauraWalton ( talk) 01:42, 2 September 2023 (UTC) reply