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This page seems to talk about molecules containing peptide bonds, but there are other amides out there, like dimethylformamide HCON(CH3)2 or sulfonamides or tertiary amides. AxelBoldt 19:12 Jan 23, 2003 (UTC)
AxelBoldt is right, there is not enough information on the differant types of amides. This article just focus' on seconday amides. It should include information on primary and tertiary amides aswell. This would help clarify the differances between the peptide link and an amide. —Preceding unsigned comment added by 195.137.80.110 ( talk) 07:22, 15 June 2006
Also, I'm not so sure you can synthesize an amide from a carboxylic acid unless it is under enzymatic catalysis.
I really think there should be more of a distinction between amides with a carbonyl group and amides such as lithium diisopropyl amide. I thought all amides had a carbonyl group until i ran across LDA. Eddietoran 19:23, 25 October 2006 (UTC)
Basicity: "the conjugate acid of an amide has a pKa around −0.5." "Conversely, under extremely acidic conditions, the carbonyl oxygen can become protonated with a pKa of roughly −1." Shouldn't those two pKa values be the same? — Preceding unsigned comment added by 66.188.175.19 ( talk) 05:18, 16 June 2017 (UTC)
The removal of water under the reaction arrow, denoted -H2O, actually has a 0 (zero) instead of O (the letter for oxygen). Could whoever made the reaction scheme picture please fix this?— Preceding unsigned comment added by 146.151.34.108 ( talk) 04:39, 12 March 2007 (UTC)
Amidation redirects here, but it's not really explained. (And I don't know enough to write about it myself.) MarcelM 17:15, 11 October 2007 (UTC)
As per the described direct amidation of carboxylic acid with amine in presence of catalyst (Rheuthenium based), there is a better and cheaper method reported in Org. Syn. 2005, which is also far more 'green'. This describes use of Boric acid in 5 mol% quantity, with azeotropically removing water. —Preceding unsigned comment added by Chinu687 ( talk • contribs) 03:38, 14 May 2008 (UTC)
I'm sure there are a lot of amides like sulfamide without any carbonyl function. Only amides from carboxylic acids are "organic". Sadorkan ( talk) 15:20, 23 December 2011 (UTC)
I second the above criticism, and I'm tagging this page as confusing. See more on my explanation for the same problem for "imide" page, the talk page at Talk:Imide#Main_.22imide.22_page_should_discuss_all_meanings.2C_not_only_the_one_in_organic_chemistry.
12.104.156.31 ( talk) 18:38, 19 March 2012 (UTC)
-- Smokefoot ( talk) 00:43, 20 March 2012 (UTC)
I think something is wrong with e- movement, bond rearrangement and charges in the figure in the "Structure and bonding" section ??? — Preceding unsigned comment added by 130.226.107.5 ( talk) 12:13, 16 March 2012 (UTC)
The audio and phonetic don't seem to match. — Preceding unsigned comment added by 161.130.25.152 ( talk) 20:44, 11 July 2012 (UTC)
Having noticed this myself, I've tagged the article with {{ Contradict-inline}} so that hopefully someone who knows which is the "correct" pronunciation can correct it. According to the OED 11th ed., both the pronunciation transcribed in the article /ˈæmaɪd/ and that spoken /ˈeɪmaɪd/ are acceptable, but I have no expertise on the subject and so don't feel justified in making the edit myself. D4g0thur 10:02, 28 August 2012 (UTC)
This
level-4 vital article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||
|
This page seems to talk about molecules containing peptide bonds, but there are other amides out there, like dimethylformamide HCON(CH3)2 or sulfonamides or tertiary amides. AxelBoldt 19:12 Jan 23, 2003 (UTC)
AxelBoldt is right, there is not enough information on the differant types of amides. This article just focus' on seconday amides. It should include information on primary and tertiary amides aswell. This would help clarify the differances between the peptide link and an amide. —Preceding unsigned comment added by 195.137.80.110 ( talk) 07:22, 15 June 2006
Also, I'm not so sure you can synthesize an amide from a carboxylic acid unless it is under enzymatic catalysis.
I really think there should be more of a distinction between amides with a carbonyl group and amides such as lithium diisopropyl amide. I thought all amides had a carbonyl group until i ran across LDA. Eddietoran 19:23, 25 October 2006 (UTC)
Basicity: "the conjugate acid of an amide has a pKa around −0.5." "Conversely, under extremely acidic conditions, the carbonyl oxygen can become protonated with a pKa of roughly −1." Shouldn't those two pKa values be the same? — Preceding unsigned comment added by 66.188.175.19 ( talk) 05:18, 16 June 2017 (UTC)
The removal of water under the reaction arrow, denoted -H2O, actually has a 0 (zero) instead of O (the letter for oxygen). Could whoever made the reaction scheme picture please fix this?— Preceding unsigned comment added by 146.151.34.108 ( talk) 04:39, 12 March 2007 (UTC)
Amidation redirects here, but it's not really explained. (And I don't know enough to write about it myself.) MarcelM 17:15, 11 October 2007 (UTC)
As per the described direct amidation of carboxylic acid with amine in presence of catalyst (Rheuthenium based), there is a better and cheaper method reported in Org. Syn. 2005, which is also far more 'green'. This describes use of Boric acid in 5 mol% quantity, with azeotropically removing water. —Preceding unsigned comment added by Chinu687 ( talk • contribs) 03:38, 14 May 2008 (UTC)
I'm sure there are a lot of amides like sulfamide without any carbonyl function. Only amides from carboxylic acids are "organic". Sadorkan ( talk) 15:20, 23 December 2011 (UTC)
I second the above criticism, and I'm tagging this page as confusing. See more on my explanation for the same problem for "imide" page, the talk page at Talk:Imide#Main_.22imide.22_page_should_discuss_all_meanings.2C_not_only_the_one_in_organic_chemistry.
12.104.156.31 ( talk) 18:38, 19 March 2012 (UTC)
-- Smokefoot ( talk) 00:43, 20 March 2012 (UTC)
I think something is wrong with e- movement, bond rearrangement and charges in the figure in the "Structure and bonding" section ??? — Preceding unsigned comment added by 130.226.107.5 ( talk) 12:13, 16 March 2012 (UTC)
The audio and phonetic don't seem to match. — Preceding unsigned comment added by 161.130.25.152 ( talk) 20:44, 11 July 2012 (UTC)
Having noticed this myself, I've tagged the article with {{ Contradict-inline}} so that hopefully someone who knows which is the "correct" pronunciation can correct it. According to the OED 11th ed., both the pronunciation transcribed in the article /ˈæmaɪd/ and that spoken /ˈeɪmaɪd/ are acceptable, but I have no expertise on the subject and so don't feel justified in making the edit myself. D4g0thur 10:02, 28 August 2012 (UTC)