A fact from Alkaptonuria appeared on Wikipedia's Main Page in the Did you know column on 7 December 2007. The text of the entry was as follows: Did you know... that alkaptonuria, a rare inborn error of metabolism, is over five times more common in Slovakia than in the rest of the world? A record of the entry may be seen at Wikipedia:Recent additions/2007/December.

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Medicine: Dermatology / Genetics Low‑importance This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine articles Low This article has been rated as Low-importance on the project's importance scale. This article is supported by the Dermatology task force. This article is supported by the Medical genetics task force.

Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Alkaptonuria. PubMed provides review articles from the past five years (limit to free review articles) The TRIP database provides clinical publications about evidence-based medicine. Other potential sources include: Centre for Reviews and Dissemination and CDC

PMID  9529368 is a recent overview, published in reaction to the linkage to the gene. Nitisinone, more commonly studied for hereditary tyrosinemia type I, is apparently being studied in this disease, see PMID  15322814. JFW |  T@lk 23:05, 2 September 2007 (UTC) reply

This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 16:23, 10 November 2007 (UTC) reply

I'm wondering if this shouldn't go for GA. JFW |  T@lk 10:36, 28 July 2008 (UTC) reply

It is my understanding that these two are the same thing. If so, why don't we merge them? If not, please tell me how they are different. Thanks, -- Brendan19 ( talk) 00:41, 7 June 2010 (UTC) reply

No, see the ochronosis article. There are other (exogenous) causes. JFW |  T@lk 10:04, 13 August 2014 (UTC) reply

doi:10.1136/jclinpath-2012-200877 is a review by the main UK expert team in Liverpool. Might be useful considering the article is currently weak in terms of sources. JFW |  T@lk 22:01, 10 August 2014 (UTC) reply

doi:10.1007/s10545-011-9363-z - molecular genetics.

doi:10.1186/1471-2415-14-12 - ocular findings systematically reviewed

doi:10.1007/s10545-008-0984-9 - historical review at 100th anniversary of Garrod's lecture

doi:10.1201/b15310-17 - chapter in Atlas of Inherited Metabolic Diseases 3E ISBN  978-1-4441-1225-2

doi:10.1016/B978-0-12-374984-0.00030-9 - entry in Brenner's Encyclopedia of Genetics ISBN  978-0-08-096156-9

doi:10.1111/pcmr.12235 - biology of hyperpigmentation syndromes (small mention)

doi:10.1007/s00296-004-0498-1 - older review (2005)

Will list more if I find anything. JFW |  T@lk 10:59, 12 August 2014 (UTC) reply

From the article:

A 1977 study showed that an ochronotic Egyptian mummy had probably suffered from alkaptonuria. Stenn FF, Milgram JW, Lee SL, Weigand RJ, Veis A (1977). "Biochemical identification of homogentisic acid pigment in an ochronotic egyptian mummy". Science. 197 (4303): 566–8. doi: 10.1126/science.327549. PMID  327549.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)

Fascinating, but I would prefer a secondary source, particularly because this is 37 years ago. JFW |  T@lk 12:32, 14 August 2014 (UTC) reply

This 1968 article from the Nederlands Tijdschrift voor Geneeskunde has a lot of historical context ( link):

• Not much about ochronosis as such
• "Scribonius" in 1548 wrote in "De Inspectione Urinatum" something about brown discoloration of urine after exposure to air
• Boedeker in 1859 wrote about a reducing substance in someone with back pain and clinical features of ochronosis (full citation: Über das Alcapton; ein neuer Beitrag zur Frage: Welche Stoffe des Harns können Kupferreduction bewirken C Boedeker - Z Rat Med, 1859)
• 1891 saw Wolkow and Baumann describe the chemical nature of homogentisic acid

It would be great to have a more recent source. JFW |  T@lk 09:40, 25 August 2014 (UTC) reply

Garrod is fulltext here: http://www.unz.org/Pub/GarrodArchibald-1909

The text is fabulous; it looks like Virchow coined the term "ochronosis" but the link with alkaptonuria was made later. JFW |  T@lk 09:49, 25 August 2014 (UTC) reply