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It looks like someone has altered hedgehog to Sonic Hedgehog in this article. KathyfromNC ( talk) 17:49, 2 July 2016 (UTC)
No I'm wrong. The gene is hedgehog for flies and sonic hedgehog for chickens. KathyfromNC ( talk) 17:55, 2 July 2016 (UTC)
Re-entered removed text - needs proper formatting before re-adding. Also to note only one link is necessary. -- Iztwoz ( talk) 11:49, 31 January 2018 (UTC)
The Hox genes, which define features along the anterior-posterior axis of a developing organism, dictate at which points along the axis that limb buds will form. [1] Though limbs emerge at different locations in different species, their positions always correlate with the level of Hox gene expression along the anterior-posterior axis. [1] All limb buds must rely on other signaling factors to obtain their forelimb or hindlimb identity as well; Hox gene expression influences expression of T-box proteins that, in turn, dictate limb identity for certain organisms. [2]
In turn, the activation of T-box proteins activates signaling cascades that involve the Wnt signaling pathway and FGF signals. [2] Before limb development begins, T-box proteins initiate FGF10 expression in the proliferating mesenchymal cells of the lateral plate mesoderm, which form the limb bud mesoderm. [2] WNT2B and WNT8C stabilize this FGF10 expression in the forelimb and hindlimb, respectively. [3] [4] This FGF10 expression stimulates WNT3 expression in the above ectodermal cells – resulting in formation of the apical ectodermal ridge (AER) as well as inducing FGF8 expression. [5] The FGF8 secreted by the AER acts to keep the cells of the limb mesenchyme in a mitotically active state and sustains their production of FGF10. [5] This positive feedback loop between the limb mesenchymal cells and the AER maintains the continued growth and development of the entire limb. [6] In addition to limb outgrowth, AER leads to the formation of the ZPA. [2]
References
![]() | This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||
|
It looks like someone has altered hedgehog to Sonic Hedgehog in this article. KathyfromNC ( talk) 17:49, 2 July 2016 (UTC)
No I'm wrong. The gene is hedgehog for flies and sonic hedgehog for chickens. KathyfromNC ( talk) 17:55, 2 July 2016 (UTC)
Re-entered removed text - needs proper formatting before re-adding. Also to note only one link is necessary. -- Iztwoz ( talk) 11:49, 31 January 2018 (UTC)
The Hox genes, which define features along the anterior-posterior axis of a developing organism, dictate at which points along the axis that limb buds will form. [1] Though limbs emerge at different locations in different species, their positions always correlate with the level of Hox gene expression along the anterior-posterior axis. [1] All limb buds must rely on other signaling factors to obtain their forelimb or hindlimb identity as well; Hox gene expression influences expression of T-box proteins that, in turn, dictate limb identity for certain organisms. [2]
In turn, the activation of T-box proteins activates signaling cascades that involve the Wnt signaling pathway and FGF signals. [2] Before limb development begins, T-box proteins initiate FGF10 expression in the proliferating mesenchymal cells of the lateral plate mesoderm, which form the limb bud mesoderm. [2] WNT2B and WNT8C stabilize this FGF10 expression in the forelimb and hindlimb, respectively. [3] [4] This FGF10 expression stimulates WNT3 expression in the above ectodermal cells – resulting in formation of the apical ectodermal ridge (AER) as well as inducing FGF8 expression. [5] The FGF8 secreted by the AER acts to keep the cells of the limb mesenchyme in a mitotically active state and sustains their production of FGF10. [5] This positive feedback loop between the limb mesenchymal cells and the AER maintains the continued growth and development of the entire limb. [6] In addition to limb outgrowth, AER leads to the formation of the ZPA. [2]
References