This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||
|
Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Xeroderma pigmentosum.
|
To-do list for Xeroderma pigmentosum:
|
The DNA is actually excised by endonucleases, not exonucleases. I'm not going to change it because I don't have a specific reference confirming it. Exonucleases actually remove from the ends of DNA strands, whereas endonucleases cut phosphodiester bonds inside DNA strands (which is what is needed for excision). In prokaryotes, the mechanism for this excision repair is that the uvrABCendonuclease nicks the DNA strand on either end of the pyrimidine dimer, and a specialized helicase (not the same helicase that participates in replication) breaks the Hydrogen bonds holding the nicked portion to the other strand. DNA Polymerase then replaces the nucleotides starting at the 3' end of the excision. Ligase connects the final phosphodiester bond and completes the repair. XP is a result from mutation of the helicase, or one of the uvr genes. I've been told that the mechanism is nearly identical in eukaryotes (the names of the endonuclease is different I believe).
this disease would suck —Preceding unsigned comment added by 164.68.181.1 ( talk • contribs)
Why are no symptoms found on this page? Sure, skin cancer... but that's not the only symptom. Do people with XP have any reactions to sunlight like burning of the skin, getting dizzy, etc? Surely there must be a source somewhere that gives some actual useful information to the common, everyday person. Vancar 16:43, 7 July 2006 (UTC)
I don't think the merger makes very much sense; presumably the enzyme is involved in more than this disease. -- Visviva 07:28, 30 July 2006 (UTC)
i think there should be more camp sundowns across the country because not many people who live in the country like the eastern shore of virginia or in virgina areas or maryland would be able to go or if they should go then they should at least by the person a plane ticket to go out to camp sundown because most parents of children who has xp might not afford it and its the only time the children gets to interact with children their age and with the same problems they have —Preceding unsigned comment added by 64.5.145.82 ( talk) 19:21, 8 January 2009 (UTC)
Why is there a redirect from Sun Allergy to this page? 83.70.41.4 10:55, 16 September 2006 (UTC)
I've moved it to Rash -- apers0n 12:34, 16 September 2006 (UTC) ahdayldhlhyflihalhfiayfhd
what is the treatment the treatment is just being yourself —Preceding unsigned comment added by 64.5.145.82 ( talk) 19:17, 8 January 2009 (UTC)
The popular culture section of the page includes the two children in the Nicole Kidman film ' The Others, yet they never explicitly identify the condition. They always refer to it as photosensitivity. Should it be removed? Or is this disease the only possible one given the symptoms in the movie? Alan daniel ( talk) 08:40, 8 June 2015 (UTC)
This is unreferenced trivia. The society and culture section is to discuss popular culture that has had an effect on the condition itself. It is not simple a list of tv shows or books that mention X or Y in passing. These can go in the articles themselves.
Doc James ( talk · contribs · email) 18:01, 28 June 2018 (UTC)
List of trivia
|
---|
References
|
I noticed that the mentioned prevalence for India is 1 per 370, this seems wildly excessive. Are there any good sources? The footnoted source doesn't open for me. -- CopperKettle ( talk) 12:42, 10 December 2022 (UTC)
This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||
|
Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Xeroderma pigmentosum.
|
To-do list for Xeroderma pigmentosum:
|
The DNA is actually excised by endonucleases, not exonucleases. I'm not going to change it because I don't have a specific reference confirming it. Exonucleases actually remove from the ends of DNA strands, whereas endonucleases cut phosphodiester bonds inside DNA strands (which is what is needed for excision). In prokaryotes, the mechanism for this excision repair is that the uvrABCendonuclease nicks the DNA strand on either end of the pyrimidine dimer, and a specialized helicase (not the same helicase that participates in replication) breaks the Hydrogen bonds holding the nicked portion to the other strand. DNA Polymerase then replaces the nucleotides starting at the 3' end of the excision. Ligase connects the final phosphodiester bond and completes the repair. XP is a result from mutation of the helicase, or one of the uvr genes. I've been told that the mechanism is nearly identical in eukaryotes (the names of the endonuclease is different I believe).
this disease would suck —Preceding unsigned comment added by 164.68.181.1 ( talk • contribs)
Why are no symptoms found on this page? Sure, skin cancer... but that's not the only symptom. Do people with XP have any reactions to sunlight like burning of the skin, getting dizzy, etc? Surely there must be a source somewhere that gives some actual useful information to the common, everyday person. Vancar 16:43, 7 July 2006 (UTC)
I don't think the merger makes very much sense; presumably the enzyme is involved in more than this disease. -- Visviva 07:28, 30 July 2006 (UTC)
i think there should be more camp sundowns across the country because not many people who live in the country like the eastern shore of virginia or in virgina areas or maryland would be able to go or if they should go then they should at least by the person a plane ticket to go out to camp sundown because most parents of children who has xp might not afford it and its the only time the children gets to interact with children their age and with the same problems they have —Preceding unsigned comment added by 64.5.145.82 ( talk) 19:21, 8 January 2009 (UTC)
Why is there a redirect from Sun Allergy to this page? 83.70.41.4 10:55, 16 September 2006 (UTC)
I've moved it to Rash -- apers0n 12:34, 16 September 2006 (UTC) ahdayldhlhyflihalhfiayfhd
what is the treatment the treatment is just being yourself —Preceding unsigned comment added by 64.5.145.82 ( talk) 19:17, 8 January 2009 (UTC)
The popular culture section of the page includes the two children in the Nicole Kidman film ' The Others, yet they never explicitly identify the condition. They always refer to it as photosensitivity. Should it be removed? Or is this disease the only possible one given the symptoms in the movie? Alan daniel ( talk) 08:40, 8 June 2015 (UTC)
This is unreferenced trivia. The society and culture section is to discuss popular culture that has had an effect on the condition itself. It is not simple a list of tv shows or books that mention X or Y in passing. These can go in the articles themselves.
Doc James ( talk · contribs · email) 18:01, 28 June 2018 (UTC)
List of trivia
|
---|
References
|
I noticed that the mentioned prevalence for India is 1 per 370, this seems wildly excessive. Are there any good sources? The footnoted source doesn't open for me. -- CopperKettle ( talk) 12:42, 10 December 2022 (UTC)