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Some issues you may want to expand on. Vincristine is a vinca alkaloid, of which other related agents include vinblastine and vinorelbin Vincristine is a neurotoxin. This is the main reason for the peripheral neuropathy (of which symptoms may included parathesia and altered motor skills). Constipation is a result of autonomic nervous system dysfunction as a result of the neurotoxic effect of vincristine. Most cancer therapies that include vincristine as an antineoplastic agent are generally limited to 2mg in a single IV dose, due to vincristine's neurotoxic properties. Vincristine is a vesicant. Care must be taken to avoid contact with the skin and tissues due to the burn and necrosis associated with contact in this manner. Care must be taken during the administration of vincristine to avoid extravasation. - Pharmer
C'mon, Wikimarkup is not hard! Just enclose a link with [[two brackets]]. That's it! JFW | T@lk 08:52, 14 October 2005 (UTC)
Don't you think that something should be included on how it poisoned and killer Chuck Schuldiner?
Maybe it was the glioma not the chemo?
The structure of this molecule is incorrect as shown. The molecule displayed in the PubChem link is correct. I would be happy to provide an updated image file, but am not sure how... any help?
C. Goodman
JFW, I favor reincluding the contamination scandal, as this did receive a fair amount of publicity and other people may come to this article in search of this story or at least for context. Andrew73 ( talk) 14:37, 1 February 2008 (UTC)
My son was just diagnosed with Juvenile pilocytic astrocytoma in his Hypothalamus. He will begin Chemotherapy with carboplatin and vincristine through a Central Line. His oncologist, Dr. Lamkin of OHSU, suggested this treatment. I haven't done much Wikipedia editing, so I didn't want to change the main page.
--- August 8th, 2009 Elizabeth —Preceding undated comment added 20:26, 1 August 2009 (UTC).
March 2, 2010 I suspect "action" in second paragraph should be "actin". Will change on confirmation if someone doesn't change it first. Will update external link to http://www.macmillan.org.uk/Cancerinformation/Cancertreatment/Treatmenttypes/Chemotherapy/Individualdrugs/Vincristine.aspx. —Preceding unsigned comment added by Twbeals31 ( talk • contribs) 20:44, 2 March 2010 (UTC)
I made cosmetic changed to the drugbox, as it was taking up the entire screen to display (my resolution is at 1280 x 1024). As I haven't edited drug boxes before, I didn't change the chemical forumla or change any of the text, only added line breaks to move the drug box down in size. Let me know if it's not right, also feel free to change it. KoshVorlon ' Naluboutes Aeria Gloris 20:11, 30 May 2011 (UTC)
I suspect that the aluminum oxide was the stationery phase for chromatography, and that trichloromethane and benzdichlormethane were the solvents (mobile phase) for eluting the vincristine from the column. If true (I do not have access to the original reference (#4)), a rewording would be "This fraction was further separated by chromatography on aluminum oxide, using trichloromethane and benzdichloromethane as eluents, and separation by pH to yield vincristine." Drbillellis 13:55, 4 July 2011 (UTC) — Preceding unsigned comment added by Drbillellis ( talk • contribs)
The current phonemic transcription /ˈɑːŋkoʊvɪn/ looks wrong (~ anchor?) (and doesnt match the ref) - surely it should be /ˈɒnkoʊvɪn/ (like (b)onk) to match // ? - Rod57 ( talk) 13:27, 17 November 2015 (UTC)
I've added a very short section on the impending shortage of this drug, mentioned in today's NYTimes. It seems (to me) very important for readers to know about this, in case they are reading the article because of a relative who needs it for childhood cancer, which I'm guessing probably motivates a lot of readers to read this Wikipedia entry. Does this violate WP:Notnews? I'm seeing "...including information on recent developments is sometimes appropriate,...", so maybe it's OK to include this. But if I'm wrong, by all means feel free to smack me down on this. Maybe rephrase in very-recent-history form? HandsomeMrToad ( talk) 08:33, 15 October 2019 (UTC)
Using "baby" is fine in this context as the medication causes birth defects in newborns. Doc James ( talk · contribs · email) 07:32, 12 May 2020 (UTC)
This is the
talk page for discussing improvements to the
Vincristine article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL |
![]() | This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||
|
![]() | Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Vincristine.
|
Some issues you may want to expand on. Vincristine is a vinca alkaloid, of which other related agents include vinblastine and vinorelbin Vincristine is a neurotoxin. This is the main reason for the peripheral neuropathy (of which symptoms may included parathesia and altered motor skills). Constipation is a result of autonomic nervous system dysfunction as a result of the neurotoxic effect of vincristine. Most cancer therapies that include vincristine as an antineoplastic agent are generally limited to 2mg in a single IV dose, due to vincristine's neurotoxic properties. Vincristine is a vesicant. Care must be taken to avoid contact with the skin and tissues due to the burn and necrosis associated with contact in this manner. Care must be taken during the administration of vincristine to avoid extravasation. - Pharmer
C'mon, Wikimarkup is not hard! Just enclose a link with [[two brackets]]. That's it! JFW | T@lk 08:52, 14 October 2005 (UTC)
Don't you think that something should be included on how it poisoned and killer Chuck Schuldiner?
Maybe it was the glioma not the chemo?
The structure of this molecule is incorrect as shown. The molecule displayed in the PubChem link is correct. I would be happy to provide an updated image file, but am not sure how... any help?
C. Goodman
JFW, I favor reincluding the contamination scandal, as this did receive a fair amount of publicity and other people may come to this article in search of this story or at least for context. Andrew73 ( talk) 14:37, 1 February 2008 (UTC)
My son was just diagnosed with Juvenile pilocytic astrocytoma in his Hypothalamus. He will begin Chemotherapy with carboplatin and vincristine through a Central Line. His oncologist, Dr. Lamkin of OHSU, suggested this treatment. I haven't done much Wikipedia editing, so I didn't want to change the main page.
--- August 8th, 2009 Elizabeth —Preceding undated comment added 20:26, 1 August 2009 (UTC).
March 2, 2010 I suspect "action" in second paragraph should be "actin". Will change on confirmation if someone doesn't change it first. Will update external link to http://www.macmillan.org.uk/Cancerinformation/Cancertreatment/Treatmenttypes/Chemotherapy/Individualdrugs/Vincristine.aspx. —Preceding unsigned comment added by Twbeals31 ( talk • contribs) 20:44, 2 March 2010 (UTC)
I made cosmetic changed to the drugbox, as it was taking up the entire screen to display (my resolution is at 1280 x 1024). As I haven't edited drug boxes before, I didn't change the chemical forumla or change any of the text, only added line breaks to move the drug box down in size. Let me know if it's not right, also feel free to change it. KoshVorlon ' Naluboutes Aeria Gloris 20:11, 30 May 2011 (UTC)
I suspect that the aluminum oxide was the stationery phase for chromatography, and that trichloromethane and benzdichlormethane were the solvents (mobile phase) for eluting the vincristine from the column. If true (I do not have access to the original reference (#4)), a rewording would be "This fraction was further separated by chromatography on aluminum oxide, using trichloromethane and benzdichloromethane as eluents, and separation by pH to yield vincristine." Drbillellis 13:55, 4 July 2011 (UTC) — Preceding unsigned comment added by Drbillellis ( talk • contribs)
The current phonemic transcription /ˈɑːŋkoʊvɪn/ looks wrong (~ anchor?) (and doesnt match the ref) - surely it should be /ˈɒnkoʊvɪn/ (like (b)onk) to match // ? - Rod57 ( talk) 13:27, 17 November 2015 (UTC)
I've added a very short section on the impending shortage of this drug, mentioned in today's NYTimes. It seems (to me) very important for readers to know about this, in case they are reading the article because of a relative who needs it for childhood cancer, which I'm guessing probably motivates a lot of readers to read this Wikipedia entry. Does this violate WP:Notnews? I'm seeing "...including information on recent developments is sometimes appropriate,...", so maybe it's OK to include this. But if I'm wrong, by all means feel free to smack me down on this. Maybe rephrase in very-recent-history form? HandsomeMrToad ( talk) 08:33, 15 October 2019 (UTC)
Using "baby" is fine in this context as the medication causes birth defects in newborns. Doc James ( talk · contribs · email) 07:32, 12 May 2020 (UTC)