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Strictly speaking this is the dose of viruses that is "guaranteed" (by statistical probability) to infect at least 50% of a set of cell cultures in tubes or plastic wells. It is used because the coefficient of variation of dilutions of viral suspensions is large. Do we need to explain this? The wiki link redirects to Virus quantification which needs some work. I wouldn't say counting viruses is harder that counting bacteria, it just takes longer. Graham Beards ( talk) 18:45, 11 April 2021 (UTC)
It might be worth adding a section noting that each individual ingredient, as well as the ingredients combined as a whole, must meet various national safety and efficacy regimes (most prominently those of the U.S. Food and Drug Administration, but also those of many other countries which have their own specific requirements in this area). Typically, of course, when a new vaccine is developed, it is tested with well-profiled off-the shelf preservatives and (if needed) adjuvants. Conversely, when a new adjuvant is developed, it is typically first tested by being substituted into an existing well-profiled vaccine. BD2412 T 04:52, 12 April 2021 (UTC)
The result was: promoted by
Vaticidalprophet (
talk) 06:40, 17 April 2021 (UTC)
Created by Colin ( talk). Self-nominated at 17:58, 13 April 2021 (UTC).
User:Sadads added a graphic from WHO, which I've copied here. I admit it is difficult to find an image for the article lead. But I'm really not sure about this one, which looks more like a PowerPoint slide than a lead image. Some other problems:
So I think at present this graphic suffers from the problem that it was designed for somebody else's article on vaccine ingredients. -- Colin° Talk 18:31, 23 April 2021 (UTC)
An oral pill formulation that may help overcome vaccine hesitancy is getting attention during 2021. Vaxart – a biotech company with this format in clinical development for a COVID-19 vaccine – uses an enteric coating to deliver an Ad5 vector compound containing the antigen and adjuvant to the intestine, explained partly here. There remain concerns about whether the pill vaccine generates enough antibody response, raising questions about the efficacy of oral formulations for respiratory infections. 2017 review here. Zefr ( talk) 20:09, 24 April 2021 (UTC)
![]() | A fact from Vaccine ingredients appeared on Wikipedia's
Main Page in the
Did you know column on 23 April 2021 (
check views). The text of the entry was as follows:
| ![]() |
![]() | This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||||||||||
|
Strictly speaking this is the dose of viruses that is "guaranteed" (by statistical probability) to infect at least 50% of a set of cell cultures in tubes or plastic wells. It is used because the coefficient of variation of dilutions of viral suspensions is large. Do we need to explain this? The wiki link redirects to Virus quantification which needs some work. I wouldn't say counting viruses is harder that counting bacteria, it just takes longer. Graham Beards ( talk) 18:45, 11 April 2021 (UTC)
It might be worth adding a section noting that each individual ingredient, as well as the ingredients combined as a whole, must meet various national safety and efficacy regimes (most prominently those of the U.S. Food and Drug Administration, but also those of many other countries which have their own specific requirements in this area). Typically, of course, when a new vaccine is developed, it is tested with well-profiled off-the shelf preservatives and (if needed) adjuvants. Conversely, when a new adjuvant is developed, it is typically first tested by being substituted into an existing well-profiled vaccine. BD2412 T 04:52, 12 April 2021 (UTC)
The result was: promoted by
Vaticidalprophet (
talk) 06:40, 17 April 2021 (UTC)
Created by Colin ( talk). Self-nominated at 17:58, 13 April 2021 (UTC).
User:Sadads added a graphic from WHO, which I've copied here. I admit it is difficult to find an image for the article lead. But I'm really not sure about this one, which looks more like a PowerPoint slide than a lead image. Some other problems:
So I think at present this graphic suffers from the problem that it was designed for somebody else's article on vaccine ingredients. -- Colin° Talk 18:31, 23 April 2021 (UTC)
An oral pill formulation that may help overcome vaccine hesitancy is getting attention during 2021. Vaxart – a biotech company with this format in clinical development for a COVID-19 vaccine – uses an enteric coating to deliver an Ad5 vector compound containing the antigen and adjuvant to the intestine, explained partly here. There remain concerns about whether the pill vaccine generates enough antibody response, raising questions about the efficacy of oral formulations for respiratory infections. 2017 review here. Zefr ( talk) 20:09, 24 April 2021 (UTC)