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Embolic and thrombotic events after COVID-19 vaccination article. This is not a forum for general discussion of the article's subject. |
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Twitter thread, direct link. TL;DR: a mouse model shows that VITT happens if, and only if adenovirus vector enters the blood stream after an accidental intravenous injection, because then platelets and adenovirus stick together and are attacked by the immune system together. Yes, I didn't expect it be that simple either. Ain92 ( talk) 11:33, 1 July 2021 (UTC)
The result of the move request was: Not Moved Mike Cline ( talk) 15:45, 11 January 2022 (UTC)
Embolic and thrombotic events after COVID-19 vaccination → Vaccine-induced immune thrombotic thrombocytopenia – The current name makes it difficult to find the article, causes it to not show up in Google searches, and violates WP:UCRN (and WP:OR?) Omegatron ( talk) 16:40, 18 December 2021 (UTC)
We believe the name “VITT” works well, for two reasons. First, the term clearly denotes the key features of the disorder, and the sequence of letters provides a useful mnemonic for disease recognition in the usual sequence of events: … Second, the term “VITT” itself need not mandate that thrombosis be present … Another term used in the United States … “TTS” … highlights the two key clinical features of thrombosis and thrombocytopenia but without denoting either preceding vaccination or alluding to its immune-mediated pathogenesis. This term has limited clinical utility, since many conditions … present with the duad of thrombosis and thrombocytopenia
Although initially several terms were used to describe the syndrome, such as vaccine-associated thrombosis with thrombocytopenia and vaccine-induced prothrombotic immune thrombocytopenia, the term that has gained widespread use is vaccine-induced immune thrombotic thrombocytopenia (VITT). Thrombosis with thrombocytopenia syndrome has also been used, but it is a more general term that can be caused by other conditions, such as antiphospholipid syndrome and thrombotic thrombocytopenic purpura.
VITT antibodies bind to platelets via an eight amino acid region of PF4 on the platelet surface, located within the heparin binding site [4]. VITT antibody binding is blocked by heparin. The amino acids bound by VITT antibodies overlap with but differ from the amino acids bound by HIT antibodies, and VITT antibody binding to platelets is stronger than HIT antibody binding. … Other adenoviral vaccines have been administered to large numbers of individuals without reported cases of VITT. Examples include Ad5-based COVID-19 vaccine (CanSino Biologics), Gam-COVID-Vac/Sputnik V (Gamaleya Institute), and Ad26.ZEBOV-GP (recombinant) Ebola vaccine (Janssen Biologics).
VITT is an immune-based complication of adenoviral-based vaccines used to immunize against SARS_CoV2.
The ChAdOx1 nCoV-19 vaccine has been shown to induce Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT)
— Omegatron ( talk) 16:40, 18 December 2021 (UTC)
— Relisting. Djm-leighpark ( talk) 08:43, 3 January 2022 (UTC)
— Shibbolethink ( ♔ ♕) 17:02, 18 December 2021 (UTC)We believe the name “VITT” works well, for two reasons. First, the term clearly denotes the key features of the disorder, and the sequence of letters provides a useful mnemonic for disease recognition in the usual sequence of events...Second, the term “VITT” itself need not mandate that thrombosis be present
User:Djm-leighpark: "Irregularities"? For notifying the main contributors to the article, to get more opinions on the move? I had no idea whether they would be supportive or not.
This title is still obviously bad. Can we come up with a better one? If I Google for "vitt", this article is on the third page of results. If I search for "tts syndrome", it's on the fourth page of results. People aren't going to search for this made-up term that isn't used anywhere in the medical literature or mentioned anywhere in the news.
The term isn't exclusive to COVID, either, so that shouldn't be in the title: "We report a case of VITT following HPV vaccination. This should raise awareness of the possibility of VITT also occurring after other vaccines, not exclusively adenoviral vector-based SARS-CoV-2 vaccines." — Omegatron ( talk) 14:22, 15 January 2022 (UTC)
While I was was not up to speed with where this article had got to when I reverted the BOLD good faith move on 19 December 2021 at Special:Diff/1060935121 I have since become incline to believe there are some indications of appetite to retain the article and there is some appetite to change the article name. But first it is necessary to confirm the scope of the article is correct, or that in needs to be modified. I personally am minded the current article scope is correct, and is defined by Thrombosis with Thrombocytopenia Syndrome (TTS) post vaccination sometimes termed Vaccine-induced immune thrombotic thrombocytopenia (VITT). The rare event syndrome seems probably associated with (certain?) adenovirus class vaccines, which are mainly currently used in COVID-19 vaccinations. In essence, does the current article scope correct? Thankyou. Djm-leighpark ( talk) 10:31, 28 December 2021 (UTC)
Proposed text:
Thrombosis and thrombosis with thrombocytopenia syndrome (TTS), may also occur with Pfizer COVID-19 vaccine and Moderna COVID-19 vaccine.Thrombosis and thrombosis with thrombocytopenia syndrome (TTS), may also occur with Pfizer COVID-19 vaccine and Moderna COVID-19 vaccine. [1] [2] [3] [4]
References
It reports that Moderna and Pfizer vaccines (mRNA as the Update PDF call it), 6 cases of "potential CVST incident cases, but all without thrombocytopenia " Disease "cerebral venus sinus thrombosis" is a very rare blood clot in the brain "venous sinuses". TTP may be associated with CVST, that is, TTP and CVST can occur at the same time, but it is rare. "Thrombocytopenia" is a bood disorder. In the PDF above it is specifically about the Janssen vaccine, of course other information are included, still the only non-mRNA vaccine approved at the time of the published update in the United States: May 2021, it was Janssen COVID-19 vaccine.
The study also mentions immune thrombocytopenia. Regarding both "Advisory Committee on Immunization Practices (ACIP)" and the Hematology study, both mRNA vaccines are linked, although rare obviously, to "thrombotic" and blood disorders generally speaking for what I understand. If I'm wrong please edit and delete, tell me to delete and correct.
Newest study which is broad and technical https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(21)00256-8/fulltext
Achezet ( talk) 15:08, 30 December 2021 (UTC)
million doses of mRNA COVID-19 vaccines administered in VSD". I really dont get this area well but seems sources are a complete mess for someone to wade through here. I believe CVST without thrombocytopenia is outside of article scope. Thankyou. Djm-leighpark ( talk) 17:11, 31 December 2021 (UTC)
This is the
talk page for discussing improvements to the
Embolic and thrombotic events after COVID-19 vaccination article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL |
Archives: Index, 1Auto-archiving period: 90 days |
This article is rated Start-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||||||||||
|
This article was nominated for merging with Oxford–AstraZeneca COVID-19 vaccine on 2021-04-05. The result of the discussion ( permanent link) was No consensus. |
The
contentious topics procedure applies to this page. This page is related to
COVID-19, broadly construed, which has been
designated as a contentious topic. Editors who repeatedly or seriously fail to adhere to the purpose of Wikipedia, any expected standards of behaviour, or any normal editorial process may be blocked or restricted by an administrator. Editors are advised to familiarise themselves with the contentious topics procedures before editing this page. |
Twitter thread, direct link. TL;DR: a mouse model shows that VITT happens if, and only if adenovirus vector enters the blood stream after an accidental intravenous injection, because then platelets and adenovirus stick together and are attacked by the immune system together. Yes, I didn't expect it be that simple either. Ain92 ( talk) 11:33, 1 July 2021 (UTC)
The result of the move request was: Not Moved Mike Cline ( talk) 15:45, 11 January 2022 (UTC)
Embolic and thrombotic events after COVID-19 vaccination → Vaccine-induced immune thrombotic thrombocytopenia – The current name makes it difficult to find the article, causes it to not show up in Google searches, and violates WP:UCRN (and WP:OR?) Omegatron ( talk) 16:40, 18 December 2021 (UTC)
We believe the name “VITT” works well, for two reasons. First, the term clearly denotes the key features of the disorder, and the sequence of letters provides a useful mnemonic for disease recognition in the usual sequence of events: … Second, the term “VITT” itself need not mandate that thrombosis be present … Another term used in the United States … “TTS” … highlights the two key clinical features of thrombosis and thrombocytopenia but without denoting either preceding vaccination or alluding to its immune-mediated pathogenesis. This term has limited clinical utility, since many conditions … present with the duad of thrombosis and thrombocytopenia
Although initially several terms were used to describe the syndrome, such as vaccine-associated thrombosis with thrombocytopenia and vaccine-induced prothrombotic immune thrombocytopenia, the term that has gained widespread use is vaccine-induced immune thrombotic thrombocytopenia (VITT). Thrombosis with thrombocytopenia syndrome has also been used, but it is a more general term that can be caused by other conditions, such as antiphospholipid syndrome and thrombotic thrombocytopenic purpura.
VITT antibodies bind to platelets via an eight amino acid region of PF4 on the platelet surface, located within the heparin binding site [4]. VITT antibody binding is blocked by heparin. The amino acids bound by VITT antibodies overlap with but differ from the amino acids bound by HIT antibodies, and VITT antibody binding to platelets is stronger than HIT antibody binding. … Other adenoviral vaccines have been administered to large numbers of individuals without reported cases of VITT. Examples include Ad5-based COVID-19 vaccine (CanSino Biologics), Gam-COVID-Vac/Sputnik V (Gamaleya Institute), and Ad26.ZEBOV-GP (recombinant) Ebola vaccine (Janssen Biologics).
VITT is an immune-based complication of adenoviral-based vaccines used to immunize against SARS_CoV2.
The ChAdOx1 nCoV-19 vaccine has been shown to induce Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT)
— Omegatron ( talk) 16:40, 18 December 2021 (UTC)
— Relisting. Djm-leighpark ( talk) 08:43, 3 January 2022 (UTC)
— Shibbolethink ( ♔ ♕) 17:02, 18 December 2021 (UTC)We believe the name “VITT” works well, for two reasons. First, the term clearly denotes the key features of the disorder, and the sequence of letters provides a useful mnemonic for disease recognition in the usual sequence of events...Second, the term “VITT” itself need not mandate that thrombosis be present
User:Djm-leighpark: "Irregularities"? For notifying the main contributors to the article, to get more opinions on the move? I had no idea whether they would be supportive or not.
This title is still obviously bad. Can we come up with a better one? If I Google for "vitt", this article is on the third page of results. If I search for "tts syndrome", it's on the fourth page of results. People aren't going to search for this made-up term that isn't used anywhere in the medical literature or mentioned anywhere in the news.
The term isn't exclusive to COVID, either, so that shouldn't be in the title: "We report a case of VITT following HPV vaccination. This should raise awareness of the possibility of VITT also occurring after other vaccines, not exclusively adenoviral vector-based SARS-CoV-2 vaccines." — Omegatron ( talk) 14:22, 15 January 2022 (UTC)
While I was was not up to speed with where this article had got to when I reverted the BOLD good faith move on 19 December 2021 at Special:Diff/1060935121 I have since become incline to believe there are some indications of appetite to retain the article and there is some appetite to change the article name. But first it is necessary to confirm the scope of the article is correct, or that in needs to be modified. I personally am minded the current article scope is correct, and is defined by Thrombosis with Thrombocytopenia Syndrome (TTS) post vaccination sometimes termed Vaccine-induced immune thrombotic thrombocytopenia (VITT). The rare event syndrome seems probably associated with (certain?) adenovirus class vaccines, which are mainly currently used in COVID-19 vaccinations. In essence, does the current article scope correct? Thankyou. Djm-leighpark ( talk) 10:31, 28 December 2021 (UTC)
Proposed text:
Thrombosis and thrombosis with thrombocytopenia syndrome (TTS), may also occur with Pfizer COVID-19 vaccine and Moderna COVID-19 vaccine.Thrombosis and thrombosis with thrombocytopenia syndrome (TTS), may also occur with Pfizer COVID-19 vaccine and Moderna COVID-19 vaccine. [1] [2] [3] [4]
References
It reports that Moderna and Pfizer vaccines (mRNA as the Update PDF call it), 6 cases of "potential CVST incident cases, but all without thrombocytopenia " Disease "cerebral venus sinus thrombosis" is a very rare blood clot in the brain "venous sinuses". TTP may be associated with CVST, that is, TTP and CVST can occur at the same time, but it is rare. "Thrombocytopenia" is a bood disorder. In the PDF above it is specifically about the Janssen vaccine, of course other information are included, still the only non-mRNA vaccine approved at the time of the published update in the United States: May 2021, it was Janssen COVID-19 vaccine.
The study also mentions immune thrombocytopenia. Regarding both "Advisory Committee on Immunization Practices (ACIP)" and the Hematology study, both mRNA vaccines are linked, although rare obviously, to "thrombotic" and blood disorders generally speaking for what I understand. If I'm wrong please edit and delete, tell me to delete and correct.
Newest study which is broad and technical https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(21)00256-8/fulltext
Achezet ( talk) 15:08, 30 December 2021 (UTC)
million doses of mRNA COVID-19 vaccines administered in VSD". I really dont get this area well but seems sources are a complete mess for someone to wade through here. I believe CVST without thrombocytopenia is outside of article scope. Thankyou. Djm-leighpark ( talk) 17:11, 31 December 2021 (UTC)