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Why would insulin be used to treat diabetes type 2 when that disease is characterized by insulin resistance? Wouldn't that make things worse (because insulin-resistant cells do not respond properly to insulin and therefore putting more insulin into the blood of an insulin-resistant person might actually make things worse)? ScamsAreHorrible172 ( talk) 07:52, 3 September 2017 (UTC)
1. Obesity does not **cause** diabetes neither does a lack of exercise. This is just the usual ignorant slander. Obesity and a lack of energy to perform physical activity are both symptoms of high insulin levels, which is associated with insulin resistance. Type 2 diabetes is even more strongly determined than type 1 but I bet the type 1 article doesn't claim type 1 is caused by being underweight and over-active.
Interestingly the wikipedia article on hyperinsulinemia actually gets the facts about type 2 right! /info/en/?search=Hyperinsulinemia
2. Not all type 2 diabetics are insulin resistant. A minority are insulin sensitive. Type 2 is characterised by a genetic fragility of the person's pancreatic beta cells. (The genes and associated causes are variable both within racial groups and across them so yes it's that vague: diabetes describes the symptom not the cause).
An example source: http://diabetes.diabetesjournals.org/content/52/1/102.short
3. Insulin resistance does not necessarily lead to diabetes. This only occurs if the person has a genetic flaw that means they cannot produce the extra insulin required. Mayo clinic autopsies of obese non-diabetic cadavers showed they had 50% more beta cell mass than normal (i.e. they were capable of increasing their insulin production).
An example source: http://care.diabetesjournals.org/content/29/3/717.short
4a. Exercise is not always effective but it's certainly worth trying.
An example source: http://care.diabetesjournals.org/content/29/6/1433.long
4. There is no insulin resistance. This theory was devised in 1932 before home glucose meters. Human insulin is maintained in a homeostatic range of 70 mg% to 140 mg% by the central nervous system (hypothalamus). Within this range blood sugar may change as frequently as every 60 seconds. The Dexcom continuous glucose meter, though very helpful, average five one-minute readings and displays a single reading. Therefore, it misses a substantial number of rapid oscillations. There is no model in biology in which sensitivity to a hormone changes after birth. There are abnormal insulins (congenital) but the infants do not survive. This is logical as insulin is required for the entry of glucose into all cells, except neurons, which absorb glucose directly. The majority of patients thought to have Type 2 diabetes do not. Doctors have been taught not to investigate the cause of the blood sugar disorder beyond doing a HgbA1c test of a simple glucose tolerance test. These are entirely worthless. The basic testing required: C-Peptide (fair accuracy), Dexcom CGM, modified GTT with insulin, gluocose and glucagon levels. When this is done most "Type 2 patients" turn out to have either Nesidioblastosis or Hypothalamic (Spontaneous) Hypoglycemia. See my textbook: "Disorders of Blood Sugar" (most online booksellers)or view my YouTube presentations (www.chicodiabetes.com). See Puglianiello and Cianfarani, 2006, Review of Diabetic Studies. Central Control of Blood Glucose. Roberto Victor Illa, M.D. — Preceding unsigned comment added by 98.244.61.51 ( talk) 04:49, 9 October 2015 (UTC)
The downsides to exercise are: an obese person is too heavy for their joints and ligaments so exercise before losing weight can cause damage (and pain)! And in the short term the effect of exercise is unpredictable: it can raise or lower blood glucose levels!
4b. Diet, specifically a carbohydrate controlled (i.e. low or very low) is the primary treatment.
5. There is no need to reduce saturated fat intake in order to manage diabetes. This is the standard Ancel Keys religion and has been so discredited that even the ADA is finally taking notice.
6. The UKPDS ia a *terrible* study to cite. The study was flawed and the conclusions drawn from it even more so. In summary:
- It attempted to lower blood glucose levels using drugs alone. The side-effects of those drugs more than cancelled out the benefit.
- The targets were in any case still well above levels at which diabetes would be diagnosed.
- Most patients in the study failed to meet even those lax targets.
- No attempt was made to control blood glucose levels using diet (no doubt because this wouldn't have allowed the sponsoring companies to sell more drugs) and neither was any attempt made to achieve normal blood glucose levels (HbA1c ~5%).
- The entirely unsupported conclusion drawn was that lowering blood glucose levels had no positive benefit: a conclusion that absolutely cannot be drawn from this flawed study.
It's laughable that the UKPDS too the stance that "mortality itself was not considered a relevant outcome" and deliberately ignored any possible harm!
Example source: http://www.diapedia.org/introduction/the-university-group-diabetes-program
You need a new medical 'expert' for this page if this is the 'quality' of material he produces. — Preceding unsigned comment added by Countbrass ( talk • contribs) 08:16, 28 December 2013 (UTC)
Coffee consumption appears to lower the risks for Diabetes Mellitus type 2. [1] -- AdeleRako ( talk) 17:19, 25 April 2014 (UTC)
===Medications===
Some drugs, used for any of several conditions, can interfere with the insulin regulation system, possibly producing drug induced hyperglycemia. Some examples follow, giving the biochemical mechanism in each case:
- Atypical Antipsychotics - Alter receptor binding characteristics, leading to increased insulin resistance.
- Beta-blockers - Inhibit insulin secretion.
- Calcium Channel Blockers - Inhibits secretion of insulin by interfering with cytosolic calcium release.
- Corticosteroids - Cause peripheral insulin resistance and gluconeogenesis.
- Fluoroquinolones - Inhibits insulin secretion by blocking ATP sensitive potassium channels.
- Niacin - causes increased insulin resistance due to increased free fatty acid mobilization.
- Phenothiazines - Inhibit insulin secretion.
- Protease Inhibitors - Inhibit the conversion of proinsulin to insulin.
- Somatropin - May decrease sensitivity to insulin, especially in those susceptible.
- Thiazide Diuretics - Inhibit insulin secretion due to hypokalemia. They also cause increased insulin resistance due to increased free fatty acid mobilization.
Doc James ( talk · contribs · email) 04:40, 10 January 2011 (UTC)
References
{{
cite journal}}
: Unknown parameter |month=
ignored (
help)CS1 maint: multiple names: authors list (
link)
Shouldn't there be a section about research into the condition? Such as for documenting that such as [2] doi: 10.1038/nature13540 -- 65.94.171.126 ( talk) 10:09, 18 July 2014 (UTC)
I recommend the following book for a broad international perspective useful for this article:
Sher man 3312 ( talk) 13:52, 23 August 2014 (UTC).
I recommend the following portal bar to be added below the navigation templates: {{Portal bar|Biology|Medicine|Health}}.
Sher man 3312 ( talk) 13:52, 23 August 2014 (UTC).
![]() | This
edit request to
Diabetes mellitus type 2 has been answered. Set the |answered= or |ans= parameter to no to reactivate your request. |
Insulin was actually discovered in 1916, by Nicolae Paulescu, 5 years before the two Canadians started their research. http://en.wikipedia.org/wiki/Insulin 139.149.1.232 ( talk) 12:56, 16 October 2014 (UTC)
doi:10.1016/S0140-6736(14)61335-0. Glucagon-like peptide-1 receptor agonist and basal insulin combination treatment for the management of type 2 diabetes: a systematic review and meta-analysis. Sounds suitable for inclusion. JFW | T@lk 20:11, 20 December 2014 (UTC)
Blood pressure lowering in DM - systematic review and meta-analysis: doi:10.1001/jama.2014.18574 JFW | T@lk 22:33, 10 February 2015 (UTC)
In Cause -> Lifestyle, the first paragraph is:
My focus being on the very last sentence of that paragraph. It seems a bit out of place; on first reading it I was confused and thought that there was some kind of connection between waist-hip ratio and diabetes. Which naturally, there is, given that it's an indicator of obesity, but it seems a bit out of the blue. I think it should be removed, or at least moved elsewhere. — Fuebar [ talk | cont 17:43, 13 March 2015 (UTC)
Not a single word about low carb diets as diabetes treatment in the article.
Here you can see a different opinion:
Study: Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base
URL: http://www.nutritionjrnl.com/article/S0899-9007%2814%2900332-3/fulltext
Abstract:
"The inability of current recommendations to control the epidemic of diabetes, the specific failure of the prevailing low-fat diets to improve obesity, cardiovascular risk, or general health and the persistent reports of some serious side effects of commonly prescribed diabetic medications, in combination with the continued success of low-carbohydrate diets in the treatment of diabetes and metabolic syndrome without significant side effects, point to the need for a reappraisal of dietary guidelines. The benefits of carbohydrate restriction in diabetes are immediate and well documented. Concerns about the efficacy and safety are long term and conjectural rather than data driven. Dietary carbohydrate restriction reliably reduces high blood glucose, does not require weight loss (although is still best for weight loss), and leads to the reduction or elimination of medication. It has never shown side effects comparable with those seen in many drugs. Here we present 12 points of evidence supporting the use of low-carbohydrate diets as the first approach to treating type 2 diabetes and as the most effective adjunct to pharmacology in type 1. They represent the best-documented, least controversial results. The insistence on long-term randomized controlled trials as the only kind of data that will be accepted is without precedent in science. The seriousness of diabetes requires that we evaluate all of the evidence that is available. The 12 points are sufficiently compelling that we feel that the burden of proof rests with those who are opposed."
People has the right to know. It is not a fringe theory, but a full fledged tratment for diabetes. Posibly it has it's downsides, but medication also do. For example, look at this:
http://blog.drbrownstein.com/metformin-and-diabetic-drugs-increase-mortality/
"A recent article titled, “14-Year Risk of All-Cause Mortality According to Hypoglycemic Drug Exposure in a General Population” assessed the safety data of diabetic drugs over a 14-year time period. The authors studied 3336 participants and 248 deaths over a 14-year time period.
The scientists compared the all-cause mortality risk in non-diabetic versus diabetic subjects. The found that untreated diabetics had a 222% increase risk of all-cause mortality. Diabetics treated with Metformin had 128% increase risk of death. Diabetics treated with sulfonylureas (e.g., Glyburide, Amaryl, Glucotrol, Glynase, DiaBeta) had a 70% increase in all-cause mortality. Diabetics treated with insulin had 329% increase in all-cause mortality."
We shall have the right to know and the right to choose.
Sincerely,
some fat dude.
--
189.213.114.161 (
talk)
05:19, 14 June 2015 (UTC)
doi:10.7326/M15-1400 Mostly benefit those with previous poor glycaemic control, and need to be >10h. JFW | T@lk 21:31, 7 October 2015 (UTC)
doi:10.1210/jc.2015-4251 JFW | T@lk 14:59, 7 March 2016 (UTC)
This "although diabetes is a more heterogeneous condition than was thought formerly. [1]"
To here [3]
Adjusted the words to simplify. Not about type 2 DM specifically but about DM generally. Doc James ( talk · contribs · email) 23:29, 17 July 2016 (UTC)
The WHO ref says "is largely the result of excess body weight and physical inactivity." NIH says "Type 2 diabetes develops most often in middle-aged and older people who are also overweight or obese... Scientists think genetic susceptibility and environmental factors are the most likely triggers of type 2 diabetes."
How about "Type 2 diabetes primarily occurs as a result of obesity and not enough exercise. [3] Some people are more genetically at risk than others. [4]" Doc James ( talk · contribs · email) 19:41, 18 July 2016 (UTC)
References
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cite web}}
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Been in place a fair bit of time. Also it does show on mobile. User needs consensus for its removal. Doc James ( talk · contribs · email) 18:11, 31 December 2016 (UTC)
There seems to be no policy reason to disallow it, and the app is proving very useful. As a small scale test of the banner, this use seems ideal. Carl Fredrik 💌 📧 12:28, 4 January 2017 (UTC)
doi:10.7326/M16-1860 JFW | T@lk 11:19, 3 January 2017 (UTC)
References
![]() | This
edit request to
Diabetes mellitus type 2 has been answered. Set the |answered= or |ans= parameter to no to reactivate your request. |
Armintarrah ( talk) 18:22, 3 January 2017 (UTC)
Review in Circulation - discusses overtreatment doi:10.1161/CIRCULATIONAHA.116.022622 JFW | T@lk 10:23, 10 January 2017 (UTC)
QG added the following today
A large number of people are being treated intensively even though the possible risks of medicine surpass possible benefits. [1]
References
This is hot off the presses and not pubmed-indexed yet. My library doesn't have access to it. So I apologize but I am commenting but have not read this ref yet. Questions - is this a MEDRS source or is it an opinion? It is important to keep sugar levels down, chronically -- this is something doctors struggle with, with their patients, as patients cannot see the damage being done by poor sugar management but chronic mismanagement ends up causing the terrible complications we all know about (retinopathy, nephropathy, circulation problems that lead to loss of limbs, etc) Jytdog ( talk) 23:27, 10 January 2017 (UTC)
added it here - basically says too many people ignore the guidelines that say base glycemic control on life expetancy and other factors - takes at least 9 years to see benefit at minimum and probably longer. Jytdog ( talk) 02:13, 12 January 2017 (UTC)
doi:10.1016/S0140-6736(17)30058-2 JFW | T@lk 14:01, 2 June 2017 (UTC)
The article currently states "Vegetarian diets in general have been related to lower diabetes risk, but do not offer advantages compared with diets which allow moderate amounts of animal products."
I think this misrepresents the referenced article. That article mentions several advantages of vegan diets, for example: "Vegan diets have gained acceptance as a dietary strategy for maintaining good health and managing disease conditions ranging from cardiovascular disease to cancer [1]. Vegan diets may prove useful as medical nutrition therapy in treating the conditions of metabolic syndrome, including obesity, diabetes and cardiovascular risk [3,4,5], and may confer protection against inflammatory conditions such as rheumatoid arthritis (RA) [6,7]."
Nowhere does the referenced article suggest that other diets also have these advantages, except as pertaining to diabetes.
Further, the phrasing of our article may mislead the reader into thinking that any moderate-meat diet is an effective way to manage diabetes. In fact, the article states that similar [improvements in metabolic conditions in type 2 diabetes patients] to vegan diets "have been achieved with other diets including the Mediterranean diet, a low-carbohydrate/high-protein diet, and a vegetarian diet." In other words, these are specific diets. — Preceding unsigned comment added by 2001:4B98:DC0:43:216:3EFF:FE79:1171 ( talk) 15:35, 6 June 2017 (UTC)
Is in contrast to the relative lack in type 2 (in type 2 insulin levels may be high with high BS, problem is more initially resistance to insulin). In type 1 the problem is absolute decreases in insulin below baseline (not a relative lack). Dozens of sources support this such as [8]. Absolute lack of insulin DOES NOT mean no insulin. Doc James ( talk · contribs · email) 22:50, 25 June 2017 (UTC)
Doc James ( talk · contribs · email) 03:45, 26 June 2017 (UTC)
![]() | This
edit request to
Diabetes mellitus type 2 has been answered. Set the |answered= or |ans= parameter to no to reactivate your request. |
Please consider changing "Diagnosis of diabetes is by blood tests such as fasting plasma glucose, oral glucose tolerance test, or A1C.[3]" to " "Diagnosis of diabetes is by blood tests such as fasting plasma glucose, oral glucose tolerance test, or Glycated Hemoglobin A1C.[3]" 198.153.148.7 ( talk) 06:02, 29 June 2017 (UTC)
doi:10.1001/jamainternmed.2017.6040 JFW | T@lk 22:02, 6 November 2017 (UTC)
![]() | This page is an archive of past discussions. Do not edit the contents of this page. If you wish to start a new discussion or revive an old one, please do so on the current talk page. |
![]() | This page is an archive of past discussions. Do not edit the contents of this page. If you wish to start a new discussion or revive an old one, please do so on the current talk page. |
Why would insulin be used to treat diabetes type 2 when that disease is characterized by insulin resistance? Wouldn't that make things worse (because insulin-resistant cells do not respond properly to insulin and therefore putting more insulin into the blood of an insulin-resistant person might actually make things worse)? ScamsAreHorrible172 ( talk) 07:52, 3 September 2017 (UTC)
1. Obesity does not **cause** diabetes neither does a lack of exercise. This is just the usual ignorant slander. Obesity and a lack of energy to perform physical activity are both symptoms of high insulin levels, which is associated with insulin resistance. Type 2 diabetes is even more strongly determined than type 1 but I bet the type 1 article doesn't claim type 1 is caused by being underweight and over-active.
Interestingly the wikipedia article on hyperinsulinemia actually gets the facts about type 2 right! /info/en/?search=Hyperinsulinemia
2. Not all type 2 diabetics are insulin resistant. A minority are insulin sensitive. Type 2 is characterised by a genetic fragility of the person's pancreatic beta cells. (The genes and associated causes are variable both within racial groups and across them so yes it's that vague: diabetes describes the symptom not the cause).
An example source: http://diabetes.diabetesjournals.org/content/52/1/102.short
3. Insulin resistance does not necessarily lead to diabetes. This only occurs if the person has a genetic flaw that means they cannot produce the extra insulin required. Mayo clinic autopsies of obese non-diabetic cadavers showed they had 50% more beta cell mass than normal (i.e. they were capable of increasing their insulin production).
An example source: http://care.diabetesjournals.org/content/29/3/717.short
4a. Exercise is not always effective but it's certainly worth trying.
An example source: http://care.diabetesjournals.org/content/29/6/1433.long
4. There is no insulin resistance. This theory was devised in 1932 before home glucose meters. Human insulin is maintained in a homeostatic range of 70 mg% to 140 mg% by the central nervous system (hypothalamus). Within this range blood sugar may change as frequently as every 60 seconds. The Dexcom continuous glucose meter, though very helpful, average five one-minute readings and displays a single reading. Therefore, it misses a substantial number of rapid oscillations. There is no model in biology in which sensitivity to a hormone changes after birth. There are abnormal insulins (congenital) but the infants do not survive. This is logical as insulin is required for the entry of glucose into all cells, except neurons, which absorb glucose directly. The majority of patients thought to have Type 2 diabetes do not. Doctors have been taught not to investigate the cause of the blood sugar disorder beyond doing a HgbA1c test of a simple glucose tolerance test. These are entirely worthless. The basic testing required: C-Peptide (fair accuracy), Dexcom CGM, modified GTT with insulin, gluocose and glucagon levels. When this is done most "Type 2 patients" turn out to have either Nesidioblastosis or Hypothalamic (Spontaneous) Hypoglycemia. See my textbook: "Disorders of Blood Sugar" (most online booksellers)or view my YouTube presentations (www.chicodiabetes.com). See Puglianiello and Cianfarani, 2006, Review of Diabetic Studies. Central Control of Blood Glucose. Roberto Victor Illa, M.D. — Preceding unsigned comment added by 98.244.61.51 ( talk) 04:49, 9 October 2015 (UTC)
The downsides to exercise are: an obese person is too heavy for their joints and ligaments so exercise before losing weight can cause damage (and pain)! And in the short term the effect of exercise is unpredictable: it can raise or lower blood glucose levels!
4b. Diet, specifically a carbohydrate controlled (i.e. low or very low) is the primary treatment.
5. There is no need to reduce saturated fat intake in order to manage diabetes. This is the standard Ancel Keys religion and has been so discredited that even the ADA is finally taking notice.
6. The UKPDS ia a *terrible* study to cite. The study was flawed and the conclusions drawn from it even more so. In summary:
- It attempted to lower blood glucose levels using drugs alone. The side-effects of those drugs more than cancelled out the benefit.
- The targets were in any case still well above levels at which diabetes would be diagnosed.
- Most patients in the study failed to meet even those lax targets.
- No attempt was made to control blood glucose levels using diet (no doubt because this wouldn't have allowed the sponsoring companies to sell more drugs) and neither was any attempt made to achieve normal blood glucose levels (HbA1c ~5%).
- The entirely unsupported conclusion drawn was that lowering blood glucose levels had no positive benefit: a conclusion that absolutely cannot be drawn from this flawed study.
It's laughable that the UKPDS too the stance that "mortality itself was not considered a relevant outcome" and deliberately ignored any possible harm!
Example source: http://www.diapedia.org/introduction/the-university-group-diabetes-program
You need a new medical 'expert' for this page if this is the 'quality' of material he produces. — Preceding unsigned comment added by Countbrass ( talk • contribs) 08:16, 28 December 2013 (UTC)
Coffee consumption appears to lower the risks for Diabetes Mellitus type 2. [1] -- AdeleRako ( talk) 17:19, 25 April 2014 (UTC)
===Medications===
Some drugs, used for any of several conditions, can interfere with the insulin regulation system, possibly producing drug induced hyperglycemia. Some examples follow, giving the biochemical mechanism in each case:
- Atypical Antipsychotics - Alter receptor binding characteristics, leading to increased insulin resistance.
- Beta-blockers - Inhibit insulin secretion.
- Calcium Channel Blockers - Inhibits secretion of insulin by interfering with cytosolic calcium release.
- Corticosteroids - Cause peripheral insulin resistance and gluconeogenesis.
- Fluoroquinolones - Inhibits insulin secretion by blocking ATP sensitive potassium channels.
- Niacin - causes increased insulin resistance due to increased free fatty acid mobilization.
- Phenothiazines - Inhibit insulin secretion.
- Protease Inhibitors - Inhibit the conversion of proinsulin to insulin.
- Somatropin - May decrease sensitivity to insulin, especially in those susceptible.
- Thiazide Diuretics - Inhibit insulin secretion due to hypokalemia. They also cause increased insulin resistance due to increased free fatty acid mobilization.
Doc James ( talk · contribs · email) 04:40, 10 January 2011 (UTC)
References
{{
cite journal}}
: Unknown parameter |month=
ignored (
help)CS1 maint: multiple names: authors list (
link)
Shouldn't there be a section about research into the condition? Such as for documenting that such as [2] doi: 10.1038/nature13540 -- 65.94.171.126 ( talk) 10:09, 18 July 2014 (UTC)
I recommend the following book for a broad international perspective useful for this article:
Sher man 3312 ( talk) 13:52, 23 August 2014 (UTC).
I recommend the following portal bar to be added below the navigation templates: {{Portal bar|Biology|Medicine|Health}}.
Sher man 3312 ( talk) 13:52, 23 August 2014 (UTC).
![]() | This
edit request to
Diabetes mellitus type 2 has been answered. Set the |answered= or |ans= parameter to no to reactivate your request. |
Insulin was actually discovered in 1916, by Nicolae Paulescu, 5 years before the two Canadians started their research. http://en.wikipedia.org/wiki/Insulin 139.149.1.232 ( talk) 12:56, 16 October 2014 (UTC)
doi:10.1016/S0140-6736(14)61335-0. Glucagon-like peptide-1 receptor agonist and basal insulin combination treatment for the management of type 2 diabetes: a systematic review and meta-analysis. Sounds suitable for inclusion. JFW | T@lk 20:11, 20 December 2014 (UTC)
Blood pressure lowering in DM - systematic review and meta-analysis: doi:10.1001/jama.2014.18574 JFW | T@lk 22:33, 10 February 2015 (UTC)
In Cause -> Lifestyle, the first paragraph is:
My focus being on the very last sentence of that paragraph. It seems a bit out of place; on first reading it I was confused and thought that there was some kind of connection between waist-hip ratio and diabetes. Which naturally, there is, given that it's an indicator of obesity, but it seems a bit out of the blue. I think it should be removed, or at least moved elsewhere. — Fuebar [ talk | cont 17:43, 13 March 2015 (UTC)
Not a single word about low carb diets as diabetes treatment in the article.
Here you can see a different opinion:
Study: Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base
URL: http://www.nutritionjrnl.com/article/S0899-9007%2814%2900332-3/fulltext
Abstract:
"The inability of current recommendations to control the epidemic of diabetes, the specific failure of the prevailing low-fat diets to improve obesity, cardiovascular risk, or general health and the persistent reports of some serious side effects of commonly prescribed diabetic medications, in combination with the continued success of low-carbohydrate diets in the treatment of diabetes and metabolic syndrome without significant side effects, point to the need for a reappraisal of dietary guidelines. The benefits of carbohydrate restriction in diabetes are immediate and well documented. Concerns about the efficacy and safety are long term and conjectural rather than data driven. Dietary carbohydrate restriction reliably reduces high blood glucose, does not require weight loss (although is still best for weight loss), and leads to the reduction or elimination of medication. It has never shown side effects comparable with those seen in many drugs. Here we present 12 points of evidence supporting the use of low-carbohydrate diets as the first approach to treating type 2 diabetes and as the most effective adjunct to pharmacology in type 1. They represent the best-documented, least controversial results. The insistence on long-term randomized controlled trials as the only kind of data that will be accepted is without precedent in science. The seriousness of diabetes requires that we evaluate all of the evidence that is available. The 12 points are sufficiently compelling that we feel that the burden of proof rests with those who are opposed."
People has the right to know. It is not a fringe theory, but a full fledged tratment for diabetes. Posibly it has it's downsides, but medication also do. For example, look at this:
http://blog.drbrownstein.com/metformin-and-diabetic-drugs-increase-mortality/
"A recent article titled, “14-Year Risk of All-Cause Mortality According to Hypoglycemic Drug Exposure in a General Population” assessed the safety data of diabetic drugs over a 14-year time period. The authors studied 3336 participants and 248 deaths over a 14-year time period.
The scientists compared the all-cause mortality risk in non-diabetic versus diabetic subjects. The found that untreated diabetics had a 222% increase risk of all-cause mortality. Diabetics treated with Metformin had 128% increase risk of death. Diabetics treated with sulfonylureas (e.g., Glyburide, Amaryl, Glucotrol, Glynase, DiaBeta) had a 70% increase in all-cause mortality. Diabetics treated with insulin had 329% increase in all-cause mortality."
We shall have the right to know and the right to choose.
Sincerely,
some fat dude.
--
189.213.114.161 (
talk)
05:19, 14 June 2015 (UTC)
doi:10.7326/M15-1400 Mostly benefit those with previous poor glycaemic control, and need to be >10h. JFW | T@lk 21:31, 7 October 2015 (UTC)
doi:10.1210/jc.2015-4251 JFW | T@lk 14:59, 7 March 2016 (UTC)
This "although diabetes is a more heterogeneous condition than was thought formerly. [1]"
To here [3]
Adjusted the words to simplify. Not about type 2 DM specifically but about DM generally. Doc James ( talk · contribs · email) 23:29, 17 July 2016 (UTC)
The WHO ref says "is largely the result of excess body weight and physical inactivity." NIH says "Type 2 diabetes develops most often in middle-aged and older people who are also overweight or obese... Scientists think genetic susceptibility and environmental factors are the most likely triggers of type 2 diabetes."
How about "Type 2 diabetes primarily occurs as a result of obesity and not enough exercise. [3] Some people are more genetically at risk than others. [4]" Doc James ( talk · contribs · email) 19:41, 18 July 2016 (UTC)
References
{{
cite web}}
: Unknown parameter |deadurl=
ignored (|url-status=
suggested) (
help)
Hello fellow Wikipedians,
I have just modified 2 external links on Diabetes mellitus type 2. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
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Cheers.— InternetArchiveBot ( Report bug) 08:39, 12 December 2016 (UTC)
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Been in place a fair bit of time. Also it does show on mobile. User needs consensus for its removal. Doc James ( talk · contribs · email) 18:11, 31 December 2016 (UTC)
There seems to be no policy reason to disallow it, and the app is proving very useful. As a small scale test of the banner, this use seems ideal. Carl Fredrik 💌 📧 12:28, 4 January 2017 (UTC)
doi:10.7326/M16-1860 JFW | T@lk 11:19, 3 January 2017 (UTC)
References
![]() | This
edit request to
Diabetes mellitus type 2 has been answered. Set the |answered= or |ans= parameter to no to reactivate your request. |
Armintarrah ( talk) 18:22, 3 January 2017 (UTC)
Review in Circulation - discusses overtreatment doi:10.1161/CIRCULATIONAHA.116.022622 JFW | T@lk 10:23, 10 January 2017 (UTC)
QG added the following today
A large number of people are being treated intensively even though the possible risks of medicine surpass possible benefits. [1]
References
This is hot off the presses and not pubmed-indexed yet. My library doesn't have access to it. So I apologize but I am commenting but have not read this ref yet. Questions - is this a MEDRS source or is it an opinion? It is important to keep sugar levels down, chronically -- this is something doctors struggle with, with their patients, as patients cannot see the damage being done by poor sugar management but chronic mismanagement ends up causing the terrible complications we all know about (retinopathy, nephropathy, circulation problems that lead to loss of limbs, etc) Jytdog ( talk) 23:27, 10 January 2017 (UTC)
added it here - basically says too many people ignore the guidelines that say base glycemic control on life expetancy and other factors - takes at least 9 years to see benefit at minimum and probably longer. Jytdog ( talk) 02:13, 12 January 2017 (UTC)
doi:10.1016/S0140-6736(17)30058-2 JFW | T@lk 14:01, 2 June 2017 (UTC)
The article currently states "Vegetarian diets in general have been related to lower diabetes risk, but do not offer advantages compared with diets which allow moderate amounts of animal products."
I think this misrepresents the referenced article. That article mentions several advantages of vegan diets, for example: "Vegan diets have gained acceptance as a dietary strategy for maintaining good health and managing disease conditions ranging from cardiovascular disease to cancer [1]. Vegan diets may prove useful as medical nutrition therapy in treating the conditions of metabolic syndrome, including obesity, diabetes and cardiovascular risk [3,4,5], and may confer protection against inflammatory conditions such as rheumatoid arthritis (RA) [6,7]."
Nowhere does the referenced article suggest that other diets also have these advantages, except as pertaining to diabetes.
Further, the phrasing of our article may mislead the reader into thinking that any moderate-meat diet is an effective way to manage diabetes. In fact, the article states that similar [improvements in metabolic conditions in type 2 diabetes patients] to vegan diets "have been achieved with other diets including the Mediterranean diet, a low-carbohydrate/high-protein diet, and a vegetarian diet." In other words, these are specific diets. — Preceding unsigned comment added by 2001:4B98:DC0:43:216:3EFF:FE79:1171 ( talk) 15:35, 6 June 2017 (UTC)
Is in contrast to the relative lack in type 2 (in type 2 insulin levels may be high with high BS, problem is more initially resistance to insulin). In type 1 the problem is absolute decreases in insulin below baseline (not a relative lack). Dozens of sources support this such as [8]. Absolute lack of insulin DOES NOT mean no insulin. Doc James ( talk · contribs · email) 22:50, 25 June 2017 (UTC)
Doc James ( talk · contribs · email) 03:45, 26 June 2017 (UTC)
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Please consider changing "Diagnosis of diabetes is by blood tests such as fasting plasma glucose, oral glucose tolerance test, or A1C.[3]" to " "Diagnosis of diabetes is by blood tests such as fasting plasma glucose, oral glucose tolerance test, or Glycated Hemoglobin A1C.[3]" 198.153.148.7 ( talk) 06:02, 29 June 2017 (UTC)
doi:10.1001/jamainternmed.2017.6040 JFW | T@lk 22:02, 6 November 2017 (UTC)
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