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Ideal sources for Wikipedia's health content are defined in the guideline
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I invite other editors to help me clarify the 'adverse effects' section in this article, as several of the bullet points seem misleading.
Specifically, the reference to the American Heart Association article "Drugs That May Cause or Exacerbate Heart Failure" is not related to tamsulosin as it relates to prostatic disease, but describes problems encountered by a separate alpha blocker used in the context of patients participating in a clinical trial designed to prevent heart disease. Increased risks of cardiac failure in these patients was described as being due to inappropriate lowering of blood pressure (presumably in hypertensive patients who would have otherwise benefited from other drugs used for hypertension); misdiagnosis; or masking of otherwise diagnosable HF, etc. The point being, this section and the issues raised don't appear directly relevant to men being treated specifically for prostate disease. I propose removing, or at the very least, qualifying this excerpt - if it must be kept in.
Another misleading bullet is "Congestive Heart Failure" (also in the Adverse Effects section). This bullet, in the subsection 'Adverse Events' makes it appear as though Tamsulosin and CHF are directly correlated. But the abstract linked to this bullet point is simply listing alpha blockers as contraindications in people already suffering from heart failure, among other cardiac diseases. Thanks for your assistance. Ronsword ( talk) 23:40, 23 January 2018 (UTC)
Regarding effects on the heart, I know first hand from trying this medication, that it can cause irregular heartbeat. This was my personal experience --- heart palpitations. I understand that because it was my personal experience, this does not qualify for the article. Nevertheless, this factor should be considered in the context of the above remarks with respect to any prospective change to the article. --- Dagme ( talk) 17:46, 1 October 2018 (UTC)
I am aware of the guidelines for source material for medical pages, and that review articles or meta-analyses are preferred. However, I wonder if we should consider adding information to the Tamsulosin page based on a recent well-done analysis that shows the risk of tamsulosin over other agents in its class, in terms of incidence of dementia. I know that Wikipedia referencing rules serve a purpose but also that there is flexibility when it is for the greater good. In this case I would argue the latter applies as a prospective trial for this will never be done. No Institutional Review Board would ever approve a prospective trial when the harm was this great.
Given this circumstance I would ask if it would be acceptable to this information to the Tamsulosin page:
Is adding something like this a possibility? How do other participants view this situation? Dr. Bob in Arizona ( talk) 02:10, 12 April 2018 (UTC)
Should be updated to show that Tamsulosin is now available over-the-counter (OTC) and is no longer ℞-only. 2601:4C4:C203:21FC:C83A:3D08:9044:5938 ( talk) 12:17, 29 September 2019 (UTC)
References
What does the Reuters article about market speculation over the immune-suppresant drug Prograf having a generic introduced in the US and the attempts of the Japanese manufacturer to delay it have to do with the name under which tamsulosin is marketed in Egypt? Am I missing something in this link? A search for "egypt" didn't find anything. A Shortfall Of Gravitas ( talk) 09:26, 1 November 2019 (UTC)
In the UK Tamsulosin is only available from pharmacies (see https://www.nhs.uk/medicines/tamsulosin/), it is not on the general sales list. 81.140.244.69 ( talk) 15:36, 30 August 2020 (UTC)
Who should not take Tamsulosin HCL? The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:
Conditions: orthostatic hypotension a form of low blood pressure priapism a prolonged erection of the penis cataract surgery floppy iris during eye surgery CYP2D6 poor metabolizer reduced activity of cytochrome p450 CYP3A4 Allergies: Tamsulosin
The final paragraph of the Mechanism section reads "Selective action of tamsulosin in alpha 1A/D receptors is controversial and over three quarters of tamsulosin registered human studies are unpublished.[18]"
Two things: 1) This is the only place in the article that mentions alpha-1D. Needs clarification. 2) I don't see anywhere in the referenced article (18) That says that 3/4 of the studies are unpublished. Perhaps I'm blind. Can this be elucidated by someone with knowledge in the area? ThreeRocks ( talk) 21:31, 25 September 2021 (UTC)
This article is rated Start-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||||
|
Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Tamsulosin.
|
I invite other editors to help me clarify the 'adverse effects' section in this article, as several of the bullet points seem misleading.
Specifically, the reference to the American Heart Association article "Drugs That May Cause or Exacerbate Heart Failure" is not related to tamsulosin as it relates to prostatic disease, but describes problems encountered by a separate alpha blocker used in the context of patients participating in a clinical trial designed to prevent heart disease. Increased risks of cardiac failure in these patients was described as being due to inappropriate lowering of blood pressure (presumably in hypertensive patients who would have otherwise benefited from other drugs used for hypertension); misdiagnosis; or masking of otherwise diagnosable HF, etc. The point being, this section and the issues raised don't appear directly relevant to men being treated specifically for prostate disease. I propose removing, or at the very least, qualifying this excerpt - if it must be kept in.
Another misleading bullet is "Congestive Heart Failure" (also in the Adverse Effects section). This bullet, in the subsection 'Adverse Events' makes it appear as though Tamsulosin and CHF are directly correlated. But the abstract linked to this bullet point is simply listing alpha blockers as contraindications in people already suffering from heart failure, among other cardiac diseases. Thanks for your assistance. Ronsword ( talk) 23:40, 23 January 2018 (UTC)
Regarding effects on the heart, I know first hand from trying this medication, that it can cause irregular heartbeat. This was my personal experience --- heart palpitations. I understand that because it was my personal experience, this does not qualify for the article. Nevertheless, this factor should be considered in the context of the above remarks with respect to any prospective change to the article. --- Dagme ( talk) 17:46, 1 October 2018 (UTC)
I am aware of the guidelines for source material for medical pages, and that review articles or meta-analyses are preferred. However, I wonder if we should consider adding information to the Tamsulosin page based on a recent well-done analysis that shows the risk of tamsulosin over other agents in its class, in terms of incidence of dementia. I know that Wikipedia referencing rules serve a purpose but also that there is flexibility when it is for the greater good. In this case I would argue the latter applies as a prospective trial for this will never be done. No Institutional Review Board would ever approve a prospective trial when the harm was this great.
Given this circumstance I would ask if it would be acceptable to this information to the Tamsulosin page:
Is adding something like this a possibility? How do other participants view this situation? Dr. Bob in Arizona ( talk) 02:10, 12 April 2018 (UTC)
Should be updated to show that Tamsulosin is now available over-the-counter (OTC) and is no longer ℞-only. 2601:4C4:C203:21FC:C83A:3D08:9044:5938 ( talk) 12:17, 29 September 2019 (UTC)
References
What does the Reuters article about market speculation over the immune-suppresant drug Prograf having a generic introduced in the US and the attempts of the Japanese manufacturer to delay it have to do with the name under which tamsulosin is marketed in Egypt? Am I missing something in this link? A search for "egypt" didn't find anything. A Shortfall Of Gravitas ( talk) 09:26, 1 November 2019 (UTC)
In the UK Tamsulosin is only available from pharmacies (see https://www.nhs.uk/medicines/tamsulosin/), it is not on the general sales list. 81.140.244.69 ( talk) 15:36, 30 August 2020 (UTC)
Who should not take Tamsulosin HCL? The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:
Conditions: orthostatic hypotension a form of low blood pressure priapism a prolonged erection of the penis cataract surgery floppy iris during eye surgery CYP2D6 poor metabolizer reduced activity of cytochrome p450 CYP3A4 Allergies: Tamsulosin
The final paragraph of the Mechanism section reads "Selective action of tamsulosin in alpha 1A/D receptors is controversial and over three quarters of tamsulosin registered human studies are unpublished.[18]"
Two things: 1) This is the only place in the article that mentions alpha-1D. Needs clarification. 2) I don't see anywhere in the referenced article (18) That says that 3/4 of the studies are unpublished. Perhaps I'm blind. Can this be elucidated by someone with knowledge in the area? ThreeRocks ( talk) 21:31, 25 September 2021 (UTC)