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This article should be updated. I'm glad it's here. But studies are now showing that synonymous mutations quite possibly be harmful, opposed to the assumption that they are neutral. Prof. Lawrence Hurst (University of Bath) has showed that some diseases owe their thanks to synonymous mutations. --jorgekluney.
This section is unsourced and certainly wrong. The term mutation is used to indicate any kind of change in the DNA sequence, including insertions and deletions and more broadly the effect of this changes (missense mutation, gain-of-function mutation). Substitution is the term for a single base-pair exchange [1]. Differences in sequence within populations are SNPs. Note that NCBI's SNP repository [2] contains also insertion and deletion polymorphisms, but use SNP to indicate true single nucleotide substitutions. I'll leave it as it is, in case there is a source for the original statement 24.255.35.103 ( talk) 21:19, 23 February 2010 (UTC)
This article is rated Start-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||||||
|
This article should be updated. I'm glad it's here. But studies are now showing that synonymous mutations quite possibly be harmful, opposed to the assumption that they are neutral. Prof. Lawrence Hurst (University of Bath) has showed that some diseases owe their thanks to synonymous mutations. --jorgekluney.
This section is unsourced and certainly wrong. The term mutation is used to indicate any kind of change in the DNA sequence, including insertions and deletions and more broadly the effect of this changes (missense mutation, gain-of-function mutation). Substitution is the term for a single base-pair exchange [1]. Differences in sequence within populations are SNPs. Note that NCBI's SNP repository [2] contains also insertion and deletion polymorphisms, but use SNP to indicate true single nucleotide substitutions. I'll leave it as it is, in case there is a source for the original statement 24.255.35.103 ( talk) 21:19, 23 February 2010 (UTC)