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This section says that dehydrosphingosine (usually called 3-ketosphinganine) is enzymatically converted to sphingosine but it isn't. The carbonyl group is reduced, forming dihydrosphingosine (sphinganine), which reacts with a fatty acid-CoA, forming dihydroceramide, which is then dehydrogenated to form the trans double bond at carbons 4 and 5. This is ceramide, which can be hydrolyzed to liberate sphingosine and fatty acid.
In the Biosynthesis section the image Sphingosine synthesis corrected.png depicts serine with an amine group on the secondary carbon and a hydroxyl group on a primary carbon. In the true structure of serine an hydroxyl group is on the secondary carbon and an amine group on the primary carbon.
The Biosynthesis section needs citations from sources verifying the information. -- Djinn32 ( talk) 00:33, 4 October 2019 (UTC)
This article is rated Start-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||||
|
This section says that dehydrosphingosine (usually called 3-ketosphinganine) is enzymatically converted to sphingosine but it isn't. The carbonyl group is reduced, forming dihydrosphingosine (sphinganine), which reacts with a fatty acid-CoA, forming dihydroceramide, which is then dehydrogenated to form the trans double bond at carbons 4 and 5. This is ceramide, which can be hydrolyzed to liberate sphingosine and fatty acid.
In the Biosynthesis section the image Sphingosine synthesis corrected.png depicts serine with an amine group on the secondary carbon and a hydroxyl group on a primary carbon. In the true structure of serine an hydroxyl group is on the secondary carbon and an amine group on the primary carbon.
The Biosynthesis section needs citations from sources verifying the information. -- Djinn32 ( talk) 00:33, 4 October 2019 (UTC)