This page is an archive of past discussions. Do not edit the contents of this page. If you wish to start a new discussion or revive an old one, please do so on the current talk page. |
Someone added the ungrammatical statement that Hb polymerisation was a form of amyloid. It isn't, really. Amyloid is the accumulation of polymerised proteins in end-organs (kidney, heart, brain etc), which generally does not seem to occur in sicklers. JFW | T@lk 10:41, 4 Jul 2004 (UTC)
Not a word about Pauling. Where do we insert this classical reference: L. Pauling, H. A. Itano, S. J. Singer, and I. C. Wells (1949) Sickle Cell Anemia, A Molecular Disease Science 110, 543 - 548. JFW | T@lk 00:47, 23 October 2005 (UTC)
I have edited this page in order to give new info to people looking for infomation about new treatments becoming available. I have given as much information as i know about what's coming out. Please give me a shout if theres an issue with my post. Also.. I was having poblems making links to the available websites that had more info for more research. I'm at HisNHers2006@yahoo.com I care about the subject and the site and I want to have the best info available for wiki users and people just checking it out. If you can help my post, please do. Also please contact me for updates.
ok gocha, but how about more on the new gene therapies that are being developed? I left a link to a great article ..did you see it? Is that bad wiki etiquette? Also How do wiki users contact each other to collaborate and discuss articles?
( talk) 14:47, 29 April 2008 (UTC)
Nigerian Well-known victims -Zulaha Hadejia -Saude Hadejia -Asmau Hadejia
Alive and living well with the disease,tho here in nigeria we have a limited knowledge of the disease. —Preceding unsigned comment added by 196.200.14.187 ( talk) 21:34, 9 December 2008 (UTC)
Whoever wants to dip into the history of the discovery: PMID 2642320. JFW | T@lk 00:48, 3 May 2006 (UTC)
Most of the information for the "Nigerian Treatment" does not belong in this article. I don't see how a US SEC document has anything to do with sickle-cell disease. The same with the comment about the Nigerian ruler. At least the trial results are relevant, although they are better served in notes. Of course, any kind of number like that has to be cited.
I look forward to seeing the citations and making this portion of the article as strong as the rest. Ted Talk/ Contributions 14:10, 21 July 2006 (UTC)
What what it is worth, here is the link to much of the information: [1]. It is, of course, copyrighted. At least some of the material being added is copied directly from this source. A recent addition also had the words "Back to top" at the bottom of the addition, further suggesting it was cut-and-pasted from some as-yet-unknown website. Most likely, violating copyright. Ted Talk/ Contributions 20:37, 21 July 2006 (UTC)
Moved - I agree shame that original research not cited as opposed to the company's own selective quotes. However on searching PubMed some validation to the product found (not under current international & US names but its former research name of 'Niprisan'). A Cochrane review cautions that reduced crises episodes reported in a later larger trial was not match by reduced complications or rates of anaemia. However more pressing is that this drug is still being evaluated, yet currently occupies a length in the article greater than other established treatments. I have therefore cut it drastically, in this article, to just a mention under the "Future treatments" section, and moved the rest to a newly creatd article of Nicosan. I've given it a little more structure, started marking up the references with fuller citation details and will continue to add a few more papers to cite (I'ld be grateful if other editors could give me about an hour to add this extra material in). NB I've added the cochrane review as it added balance and thus NPOV to what was previously just a quote from the company's own claims. David Ruben Talk 23:37, 21 July 2006 (UTC)
The STOP trial has shed some light on the use of transfusion to prevent stroke in children with HbSS and the role of transcranial doppler [2]. JFW | T@lk 20:14, 26 July 2006 (UTC)
from the first paragraph: "Once the two mutated genes inherited from each parent link together, the DNA nucleotides are pushed into the bloodstream after the "T" is replaced with a "G". The nucleotide then copies itself in the bloodstream and it eventually makes the proteins inside the bloodcells stretch out and form into a sickle shape. The whole paragraph is really confused and confusing and some of it doesn't make sense (The nucleotide then copies itself in the bloodstream??) Does anyone want to write it better? (I'd like too but I'm not sufficiently informed) Plch 22:34, 17 March 2007 (UTC)
this article lacks that it makes you look pale.
What is "black"? This doesn't sound like a scientific or medical determination. Please re-word to refer to "darker skin" or climatic region. Leon Spencer, Animis Opibusque Parati 00:49, 31 March 2008 (UTC)
There appears to be an increased thrombosis risk. doi: 10.1111/j.1365-2141.2007.06740.x addresses this is more detail. JFW | T@lk 15:05, 12 September 2007 (UTC)
This article from The Washington Post (December 7, 2007) gives evidence that there are advances in treating sickle cell anemia underway. Granted it's in mice, but perhaps it should be documented here? I personally don't feel capable of doing anything constructive or encyclopedic with this info, but if anyone has a way to find more references and come up with a good way of introducing the topic, it seems worthy of inclusion. Any thoughts? Isaiah ( talk) 13:36, 7 December 2007 (UTC)
Can someone please standardize the use of the term "sickle-cell" or "sickle cell" throughout the article? I see the term used interchangeably with or without the dash all over the place. I'd do it myself, but I'd prefer that we use the more correct spelling, if there is one, and I don't know which that is. Considering the title of the article I'd go with the one using the dash currently, but I think a more authoritative source is in order. Thanks. -- Hi Ev 07:55, 16 December 2007 (UTC)
When "sickle cell" is used adjectivally, it should be hyphenated. And when it is used nominally, it should be broken with a space. So, "sickle-cell disease involves sickle cells" is not inconsistent but standard English. 68.188.2.182 ( talk) 01:13, 9 February 2008 (UTC)
The defect does not lie in the delta chain. So is also the case in Thalessimias. Then why does Hb F predominate in Sickle Cell Disease and Hb A2 predominate in Thalessimias when both should be raised in both the diseases. 59.180.25.104 ( talk) 12:16, 28 February 2008 (UTC)Bis
Most information listed under "Vaso-occlusive crisis" is listed again under "Complications". But I'm new here, so I'm not comfortable changing it myself. Someone may have done it on purpose, after all. —Preceding unsigned comment added by 64.198.112.213 ( talk) 16:09, 29 February 2008 (UTC)
I think it is also a reasonable edit that needs to be made since information is listed twice.-- DavidD4scnrt ( talk) 07:48, 16 April 2008 (UTC)
Article cites "Sickle-cell disease occurs more commonly in people (or their descendants) from parts of the world such as sub-Saharan Africa..." This is incorrect. "Sub-Saharan Africa" is a geologicial region - not a group of people. I think you want to say tropical and subtropical climates around the world. Sickle-cell (or the trait) has long been common in people of African descent due to climate - since ancient times.
Yahoo Article:Study shows life was tough for ancient Egyptians
"Studies on the remains of ordinary ancient Egyptians in a cemetery in Tell el-Amarna showed that many of them suffered from anemia, fractured bones, stunted growth and high juvenile mortality rates, according to professors Barry Kemp and Jerome Rose, who led the research."
An article citing the history of sickle-cell:
"Although the disease does not distinguish between the rich and the poor, it does single out those from the tropical and subtropical climates of the Old World...One long-held theory as to why it was so common in the tropics was its association with malaria. In the 1940s, E.A.Beet, a British medical officer stationed in Northern Rhodesia (now Zimbabwe), observed that blood from malaria patients who had sickle cell trait had fewer malarial parasites than blood from patients without the trait. Following this observation, a physician in Zaire reported that there were fewer cases of severe malaria among people with sickle cell trait than among those without it."--
Innvista Health
Leon Spencer, Animis Opibusque Parati 00:46, 31 March 2008 (UTC)
The reference to "sub-Saharan Africa" is grammatically correct (you seem to have overlooked the preceding phrase). You are incorrect to say that sub-Saharan Africa is "a geological region". It is not. I think you mean "a geographical region". — Preceding unsigned comment added by 86.130.190.87 ( talk) 13:31, 5 January 2013 (UTC)
doi: 10.1111/j.1365-2141.2005.05625.x JFW | T@lk 15:18, 2 April 2008 (UTC)
The NIH held a consensus conference on 17–22 September 2007. Hydroxyurea was discussed in extenso.
It's actually fascinating that despite all the reviews and conferences, longer-term outcome trials are still sparse. JFW | T@lk 05:40, 6 May 2008 (UTC)
People who have the sickle cell trait (one recessive gene) do not have 'sickle cell disease' or 'sickle cell anemia.' They have 'sickle cell trait.' This article should probably reflect that. Woland ( talk) 21:03, 20 May 2008 (UTC)
The text was just changed, all 'disease' became 'illness'. Not a way. I think it should be changed back. -- Dumarest ( talk) 11:30, 9 June 2008 (UTC)
Really not sure if it needs direct mention, but the UK NCEPOD has reported on sickle cell disease: http://www.ncepod.org.uk/2008sc.htm JFW | T@lk 15:38, 26 June 2008 (UTC)
Wondering if we should move the sickle cell crises info to its own page? There is a big difference between the condition most of the time and during crises.-- Doc James ( talk) 18:56, 20 December 2008 (UTC)
This map isn't accurate (compare to File:Paludisme - Frequence statistique.png), does it show historical rather than modern distribution? Tim Vickers ( talk) 22:20, 16 January 2009 (UTC)
Endemic malaria was quite prevalent in certain areas of Europe until the 19th century at least. When they dealt with the swamps, things got a lot better. I am certainly aware of reports of malaria in Northern Germany in the early 19th century. JFW | T@lk 09:08, 18 January 2009 (UTC)
On the website of the BBC, I just read about a woman who received radiotherapy treatment for sickle-cell anaemia. This might lead to an interesting addition to the article, if anybody knows a bit more about the subject. -- Irene1949 ( talk) 19:04, 16 February 2009 (UTC)
doi: 10.1111/j.1365-2141.2009.07602.x Br J Haem this week. JFW | T@lk 10:46, 8 April 2009 (UTC)
The recent vandalism has made me look at the names. The person credited for naming it "sickle cell anemia" is currently listed as Vernon Mason in 1922. It is unreferenced. On a casual Google search I don't come across his name independently except where it was mirrored or sourced from here. I do find an E.Vernon Hahn as an early investigator (1927). Do we have the facts correct here? -- MartinezMD ( talk) 21:29, 21 April 2009 (UTC)
Hi, ive seen a sentence thats implys that sickle-cell disease affected person had a 0.8 chance per year of having a crisis which it says on another part of the article that the chance of having a crisis varys greatly between patients that has a reference whereas this just says "citation-needed". Should this be changed? Spykid99 ( talk) 07:01, 22 April 2009 (UTC)
I have just removed sort of duplication in this section -- but I am unsure of part of this. The inheritance material is duplicative, but is sickle-cell actually a codominant allele? -- Dumarest ( talk) 12:05, 12 July 2009 (UTC)
According to Brooker (2005) sickle-cell is an example of overdominance; not codominance. Overdominance is when "a heterozygote is more vigorous than both of the corresponding homozygotes" (p. 84). In this particular circumstance, the heterozygous disease has an advantage over the homozygous dominant because it allows the body to be resistant to malaria. Brooker also describes codominance. It is "the phenomenon in which two alleles are both expressed in the heterozygous individual" (p.81). A perfect example of codominance is blood type. People can have type A, B, AB, and O blood. Each allele can have I^A, I^B, and i. Since both alleles are expressed there is codominance (p. 81). Furthermore, the description of sickle cell disease inheritance is extremely similar to the description of Simple-Mendelian inheritance. Therefore, the proper statement should read "Sickle-cell disease (SCD), or sickle-cell anaemia (or anemia; SCA) or drepanocytosis, is an autosomal recessive genetic blood disorder, with overdominance, characterized by red blood cells that assume an abnormal, rigid, sickle shape." User Dumarest was onto something!
Reference: Brooker, R.J. (2005). Genetics: Analysis & principles (2nd ed.). New York: McGraw Hill. — Preceding unsigned comment added by Mattemerson ( talk • contribs) 01:07, 15 March 2011 (UTC)
Are the life expectancies in the first paragraph still accurate? The article cited to support them was published in 1994, and the patients in the study were enrolled between 1978 and 1988. Treatment has evolved significantly since the 80's. Are there any recent studies that investigate life expectancy? Whizot ( talk) 00:52, 18 January 2010 (UTC)
I believe it is confusing to use both above terms, Sickle Cell Disease and Sickle Cell Anemia interchangeably when they aren't interchangeable.
Sickle Cell Disease according to:
Sickle Cell Disease Association of America
Media:(www.sicklecelldisease.org)Cite error: There are <ref>
tags on this page without content in them (see the
help page). "refers to the group of inherited blood disorders that affect red blood cells and due to abnormal hemoglobin S. Sickle Cell Anemia on the other hand refers to specific forms of the disease which based on their point mutation are expressed in different ways. Some of the common forms of Sickle Cell Disease are: Sickle Cell Anemia SS, Sickle-Hemoglobin C (S,C), Sickle Beta Plus and Sickle Beta Zero Thalassemia."
Wikipedia states: "Sickle-cell disease, or sickle-cell anaemia (or drepanocytosis), is a genetic life-long blood disorder characterized by red blood cells that assume an abnormal, rigid, sickle shape. When above delineaion is explained then the first sentence on the Wiki page is incorrect. Please consider changing. -- MTD2010 ( talk) 07:31, 25 February 2010 (UTC)
There is no African American in our families and my daughter was asked if American (Indian) blood possible. I see nothing on the subject and would like to know more. There is Indian on both sides of family. —Preceding unsigned comment added by 75.228.209.58 ( talk) 19:09, 9 May 2010 (UTC)
Some sentences are not seperated with a space after the period.
I'm unable to edit it... —Preceding unsigned comment added by 87.69.218.34 ( talk) 08:00, 15 May 2010 (UTC)
Desfaral for the chelatation of excess Iron (due to HbS breakdown) —Preceding unsigned comment added by Avkrules ( talk • contribs) 06:42, 6 July 2010 (UTC)
Are the two different (if so how) do we need to consider merging? Suitrader ( talk) —Preceding undated comment added 04:59, 15 August 2010 (UTC).
I've heard that those who have sickle-cell disease are virtually unaffected by the human immunodeficiency virus, yet I see no mention of it in this topic. Should it not be mentioned? Thanks, Topcount345 ( talk) 08:13, 15 August 2010 (UTC)
It has been proposed at Wikipedia talk:Invitation to edit that, because of the relatively high number of IP editors attracted to Sickle-cell disease, it form part of a one month trial of a strategy aimed at improving the quality of new editors' contributions to health-related articles. It would involve placing this:
You can edit this page. Click here to find out how.
at the top of the article, linking to this mini-tutorial about MEDRS sourcing, citing and content, as well as basic procedures, and links to help pages. Your comments regarding the strategy are invited at the project talk page, and comments here, regarding the appropriateness of trialling it on this article, would be appreciated. Anthony ( talk) 12:06, 31 August 2010 (UTC)
Just heard on the news about a find of old slides, showing a sickle cell crisis in sickle cell trait under a situation of difficult breathing resulting in low oxygen in the blood, slides from the early 20th century. Any more data on this?? ( Dumarest ( talk) 12:20, 29 November 2010 (UTC)).
Review: doi: 10.1016/S0140-6736(10)61029-X JFW | T@lk 08:32, 8 December 2010 (UTC)
Indicated in a recent edit. What does that word mean?? ( Dumarest ( talk) 02:04, 15 March 2011 (UTC)).
The article is currently mostly based on primary research studies. WP:MEDRS needs to be applied. The Lancet review above can be used to replace a lot of primary sources, and I think it should be easy to find other recent reviews. JFW | T@lk 10:36, 30 January 2011 (UTC)
I would request all of you to kindly participate in the simple language wikipedia article on Sickle-cell_disease and also I have started a list of useful resources here simple:Talk:Sickle-cell_disease..Kindly collaboarate nd build up this list.. and if possible create a wikiproject protal for it.. It will help thousands of english speaking as well as non-english speaking patients and families.. as we can easily use that template and translate it into other language wikipages and make those pages more lucid and user friendly rather than keeping this subject only for scholars who can always read the english regular version..Thanks and regards -- Dr.saptarshi ( talk) 11:29, 22 April 2012 (UTC)
I would like to suggest not redirecting Hb S to the Sickle-cell disease page. Other variant hemoglobins (Hb C, Hb E) have their own entries, and so should Hb S. Although obviously highly relevant to Sickle-cell disease, it is nevertheless a separate entity. 86.29.186.248 ( talk) 12:42, 25 July 2012 (UTC)
And that comes up again! I am getting tired of the multiple editings changing the 'e/ae' letters. We need an editorial ruling! ( Dumarest ( talk) 11:40, 27 September 2012 (UTC))
71.127.55.155 ( talk) 04:08,
Curious as to why my mention of the movie TO ALL MY FRIENDS ON SHORE was deleted as not being in good faith. Certainly it was not intended as malicious, and I believe that the film was the first instance of sickle cell anemia being brought to the attention of the public. It was also a critically acclaimed effort. A quick check of Internet Movie Data Base will show that it was not regarded as trivial, but as an important production that is still regarded by many as top-notch in both screenwriting and production. I'm personally not aware of any efforts to dramatize the plight of sickle cell victims since that film came out in 1972, which I also find notable.
Anyone have any thoughts on this? I'd like to know if there could be a "in popular media" section added, or if some revision of my initial effort would be more acceptable.
Thanks Oldsmobile ( talk) 04:14, 28 November 2012 (UTC)
A troublesome complication reviewed doi:10.1111/bjh.12199 JFW | T@lk 19:50, 7 January 2013 (UTC)
doi:10.1111/bjh.12300 Br J Haem 14:54, 25 April 2013 (UTC)
This page is an archive of past discussions. Do not edit the contents of this page. If you wish to start a new discussion or revive an old one, please do so on the current talk page. |
Someone added the ungrammatical statement that Hb polymerisation was a form of amyloid. It isn't, really. Amyloid is the accumulation of polymerised proteins in end-organs (kidney, heart, brain etc), which generally does not seem to occur in sicklers. JFW | T@lk 10:41, 4 Jul 2004 (UTC)
Not a word about Pauling. Where do we insert this classical reference: L. Pauling, H. A. Itano, S. J. Singer, and I. C. Wells (1949) Sickle Cell Anemia, A Molecular Disease Science 110, 543 - 548. JFW | T@lk 00:47, 23 October 2005 (UTC)
I have edited this page in order to give new info to people looking for infomation about new treatments becoming available. I have given as much information as i know about what's coming out. Please give me a shout if theres an issue with my post. Also.. I was having poblems making links to the available websites that had more info for more research. I'm at HisNHers2006@yahoo.com I care about the subject and the site and I want to have the best info available for wiki users and people just checking it out. If you can help my post, please do. Also please contact me for updates.
ok gocha, but how about more on the new gene therapies that are being developed? I left a link to a great article ..did you see it? Is that bad wiki etiquette? Also How do wiki users contact each other to collaborate and discuss articles?
( talk) 14:47, 29 April 2008 (UTC)
Nigerian Well-known victims -Zulaha Hadejia -Saude Hadejia -Asmau Hadejia
Alive and living well with the disease,tho here in nigeria we have a limited knowledge of the disease. —Preceding unsigned comment added by 196.200.14.187 ( talk) 21:34, 9 December 2008 (UTC)
Whoever wants to dip into the history of the discovery: PMID 2642320. JFW | T@lk 00:48, 3 May 2006 (UTC)
Most of the information for the "Nigerian Treatment" does not belong in this article. I don't see how a US SEC document has anything to do with sickle-cell disease. The same with the comment about the Nigerian ruler. At least the trial results are relevant, although they are better served in notes. Of course, any kind of number like that has to be cited.
I look forward to seeing the citations and making this portion of the article as strong as the rest. Ted Talk/ Contributions 14:10, 21 July 2006 (UTC)
What what it is worth, here is the link to much of the information: [1]. It is, of course, copyrighted. At least some of the material being added is copied directly from this source. A recent addition also had the words "Back to top" at the bottom of the addition, further suggesting it was cut-and-pasted from some as-yet-unknown website. Most likely, violating copyright. Ted Talk/ Contributions 20:37, 21 July 2006 (UTC)
Moved - I agree shame that original research not cited as opposed to the company's own selective quotes. However on searching PubMed some validation to the product found (not under current international & US names but its former research name of 'Niprisan'). A Cochrane review cautions that reduced crises episodes reported in a later larger trial was not match by reduced complications or rates of anaemia. However more pressing is that this drug is still being evaluated, yet currently occupies a length in the article greater than other established treatments. I have therefore cut it drastically, in this article, to just a mention under the "Future treatments" section, and moved the rest to a newly creatd article of Nicosan. I've given it a little more structure, started marking up the references with fuller citation details and will continue to add a few more papers to cite (I'ld be grateful if other editors could give me about an hour to add this extra material in). NB I've added the cochrane review as it added balance and thus NPOV to what was previously just a quote from the company's own claims. David Ruben Talk 23:37, 21 July 2006 (UTC)
The STOP trial has shed some light on the use of transfusion to prevent stroke in children with HbSS and the role of transcranial doppler [2]. JFW | T@lk 20:14, 26 July 2006 (UTC)
from the first paragraph: "Once the two mutated genes inherited from each parent link together, the DNA nucleotides are pushed into the bloodstream after the "T" is replaced with a "G". The nucleotide then copies itself in the bloodstream and it eventually makes the proteins inside the bloodcells stretch out and form into a sickle shape. The whole paragraph is really confused and confusing and some of it doesn't make sense (The nucleotide then copies itself in the bloodstream??) Does anyone want to write it better? (I'd like too but I'm not sufficiently informed) Plch 22:34, 17 March 2007 (UTC)
this article lacks that it makes you look pale.
What is "black"? This doesn't sound like a scientific or medical determination. Please re-word to refer to "darker skin" or climatic region. Leon Spencer, Animis Opibusque Parati 00:49, 31 March 2008 (UTC)
There appears to be an increased thrombosis risk. doi: 10.1111/j.1365-2141.2007.06740.x addresses this is more detail. JFW | T@lk 15:05, 12 September 2007 (UTC)
This article from The Washington Post (December 7, 2007) gives evidence that there are advances in treating sickle cell anemia underway. Granted it's in mice, but perhaps it should be documented here? I personally don't feel capable of doing anything constructive or encyclopedic with this info, but if anyone has a way to find more references and come up with a good way of introducing the topic, it seems worthy of inclusion. Any thoughts? Isaiah ( talk) 13:36, 7 December 2007 (UTC)
Can someone please standardize the use of the term "sickle-cell" or "sickle cell" throughout the article? I see the term used interchangeably with or without the dash all over the place. I'd do it myself, but I'd prefer that we use the more correct spelling, if there is one, and I don't know which that is. Considering the title of the article I'd go with the one using the dash currently, but I think a more authoritative source is in order. Thanks. -- Hi Ev 07:55, 16 December 2007 (UTC)
When "sickle cell" is used adjectivally, it should be hyphenated. And when it is used nominally, it should be broken with a space. So, "sickle-cell disease involves sickle cells" is not inconsistent but standard English. 68.188.2.182 ( talk) 01:13, 9 February 2008 (UTC)
The defect does not lie in the delta chain. So is also the case in Thalessimias. Then why does Hb F predominate in Sickle Cell Disease and Hb A2 predominate in Thalessimias when both should be raised in both the diseases. 59.180.25.104 ( talk) 12:16, 28 February 2008 (UTC)Bis
Most information listed under "Vaso-occlusive crisis" is listed again under "Complications". But I'm new here, so I'm not comfortable changing it myself. Someone may have done it on purpose, after all. —Preceding unsigned comment added by 64.198.112.213 ( talk) 16:09, 29 February 2008 (UTC)
I think it is also a reasonable edit that needs to be made since information is listed twice.-- DavidD4scnrt ( talk) 07:48, 16 April 2008 (UTC)
Article cites "Sickle-cell disease occurs more commonly in people (or their descendants) from parts of the world such as sub-Saharan Africa..." This is incorrect. "Sub-Saharan Africa" is a geologicial region - not a group of people. I think you want to say tropical and subtropical climates around the world. Sickle-cell (or the trait) has long been common in people of African descent due to climate - since ancient times.
Yahoo Article:Study shows life was tough for ancient Egyptians
"Studies on the remains of ordinary ancient Egyptians in a cemetery in Tell el-Amarna showed that many of them suffered from anemia, fractured bones, stunted growth and high juvenile mortality rates, according to professors Barry Kemp and Jerome Rose, who led the research."
An article citing the history of sickle-cell:
"Although the disease does not distinguish between the rich and the poor, it does single out those from the tropical and subtropical climates of the Old World...One long-held theory as to why it was so common in the tropics was its association with malaria. In the 1940s, E.A.Beet, a British medical officer stationed in Northern Rhodesia (now Zimbabwe), observed that blood from malaria patients who had sickle cell trait had fewer malarial parasites than blood from patients without the trait. Following this observation, a physician in Zaire reported that there were fewer cases of severe malaria among people with sickle cell trait than among those without it."--
Innvista Health
Leon Spencer, Animis Opibusque Parati 00:46, 31 March 2008 (UTC)
The reference to "sub-Saharan Africa" is grammatically correct (you seem to have overlooked the preceding phrase). You are incorrect to say that sub-Saharan Africa is "a geological region". It is not. I think you mean "a geographical region". — Preceding unsigned comment added by 86.130.190.87 ( talk) 13:31, 5 January 2013 (UTC)
doi: 10.1111/j.1365-2141.2005.05625.x JFW | T@lk 15:18, 2 April 2008 (UTC)
The NIH held a consensus conference on 17–22 September 2007. Hydroxyurea was discussed in extenso.
It's actually fascinating that despite all the reviews and conferences, longer-term outcome trials are still sparse. JFW | T@lk 05:40, 6 May 2008 (UTC)
People who have the sickle cell trait (one recessive gene) do not have 'sickle cell disease' or 'sickle cell anemia.' They have 'sickle cell trait.' This article should probably reflect that. Woland ( talk) 21:03, 20 May 2008 (UTC)
The text was just changed, all 'disease' became 'illness'. Not a way. I think it should be changed back. -- Dumarest ( talk) 11:30, 9 June 2008 (UTC)
Really not sure if it needs direct mention, but the UK NCEPOD has reported on sickle cell disease: http://www.ncepod.org.uk/2008sc.htm JFW | T@lk 15:38, 26 June 2008 (UTC)
Wondering if we should move the sickle cell crises info to its own page? There is a big difference between the condition most of the time and during crises.-- Doc James ( talk) 18:56, 20 December 2008 (UTC)
This map isn't accurate (compare to File:Paludisme - Frequence statistique.png), does it show historical rather than modern distribution? Tim Vickers ( talk) 22:20, 16 January 2009 (UTC)
Endemic malaria was quite prevalent in certain areas of Europe until the 19th century at least. When they dealt with the swamps, things got a lot better. I am certainly aware of reports of malaria in Northern Germany in the early 19th century. JFW | T@lk 09:08, 18 January 2009 (UTC)
On the website of the BBC, I just read about a woman who received radiotherapy treatment for sickle-cell anaemia. This might lead to an interesting addition to the article, if anybody knows a bit more about the subject. -- Irene1949 ( talk) 19:04, 16 February 2009 (UTC)
doi: 10.1111/j.1365-2141.2009.07602.x Br J Haem this week. JFW | T@lk 10:46, 8 April 2009 (UTC)
The recent vandalism has made me look at the names. The person credited for naming it "sickle cell anemia" is currently listed as Vernon Mason in 1922. It is unreferenced. On a casual Google search I don't come across his name independently except where it was mirrored or sourced from here. I do find an E.Vernon Hahn as an early investigator (1927). Do we have the facts correct here? -- MartinezMD ( talk) 21:29, 21 April 2009 (UTC)
Hi, ive seen a sentence thats implys that sickle-cell disease affected person had a 0.8 chance per year of having a crisis which it says on another part of the article that the chance of having a crisis varys greatly between patients that has a reference whereas this just says "citation-needed". Should this be changed? Spykid99 ( talk) 07:01, 22 April 2009 (UTC)
I have just removed sort of duplication in this section -- but I am unsure of part of this. The inheritance material is duplicative, but is sickle-cell actually a codominant allele? -- Dumarest ( talk) 12:05, 12 July 2009 (UTC)
According to Brooker (2005) sickle-cell is an example of overdominance; not codominance. Overdominance is when "a heterozygote is more vigorous than both of the corresponding homozygotes" (p. 84). In this particular circumstance, the heterozygous disease has an advantage over the homozygous dominant because it allows the body to be resistant to malaria. Brooker also describes codominance. It is "the phenomenon in which two alleles are both expressed in the heterozygous individual" (p.81). A perfect example of codominance is blood type. People can have type A, B, AB, and O blood. Each allele can have I^A, I^B, and i. Since both alleles are expressed there is codominance (p. 81). Furthermore, the description of sickle cell disease inheritance is extremely similar to the description of Simple-Mendelian inheritance. Therefore, the proper statement should read "Sickle-cell disease (SCD), or sickle-cell anaemia (or anemia; SCA) or drepanocytosis, is an autosomal recessive genetic blood disorder, with overdominance, characterized by red blood cells that assume an abnormal, rigid, sickle shape." User Dumarest was onto something!
Reference: Brooker, R.J. (2005). Genetics: Analysis & principles (2nd ed.). New York: McGraw Hill. — Preceding unsigned comment added by Mattemerson ( talk • contribs) 01:07, 15 March 2011 (UTC)
Are the life expectancies in the first paragraph still accurate? The article cited to support them was published in 1994, and the patients in the study were enrolled between 1978 and 1988. Treatment has evolved significantly since the 80's. Are there any recent studies that investigate life expectancy? Whizot ( talk) 00:52, 18 January 2010 (UTC)
I believe it is confusing to use both above terms, Sickle Cell Disease and Sickle Cell Anemia interchangeably when they aren't interchangeable.
Sickle Cell Disease according to:
Sickle Cell Disease Association of America
Media:(www.sicklecelldisease.org)Cite error: There are <ref>
tags on this page without content in them (see the
help page). "refers to the group of inherited blood disorders that affect red blood cells and due to abnormal hemoglobin S. Sickle Cell Anemia on the other hand refers to specific forms of the disease which based on their point mutation are expressed in different ways. Some of the common forms of Sickle Cell Disease are: Sickle Cell Anemia SS, Sickle-Hemoglobin C (S,C), Sickle Beta Plus and Sickle Beta Zero Thalassemia."
Wikipedia states: "Sickle-cell disease, or sickle-cell anaemia (or drepanocytosis), is a genetic life-long blood disorder characterized by red blood cells that assume an abnormal, rigid, sickle shape. When above delineaion is explained then the first sentence on the Wiki page is incorrect. Please consider changing. -- MTD2010 ( talk) 07:31, 25 February 2010 (UTC)
There is no African American in our families and my daughter was asked if American (Indian) blood possible. I see nothing on the subject and would like to know more. There is Indian on both sides of family. —Preceding unsigned comment added by 75.228.209.58 ( talk) 19:09, 9 May 2010 (UTC)
Some sentences are not seperated with a space after the period.
I'm unable to edit it... —Preceding unsigned comment added by 87.69.218.34 ( talk) 08:00, 15 May 2010 (UTC)
Desfaral for the chelatation of excess Iron (due to HbS breakdown) —Preceding unsigned comment added by Avkrules ( talk • contribs) 06:42, 6 July 2010 (UTC)
Are the two different (if so how) do we need to consider merging? Suitrader ( talk) —Preceding undated comment added 04:59, 15 August 2010 (UTC).
I've heard that those who have sickle-cell disease are virtually unaffected by the human immunodeficiency virus, yet I see no mention of it in this topic. Should it not be mentioned? Thanks, Topcount345 ( talk) 08:13, 15 August 2010 (UTC)
It has been proposed at Wikipedia talk:Invitation to edit that, because of the relatively high number of IP editors attracted to Sickle-cell disease, it form part of a one month trial of a strategy aimed at improving the quality of new editors' contributions to health-related articles. It would involve placing this:
You can edit this page. Click here to find out how.
at the top of the article, linking to this mini-tutorial about MEDRS sourcing, citing and content, as well as basic procedures, and links to help pages. Your comments regarding the strategy are invited at the project talk page, and comments here, regarding the appropriateness of trialling it on this article, would be appreciated. Anthony ( talk) 12:06, 31 August 2010 (UTC)
Just heard on the news about a find of old slides, showing a sickle cell crisis in sickle cell trait under a situation of difficult breathing resulting in low oxygen in the blood, slides from the early 20th century. Any more data on this?? ( Dumarest ( talk) 12:20, 29 November 2010 (UTC)).
Review: doi: 10.1016/S0140-6736(10)61029-X JFW | T@lk 08:32, 8 December 2010 (UTC)
Indicated in a recent edit. What does that word mean?? ( Dumarest ( talk) 02:04, 15 March 2011 (UTC)).
The article is currently mostly based on primary research studies. WP:MEDRS needs to be applied. The Lancet review above can be used to replace a lot of primary sources, and I think it should be easy to find other recent reviews. JFW | T@lk 10:36, 30 January 2011 (UTC)
I would request all of you to kindly participate in the simple language wikipedia article on Sickle-cell_disease and also I have started a list of useful resources here simple:Talk:Sickle-cell_disease..Kindly collaboarate nd build up this list.. and if possible create a wikiproject protal for it.. It will help thousands of english speaking as well as non-english speaking patients and families.. as we can easily use that template and translate it into other language wikipages and make those pages more lucid and user friendly rather than keeping this subject only for scholars who can always read the english regular version..Thanks and regards -- Dr.saptarshi ( talk) 11:29, 22 April 2012 (UTC)
I would like to suggest not redirecting Hb S to the Sickle-cell disease page. Other variant hemoglobins (Hb C, Hb E) have their own entries, and so should Hb S. Although obviously highly relevant to Sickle-cell disease, it is nevertheless a separate entity. 86.29.186.248 ( talk) 12:42, 25 July 2012 (UTC)
And that comes up again! I am getting tired of the multiple editings changing the 'e/ae' letters. We need an editorial ruling! ( Dumarest ( talk) 11:40, 27 September 2012 (UTC))
71.127.55.155 ( talk) 04:08,
Curious as to why my mention of the movie TO ALL MY FRIENDS ON SHORE was deleted as not being in good faith. Certainly it was not intended as malicious, and I believe that the film was the first instance of sickle cell anemia being brought to the attention of the public. It was also a critically acclaimed effort. A quick check of Internet Movie Data Base will show that it was not regarded as trivial, but as an important production that is still regarded by many as top-notch in both screenwriting and production. I'm personally not aware of any efforts to dramatize the plight of sickle cell victims since that film came out in 1972, which I also find notable.
Anyone have any thoughts on this? I'd like to know if there could be a "in popular media" section added, or if some revision of my initial effort would be more acceptable.
Thanks Oldsmobile ( talk) 04:14, 28 November 2012 (UTC)
A troublesome complication reviewed doi:10.1111/bjh.12199 JFW | T@lk 19:50, 7 January 2013 (UTC)
doi:10.1111/bjh.12300 Br J Haem 14:54, 25 April 2013 (UTC)