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The article said Dravet could be treated with drugs "like phenytoin or carbamazepine" - I have removed that bit because many people recommend explicitly avoiding those drugs (see below). I made an edit but someone may well undo it so I'll try and put better info here.
Most people with an SCN1A mutation (and hence Dravet) will have a loss of function on their sodium channel and so should avoid AEDs that are sodium blockers - see here SCN1A Patients Advised to Avoid Sodium Channel Blockers. Although some missense mutations might lead to a gain in function of sodium channel. I suppose the best way to say it might be 'use sodium blockers with caution'.
The Dravet Foundation treatment page says common treatments are clobazam, clonazepam, leviteracetam, stiripentol, topiramate and valproic acid. It says the following are contraindicated because they may make seizures worse: carbamazepine, fosphenytoin, lamotrigine, oxcarbazepine, phenytoin, vigabatrin.
NICE (who write up the guidlines for the NHS in the UK) give a similar list of drugs to avoid. See section 1.9.9.4 in NICE guide to Epilepsies: diagnosis and management - it says "Do not offer carbamazepine, gabapentin, lamotrigine, oxcarbazepine, phenytoin, pregabalin, tiagabine or vigabatrin." 82.38.169.122 ( talk) 17:05, 1 January 2016 (UTC)
Cannabis has been shown to have considerable efficacy in reduction of seizures and other symptoms of Dravet's Syndrome. It's actually a very well known issue- why isn't it mentioned? There is considerable evidence that attests to this- both anecdotal and empirical. — Preceding unsigned comment added by 76.200.118.133 ( talk) 01:09, 13 June 2015 (UTC)
People have thoughts? Doc James ( talk · contribs · email) 14:33, 2 July 2015 (UTC)
The result of the move request was: moved. Jenks24 ( talk) 11:20, 20 August 2015 (UTC)
Severe myoclonic epilepsy of infancy →
Dravet syndrome – Dravet syndrome is the common name of this disease.
Andrea Carter (
at your service |
my evil deads)
20:16, 12 August 2015 (UTC)
With all the hype about medical cannabis and cannabidiol being a treatment for this disease, the effectiveness of which is beyond the scope of this discussion, more people are aware of this disease. Most certainly people are going to want to research the disease. Most non-professionals know of this disease as "Dravet syndrome." I propose we rename the article to Dravet syndrome. What do y'all think? Andrea Carter ( at your service | my evil deads) 20:16, 12 August 2015 (UTC)
I think it is reasonable to include a sentence or two from this NEJM study. [1]
User:Alexbrn I think it is an appropriate exception to WP:MEDRS as (1) this is a rare condition (2) this is a well done RCT (3) it was published in the NEJM.
Others thoughts? Doc James ( talk · contribs · email) 01:54, 27 May 2017 (UTC)
I have corrected the ICD 10 code from G40.4 to G40.3. Dravet Syndrome is not listed in ICD by that name but this is the code provided for Dravet Syndrome in the SNOMED CT classification browser. It is also the code you will find when you index trail epilepsy > myoclonic. Furthermore, the ICD 9 code listed is 345.1 which when you cross-map it to ICD 10 also gives you G40.3.
I hope this edit is acceptable, if anybody has contradictory sources that support the G40.4 code I'd be happy to review further. — Preceding unsigned comment added by Tattycakes ( talk • contribs) 09:38, 1 November 2019 (UTC)
This is the
talk page for discussing improvements to the
Dravet syndrome article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL |
![]() | This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||||||||||||||||||||||||||||||||
|
![]() | Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Dravet syndrome.
|
The article said Dravet could be treated with drugs "like phenytoin or carbamazepine" - I have removed that bit because many people recommend explicitly avoiding those drugs (see below). I made an edit but someone may well undo it so I'll try and put better info here.
Most people with an SCN1A mutation (and hence Dravet) will have a loss of function on their sodium channel and so should avoid AEDs that are sodium blockers - see here SCN1A Patients Advised to Avoid Sodium Channel Blockers. Although some missense mutations might lead to a gain in function of sodium channel. I suppose the best way to say it might be 'use sodium blockers with caution'.
The Dravet Foundation treatment page says common treatments are clobazam, clonazepam, leviteracetam, stiripentol, topiramate and valproic acid. It says the following are contraindicated because they may make seizures worse: carbamazepine, fosphenytoin, lamotrigine, oxcarbazepine, phenytoin, vigabatrin.
NICE (who write up the guidlines for the NHS in the UK) give a similar list of drugs to avoid. See section 1.9.9.4 in NICE guide to Epilepsies: diagnosis and management - it says "Do not offer carbamazepine, gabapentin, lamotrigine, oxcarbazepine, phenytoin, pregabalin, tiagabine or vigabatrin." 82.38.169.122 ( talk) 17:05, 1 January 2016 (UTC)
Cannabis has been shown to have considerable efficacy in reduction of seizures and other symptoms of Dravet's Syndrome. It's actually a very well known issue- why isn't it mentioned? There is considerable evidence that attests to this- both anecdotal and empirical. — Preceding unsigned comment added by 76.200.118.133 ( talk) 01:09, 13 June 2015 (UTC)
People have thoughts? Doc James ( talk · contribs · email) 14:33, 2 July 2015 (UTC)
The result of the move request was: moved. Jenks24 ( talk) 11:20, 20 August 2015 (UTC)
Severe myoclonic epilepsy of infancy →
Dravet syndrome – Dravet syndrome is the common name of this disease.
Andrea Carter (
at your service |
my evil deads)
20:16, 12 August 2015 (UTC)
With all the hype about medical cannabis and cannabidiol being a treatment for this disease, the effectiveness of which is beyond the scope of this discussion, more people are aware of this disease. Most certainly people are going to want to research the disease. Most non-professionals know of this disease as "Dravet syndrome." I propose we rename the article to Dravet syndrome. What do y'all think? Andrea Carter ( at your service | my evil deads) 20:16, 12 August 2015 (UTC)
I think it is reasonable to include a sentence or two from this NEJM study. [1]
User:Alexbrn I think it is an appropriate exception to WP:MEDRS as (1) this is a rare condition (2) this is a well done RCT (3) it was published in the NEJM.
Others thoughts? Doc James ( talk · contribs · email) 01:54, 27 May 2017 (UTC)
I have corrected the ICD 10 code from G40.4 to G40.3. Dravet Syndrome is not listed in ICD by that name but this is the code provided for Dravet Syndrome in the SNOMED CT classification browser. It is also the code you will find when you index trail epilepsy > myoclonic. Furthermore, the ICD 9 code listed is 345.1 which when you cross-map it to ICD 10 also gives you G40.3.
I hope this edit is acceptable, if anybody has contradictory sources that support the G40.4 code I'd be happy to review further. — Preceding unsigned comment added by Tattycakes ( talk • contribs) 09:38, 1 November 2019 (UTC)