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This sounds like something I'd like to experiment with. Where can I acquire some? Miserlou 03:10, 6 November 2007 (UTC)
I think this article misses the whole point of why Ro15-4513 or any ligand with similar properties was never developed as a drug. To paraphrase a sentence from the current version of the article:
while Ro15-4513 is an effective antidote against moderate levels of alcohol intoxication, it might will be ineffective at treating life-threatening overdoses
With respect to antagonizing the effects of alcohol, Ro15-4513 only blocks the intoxicating effects of alcohol on higher CNS functions, but not the life threatening toxic effects. If an alcoholic took Ro15-4513, the alcoholic would likely continue to drink in search of a high but never reach it. This would lead to a high risk of death. To say that drug companies never developed such a drug for legal reasons is an understatement. It would be unethical to develop such a drug and if such a drug were developed, no regulatory authority that was functioning properly would ever approve it.
Therefore I feel that this article needs a major rewrite to emphasize that it would be unethical to develop such a drug. Boghog2 ( talk) 20:22, 9 April 2008 (UTC)
I think the possibilities of using Ro15-4513 as a drug to counteract the effects of alcohol use are no longer the concern of most that use it. Its use as a precursor/template for other drugs aside, the anti-alcohol effects are fading into history and as they do, this article grows out of date. Although the search for a drug that can effectively remove the side-effects of alcohol use is still on, and indeed the addictive and dangerous effects, Ro15-4513 is being pushed forward as an investigative ligand for GABA research. The finer mechanisms of GABAergic transmission, especially concerning the less common receptor subtypes in the limbic system and cortex, are still the subjects of major debate, and ligands selective for different subtypes are helping to pin down the functions of the different receptors, both at the synapse and holistically, as players in emotional control, impulse control or, importantly, vulnerability to addictive behaviour. Bluefloyd1 ( talk) 10:08, 24 April 2008 (UTC)
RO15-4513 is a complex mixed action drug. Depending on the receptor subtype of GABAA, it can function as an partial agonist, partial inverse agonist, or neutral antagonist. It may be misleading to introduce the drug as a weak partial inverse agonist of diazepam sensitive GABAA receptors. — Preceding unsigned comment added by AstarothN ( talk • contribs) 17:08, 4 June 2014 (UTC)
RO15-4513 is a complex mixed action drug. Depending on the receptor subtype of GABAA, it can function as an partial agonist, partial inverse agonist, or neutral antagonist. It may be misleading to introduce the drug as a weak partial inverse agonist of diazepam sensitive GABAA receptors. — Preceding unsigned comment added by AstarothN ( talk • contribs) 17:11, 4 June 2014 (UTC)
This is the
talk page for discussing improvements to the
Ro15-4513 article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find sources: Google ( books · news · scholar · free images · WP refs) · FENS · JSTOR · TWL |
This article is rated Start-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||
|
Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Ro15-4513.
|
This sounds like something I'd like to experiment with. Where can I acquire some? Miserlou 03:10, 6 November 2007 (UTC)
I think this article misses the whole point of why Ro15-4513 or any ligand with similar properties was never developed as a drug. To paraphrase a sentence from the current version of the article:
while Ro15-4513 is an effective antidote against moderate levels of alcohol intoxication, it might will be ineffective at treating life-threatening overdoses
With respect to antagonizing the effects of alcohol, Ro15-4513 only blocks the intoxicating effects of alcohol on higher CNS functions, but not the life threatening toxic effects. If an alcoholic took Ro15-4513, the alcoholic would likely continue to drink in search of a high but never reach it. This would lead to a high risk of death. To say that drug companies never developed such a drug for legal reasons is an understatement. It would be unethical to develop such a drug and if such a drug were developed, no regulatory authority that was functioning properly would ever approve it.
Therefore I feel that this article needs a major rewrite to emphasize that it would be unethical to develop such a drug. Boghog2 ( talk) 20:22, 9 April 2008 (UTC)
I think the possibilities of using Ro15-4513 as a drug to counteract the effects of alcohol use are no longer the concern of most that use it. Its use as a precursor/template for other drugs aside, the anti-alcohol effects are fading into history and as they do, this article grows out of date. Although the search for a drug that can effectively remove the side-effects of alcohol use is still on, and indeed the addictive and dangerous effects, Ro15-4513 is being pushed forward as an investigative ligand for GABA research. The finer mechanisms of GABAergic transmission, especially concerning the less common receptor subtypes in the limbic system and cortex, are still the subjects of major debate, and ligands selective for different subtypes are helping to pin down the functions of the different receptors, both at the synapse and holistically, as players in emotional control, impulse control or, importantly, vulnerability to addictive behaviour. Bluefloyd1 ( talk) 10:08, 24 April 2008 (UTC)
RO15-4513 is a complex mixed action drug. Depending on the receptor subtype of GABAA, it can function as an partial agonist, partial inverse agonist, or neutral antagonist. It may be misleading to introduce the drug as a weak partial inverse agonist of diazepam sensitive GABAA receptors. — Preceding unsigned comment added by AstarothN ( talk • contribs) 17:08, 4 June 2014 (UTC)
RO15-4513 is a complex mixed action drug. Depending on the receptor subtype of GABAA, it can function as an partial agonist, partial inverse agonist, or neutral antagonist. It may be misleading to introduce the drug as a weak partial inverse agonist of diazepam sensitive GABAA receptors. — Preceding unsigned comment added by AstarothN ( talk • contribs) 17:11, 4 June 2014 (UTC)