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There is no ribavirin article talk page, so I'm starting it here.
My name is Steve Harris. I'm a physician in the U.S.A. I'm new to Wikipedia, and for my maiden project I've decided to flesh out the Wikipedia ribavirin article. When I was a university student in the late 1970's at Brigham Young University, I had the opportunity to work with Dr. Roland Robins, co-discoverer of ribavirin, now deceased. Our project was ribavirin derivatives. A review chapter on activity/structure I wrote with Robins in 1980 will be listed in the references to the Wikipedia ribavirin article. With new and emerging viral epidemics, I think that interest in this newly generic drug and its derivatives, is destined to expand. I have no commercial interest in ribivirin, but it's near to my heart for reasons that are basically sentimental. I welcome direct and indirect comments from experts and insiders who want to contribute. My log-on name is sbharris. I can be emailed at sbharris@[ROMAN9].netcom.com. You have to know how to make a roman numeral nine to fix the address.
I did get a note from a Dutch physician-contributer asking that I try to save up all editing changes into as few sessions as possible, to make tracking easier. I apologize for that. Some of the difficulty is that the Wiki servers have been locking up, and sometimes large editing changes from a long session are "lost." Frequent saving prevents that. I am thinking of editing the entire article offline, then doing a complete replacement each session. Would that be a better solution? Sbharris
Thanks, JFW. I'll be supplying references shortly. Sbharris
Okay, I've added references and some other stuff. I'm now mostly done, although other references could be added at a few points (readers are invited to point out places where things are said that require additional references). I don't want to multiply references to review article length. I think the most helpful thing to do in this regard would be to add notes to the external links to other reviews, to tell people what they can expect to find there. For some reason I rarely see this done in Wiki articles. Sbharris 06:45, 24 November 2005 (UTC)
By the way, I wonder if I could propose a stub for the antiviral drug Viramidine (discussed in the last external link in ribavirin) which is also discussed in the article, under DERIVATIVES? Viramidine is in phase III trials, and will probably be approved, and important enough to list. It needs a stub showing the structure of ribavirin, but with the -CO-NH2 replaced with -C(NH)-NH2. In it, I'll put enough info in to reference it back to ribavirin, and otherwise fix it up. Sbharris 07:48, 24 November 2005 (UTC)
Indeed. Yes, I think it will make a major change in management of a number of viral diseases, though won't help much against retroviruses per se. It will be great against hepatitis C, yellow fever, hepatitis B, and other liver-targeting viruses. It may also eventually end up replacing ribavirin for the hemorrhagic fevers, since the tox profile's a little better. I've asked Mykhal if he won't draw me the structure as a Viramidine.png, which I can then insert. I can use the ribavirin template for the stub, from there. Do I just start it as a new Wiki page and rely on the internal links to crossreference it? This one won't be long since it will just refer back to ribavirin for much info, but it needs to have a page to itself. Sbharris 05:59, 25 November 2005 (UTC)
Sbharris, could you provide a link description for the external links you've provided (see Wikipedia:Describe external links). Also, could you add the PMID number after the articles you've referenced (just type PMID 12345678, the Wiki will recognise it and turn it into a link). JFW | T@lk 08:08, 24 November 2005 (UTC)
Will do Sbharris 05:59, 25 November 2005 (UTC)
Is the information correct on mechanisms of action? The first sentence states: "Ribavirin's carboxamide group can resemble adenosine or guanosine, depending on its rotation..." and that "when it's incorporated in to RNA it will pair with cytosine or uridine." Should the nucleobases be stated here rather than the nucleosides, since RNA is made up of nucleobases? i.e. ribavirin's carboxamide group resembles adenine or guanine and can pair with cytosine or uracil? I didn't want to change this myself, as I am using this page for reference. If I have got this completely wrong, and the above is all correct, could someone give me a brief answer as to why nucleosides are stated instead of nucleobases? Thanks ~~CG~~
while the case is still under dispute, a girl who has been "cured of rabies" ( http://content.nejm.org/cgi/content/full/352/24/2508) was treated with, among other drugs, ribavirin. should this be mentioned? 66.108.40.86 ( talk) 03:34, 7 December 2008 (UTC)phil
If you like. But as a single case, I don't know if it's worth it. Many things have been recommended for rabies, including this drug, which is active in vitro, but the numbers are too small to say what, if anything, works. Here would be your cite.
Clin Infect Dis. 2003 Jan 1;36(1):60-3. Epub 2002 Dec 11. Management of rabies in humans. Jackson AC, Warrell MJ, Rupprecht CE, Ertl HC, Dietzschold B, O'Reilly M, Leach RP, Fu ZF, Wunner WH, Bleck TP, Wilde H.
Department of Medicine, Queen's University, Kingston, Ontario, Canada K7L 2V7. jacksona@post.queensu.ca
Rabies is a fatal disease in humans, and, to date, the only survivors of the disease have received rabies vaccine before the onset of illness. The approach to management of the rabies normally should be palliative. In unusual circumstances, a decision may be made to use an aggressive approach to therapy for patients who present at an early stage of clinical disease. No single therapeutic agent is likely to be effective, but a combination of specific therapies could be considered, including rabies vaccine, rabies immunoglobulin, monoclonal antibodies, ribavirin, interferon-alpha, and ketamine. Corticosteroids should not be used. As research advances, new agents may become available in the future for the treatment of human rabies. PMID 12491203 S B H arris 05:00, 7 December 2008 (UTC)
I removed the statement in the opening paragraph that ribavirin is used off-label for RSV - aerosolised ribavirin is licensed: http://www.uptodate.com/contents/respiratory-syncytial-virus-infection-treatment, http://www.medicines.org.uk/emc/medicine/866, etc. 82.19.152.29 ( talk) 20:31, 26 June 2015 (UTC)
User:Sro23 please explain why you are removing this. Thanks. Jytdog ( talk) 23:13, 18 August 2016 (UTC)
One of the recommendations for writing in easier to understand language is to define more detailed concepts in the text.
Thus we have defined the World Health Organization's List of Essential Medicines, as the "most effective and safe medicines needed in a health system".
Doc James ( talk · contribs · email) 13:13, 30 March 2017 (UTC)
User:Muscleups about this and this -- the lead summarize the body. It is important to say "we don't know" when we don't know. It isn't redundant. Jytdog ( talk) 16:00, 10 August 2017 (UTC)
It is highly important for reactions 2C0F:FC88:9:73BC:A8B9:EB5:2CB6:CB6 ( talk) 06:16, 9 May 2022 (UTC)
This is the
talk page for discussing improvements to the
Ribavirin article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL |
![]() | Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Ribavirin.
|
![]() | This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||
|
There is no ribavirin article talk page, so I'm starting it here.
My name is Steve Harris. I'm a physician in the U.S.A. I'm new to Wikipedia, and for my maiden project I've decided to flesh out the Wikipedia ribavirin article. When I was a university student in the late 1970's at Brigham Young University, I had the opportunity to work with Dr. Roland Robins, co-discoverer of ribavirin, now deceased. Our project was ribavirin derivatives. A review chapter on activity/structure I wrote with Robins in 1980 will be listed in the references to the Wikipedia ribavirin article. With new and emerging viral epidemics, I think that interest in this newly generic drug and its derivatives, is destined to expand. I have no commercial interest in ribivirin, but it's near to my heart for reasons that are basically sentimental. I welcome direct and indirect comments from experts and insiders who want to contribute. My log-on name is sbharris. I can be emailed at sbharris@[ROMAN9].netcom.com. You have to know how to make a roman numeral nine to fix the address.
I did get a note from a Dutch physician-contributer asking that I try to save up all editing changes into as few sessions as possible, to make tracking easier. I apologize for that. Some of the difficulty is that the Wiki servers have been locking up, and sometimes large editing changes from a long session are "lost." Frequent saving prevents that. I am thinking of editing the entire article offline, then doing a complete replacement each session. Would that be a better solution? Sbharris
Thanks, JFW. I'll be supplying references shortly. Sbharris
Okay, I've added references and some other stuff. I'm now mostly done, although other references could be added at a few points (readers are invited to point out places where things are said that require additional references). I don't want to multiply references to review article length. I think the most helpful thing to do in this regard would be to add notes to the external links to other reviews, to tell people what they can expect to find there. For some reason I rarely see this done in Wiki articles. Sbharris 06:45, 24 November 2005 (UTC)
By the way, I wonder if I could propose a stub for the antiviral drug Viramidine (discussed in the last external link in ribavirin) which is also discussed in the article, under DERIVATIVES? Viramidine is in phase III trials, and will probably be approved, and important enough to list. It needs a stub showing the structure of ribavirin, but with the -CO-NH2 replaced with -C(NH)-NH2. In it, I'll put enough info in to reference it back to ribavirin, and otherwise fix it up. Sbharris 07:48, 24 November 2005 (UTC)
Indeed. Yes, I think it will make a major change in management of a number of viral diseases, though won't help much against retroviruses per se. It will be great against hepatitis C, yellow fever, hepatitis B, and other liver-targeting viruses. It may also eventually end up replacing ribavirin for the hemorrhagic fevers, since the tox profile's a little better. I've asked Mykhal if he won't draw me the structure as a Viramidine.png, which I can then insert. I can use the ribavirin template for the stub, from there. Do I just start it as a new Wiki page and rely on the internal links to crossreference it? This one won't be long since it will just refer back to ribavirin for much info, but it needs to have a page to itself. Sbharris 05:59, 25 November 2005 (UTC)
Sbharris, could you provide a link description for the external links you've provided (see Wikipedia:Describe external links). Also, could you add the PMID number after the articles you've referenced (just type PMID 12345678, the Wiki will recognise it and turn it into a link). JFW | T@lk 08:08, 24 November 2005 (UTC)
Will do Sbharris 05:59, 25 November 2005 (UTC)
Is the information correct on mechanisms of action? The first sentence states: "Ribavirin's carboxamide group can resemble adenosine or guanosine, depending on its rotation..." and that "when it's incorporated in to RNA it will pair with cytosine or uridine." Should the nucleobases be stated here rather than the nucleosides, since RNA is made up of nucleobases? i.e. ribavirin's carboxamide group resembles adenine or guanine and can pair with cytosine or uracil? I didn't want to change this myself, as I am using this page for reference. If I have got this completely wrong, and the above is all correct, could someone give me a brief answer as to why nucleosides are stated instead of nucleobases? Thanks ~~CG~~
while the case is still under dispute, a girl who has been "cured of rabies" ( http://content.nejm.org/cgi/content/full/352/24/2508) was treated with, among other drugs, ribavirin. should this be mentioned? 66.108.40.86 ( talk) 03:34, 7 December 2008 (UTC)phil
If you like. But as a single case, I don't know if it's worth it. Many things have been recommended for rabies, including this drug, which is active in vitro, but the numbers are too small to say what, if anything, works. Here would be your cite.
Clin Infect Dis. 2003 Jan 1;36(1):60-3. Epub 2002 Dec 11. Management of rabies in humans. Jackson AC, Warrell MJ, Rupprecht CE, Ertl HC, Dietzschold B, O'Reilly M, Leach RP, Fu ZF, Wunner WH, Bleck TP, Wilde H.
Department of Medicine, Queen's University, Kingston, Ontario, Canada K7L 2V7. jacksona@post.queensu.ca
Rabies is a fatal disease in humans, and, to date, the only survivors of the disease have received rabies vaccine before the onset of illness. The approach to management of the rabies normally should be palliative. In unusual circumstances, a decision may be made to use an aggressive approach to therapy for patients who present at an early stage of clinical disease. No single therapeutic agent is likely to be effective, but a combination of specific therapies could be considered, including rabies vaccine, rabies immunoglobulin, monoclonal antibodies, ribavirin, interferon-alpha, and ketamine. Corticosteroids should not be used. As research advances, new agents may become available in the future for the treatment of human rabies. PMID 12491203 S B H arris 05:00, 7 December 2008 (UTC)
I removed the statement in the opening paragraph that ribavirin is used off-label for RSV - aerosolised ribavirin is licensed: http://www.uptodate.com/contents/respiratory-syncytial-virus-infection-treatment, http://www.medicines.org.uk/emc/medicine/866, etc. 82.19.152.29 ( talk) 20:31, 26 June 2015 (UTC)
User:Sro23 please explain why you are removing this. Thanks. Jytdog ( talk) 23:13, 18 August 2016 (UTC)
One of the recommendations for writing in easier to understand language is to define more detailed concepts in the text.
Thus we have defined the World Health Organization's List of Essential Medicines, as the "most effective and safe medicines needed in a health system".
Doc James ( talk · contribs · email) 13:13, 30 March 2017 (UTC)
User:Muscleups about this and this -- the lead summarize the body. It is important to say "we don't know" when we don't know. It isn't redundant. Jytdog ( talk) 16:00, 10 August 2017 (UTC)
It is highly important for reactions 2C0F:FC88:9:73BC:A8B9:EB5:2CB6:CB6 ( talk) 06:16, 9 May 2022 (UTC)