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"The nucleus raphe dorsalis is rich in 5-HT1a autoreceptors and is therefore a target of serotonin specific reuptake inhibitors, or SSRI’s. This nucleus is composed of small, medium and large cells, oddly enough it has been shown that the large cells contain norepinephrine (Steinbusch HW, Nieuwenhuys R, Verhofstad AA, Van der Kooy D. The nucleus raphe dorsalis of the rat and its projection upon the caudatoputamen. A combined cytoarchitectonic, immunohistochemical and retrograde transport study. Journal of Physiology (Paris). 1981;77(2-3):157-74). This is unusual because the raphe nuclei have traditionally been thought of as specifically serotonergic, and to have non-serotonin related neurons comes as quite a surprise"
There are too many inline references in this page, I'm going to change them to endnotes along the lines of the Dorsal raphe section.
Does anyone know of any drugs that specifically target the neurons of the raphe system? I know vagus nerve stimulation can directly affect this area, but I don't know of any drugs that are selective for this region. Zuiram 20:40, 27 September 2006 (UTC)
The article mentions "Their main function is to release serotonin to the rest of the brain". What does this mean exactly? I thought seratonin, and other NTs, were synthesized in each neuron. Am I mistaken? If the article is correct, this implies that seratonin is created in this center and distributed somehow to other parts of the brain for re-use. If this indeed happens, please elaborate on this process. -- 1000Faces ( talk) 03:20, 18 November 2007 (UTC)
The connection between these areas, particularly between the nucleus raphe dorsalis and the orbital cortices, is thought to have influences on depression and obsessive compulsive disorder prognosis. There is no data suggesting any correlation between serotonin and depression and the citation you provide is strictly an anatomical study performed in rats. 68.96.239.121 ( talk) 04:47, 20 February 2023 (UTC)
A user recently added a hoax tag to the article without proper explanation. Please discuss such things on the article talk page before doing them in the future. 0x69494411 15:39, 24 September 2023 (UTC)
![]() | This article is rated Start-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||||||
|
"The nucleus raphe dorsalis is rich in 5-HT1a autoreceptors and is therefore a target of serotonin specific reuptake inhibitors, or SSRI’s. This nucleus is composed of small, medium and large cells, oddly enough it has been shown that the large cells contain norepinephrine (Steinbusch HW, Nieuwenhuys R, Verhofstad AA, Van der Kooy D. The nucleus raphe dorsalis of the rat and its projection upon the caudatoputamen. A combined cytoarchitectonic, immunohistochemical and retrograde transport study. Journal of Physiology (Paris). 1981;77(2-3):157-74). This is unusual because the raphe nuclei have traditionally been thought of as specifically serotonergic, and to have non-serotonin related neurons comes as quite a surprise"
There are too many inline references in this page, I'm going to change them to endnotes along the lines of the Dorsal raphe section.
Does anyone know of any drugs that specifically target the neurons of the raphe system? I know vagus nerve stimulation can directly affect this area, but I don't know of any drugs that are selective for this region. Zuiram 20:40, 27 September 2006 (UTC)
The article mentions "Their main function is to release serotonin to the rest of the brain". What does this mean exactly? I thought seratonin, and other NTs, were synthesized in each neuron. Am I mistaken? If the article is correct, this implies that seratonin is created in this center and distributed somehow to other parts of the brain for re-use. If this indeed happens, please elaborate on this process. -- 1000Faces ( talk) 03:20, 18 November 2007 (UTC)
The connection between these areas, particularly between the nucleus raphe dorsalis and the orbital cortices, is thought to have influences on depression and obsessive compulsive disorder prognosis. There is no data suggesting any correlation between serotonin and depression and the citation you provide is strictly an anatomical study performed in rats. 68.96.239.121 ( talk) 04:47, 20 February 2023 (UTC)
A user recently added a hoax tag to the article without proper explanation. Please discuss such things on the article talk page before doing them in the future. 0x69494411 15:39, 24 September 2023 (UTC)