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Archive 1 |
The two paragraphs which come under the heading Comparison with DNA seem to be self-contradictory. The first states that “RNA is a single-stranded molecule in most of its biological roles”, while the second states that “most biologically active RNAs … are extensively base paired to form double stranded helices”. This is non-sense. 141.5.20.120 ( talk) 11:14, 24 September 2008 (UTC)
With recent emergence of research interest in the use of RNA for therapeutic purposes from academia, biotech and pharma alike, a joint effort is desirable to include a small introductory mention (one-line in the intro para) followed by a detailed description of this field
Ribosomal RNA??
"exploit this property by" removed (anthromorphic - people exploit things, molecules do not)
", and so has fallen out of favour among complex organisms as the preferred genetic material" also removed - most organisms don't know what kinds of molecules they contain and couldn't desired to change them even if they knew.
>>>Should use "naturally selected" or "eliminated by natural selection" ?
It looks like we are quite pedant,isn't it? It's quite obvious that words like "exploit this property" referring to RNA molecules are just a convenient metaphor... Just have a look to *every* peer-reviewed scientific journal to find *thousands* of such metaphors.
When giving a scientific explanation, many times euphemisms are utilized to make things easier to understand. Going through an article and removing metaphors because it does not suit your idea of the english langauge is not improving the article, it is merely being a langauge snob.
"RNA transmits information from DNA to proteins" is a form of a Lies-To-Children It might not be a good idea to mention it in an encyclopedic article in exactly that form, even though it's good enough for a school textbook. Technically only mRNA does transmission. Other kinds of RNA may or may not be involved.
Kim Bruning 20:02, 24 Mar 2004 (UTC)
I've seen references as old as from 1976 to dsRNA, but despite fairly aggressive searching, I have not been able to convince myself of who discovered it, how they did so, and when. Did dsRNA discovery coincide with DNA discovery? Keesiewonder 22:32, 11 November 2006 (UTC)
OK, I read this article today and I found the following paragraph. I think someone is clearly yanking my chain here:
In the late 1990s and early 2000, there has been persistent evidence of more complex sex occurring in mammalian cells (and possibly others). This could point towards a more widespread use of dildos in biology, particularly in gene regulation. A particular class of dildos, micro dildo, has been found in many metazoans (from Caenorhabditis elegans to Homo sapiens) and clearly plays an important role in regulating other horny people.
Cuardin 12:24, 17 December 2006 (UTC)
Hi there. I wondered if the contributors to this page might have some input on this article. TimVickers 22:41, 24 December 2006 (UTC)
I came to this article to find out what the relative amounts of the respective forms of RNA would be inside your average cell. The article doesn't even make any attempt to express this. I am going to be looking elsewhere, but if anyone has information handy and can add it into the articlebefore I do - that would be great.-- 138.77.2.130 04:29, 9 May 2007 (UTC)
K-crash 16:30, 22 August 2007 (UTC) i wonder,why there must be 3 bases in either RNA and DNA?why not they exist as 4 bases/pair since they have 4 bases?what is the rule or evidence that shows RNA and DNA must be in 3 bases?
The secondary structure section looks pretty thin currently. It would be good to have a figure showing an RNA helix, links to the stem-loop article. Describe covariation versus sequence conservation. Alexbateman 07:58, 17 June 2007 (UTC)
I believe this article could do more to impress upon the reader the amazing diversity (and emerging importance) of RNA. Consider, for a moment, the following:
On the issue of diversity, I don't think ncRNA should be at the same level as tRNA, mRNA, etc as it is now. It's either coding (mRNA) or non-coding (everything else). The list is also redundant (and in danger of becoming out of sync) with same list in the ncRNA page. -Lp 70.81.26.125 16:51, 1 September 2007 (UTC)
The article is actually pretty close to meeting the Good article criteria, although there's still a couple of issues. I already fixed a couple of minor grammatical/spelling/MOS issues, but a few larger issues remain:
I think that should cover the key issues with the article. I think once these are fixed, the article can be promoted to GA status. I'll put this on hold at WP:GAN until 1/19/2007, and review it again. Cheers! Dr. Cash ( talk) 04:56, 13 January 2008 (UTC)
Just wondering why there has been absolutely no mention of these. They are required for an RNA molecule to leave the nucleus. Without them they are degraded by various enzymes in the cytoplasm. A 5' Cap is added almost as soon as transcription begins!! TheTrojanHought ( talk) 11:22, 23 February 2008 (UTC)
To avoid repetition with the ncRNA article I propose that *we* make a dedicated 'List of RNAs' article and link to it from the 'List of RNAs' and 'Types of non-coding RNAs' sections of the RNA and ncRNA articles. --Ppgardne 13:17, 24 March 2008 (UTC)
I don't like File:NA-comparedto-DNA thymineAndUracilCorrected.png. The helical structure of RNA in the picture has nothing to do with reality, and I saw another Wikipedia article where an editor had assumed that RNA forms a single-sranded helix based on this picture... the result of its misleading nature. There are already the links to the purines and pyrimidines in the article for people to look at. Narayanese ( talk) 01:58, 21 January 2009 (UTC)
I believe the structure picture is incorrect. The bonds between the phosphate and the ribose are on the wrong oxygens of the phosophate. There is also the fact that RNA exists in double stranded form in viruses. —Preceding unsigned comment added by 98.196.144.88 ( talk) 03:18, 2 May 2009 (UTC)
No, the depiction of the phosphodiester bonds is accurate. Phosphate has a tetrahedral geometry, so any two of its oxygens (such as the two involved in these bonds) are adjacent to each other. When flattened into two dimensions, this looks just like the structure picture on this page. 97.113.147.245 ( talk) 17:33, 17 January 2010 (UTC)
Hello, at least one company to my knowledge makes a multivitamin/supplement type product containing between 10 and 150mg of RNA per day. Nothing in the article at all about this yet it reached good article status. 76.10.164.191 ( talk) 10:35, 23 January 2010 (UTC)
"Ribonucleic acid (RNA) is one of the three major macromolecules (along with DNA and proteins) that are essential for all known forms of life." What about polysaccharides and lipids? —Preceding unsigned comment added by 24.203.4.38 ( talk) 03:36, 1 March 2011 (UTC)
"New research links RNA modification with obesity" -- Jo3sampl ( talk) 21:49, 19 October 2011 (UTC)
I've been looking all over the internet to find a model of RNA for my Molecules app on my Mac ( http://itunes.apple.com/us/app/molecules/id444014972?mt=12), but I can't find one anywhere. Could someone help me find on please? Mchcopl ( talk) 14:28, 1 May 2012 (UTC)!
The complementary base to adenine in DNA is thymine, whereas in RNA, it is uracil, which is an unmethylated form of thymine.[4]
I have doubts about that. Normally RNA is single stranded, and sometimes it doesn't contains uracil (ebola virus). Does all dsRNA virus contains uracil ? — Preceding unsigned comment added by 192.222.134.138 ( talk) 17:45, 10 February 2016 (UTC)
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I don't like the recently added figure. The main difference between RNA and DNA are the hydroxyl groups on RNA. The figure does not show them and implies the only differences are uracil <-> thymine, and that RNA is single-stranded, which is not universally true. Rotavirus like many other viruses has a genome of double-stranded RNA. True, it's a pretty picture, but it's wrong. Graham Colm ( talk) 19:19, 23 March 2010 (UTC)
The main difference of RNA and DNA is that, RNA is single stand while DNA is double stand or double helix structure and it contains hydrogen bonding between them . RNA stands for ribo nucleic acid while DNA stands for deoxyribo nucleic acid, I other words RNA contain ribose sugar while DNA contain deoxyribo sugar. Shoaib Afzal Khan ( talk) 09:21, 3 August 2016 (UTC)
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This article currently does not mention the meaning of ssRNA even though ssRNA redirects to it. I propose to add a brief description that "ssRNA" stands for single-stranded RNA. Somerandomuser ( talk) 22:52, 17 May 2017 (UTC)
I am in a Fellows class, just learning Wikipedia editing. I'm a retired professor with a Yale PhD in genetics and I've published a text on Molecular Genetics. I think that there are several types of regulatory RNA now known that deserve a clearer exposition of their characteristics. I've had conversation with some others about a disambiguation page to let people who enter "Regulatory RNA" get a choice and not just be sent to RNA interference. It is the only regulatory RNA system recognized with a Nobel prize to date, but there are also long noncoding RNAs like Xist and enhancer RNAs as well as riboswitches, CRISPR, and small bacterial RNAs. I have taken a copy of this section into my sandbox to work on. Ideas, comments welcome. LLMHoopes ( talk) 03:51, 24 August 2018 (UTC)
I am a Fellow at Weki ed and I first proposed to add a page on Regulatory RNA. It was suggested that I make a disambiguation page instead but when I tried that it was not accepted. So now I'm contributing a section for the RNA article on the subject. I want it to be possible for people to find the types of regulatory RNA besides just interference by miRNA and then go to the articles on them to read more. Open to suggestions. LLMHoopes ( talk) 01:44, 12 September 2018 (UTC)
![]() | This is an archive of past discussions. Do not edit the contents of this page. If you wish to start a new discussion or revive an old one, please do so on the current talk page. |
Archive 1 |
The two paragraphs which come under the heading Comparison with DNA seem to be self-contradictory. The first states that “RNA is a single-stranded molecule in most of its biological roles”, while the second states that “most biologically active RNAs … are extensively base paired to form double stranded helices”. This is non-sense. 141.5.20.120 ( talk) 11:14, 24 September 2008 (UTC)
With recent emergence of research interest in the use of RNA for therapeutic purposes from academia, biotech and pharma alike, a joint effort is desirable to include a small introductory mention (one-line in the intro para) followed by a detailed description of this field
Ribosomal RNA??
"exploit this property by" removed (anthromorphic - people exploit things, molecules do not)
", and so has fallen out of favour among complex organisms as the preferred genetic material" also removed - most organisms don't know what kinds of molecules they contain and couldn't desired to change them even if they knew.
>>>Should use "naturally selected" or "eliminated by natural selection" ?
It looks like we are quite pedant,isn't it? It's quite obvious that words like "exploit this property" referring to RNA molecules are just a convenient metaphor... Just have a look to *every* peer-reviewed scientific journal to find *thousands* of such metaphors.
When giving a scientific explanation, many times euphemisms are utilized to make things easier to understand. Going through an article and removing metaphors because it does not suit your idea of the english langauge is not improving the article, it is merely being a langauge snob.
"RNA transmits information from DNA to proteins" is a form of a Lies-To-Children It might not be a good idea to mention it in an encyclopedic article in exactly that form, even though it's good enough for a school textbook. Technically only mRNA does transmission. Other kinds of RNA may or may not be involved.
Kim Bruning 20:02, 24 Mar 2004 (UTC)
I've seen references as old as from 1976 to dsRNA, but despite fairly aggressive searching, I have not been able to convince myself of who discovered it, how they did so, and when. Did dsRNA discovery coincide with DNA discovery? Keesiewonder 22:32, 11 November 2006 (UTC)
OK, I read this article today and I found the following paragraph. I think someone is clearly yanking my chain here:
In the late 1990s and early 2000, there has been persistent evidence of more complex sex occurring in mammalian cells (and possibly others). This could point towards a more widespread use of dildos in biology, particularly in gene regulation. A particular class of dildos, micro dildo, has been found in many metazoans (from Caenorhabditis elegans to Homo sapiens) and clearly plays an important role in regulating other horny people.
Cuardin 12:24, 17 December 2006 (UTC)
Hi there. I wondered if the contributors to this page might have some input on this article. TimVickers 22:41, 24 December 2006 (UTC)
I came to this article to find out what the relative amounts of the respective forms of RNA would be inside your average cell. The article doesn't even make any attempt to express this. I am going to be looking elsewhere, but if anyone has information handy and can add it into the articlebefore I do - that would be great.-- 138.77.2.130 04:29, 9 May 2007 (UTC)
K-crash 16:30, 22 August 2007 (UTC) i wonder,why there must be 3 bases in either RNA and DNA?why not they exist as 4 bases/pair since they have 4 bases?what is the rule or evidence that shows RNA and DNA must be in 3 bases?
The secondary structure section looks pretty thin currently. It would be good to have a figure showing an RNA helix, links to the stem-loop article. Describe covariation versus sequence conservation. Alexbateman 07:58, 17 June 2007 (UTC)
I believe this article could do more to impress upon the reader the amazing diversity (and emerging importance) of RNA. Consider, for a moment, the following:
On the issue of diversity, I don't think ncRNA should be at the same level as tRNA, mRNA, etc as it is now. It's either coding (mRNA) or non-coding (everything else). The list is also redundant (and in danger of becoming out of sync) with same list in the ncRNA page. -Lp 70.81.26.125 16:51, 1 September 2007 (UTC)
The article is actually pretty close to meeting the Good article criteria, although there's still a couple of issues. I already fixed a couple of minor grammatical/spelling/MOS issues, but a few larger issues remain:
I think that should cover the key issues with the article. I think once these are fixed, the article can be promoted to GA status. I'll put this on hold at WP:GAN until 1/19/2007, and review it again. Cheers! Dr. Cash ( talk) 04:56, 13 January 2008 (UTC)
Just wondering why there has been absolutely no mention of these. They are required for an RNA molecule to leave the nucleus. Without them they are degraded by various enzymes in the cytoplasm. A 5' Cap is added almost as soon as transcription begins!! TheTrojanHought ( talk) 11:22, 23 February 2008 (UTC)
To avoid repetition with the ncRNA article I propose that *we* make a dedicated 'List of RNAs' article and link to it from the 'List of RNAs' and 'Types of non-coding RNAs' sections of the RNA and ncRNA articles. --Ppgardne 13:17, 24 March 2008 (UTC)
I don't like File:NA-comparedto-DNA thymineAndUracilCorrected.png. The helical structure of RNA in the picture has nothing to do with reality, and I saw another Wikipedia article where an editor had assumed that RNA forms a single-sranded helix based on this picture... the result of its misleading nature. There are already the links to the purines and pyrimidines in the article for people to look at. Narayanese ( talk) 01:58, 21 January 2009 (UTC)
I believe the structure picture is incorrect. The bonds between the phosphate and the ribose are on the wrong oxygens of the phosophate. There is also the fact that RNA exists in double stranded form in viruses. —Preceding unsigned comment added by 98.196.144.88 ( talk) 03:18, 2 May 2009 (UTC)
No, the depiction of the phosphodiester bonds is accurate. Phosphate has a tetrahedral geometry, so any two of its oxygens (such as the two involved in these bonds) are adjacent to each other. When flattened into two dimensions, this looks just like the structure picture on this page. 97.113.147.245 ( talk) 17:33, 17 January 2010 (UTC)
Hello, at least one company to my knowledge makes a multivitamin/supplement type product containing between 10 and 150mg of RNA per day. Nothing in the article at all about this yet it reached good article status. 76.10.164.191 ( talk) 10:35, 23 January 2010 (UTC)
"Ribonucleic acid (RNA) is one of the three major macromolecules (along with DNA and proteins) that are essential for all known forms of life." What about polysaccharides and lipids? —Preceding unsigned comment added by 24.203.4.38 ( talk) 03:36, 1 March 2011 (UTC)
"New research links RNA modification with obesity" -- Jo3sampl ( talk) 21:49, 19 October 2011 (UTC)
I've been looking all over the internet to find a model of RNA for my Molecules app on my Mac ( http://itunes.apple.com/us/app/molecules/id444014972?mt=12), but I can't find one anywhere. Could someone help me find on please? Mchcopl ( talk) 14:28, 1 May 2012 (UTC)!
The complementary base to adenine in DNA is thymine, whereas in RNA, it is uracil, which is an unmethylated form of thymine.[4]
I have doubts about that. Normally RNA is single stranded, and sometimes it doesn't contains uracil (ebola virus). Does all dsRNA virus contains uracil ? — Preceding unsigned comment added by 192.222.134.138 ( talk) 17:45, 10 February 2016 (UTC)
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Cheers. — cyberbot II Talk to my owner:Online 12:15, 27 August 2015 (UTC)
I don't like the recently added figure. The main difference between RNA and DNA are the hydroxyl groups on RNA. The figure does not show them and implies the only differences are uracil <-> thymine, and that RNA is single-stranded, which is not universally true. Rotavirus like many other viruses has a genome of double-stranded RNA. True, it's a pretty picture, but it's wrong. Graham Colm ( talk) 19:19, 23 March 2010 (UTC)
The main difference of RNA and DNA is that, RNA is single stand while DNA is double stand or double helix structure and it contains hydrogen bonding between them . RNA stands for ribo nucleic acid while DNA stands for deoxyribo nucleic acid, I other words RNA contain ribose sugar while DNA contain deoxyribo sugar. Shoaib Afzal Khan ( talk) 09:21, 3 August 2016 (UTC)
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This article currently does not mention the meaning of ssRNA even though ssRNA redirects to it. I propose to add a brief description that "ssRNA" stands for single-stranded RNA. Somerandomuser ( talk) 22:52, 17 May 2017 (UTC)
I am in a Fellows class, just learning Wikipedia editing. I'm a retired professor with a Yale PhD in genetics and I've published a text on Molecular Genetics. I think that there are several types of regulatory RNA now known that deserve a clearer exposition of their characteristics. I've had conversation with some others about a disambiguation page to let people who enter "Regulatory RNA" get a choice and not just be sent to RNA interference. It is the only regulatory RNA system recognized with a Nobel prize to date, but there are also long noncoding RNAs like Xist and enhancer RNAs as well as riboswitches, CRISPR, and small bacterial RNAs. I have taken a copy of this section into my sandbox to work on. Ideas, comments welcome. LLMHoopes ( talk) 03:51, 24 August 2018 (UTC)
I am a Fellow at Weki ed and I first proposed to add a page on Regulatory RNA. It was suggested that I make a disambiguation page instead but when I tried that it was not accepted. So now I'm contributing a section for the RNA article on the subject. I want it to be possible for people to find the types of regulatory RNA besides just interference by miRNA and then go to the articles on them to read more. Open to suggestions. LLMHoopes ( talk) 01:44, 12 September 2018 (UTC)