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I removed "15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2)is a PGD2 derivative that acts on PPAR intracellular receptors" because this proposition has since been proven false. [1] Mazzo 01:09, 11 August 2006 (UTC)
I don't understand adding a Parturition link right after the childbirth one. Not only do they mean the same thing, but Parturition just gets redirected to childbirth. But I'm leaving the link in for the moment. David.Throop 15:48, 15 February 2006 (UTC)
Hi,
Just to point out that the conversion of prostacyclin to both prostaglandin and thromboxane first involves the enzyme 'cyclo-oygenase' before postacyclin synthatase and thromboxane synthatase respectively.
The relavance of this is in the treatment fo hypertension. Drugs called NSAIDs inhibit cyclo-oxygenase. This leads to the reduced production of thromboxane (a vasoconstrictor and coagulant) but not prostacyclin as the former is produced in platelets which do not have the capacity to synthesise new cyclo-oxygenase whereas new prostacyclin can be produced by the nuclei of the endothelial cells it is produced in.
Prostaglandins and prostaglandin-like substances have also been found in plants. This fact maybe should be mentioned in the article. Tavilis 19:31, 8 September 2006 (UTC)
User:Arcadian has split the section on inhibition off as another section. That's OK, but I think it's mis-titled.
An antagonist (in these contexts) is a substance that binds a receptor. (Who says so? Well, follow the links from Prostaglandin antagonist to Hormone antagonist to Receptor antagonist.) NSAIDs compete for COX; aspirin actually irreversably reacts with COX. COX and phospholipases aren't receptors. They're enzymes.
The body itself does produce prostaglandin antagonists. E.g., the prostaglandins made from EPA and DGLA (sometimes) reduce inflammation by acting as antagonists for the prostaglandin receptors. That is, they block the action of the AA-derived PGs.
So I think the new article should be titled Prostaglandin inhibition.
Also, when splitting off a section into it's own article, one should leave a couple of sentences that summarize the section. David.Throop 19:19, 28 February 2007 (UTC)
isn't this a prostaglandin too? should it go in the chart? —Preceding unsigned comment added by 128.125.28.128 ( talk) 17:49, 26 September 2008 (UTC)
What three animals will prostaglandin injections not work on? —Preceding unsigned comment added by 75.43.15.193 ( talk) 20:37, 1 November 2009 (UTC) arachidonic acid is precurser and phaspholipase a2 is enzyme for conversion of eicosanoids to prostanoids and leucotriens.by cycloxygenase and lipoxygenase path way
This article focuses on Series 2 prostaglandins (derivatives of Arachidonic Acid) and basically ignores series 1 (DHGLA derivatives and series 3 (EPA derivatives). I feel like this article needs to be completely overhauled but I don't know where to begin. Pelirojopajaro ( talk) 17:24, 11 July 2012 (UTC)
I see a lot of advertisements for trimix gel. Is this a thing? (See Talk:Trimix (injection)]]. 76.194.214.123 ( talk) 09:00, 30 June 2014 (UTC)
![]() | This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
|
I removed "15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2)is a PGD2 derivative that acts on PPAR intracellular receptors" because this proposition has since been proven false. [1] Mazzo 01:09, 11 August 2006 (UTC)
I don't understand adding a Parturition link right after the childbirth one. Not only do they mean the same thing, but Parturition just gets redirected to childbirth. But I'm leaving the link in for the moment. David.Throop 15:48, 15 February 2006 (UTC)
Hi,
Just to point out that the conversion of prostacyclin to both prostaglandin and thromboxane first involves the enzyme 'cyclo-oygenase' before postacyclin synthatase and thromboxane synthatase respectively.
The relavance of this is in the treatment fo hypertension. Drugs called NSAIDs inhibit cyclo-oxygenase. This leads to the reduced production of thromboxane (a vasoconstrictor and coagulant) but not prostacyclin as the former is produced in platelets which do not have the capacity to synthesise new cyclo-oxygenase whereas new prostacyclin can be produced by the nuclei of the endothelial cells it is produced in.
Prostaglandins and prostaglandin-like substances have also been found in plants. This fact maybe should be mentioned in the article. Tavilis 19:31, 8 September 2006 (UTC)
User:Arcadian has split the section on inhibition off as another section. That's OK, but I think it's mis-titled.
An antagonist (in these contexts) is a substance that binds a receptor. (Who says so? Well, follow the links from Prostaglandin antagonist to Hormone antagonist to Receptor antagonist.) NSAIDs compete for COX; aspirin actually irreversably reacts with COX. COX and phospholipases aren't receptors. They're enzymes.
The body itself does produce prostaglandin antagonists. E.g., the prostaglandins made from EPA and DGLA (sometimes) reduce inflammation by acting as antagonists for the prostaglandin receptors. That is, they block the action of the AA-derived PGs.
So I think the new article should be titled Prostaglandin inhibition.
Also, when splitting off a section into it's own article, one should leave a couple of sentences that summarize the section. David.Throop 19:19, 28 February 2007 (UTC)
isn't this a prostaglandin too? should it go in the chart? —Preceding unsigned comment added by 128.125.28.128 ( talk) 17:49, 26 September 2008 (UTC)
What three animals will prostaglandin injections not work on? —Preceding unsigned comment added by 75.43.15.193 ( talk) 20:37, 1 November 2009 (UTC) arachidonic acid is precurser and phaspholipase a2 is enzyme for conversion of eicosanoids to prostanoids and leucotriens.by cycloxygenase and lipoxygenase path way
This article focuses on Series 2 prostaglandins (derivatives of Arachidonic Acid) and basically ignores series 1 (DHGLA derivatives and series 3 (EPA derivatives). I feel like this article needs to be completely overhauled but I don't know where to begin. Pelirojopajaro ( talk) 17:24, 11 July 2012 (UTC)
I see a lot of advertisements for trimix gel. Is this a thing? (See Talk:Trimix (injection)]]. 76.194.214.123 ( talk) 09:00, 30 June 2014 (UTC)