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I wrote this page today because it seemed important to have and was missing. I have filled in a broad selection of literature, but from human studies and from animal studies. There are many things that could be improved:
-- Deleet ( talk) 21:01, 30 October 2016 (UTC)
Mendelian randomisation is interesting, but why is it mentioned as something that PRS can be used for? I mean sure, you can use "many SNPs as instruments" which is kinda like PRS - but still PRS is not really in itself a MR tool is it? Yinwang888 ( talk) 01:18, 8 February 2020 (UTC)
The discussed sentence appears to have been removed or edited at this point -- Stal potaten ( talk) 22:52, 13 April 2021 (UTC)
In a genome-wide association study (GWAS), polygenic scores having substantially higher predictive performance than the genome-wide statistically-significant hits indicates that the trait in question is affected by a larger number of variants than just the hits and larger sample sizes will yield more hits; a conjunction of low variance explained and high heritability as measured by genome-wide complex trait analysis (GCTA), twin studies or other methods, indicates that a trait may be massively polygenic and affected by thousands of variants.
To start with: "hit indicates" or "hits indicate", but the problem clearly runs deeper than that. — MaxEnt 01:00, 7 May 2020 (UTC)
I have in a series of edits added a few sections and (in my eyes) improved many of the already existing ones. The page may still not give an entirely coherent read but is more comprehensive, somewhat easier to read and contains more updated results. Although not perfect, I think the page does no longer merit the flags.
Unless a discussion here starts within a week, I intend to resolve the old flags. -- Stal potaten ( talk) 22:59, 13 April 2021 (UTC)
As part of my wiki course, I am proposing to do the following changes: Restructure to include the following sections:
Details of changes I am thinking of: 1) Rework the very first section introduction polygenic risk score: - Simplify language and increase accuracy of the statements - Provide brief outline of the remaining sections - Detail the future potential of PRSs 2) Update the history section with more contemporary findings. - Avoid claims of primacy. - Remove jargon and esoteric detail 3) Simplify methods of construction PRS and remove unscary detail. 4) Discuss various non-clinical applications of polygenic risk scores 5) Discuss the clinical application of prs risk scores 6) Include paragraph on generalizability across ancestries 7) Discuss limitations
I am considering removing the references to non-human polygenic risk scores and having that as a seperate page
69.138.56.118 ( talk) 17:04, 2 November 2021 (UTC) 02:41, 2 November 2021 (UTC) — Preceding unsigned comment added by Aa2021dna ( talk • contribs)
Storyminusthes ( talk) 17:12, 15 November 2021 (UTC)
Lead:
It does not appear you have edited the lead at all, so I did not devote a lot of attention to it. However, it does look like the last paragraph of the lead could use some work, as there are some somewhat arbitrarily chosen references to primary papers that probably aren't necessary.
Content:
Tone and Balance
Sources and References
Organization
It’s highly likely this article is incomprehensible to the average reader. This is an encyclopedia not a scientific journal. It needs to be rewritten top to bottom in vernacular English. A good example of this can be found here: http://polygenicscores.org/explained/index.html Alcmaeonid ( talk) 06:40, 2 October 2021 (UTC)
This article was the subject of a Wiki Education Foundation-supported course assignment, between 26 October 2021 and 19 November 2021. Further details are available on the course page. Student editor(s): Aa2021dna. Peer reviewers: Storyminusthes.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 02:31, 18 January 2022 (UTC)
This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||||||||||||||||
|
Daily pageviews of this article
A graph should have been displayed here but
graphs are temporarily disabled. Until they are enabled again, visit the interactive graph at
pageviews.wmcloud.org |
I wrote this page today because it seemed important to have and was missing. I have filled in a broad selection of literature, but from human studies and from animal studies. There are many things that could be improved:
-- Deleet ( talk) 21:01, 30 October 2016 (UTC)
Mendelian randomisation is interesting, but why is it mentioned as something that PRS can be used for? I mean sure, you can use "many SNPs as instruments" which is kinda like PRS - but still PRS is not really in itself a MR tool is it? Yinwang888 ( talk) 01:18, 8 February 2020 (UTC)
The discussed sentence appears to have been removed or edited at this point -- Stal potaten ( talk) 22:52, 13 April 2021 (UTC)
In a genome-wide association study (GWAS), polygenic scores having substantially higher predictive performance than the genome-wide statistically-significant hits indicates that the trait in question is affected by a larger number of variants than just the hits and larger sample sizes will yield more hits; a conjunction of low variance explained and high heritability as measured by genome-wide complex trait analysis (GCTA), twin studies or other methods, indicates that a trait may be massively polygenic and affected by thousands of variants.
To start with: "hit indicates" or "hits indicate", but the problem clearly runs deeper than that. — MaxEnt 01:00, 7 May 2020 (UTC)
I have in a series of edits added a few sections and (in my eyes) improved many of the already existing ones. The page may still not give an entirely coherent read but is more comprehensive, somewhat easier to read and contains more updated results. Although not perfect, I think the page does no longer merit the flags.
Unless a discussion here starts within a week, I intend to resolve the old flags. -- Stal potaten ( talk) 22:59, 13 April 2021 (UTC)
As part of my wiki course, I am proposing to do the following changes: Restructure to include the following sections:
Details of changes I am thinking of: 1) Rework the very first section introduction polygenic risk score: - Simplify language and increase accuracy of the statements - Provide brief outline of the remaining sections - Detail the future potential of PRSs 2) Update the history section with more contemporary findings. - Avoid claims of primacy. - Remove jargon and esoteric detail 3) Simplify methods of construction PRS and remove unscary detail. 4) Discuss various non-clinical applications of polygenic risk scores 5) Discuss the clinical application of prs risk scores 6) Include paragraph on generalizability across ancestries 7) Discuss limitations
I am considering removing the references to non-human polygenic risk scores and having that as a seperate page
69.138.56.118 ( talk) 17:04, 2 November 2021 (UTC) 02:41, 2 November 2021 (UTC) — Preceding unsigned comment added by Aa2021dna ( talk • contribs)
Storyminusthes ( talk) 17:12, 15 November 2021 (UTC)
Lead:
It does not appear you have edited the lead at all, so I did not devote a lot of attention to it. However, it does look like the last paragraph of the lead could use some work, as there are some somewhat arbitrarily chosen references to primary papers that probably aren't necessary.
Content:
Tone and Balance
Sources and References
Organization
It’s highly likely this article is incomprehensible to the average reader. This is an encyclopedia not a scientific journal. It needs to be rewritten top to bottom in vernacular English. A good example of this can be found here: http://polygenicscores.org/explained/index.html Alcmaeonid ( talk) 06:40, 2 October 2021 (UTC)
This article was the subject of a Wiki Education Foundation-supported course assignment, between 26 October 2021 and 19 November 2021. Further details are available on the course page. Student editor(s): Aa2021dna. Peer reviewers: Storyminusthes.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 02:31, 18 January 2022 (UTC)