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Talk:Polycystic ovary syndrome/unanswered question dump
This article was the subject of a Wiki Education Foundation-supported course assignment, between 14 June 2021 and 11 July 2021. Further details are available
on the course page. Student editor(s):
Petitee. Peer reviewers:
MariferL.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 02:31, 18 January 2022 (UTC)
This article was the subject of a Wiki Education Foundation-supported course assignment, between 3 September 2020 and 14 December 2020. Further details are available
on the course page. Student editor(s):
Kkher.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 06:54, 17 January 2022 (UTC)
Although this piece references "genetic causes" as an established scientific fact, nothing could be further from the truth, and of the two sources referenced, one is a 2002 paper which talks about a couple of gene loci, but not a genetic cause, and the other reference simply talks about genetic screening technologies but does not say that PCOS is "genetically caused". The reality is that it's probably gene-environment interactions(like most everything else), and this piece completely glosses over that issue and certainly could lead the unsophisticated or poorly informed reader to believe that a genetic cause in a simple sense was a virtual certainty – hardly the case. First of all, PCOS has a very strong association with maternal obesity, and with metabolic syndrome and insulin resistance, clues that this is not simply due to some 'aberrant' gene, but more likely an aberrant form of epigenetic metabolic programming associated with maternal obesity and its effects on the developing fetus. There are probably multiple Genetic polymorphisms that might contribute to PCOS, but that's really quite a far cry from dismissing all the environmental and lifestyle variables that look increasingly critical to this syndrome. This syndrome has only recently emerged in the context of the explosion of obesity in the United States, and it was thought to be exceptionally rare before that. I have cut and pasted a somewhat more balanced review of the genetic and environmental issues, which clearly needs some form of corrective attention in this treatment.
Steroids. 2011 Dec 8. [Epub ahead of print] Metabolic and cardiovascular genes in polycystic ovary syndrome: A candidate-wide association study (CWAS). Jones MR, Chua AK, Mengesha EA, Taylor KD, Chen YD, Li X, Krauss RM, Rotter JI; Reproductive Medicine Network, Legro RS, Azziz R, Goodarzi MO. Source
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States. Abstract
The role of metabolic disturbance in polycystic ovary syndrome (PCOS) has been well established, with insulin resistance and the resulting compensatory hyperinsulinemia thought to promote hyperandrogenemia. Genome-wide association studies (GWAS) have established a large number of loci for metabolic conditions such as type 2 diabetes and obesity. A subset of these loci has been investigated for a role in PCOS; these studies generally have not revealed a confirmed role for these loci in PCOS risk. However, a large scale investigation of genes related to these pathways has not previously been performed. We conducted a two stage case control association study of 121,715 single nucleotide polymorphisms (SNPs) selected to represent susceptibility loci associated with traits such as type 2 diabetes, obesity measures, lipid levels and cardiovascular function using the Cardio-Metabochip in 847 PCOS cases and 845 controls. Several hypothesis-generating associations with PCOS were observed (top SNP rs2129107, P=3.8×10(-6)). We did not find any loci definitively associated with PCOS after strict correction for multiple testing, suggesting that cardio-metabolic loci are not major risk factors underlying the susceptibility to PCOS.
Douglas F Watt, PhD 209.6.17.71 ( talk) 00:40, 3 January 2012 (UTC)
Prevalence in this article is stated as 5%, based on a single study. Yet there have been a plethora of studies attempting to establish the prevalence of PCOS, with results ranging from 5 to 15% (iirc). A single percentage ignores that range. It also ignores the fact that the diagnostic criteria for PCOS is in dispute, which means that to be specific (rather than giving a range), you need to specify which definition was used to establish that percentage. How is this usually dealt with here on Wikipedia? 24.1.140.128 ( talk) 05:01, 15 January 2010 (UTC)milara
Cortisol levels seem to be critical to PCOS. Why no mention? —Preceding unsigned comment added by 75.82.70.58 ( talk) 06:24, 10 May 2009 (UTC)
All you have to do is google "PCOS support group" and you will get literally scores of precise links where there are hundreds of people waiting to answer all your questions in warm fuzzy manners. Once again, wikipedia is not a source of medical advice unless you want to risk getting it from an anonymous 15 year old (I am not exaggerating), nor is it a support group or discussion forum. It seems harsh, but this page is especially hard hit. I will move all the above to an archive. Thanks for understanding. alteripse 21:05, 28 May 2007 (UTC)
I have deleted a bunch of external links to support groups and magazine articles about PCOS. The biggest problem is that half of the websites were listed twice (except the Australian group, which had four links), but in general I believe we need to remember that Wikipedia is not an advertising opportunity for our favorite organizations. Women with PCOS are smart enough to do their own Internet searches if they want more resources. WhatamIdoing ( talk) 03:00, 27 November 2007 (UTC)
An anon added unsourced information about gestational diabetes recently. It was promptly removed. It might be worth sorting that out. PMID 18710713 is a (very) recent systematic study on the issue, and I found its conclusion slightly unusual: The odds ratio is 2.89, but they'd don't trust it. WhatamIdoing ( talk) 15:00, 2 September 2008 (UTC)
Thought my source could be used as an additional resource for those accessing this PCOS page. Northwestern University's Feinberg School of Medicine ( http://www.pcos.northwestern.edu/) provides information for those women wanting to get involved in PCOS research studies and whether certain genes increase a woman's chance of getting PCOS. Makofin ( talk) 20:14, 19 November 2008 (UTC)Makofin
The University of Pennsylvania and Penn State University are conducting a NIH clinical randomized research trial to establish the relative roles of treatment of hyperandrogenism versus obesity in treating infertility and improving pregnancy outcomes among PCOS women. For more information about this study, acccess this link. ( http://webapp.hmc.psu.edu/owlpcos/website/index.cfm) Owlpcos ( talk) 18:53, 29 July 2009 (UTC) [1]
The recently added paragraph about ayurvedic remedies is uncited and poorly worded. I am not sure the information belongs in the article, but would have felt brash to delete it without discussion. -- shingra ( talk) 12:15, 27 May 2010 (UTC)
This article previously mentioned trans fats as a potential cause of PCOS, but the entry was removed, mainly because the two sources ( [2] and [3]) actually had not studied on people with PCOS, so their conclusions cannot be held as be valid for people with PCOS. My opinion in this case is that, because of the potential controversy of the subject, a reliable medical source (and one that specifically includes people with PCOS) is necessary for any mention of trans fats in the Cause section. Mikael Häggström ( talk) 10:45, 21 September 2011 (UTC)
50 pages! doi:10.1210/er.2011-1034 JFW | T@lk 11:33, 9 December 2012 (UTC)
this is for the discussion of the myo-inositol reference inserted a few minutes ago. As mentioned, this is a primary source, and so frowned upon by WP:MEDRS standards. But I've already engaged on user's talk page, so this is mainly for completeness' sake. I think the discussion should probably go here before re-inserting it, if it's found to be worthwhile to re-insert. -- [ UseTheCommandLine ~/ talk ]# ▄ 04:03, 17 August 2013 (UTC)
I saw a discussion at WT:MED that really belongs here, but changing all instances of "women" to "people with ovaries" seems problematic to me. To copy what I said there (because this discussion really belongs here anyway):
Bold claims are made that it isn't ovarian in nature in the lede, but zero citations. While modern medical science can change views rapidly in some areas, such changes always require a citation when documented. If citations are not found soon, I'll request Wiki Medicine to conduct a review/rewrite of what was once a B class article, but is far from being an F- article currently. Wzrd1 ( talk) 06:17, 7 November 2014 (UTC)
Lotrozole appears to be more effective than clomiphene in inducing ovulation. It has a higher percentage of live births and the same ammount of congenital anomalies. For some reason i can't edit the page.
Here's the source: http://www.nejm.org/doi/full/10.1056/NEJMoa1313517 — Preceding unsigned comment added by 193.2.8.42 ( talk) 15:00, 27 January 2015 (UTC)
I agree, but the name is LETROZOLE, mentioned in ACOG Practice Bulletin 194-June 2018, where they claim: "Therefore, for women with PCOS, letrozole should be considered as first-line therapy for ovulation induction because of the increased live birth rate compared with clomiphene citrate". Additional references:
Franik S, Kremer JAM, Nelen WLDM, Farquhar C. Aromatase inhibitors for subfertile women with polycystic ovary syndrome. Cochrane Database of Systematic Reviews 2014, Issue 2. Art.No.: CD010287
Consensus on infertility treatment related to polycystic ovary syndrome. Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Hum Reprod 2008; 23:462–77. Legro RS, Brzyski RG, Diamond MP, Coutifaris C, Schlaff WD, Casson P, et al. Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. NICHD Reproductive Medicine Network [published erratum appears in N Engl J Med 2014;317:1465]. N Engl J Med 2014;371:119–29.
Casper RF. Letrozole versus clomiphene citrate: which is better for ovulation induction? Fertil Steril 2009;92:858–9. — Preceding unsigned comment added by Alparla ( talk • contribs) 16:29, 24 October 2019 (UTC)
about this dif by Alexander Bloome. Sources there are:
{{
cite journal}}
: Vancouver style error: suffix in name 1 (
help){{
cite journal}}
: Cite has empty unknown parameter: |1=
(
help); Vancouver style error: punctuation in name 4 (
help)This comprehensive article from pubmed / hormones.gr explains in-depth the issue of Anti-Mullerian-Hormone excess in PCOS women and the effect on the development of the leading follicle in menstrual cycle resulting in the common ultrasound picture of "cystic" ovaries: http://www.hormones.gr/721/article/the-clinical-significance-of-anti-m252llerian-hormone%E2%80%A6.html . I'd recommend to read the article fully and update the corresponding section of causes, diagnosis and treatment here in this wikipedia article. A possible way to restore menstrual cycle in PCOS women suffering from excessive AMH-increase would then be to "pump out" dysfunct follicles using either downregulation or alternating menstrual cycles with and without hormonal contraceptives and after 4 months seeing the result of having normally functional follicles and developing leading follicles as every other woman in reproductive age without PCOS would do. There are recent studies in pubmed about detailed sample values of AMH and their effect on pregnancy and live birth rates showing a close relationship of AMH and the success of reproductive medicine in PCOS women: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518483/ . Also measuring AMH levels can be used to assess the success of metformin or glitazone therapy of PCOS: http://www.ncbi.nlm.nih.gov/pubmed/25935176
All in all, nearly unbelievable why the role of AMH in PCOS women is so widely unknown seemingly... Malv0isin ( talk) 02:28, 12 September 2015 (UTC)
http://www.nature.com/ncomms/2015/150929/ncomms9464/full/ncomms9464.html , 10000 patients, 100000 controls, seems like finally an adequate-in-number study about PCOS. I would say this qualifies as being as good as a review, so how about updating the whole Causes section of this article with the new insights about EGF-Receptor and FSHB-locus and AMH associated with PCOS susceptibility alleles. Damn interesting stuff.
Also I'm missing the part about TSH and Hashimoto's thyreoiditis which is long-known (since 2004) and wide-spread-known as being associated with PCOS. Malv0isin ( talk) 15:48, 2 November 2015 (UTC)
It's simply not clear, that PCOS is caused by ELEVATED ANDROGENS (male hormones). It just says "symptoms due to a hormone imbalance". What does that mean??? It's not clear enough 182.255.99.214 ( talk) 10:44, 26 January 2016 (UTC)
doi:10.1056/NEJMcp1514916 JFW | T@lk 16:16, 7 July 2016 (UTC)
" Myo-inositol and D-chiro-inositol both seems to be effective in reducing hyperandrogenism and improving ovulation in PCOS. <ref>{{Cite journal|last=Amoah-Arko|first=Afua|last2=Evans|first2=Meirion|last3=Rees|first3=Aled|date=2017-10-20|title=Effects of myoinositol and D-chiro inositol on hyperandrogenism and ovulation in women with polycystic ovary syndrome: a systematic review|url=http://www.endocrine-abstracts.org/ea/0050/ea0050p363.htm|language=en|doi=10.1530/endoabs.50.P363}}</ref>"
This review does not appear to be pubmed indexed? Doc James ( talk · contribs · email) 23:58, 21 December 2017 (UTC)
There is growing evidence that children to mothers with PCOS have a higher probability of being diagnosed with autism. Is this relevant information that should be incorporated into the article?
https://www.nature.com/articles/mp2015183
https://www.nature.com/articles/s41398-018-0186-7 — Preceding unsigned comment added by 85.226.149.234 ( talk) 10:50, 24 August 2018 (UTC)
the 'Definition" section should not be at the beginning of article (should be in 'diagnosis')-- Ozzie10aaaa ( talk) 13:42, 13 October 2021 (UTC)
This article was the subject of a Wiki Education Foundation-supported course assignment, between 1 September 2021 and 20 December 2021. Further details are available
on the course page. Student editor(s):
Cocoloco7961.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 08:50, 18 January 2022 (UTC)
Its an hormone disorder, therefore obesity is not a risk factor, rather a symptom or sign. 2.28.187.166 ( talk) 23:19, 13 March 2022 (UTC)
I think the subsection on "Public figures" within the "Society and culture" category could be considered superfluous trivia and should be removed, but I would like to seek the opinions of others before proceeding. Mooonswimmer 21:16, 19 August 2023 (UTC)
This article was the subject of a Wiki Education Foundation-supported course assignment, between 26 January 2024 and 14 May 2024. Further details are available
on the course page. Student editor(s):
Nicoleschully (
article contribs). Peer reviewers:
Sairah Mamik,
Charlottebaker1.
— Assignment last updated by Nicoleschully ( talk) 19:17, 25 April 2024 (UTC)
I think the mental health portion of this page is much smaller than it needs to be. The sources are also outdated and I plan to update them while adding more information. Nicoleschully ( talk) 19:14, 25 April 2024 (UTC)
![]() | This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||||||||
|
![]() | Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Polycystic ovary syndrome.
|
Talk:Polycystic ovary syndrome/unanswered question dump
This article was the subject of a Wiki Education Foundation-supported course assignment, between 14 June 2021 and 11 July 2021. Further details are available
on the course page. Student editor(s):
Petitee. Peer reviewers:
MariferL.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 02:31, 18 January 2022 (UTC)
This article was the subject of a Wiki Education Foundation-supported course assignment, between 3 September 2020 and 14 December 2020. Further details are available
on the course page. Student editor(s):
Kkher.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 06:54, 17 January 2022 (UTC)
Although this piece references "genetic causes" as an established scientific fact, nothing could be further from the truth, and of the two sources referenced, one is a 2002 paper which talks about a couple of gene loci, but not a genetic cause, and the other reference simply talks about genetic screening technologies but does not say that PCOS is "genetically caused". The reality is that it's probably gene-environment interactions(like most everything else), and this piece completely glosses over that issue and certainly could lead the unsophisticated or poorly informed reader to believe that a genetic cause in a simple sense was a virtual certainty – hardly the case. First of all, PCOS has a very strong association with maternal obesity, and with metabolic syndrome and insulin resistance, clues that this is not simply due to some 'aberrant' gene, but more likely an aberrant form of epigenetic metabolic programming associated with maternal obesity and its effects on the developing fetus. There are probably multiple Genetic polymorphisms that might contribute to PCOS, but that's really quite a far cry from dismissing all the environmental and lifestyle variables that look increasingly critical to this syndrome. This syndrome has only recently emerged in the context of the explosion of obesity in the United States, and it was thought to be exceptionally rare before that. I have cut and pasted a somewhat more balanced review of the genetic and environmental issues, which clearly needs some form of corrective attention in this treatment.
Steroids. 2011 Dec 8. [Epub ahead of print] Metabolic and cardiovascular genes in polycystic ovary syndrome: A candidate-wide association study (CWAS). Jones MR, Chua AK, Mengesha EA, Taylor KD, Chen YD, Li X, Krauss RM, Rotter JI; Reproductive Medicine Network, Legro RS, Azziz R, Goodarzi MO. Source
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States. Abstract
The role of metabolic disturbance in polycystic ovary syndrome (PCOS) has been well established, with insulin resistance and the resulting compensatory hyperinsulinemia thought to promote hyperandrogenemia. Genome-wide association studies (GWAS) have established a large number of loci for metabolic conditions such as type 2 diabetes and obesity. A subset of these loci has been investigated for a role in PCOS; these studies generally have not revealed a confirmed role for these loci in PCOS risk. However, a large scale investigation of genes related to these pathways has not previously been performed. We conducted a two stage case control association study of 121,715 single nucleotide polymorphisms (SNPs) selected to represent susceptibility loci associated with traits such as type 2 diabetes, obesity measures, lipid levels and cardiovascular function using the Cardio-Metabochip in 847 PCOS cases and 845 controls. Several hypothesis-generating associations with PCOS were observed (top SNP rs2129107, P=3.8×10(-6)). We did not find any loci definitively associated with PCOS after strict correction for multiple testing, suggesting that cardio-metabolic loci are not major risk factors underlying the susceptibility to PCOS.
Douglas F Watt, PhD 209.6.17.71 ( talk) 00:40, 3 January 2012 (UTC)
Prevalence in this article is stated as 5%, based on a single study. Yet there have been a plethora of studies attempting to establish the prevalence of PCOS, with results ranging from 5 to 15% (iirc). A single percentage ignores that range. It also ignores the fact that the diagnostic criteria for PCOS is in dispute, which means that to be specific (rather than giving a range), you need to specify which definition was used to establish that percentage. How is this usually dealt with here on Wikipedia? 24.1.140.128 ( talk) 05:01, 15 January 2010 (UTC)milara
Cortisol levels seem to be critical to PCOS. Why no mention? —Preceding unsigned comment added by 75.82.70.58 ( talk) 06:24, 10 May 2009 (UTC)
All you have to do is google "PCOS support group" and you will get literally scores of precise links where there are hundreds of people waiting to answer all your questions in warm fuzzy manners. Once again, wikipedia is not a source of medical advice unless you want to risk getting it from an anonymous 15 year old (I am not exaggerating), nor is it a support group or discussion forum. It seems harsh, but this page is especially hard hit. I will move all the above to an archive. Thanks for understanding. alteripse 21:05, 28 May 2007 (UTC)
I have deleted a bunch of external links to support groups and magazine articles about PCOS. The biggest problem is that half of the websites were listed twice (except the Australian group, which had four links), but in general I believe we need to remember that Wikipedia is not an advertising opportunity for our favorite organizations. Women with PCOS are smart enough to do their own Internet searches if they want more resources. WhatamIdoing ( talk) 03:00, 27 November 2007 (UTC)
An anon added unsourced information about gestational diabetes recently. It was promptly removed. It might be worth sorting that out. PMID 18710713 is a (very) recent systematic study on the issue, and I found its conclusion slightly unusual: The odds ratio is 2.89, but they'd don't trust it. WhatamIdoing ( talk) 15:00, 2 September 2008 (UTC)
Thought my source could be used as an additional resource for those accessing this PCOS page. Northwestern University's Feinberg School of Medicine ( http://www.pcos.northwestern.edu/) provides information for those women wanting to get involved in PCOS research studies and whether certain genes increase a woman's chance of getting PCOS. Makofin ( talk) 20:14, 19 November 2008 (UTC)Makofin
The University of Pennsylvania and Penn State University are conducting a NIH clinical randomized research trial to establish the relative roles of treatment of hyperandrogenism versus obesity in treating infertility and improving pregnancy outcomes among PCOS women. For more information about this study, acccess this link. ( http://webapp.hmc.psu.edu/owlpcos/website/index.cfm) Owlpcos ( talk) 18:53, 29 July 2009 (UTC) [1]
The recently added paragraph about ayurvedic remedies is uncited and poorly worded. I am not sure the information belongs in the article, but would have felt brash to delete it without discussion. -- shingra ( talk) 12:15, 27 May 2010 (UTC)
This article previously mentioned trans fats as a potential cause of PCOS, but the entry was removed, mainly because the two sources ( [2] and [3]) actually had not studied on people with PCOS, so their conclusions cannot be held as be valid for people with PCOS. My opinion in this case is that, because of the potential controversy of the subject, a reliable medical source (and one that specifically includes people with PCOS) is necessary for any mention of trans fats in the Cause section. Mikael Häggström ( talk) 10:45, 21 September 2011 (UTC)
50 pages! doi:10.1210/er.2011-1034 JFW | T@lk 11:33, 9 December 2012 (UTC)
this is for the discussion of the myo-inositol reference inserted a few minutes ago. As mentioned, this is a primary source, and so frowned upon by WP:MEDRS standards. But I've already engaged on user's talk page, so this is mainly for completeness' sake. I think the discussion should probably go here before re-inserting it, if it's found to be worthwhile to re-insert. -- [ UseTheCommandLine ~/ talk ]# ▄ 04:03, 17 August 2013 (UTC)
I saw a discussion at WT:MED that really belongs here, but changing all instances of "women" to "people with ovaries" seems problematic to me. To copy what I said there (because this discussion really belongs here anyway):
Bold claims are made that it isn't ovarian in nature in the lede, but zero citations. While modern medical science can change views rapidly in some areas, such changes always require a citation when documented. If citations are not found soon, I'll request Wiki Medicine to conduct a review/rewrite of what was once a B class article, but is far from being an F- article currently. Wzrd1 ( talk) 06:17, 7 November 2014 (UTC)
Lotrozole appears to be more effective than clomiphene in inducing ovulation. It has a higher percentage of live births and the same ammount of congenital anomalies. For some reason i can't edit the page.
Here's the source: http://www.nejm.org/doi/full/10.1056/NEJMoa1313517 — Preceding unsigned comment added by 193.2.8.42 ( talk) 15:00, 27 January 2015 (UTC)
I agree, but the name is LETROZOLE, mentioned in ACOG Practice Bulletin 194-June 2018, where they claim: "Therefore, for women with PCOS, letrozole should be considered as first-line therapy for ovulation induction because of the increased live birth rate compared with clomiphene citrate". Additional references:
Franik S, Kremer JAM, Nelen WLDM, Farquhar C. Aromatase inhibitors for subfertile women with polycystic ovary syndrome. Cochrane Database of Systematic Reviews 2014, Issue 2. Art.No.: CD010287
Consensus on infertility treatment related to polycystic ovary syndrome. Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Hum Reprod 2008; 23:462–77. Legro RS, Brzyski RG, Diamond MP, Coutifaris C, Schlaff WD, Casson P, et al. Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. NICHD Reproductive Medicine Network [published erratum appears in N Engl J Med 2014;317:1465]. N Engl J Med 2014;371:119–29.
Casper RF. Letrozole versus clomiphene citrate: which is better for ovulation induction? Fertil Steril 2009;92:858–9. — Preceding unsigned comment added by Alparla ( talk • contribs) 16:29, 24 October 2019 (UTC)
about this dif by Alexander Bloome. Sources there are:
{{
cite journal}}
: Vancouver style error: suffix in name 1 (
help){{
cite journal}}
: Cite has empty unknown parameter: |1=
(
help); Vancouver style error: punctuation in name 4 (
help)This comprehensive article from pubmed / hormones.gr explains in-depth the issue of Anti-Mullerian-Hormone excess in PCOS women and the effect on the development of the leading follicle in menstrual cycle resulting in the common ultrasound picture of "cystic" ovaries: http://www.hormones.gr/721/article/the-clinical-significance-of-anti-m252llerian-hormone%E2%80%A6.html . I'd recommend to read the article fully and update the corresponding section of causes, diagnosis and treatment here in this wikipedia article. A possible way to restore menstrual cycle in PCOS women suffering from excessive AMH-increase would then be to "pump out" dysfunct follicles using either downregulation or alternating menstrual cycles with and without hormonal contraceptives and after 4 months seeing the result of having normally functional follicles and developing leading follicles as every other woman in reproductive age without PCOS would do. There are recent studies in pubmed about detailed sample values of AMH and their effect on pregnancy and live birth rates showing a close relationship of AMH and the success of reproductive medicine in PCOS women: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518483/ . Also measuring AMH levels can be used to assess the success of metformin or glitazone therapy of PCOS: http://www.ncbi.nlm.nih.gov/pubmed/25935176
All in all, nearly unbelievable why the role of AMH in PCOS women is so widely unknown seemingly... Malv0isin ( talk) 02:28, 12 September 2015 (UTC)
http://www.nature.com/ncomms/2015/150929/ncomms9464/full/ncomms9464.html , 10000 patients, 100000 controls, seems like finally an adequate-in-number study about PCOS. I would say this qualifies as being as good as a review, so how about updating the whole Causes section of this article with the new insights about EGF-Receptor and FSHB-locus and AMH associated with PCOS susceptibility alleles. Damn interesting stuff.
Also I'm missing the part about TSH and Hashimoto's thyreoiditis which is long-known (since 2004) and wide-spread-known as being associated with PCOS. Malv0isin ( talk) 15:48, 2 November 2015 (UTC)
It's simply not clear, that PCOS is caused by ELEVATED ANDROGENS (male hormones). It just says "symptoms due to a hormone imbalance". What does that mean??? It's not clear enough 182.255.99.214 ( talk) 10:44, 26 January 2016 (UTC)
doi:10.1056/NEJMcp1514916 JFW | T@lk 16:16, 7 July 2016 (UTC)
" Myo-inositol and D-chiro-inositol both seems to be effective in reducing hyperandrogenism and improving ovulation in PCOS. <ref>{{Cite journal|last=Amoah-Arko|first=Afua|last2=Evans|first2=Meirion|last3=Rees|first3=Aled|date=2017-10-20|title=Effects of myoinositol and D-chiro inositol on hyperandrogenism and ovulation in women with polycystic ovary syndrome: a systematic review|url=http://www.endocrine-abstracts.org/ea/0050/ea0050p363.htm|language=en|doi=10.1530/endoabs.50.P363}}</ref>"
This review does not appear to be pubmed indexed? Doc James ( talk · contribs · email) 23:58, 21 December 2017 (UTC)
There is growing evidence that children to mothers with PCOS have a higher probability of being diagnosed with autism. Is this relevant information that should be incorporated into the article?
https://www.nature.com/articles/mp2015183
https://www.nature.com/articles/s41398-018-0186-7 — Preceding unsigned comment added by 85.226.149.234 ( talk) 10:50, 24 August 2018 (UTC)
the 'Definition" section should not be at the beginning of article (should be in 'diagnosis')-- Ozzie10aaaa ( talk) 13:42, 13 October 2021 (UTC)
This article was the subject of a Wiki Education Foundation-supported course assignment, between 1 September 2021 and 20 December 2021. Further details are available
on the course page. Student editor(s):
Cocoloco7961.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 08:50, 18 January 2022 (UTC)
Its an hormone disorder, therefore obesity is not a risk factor, rather a symptom or sign. 2.28.187.166 ( talk) 23:19, 13 March 2022 (UTC)
I think the subsection on "Public figures" within the "Society and culture" category could be considered superfluous trivia and should be removed, but I would like to seek the opinions of others before proceeding. Mooonswimmer 21:16, 19 August 2023 (UTC)
This article was the subject of a Wiki Education Foundation-supported course assignment, between 26 January 2024 and 14 May 2024. Further details are available
on the course page. Student editor(s):
Nicoleschully (
article contribs). Peer reviewers:
Sairah Mamik,
Charlottebaker1.
— Assignment last updated by Nicoleschully ( talk) 19:17, 25 April 2024 (UTC)
I think the mental health portion of this page is much smaller than it needs to be. The sources are also outdated and I plan to update them while adding more information. Nicoleschully ( talk) 19:14, 25 April 2024 (UTC)