This is the
talk page for discussing improvements to the
Phosphodiesterase article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL |
This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||||||
|
Iiuc, phosphodiesterase normally refers specifically to enzymes that degrade cyclic AMP, and has nothing to do with the bonds between adjacent nucleotides that are the main focus of the redirect article. If it's going to redirect somewhere, it should be to cyclic AMP. But I'm not going to start a redirect war. -- dsws 03:49, 12 July 2005 (UTC)
If you say that there are 11 families of PDEs it would be good to mention that this is only true for mammalian cells.
Technically a phosphodiesterase is any enzyme that breaks a phosphodiester bond. This includes DNAses (including restriction enzymes)and RNAses, clycic nucleotide phosphidesterases, and phospholipases C & D. Cyclic nucleotide PDEs may be the family that comes to most peoples' minds when they think of phosphodiesterases but I think the current description is too narrow. I'm happy to expand the page a bit if there's support for this idea... Roadnottaken 16:15, 21 March 2007 (UTC)
I think it would be good to add a section regarding its role in endocrine controlled metabolism, namely insulin-sensitive PDE which decreases levels of cAMP. — Preceding unsigned comment added by Thetokster ( talk • contribs) 09:54, 25 May 2011 (UTC)
doi:10.1210/er.2013-1053 Endocr Rev JFW | T@lk 19:47, 31 March 2014 (UTC)
This is the
talk page for discussing improvements to the
Phosphodiesterase article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL |
This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||||||
|
Iiuc, phosphodiesterase normally refers specifically to enzymes that degrade cyclic AMP, and has nothing to do with the bonds between adjacent nucleotides that are the main focus of the redirect article. If it's going to redirect somewhere, it should be to cyclic AMP. But I'm not going to start a redirect war. -- dsws 03:49, 12 July 2005 (UTC)
If you say that there are 11 families of PDEs it would be good to mention that this is only true for mammalian cells.
Technically a phosphodiesterase is any enzyme that breaks a phosphodiester bond. This includes DNAses (including restriction enzymes)and RNAses, clycic nucleotide phosphidesterases, and phospholipases C & D. Cyclic nucleotide PDEs may be the family that comes to most peoples' minds when they think of phosphodiesterases but I think the current description is too narrow. I'm happy to expand the page a bit if there's support for this idea... Roadnottaken 16:15, 21 March 2007 (UTC)
I think it would be good to add a section regarding its role in endocrine controlled metabolism, namely insulin-sensitive PDE which decreases levels of cAMP. — Preceding unsigned comment added by Thetokster ( talk • contribs) 09:54, 25 May 2011 (UTC)
doi:10.1210/er.2013-1053 Endocr Rev JFW | T@lk 19:47, 31 March 2014 (UTC)