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According to John van Drie at http://pharmacophore.org/, the origin of the term pharmacophore should be attributed to Monty Kier, not Ehrlich: "The concept of a p,nk,nharmacophore is widely but erroneously believed to originate from Ehrlich in the early 20th century, a mistake due to Ariens, propagated by P. Gund, and further propagated by O. Guener"
All of my statements are supported by exhaustive journal references, in the IEJMD article whose link precedes the words cited above. Proving a negative (ie proving Ehrlich never coined the term pharmacophore) is always difficult. It is a trivial matter to verify the Ehrlich citation is incorrect - just walk to a nearby old chemistry library containing that journal, and you won't find the quoted text in that article. In that IEJMD article, I cite numerous references in my attempt to show that the term originates from Kier, not Ehrlich. I would like to simply totally revamp this Wikipedia page; I know more about this subject than almost anyone. Should I just do that? JHvD ( talk) 18:36, 27 July 2009 (UTC)
If there are errors, this page should be rewritten. I would suggest that you retain and identify the errors so that readers can appreciate how misconceptions have crept into the literature. I would appreciate seeing all the references; it just adds to the credibility of the contribution. Nakatsuk 12:55, 22 October 2010 (UTC) —Preceding unsigned comment added by Nakatsuk ( talk • contribs)
I have changed the article according to the suggestions of van Drie. I am not a native speaker und would appreciate it someone find time to proof-read the changes. I read the whole publication by Paul Ehrlich (I am German) and can confirm that they do not mention pharmacophores or any related concept. HerrMarder ( talk) 12:47, 31 January 2011 (UTC)
This is the
talk page for discussing improvements to the
Pharmacophore article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find sources: Google ( books · news · scholar · free images · WP refs) · FENS · JSTOR · TWL |
This article is rated Start-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||||
|
According to John van Drie at http://pharmacophore.org/, the origin of the term pharmacophore should be attributed to Monty Kier, not Ehrlich: "The concept of a p,nk,nharmacophore is widely but erroneously believed to originate from Ehrlich in the early 20th century, a mistake due to Ariens, propagated by P. Gund, and further propagated by O. Guener"
All of my statements are supported by exhaustive journal references, in the IEJMD article whose link precedes the words cited above. Proving a negative (ie proving Ehrlich never coined the term pharmacophore) is always difficult. It is a trivial matter to verify the Ehrlich citation is incorrect - just walk to a nearby old chemistry library containing that journal, and you won't find the quoted text in that article. In that IEJMD article, I cite numerous references in my attempt to show that the term originates from Kier, not Ehrlich. I would like to simply totally revamp this Wikipedia page; I know more about this subject than almost anyone. Should I just do that? JHvD ( talk) 18:36, 27 July 2009 (UTC)
If there are errors, this page should be rewritten. I would suggest that you retain and identify the errors so that readers can appreciate how misconceptions have crept into the literature. I would appreciate seeing all the references; it just adds to the credibility of the contribution. Nakatsuk 12:55, 22 October 2010 (UTC) —Preceding unsigned comment added by Nakatsuk ( talk • contribs)
I have changed the article according to the suggestions of van Drie. I am not a native speaker und would appreciate it someone find time to proof-read the changes. I read the whole publication by Paul Ehrlich (I am German) and can confirm that they do not mention pharmacophores or any related concept. HerrMarder ( talk) 12:47, 31 January 2011 (UTC)