This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||
|
Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Pentamidine.
|
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Jcua28, Mlmtabs, NedaNassr, Kbrown18. Peer reviewers: WucCP133, Dgarcia24, Maryam.havaei, Lizethrivera0720.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 06:21, 17 January 2022 (UTC)
What's this? -- JeLuF 14:21 Dec 31, 2002 (UTC)
This stublet tells us absolutely nothing about the drug... what is it used for? etc... KJ
Seems to be solved by now. -- JeLuF 20:29 Jan 2, 2003 (UTC)
Kbrown18, Mlmtabs, NedaNassr, and Jcua28 will update the page accordingly:
Kbrown18 ( talk) 18:49, 3 November 2016 (UTC)
In the acute treatment of PCP, pentamidine is considered equally or slightly less active than co-trimoxazole (brand names Bactrim, Septrin, or Septra). Clinical evidence suggests that pentamidine is often better tolerated than co-trimoxazole because a high dose of co-trimoxazole is needed, which is associated with a high incidence and severity of side effects such as hepatitis, bone-marrow-damage, renal-damage, and life-threatening skin disease (Lyell-syndrome). Moreover, many patients are or become allergic to co-trimoxazole. For treatment of PCP, 4 milligrams of pentamidine per kilogram of body weight is given intravenously once daily for 14 to 21 days. Treatment exceeding 21 days may be necessary, but is associated with increased toxicity. Intramuscular injection is not recommended. The effect of pentamidine often becomes evident within the first 2 days of treatment, with reduction in fever and improvement of respiratory function. In any case, improvements of chest radiograph (x-ray) studies occur within 6 to 8 days, provided therapy is successful. Pentamidine therapy cures 50 to 70% of all patients treated.
Primary and secondary prophylaxis of PCP Primary prophylaxis of severely immunocompromised patients can be indicated where PCP has not yet been diagnosed. Secondary prophylaxis aims to prevent recurrent infections by PCP. For both forms of prophylaxis, an aerosolized formulation of pentamidine given by nebulizer once monthly in a dose of 300 mg is used. In primary prophylaxis, this reduces the long term likelihood of PCP by 70% when compared to no prophylaxis. The aerosolized route of administration is well suited for pregnant women in their first trimester (when TMP-SMX is contraindicated). Aerosolized administration may lead to an atypical PCP infection involving the upper lobes.
Other
For other indications, such as leishmaniasis or sleeping sickness, special treatment schedules developed by the World Health Organization (WHO) or Centers for Disease Control (CDC) exist.Mlmtabs ( talk) 20:27, 7 November 2016 (UTC)
STUDENT 1 – Does the draft submission reflect a neutral point of view? If not, specify… Yes, the draft submission on Pentamidine reflects a neutral point of view. The article summarizes publicly available information and does not include clinical conclusions based on primary research or opinions by the editors. WucCP133 ( talk) 21:28, 15 November 2016 (UTC)
STUDENT 2 – Are the points included verifiable with cited secondary sources that are freely accessible? If not, specify...No, not all sources are freely accessible, specifically Foye's Principles of Medicinal Chemistry (Seventh ed.), which is a book. A person would have to track down and purchase the book in order to cross reference the content used. Besides this, all other sources are freely accessible to the public. Albeit, there are multiple sources listed more than once in the references section. For example, the second source is listed again as the sixteenth source.
STUDENT 3 – Are the edits formatted consistent with Wikipedia’s manual of style for medicine-related articles? If not, specify… Yes, the edits are overall consistent with Wikipedia’s manual of style for medicine-related articles. -Per Wikipedia Manual of Style/Linking, only the first occurrence of a term in the text of the article should be linked, therefore you may link trimethoprim-sulfamethoxazole in the Pregnancy section instead of the one in the Children section that comes later in the text. -Per Wikipedia in class workshop, use of pregnancy category should be avoided as different pregnancy category systems are used worldwide and the U.S pregnancy category may not be as clear to readers from other countries. Maryam.havaei ( talk) 09:57, 16 November 2016 (UTC)
STUDENT 4 - Is there any evidence of plagiarism or copyright violation? If yes, specify... No, there is no evidence of plagiarism or copyright violations. Each added submission is followed by suitably cited sources. The editing that was submitted by each student was written in his/her own words and is supported by the sources included. When analyzed through a plagiarism checker, more than 96% of the text was found to be from http://en.wikipedia.org/wiki/Pentamidine without any other contributing sources. User:lizethrivera0720 ( talk) 22:03, 15 November 2016 (UTC)
This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||
|
Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Pentamidine.
|
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Jcua28, Mlmtabs, NedaNassr, Kbrown18. Peer reviewers: WucCP133, Dgarcia24, Maryam.havaei, Lizethrivera0720.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 06:21, 17 January 2022 (UTC)
What's this? -- JeLuF 14:21 Dec 31, 2002 (UTC)
This stublet tells us absolutely nothing about the drug... what is it used for? etc... KJ
Seems to be solved by now. -- JeLuF 20:29 Jan 2, 2003 (UTC)
Kbrown18, Mlmtabs, NedaNassr, and Jcua28 will update the page accordingly:
Kbrown18 ( talk) 18:49, 3 November 2016 (UTC)
In the acute treatment of PCP, pentamidine is considered equally or slightly less active than co-trimoxazole (brand names Bactrim, Septrin, or Septra). Clinical evidence suggests that pentamidine is often better tolerated than co-trimoxazole because a high dose of co-trimoxazole is needed, which is associated with a high incidence and severity of side effects such as hepatitis, bone-marrow-damage, renal-damage, and life-threatening skin disease (Lyell-syndrome). Moreover, many patients are or become allergic to co-trimoxazole. For treatment of PCP, 4 milligrams of pentamidine per kilogram of body weight is given intravenously once daily for 14 to 21 days. Treatment exceeding 21 days may be necessary, but is associated with increased toxicity. Intramuscular injection is not recommended. The effect of pentamidine often becomes evident within the first 2 days of treatment, with reduction in fever and improvement of respiratory function. In any case, improvements of chest radiograph (x-ray) studies occur within 6 to 8 days, provided therapy is successful. Pentamidine therapy cures 50 to 70% of all patients treated.
Primary and secondary prophylaxis of PCP Primary prophylaxis of severely immunocompromised patients can be indicated where PCP has not yet been diagnosed. Secondary prophylaxis aims to prevent recurrent infections by PCP. For both forms of prophylaxis, an aerosolized formulation of pentamidine given by nebulizer once monthly in a dose of 300 mg is used. In primary prophylaxis, this reduces the long term likelihood of PCP by 70% when compared to no prophylaxis. The aerosolized route of administration is well suited for pregnant women in their first trimester (when TMP-SMX is contraindicated). Aerosolized administration may lead to an atypical PCP infection involving the upper lobes.
Other
For other indications, such as leishmaniasis or sleeping sickness, special treatment schedules developed by the World Health Organization (WHO) or Centers for Disease Control (CDC) exist.Mlmtabs ( talk) 20:27, 7 November 2016 (UTC)
STUDENT 1 – Does the draft submission reflect a neutral point of view? If not, specify… Yes, the draft submission on Pentamidine reflects a neutral point of view. The article summarizes publicly available information and does not include clinical conclusions based on primary research or opinions by the editors. WucCP133 ( talk) 21:28, 15 November 2016 (UTC)
STUDENT 2 – Are the points included verifiable with cited secondary sources that are freely accessible? If not, specify...No, not all sources are freely accessible, specifically Foye's Principles of Medicinal Chemistry (Seventh ed.), which is a book. A person would have to track down and purchase the book in order to cross reference the content used. Besides this, all other sources are freely accessible to the public. Albeit, there are multiple sources listed more than once in the references section. For example, the second source is listed again as the sixteenth source.
STUDENT 3 – Are the edits formatted consistent with Wikipedia’s manual of style for medicine-related articles? If not, specify… Yes, the edits are overall consistent with Wikipedia’s manual of style for medicine-related articles. -Per Wikipedia Manual of Style/Linking, only the first occurrence of a term in the text of the article should be linked, therefore you may link trimethoprim-sulfamethoxazole in the Pregnancy section instead of the one in the Children section that comes later in the text. -Per Wikipedia in class workshop, use of pregnancy category should be avoided as different pregnancy category systems are used worldwide and the U.S pregnancy category may not be as clear to readers from other countries. Maryam.havaei ( talk) 09:57, 16 November 2016 (UTC)
STUDENT 4 - Is there any evidence of plagiarism or copyright violation? If yes, specify... No, there is no evidence of plagiarism or copyright violations. Each added submission is followed by suitably cited sources. The editing that was submitted by each student was written in his/her own words and is supported by the sources included. When analyzed through a plagiarism checker, more than 96% of the text was found to be from http://en.wikipedia.org/wiki/Pentamidine without any other contributing sources. User:lizethrivera0720 ( talk) 22:03, 15 November 2016 (UTC)