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This section is actually describing clinical pharmacokinetics. Needs to describe mechanism of the drug, e.g. proton pump inhibitor. Receptor binding, etc. Times to onset, duration, peak effect are kinetic parameters. 121.75.48.151 ( talk) 18:51, 18 March 2016 (UTC)
"Omeprazole is completely metabolized by the cytochrome P450 system, mainly in the liver. Identified metabolites are the sulfone, the sulfide, and hydroxy-omeprazole, which exert no significant effect on acid secretion. About 80% of an orally given dose is excreted as metabolites in the urine, and the remainder is found in the feces, primarily originating from bile secretion."
This should be more specific. And a source is missing!
"CYP2C19 is the principal enzyme that metabolizes omeprazole to inactive metabolites."
source:
https://www.ncbi.nlm.nih.gov/books/NBK100895/
--
85.176.29.147 (
talk)
19:55, 28 March 2018 (UTC)
In 'Pharmacology' a CH3 group is added to the pyridine structure. Is this (unmentioned) CYP-Metabolisation or an error? —Preceding unsigned comment added by 88.68.176.11 ( talk) 20:01, 14 November 2010 (UTC)
In the article it mentions that Omeprazole is available in countries over the counter, yet no references, or names of countries where this is the case are provided. 62.31.151.148 ( talk) 16:48, 31 May 2009 (UTC)
Should there really be like 100 brand names? I would assume the original brand name should be in the article, but not a gigantic list of every countrys' name for it. —Preceding unsigned comment added by 69.205.97.220 ( talk) 07:13, 28 January 2009 (UTC)
I removed the comment about Salmonella, because it doesn't usually infect the upper gastrointestinal tract does it? Also, PPIs don't completely stop gastric acid secretion. Techelf 11:55, 27 Jun 2004 (UTC)
I have a problem with the "it is falsely believed" part about allegations that AstraZeneca developed Nexium to mitigate the financial hit from Prilosec's going generic.
The article on esomeprazole (Nexium) reports a live controversy on the subject, linking a New Yorker article by Malcolm Gladwell.
So, anyone with more expertise -- should that language be altered to make it more neutral? -- Andersonblog 21:42, 26 November 2006 (UTC)
I also have a problem with the "it is falsely believed" part. Although Nexium may consist only of the active enantiomers, I'm not sure that this is clinically significant. In other words, Nexium may be more potent an agent in decreasing acid production, but a patient taking Nexium will show no significant clinical difference from a patient taking Prilosec. Prilosec may not be as efficient, but it still gets the job done.
—The preceding
unsigned comment was added by
192.35.79.70 (
talk •
contribs)
07:38, 29 November 2006 (UTC).
Valpopa's edits leave a sentence fragment, in addition to providing no citation and not
clearly relating to the preceeding text (at least as far as I am able to understand). Should they
just be reverted?
Ysth
23:20, 4 June 2007 (UTC)
Please, we all know that all drug company look for a way to slightly change the formula of a drug so that they can sell it for another 7 year as non generic! Wake up!!!! —Preceding unsigned comment added by 72.205.242.44 ( talk) 15:07, 16 February 2008 (UTC)
Does anyone know of any side effects? -- 204.49.34.2 12:41, 15 June 2007 (UTC)
Anaphylatic Reactions cited at: http://www.theannals.com/cgi/content/abstract/34/4/474 —Preceding unsigned comment added by 71.127.17.39 ( talk) 05:31, 19 January 2009 (UTC)
This class of drugs has serious side effects that are only now being understood. In particular osteoperosis with just a few years of use, because it intereferes with calcium absorbtion. This is a very dangerous remedy for heartburn. There needs to be a more extensive entry on the side effects with recent research.
"While it has been proven that only enantiomers in the "active" form are effective and others are not, due to the fact that the type of cytochrome which metabolizes the drug." There is no main clause in this sentence. Does the writer mean "It has been proven that only enantiomers in the "active" form are effective because of the type of cytochrome which metabolizes the drug"? If this does not alter the meaning it would be a more elegant way of expressing it. A.McMillan.
Would it be unethical to mention in this article how good this drug is at treating the common alcohol 'hangover'? One of these the night before and then another in the morning and I'm right as rain. 81.106.138.53 ( talk) 22:10, 1 January 2008 (UTC)otto was here
The language on the packaging says to take "before eating." This could be taken two ways: take the pill on an empty stomach, and wait a while before eating, or alternatively: take the pill on an empty stomach and then eat something immediately thereafter. It sounds like to former is what is intended, but it would be good for a qualified pharmacologist to enhance the language in the "Absorption and distribution" section to be explicit. ( 140.232.0.70 ( talk) 18:25, 23 November 2009 (UTC))
I have noticed that Omeprazole shares metabolic mechanisms with other drugs such as Clonazepam, and SSRIs like Escitalopram and Citalopram. In fact, these other pages make reference to the fact that using Omeprazole with these drugs can lead to heightened serum levels due to their shared hepatic clearance mechanisms. I think this information should be included in this article. Please include with a primary source. -- 1000Faces ( talk) 16:18, 1 December 2009 (UTC)
http://img440.imageshack.us/img440/7695/scan033w.jpg —Preceding unsigned comment added by Muleattack ( talk • contribs) 01:00, 10 October 2010 (UTC)
Has anybody heard of constipation being a side effect for this drug?
Chocom (
talk)
14:18, 17 January 2011 (UTC)
Look at the scan I provided above, it's a common side effect. Muleattack ( talk) 16:56, 17 January 2011 (UTC)
In Bangladesh Apex Pharma Limited also marketed omeprazole under the brand name "Aspra" which is a very good medicine 190.212.31.1 ( talk) 05:10, 15 June 2011 (UTC)
Would this link be appropriate? http://www.acidrefluxsymptomsnow.com — Preceding unsigned comment added by TomLibelt ( talk • contribs) 05:19, 10 December 2011 (UTC)
Which works better, omeprazole or zantac? — Preceding unsigned comment added by 67.58.92.76 ( talk) 21:56, 6 June 2013 (UTC)
Could someone more experienced than me edit the Interactions section for this medication? It has SERIOUS grammatical issues, but I don't want to change anything, because I'm not sure if the information is correct, either. Help! — Preceding unsigned comment added by 69.169.139.88 ( talk) 17:53, 9 November 2013 (UTC)
Anecdotal - Lucky me! I ended up in the emergency room with severe abdominal pain, dehydration, uncontrollable nausea and retching after being prescribed with this med. Initially, I was simply uncomfortable and thought it was a stomach bug. But five weeks later and 15 pounds lighter I figured out that my problems began three days after taking this med. The package insert states that these side effects are more common in those who take the drug when compared with placebo. Two days after I stopped taking this med, my symptoms disappeared.
bpage ( talk) 23:43, 29 March 2014 (UTC)
It has been verified that Warfarine is metabolized partly or fully by the enzyme CYP3A4. Roshu Bangal ( talk) 18:41, 23 August 2015 (UTC)
The structures on the right side of the "chemistry" sections have phenyl instead of pyrimidine groups — Preceding unsigned comment added by 66.243.219.231 ( talk) 15:47, 12 September 2017 (UTC)
"Microscopic Colitis Associated With Omeprazole and Esomeprazole Exposure"
Wilcox, Gilbert M. MD*; Mattia, Anthony R. MD†
Journal of Clinical Gastroenterology 43(6):p 551-553, July 2009. | DOI: 10.1097/MCG.0b013e31817d3fa1
https://journals.lww.com/jcge/Abstract/2009/07000/Microscopic_Colitis_Associated_With_Omeprazole_and.8.aspx
Thank you for your time, Wordreader ( talk) 21:57, 17 June 2023 (UTC)
![]() | This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||
|
![]() | Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Omeprazole.
|
This section is actually describing clinical pharmacokinetics. Needs to describe mechanism of the drug, e.g. proton pump inhibitor. Receptor binding, etc. Times to onset, duration, peak effect are kinetic parameters. 121.75.48.151 ( talk) 18:51, 18 March 2016 (UTC)
"Omeprazole is completely metabolized by the cytochrome P450 system, mainly in the liver. Identified metabolites are the sulfone, the sulfide, and hydroxy-omeprazole, which exert no significant effect on acid secretion. About 80% of an orally given dose is excreted as metabolites in the urine, and the remainder is found in the feces, primarily originating from bile secretion."
This should be more specific. And a source is missing!
"CYP2C19 is the principal enzyme that metabolizes omeprazole to inactive metabolites."
source:
https://www.ncbi.nlm.nih.gov/books/NBK100895/
--
85.176.29.147 (
talk)
19:55, 28 March 2018 (UTC)
In 'Pharmacology' a CH3 group is added to the pyridine structure. Is this (unmentioned) CYP-Metabolisation or an error? —Preceding unsigned comment added by 88.68.176.11 ( talk) 20:01, 14 November 2010 (UTC)
In the article it mentions that Omeprazole is available in countries over the counter, yet no references, or names of countries where this is the case are provided. 62.31.151.148 ( talk) 16:48, 31 May 2009 (UTC)
Should there really be like 100 brand names? I would assume the original brand name should be in the article, but not a gigantic list of every countrys' name for it. —Preceding unsigned comment added by 69.205.97.220 ( talk) 07:13, 28 January 2009 (UTC)
I removed the comment about Salmonella, because it doesn't usually infect the upper gastrointestinal tract does it? Also, PPIs don't completely stop gastric acid secretion. Techelf 11:55, 27 Jun 2004 (UTC)
I have a problem with the "it is falsely believed" part about allegations that AstraZeneca developed Nexium to mitigate the financial hit from Prilosec's going generic.
The article on esomeprazole (Nexium) reports a live controversy on the subject, linking a New Yorker article by Malcolm Gladwell.
So, anyone with more expertise -- should that language be altered to make it more neutral? -- Andersonblog 21:42, 26 November 2006 (UTC)
I also have a problem with the "it is falsely believed" part. Although Nexium may consist only of the active enantiomers, I'm not sure that this is clinically significant. In other words, Nexium may be more potent an agent in decreasing acid production, but a patient taking Nexium will show no significant clinical difference from a patient taking Prilosec. Prilosec may not be as efficient, but it still gets the job done.
—The preceding
unsigned comment was added by
192.35.79.70 (
talk •
contribs)
07:38, 29 November 2006 (UTC).
Valpopa's edits leave a sentence fragment, in addition to providing no citation and not
clearly relating to the preceeding text (at least as far as I am able to understand). Should they
just be reverted?
Ysth
23:20, 4 June 2007 (UTC)
Please, we all know that all drug company look for a way to slightly change the formula of a drug so that they can sell it for another 7 year as non generic! Wake up!!!! —Preceding unsigned comment added by 72.205.242.44 ( talk) 15:07, 16 February 2008 (UTC)
Does anyone know of any side effects? -- 204.49.34.2 12:41, 15 June 2007 (UTC)
Anaphylatic Reactions cited at: http://www.theannals.com/cgi/content/abstract/34/4/474 —Preceding unsigned comment added by 71.127.17.39 ( talk) 05:31, 19 January 2009 (UTC)
This class of drugs has serious side effects that are only now being understood. In particular osteoperosis with just a few years of use, because it intereferes with calcium absorbtion. This is a very dangerous remedy for heartburn. There needs to be a more extensive entry on the side effects with recent research.
"While it has been proven that only enantiomers in the "active" form are effective and others are not, due to the fact that the type of cytochrome which metabolizes the drug." There is no main clause in this sentence. Does the writer mean "It has been proven that only enantiomers in the "active" form are effective because of the type of cytochrome which metabolizes the drug"? If this does not alter the meaning it would be a more elegant way of expressing it. A.McMillan.
Would it be unethical to mention in this article how good this drug is at treating the common alcohol 'hangover'? One of these the night before and then another in the morning and I'm right as rain. 81.106.138.53 ( talk) 22:10, 1 January 2008 (UTC)otto was here
The language on the packaging says to take "before eating." This could be taken two ways: take the pill on an empty stomach, and wait a while before eating, or alternatively: take the pill on an empty stomach and then eat something immediately thereafter. It sounds like to former is what is intended, but it would be good for a qualified pharmacologist to enhance the language in the "Absorption and distribution" section to be explicit. ( 140.232.0.70 ( talk) 18:25, 23 November 2009 (UTC))
I have noticed that Omeprazole shares metabolic mechanisms with other drugs such as Clonazepam, and SSRIs like Escitalopram and Citalopram. In fact, these other pages make reference to the fact that using Omeprazole with these drugs can lead to heightened serum levels due to their shared hepatic clearance mechanisms. I think this information should be included in this article. Please include with a primary source. -- 1000Faces ( talk) 16:18, 1 December 2009 (UTC)
http://img440.imageshack.us/img440/7695/scan033w.jpg —Preceding unsigned comment added by Muleattack ( talk • contribs) 01:00, 10 October 2010 (UTC)
Has anybody heard of constipation being a side effect for this drug?
Chocom (
talk)
14:18, 17 January 2011 (UTC)
Look at the scan I provided above, it's a common side effect. Muleattack ( talk) 16:56, 17 January 2011 (UTC)
In Bangladesh Apex Pharma Limited also marketed omeprazole under the brand name "Aspra" which is a very good medicine 190.212.31.1 ( talk) 05:10, 15 June 2011 (UTC)
Would this link be appropriate? http://www.acidrefluxsymptomsnow.com — Preceding unsigned comment added by TomLibelt ( talk • contribs) 05:19, 10 December 2011 (UTC)
Which works better, omeprazole or zantac? — Preceding unsigned comment added by 67.58.92.76 ( talk) 21:56, 6 June 2013 (UTC)
Could someone more experienced than me edit the Interactions section for this medication? It has SERIOUS grammatical issues, but I don't want to change anything, because I'm not sure if the information is correct, either. Help! — Preceding unsigned comment added by 69.169.139.88 ( talk) 17:53, 9 November 2013 (UTC)
Anecdotal - Lucky me! I ended up in the emergency room with severe abdominal pain, dehydration, uncontrollable nausea and retching after being prescribed with this med. Initially, I was simply uncomfortable and thought it was a stomach bug. But five weeks later and 15 pounds lighter I figured out that my problems began three days after taking this med. The package insert states that these side effects are more common in those who take the drug when compared with placebo. Two days after I stopped taking this med, my symptoms disappeared.
bpage ( talk) 23:43, 29 March 2014 (UTC)
It has been verified that Warfarine is metabolized partly or fully by the enzyme CYP3A4. Roshu Bangal ( talk) 18:41, 23 August 2015 (UTC)
The structures on the right side of the "chemistry" sections have phenyl instead of pyrimidine groups — Preceding unsigned comment added by 66.243.219.231 ( talk) 15:47, 12 September 2017 (UTC)
"Microscopic Colitis Associated With Omeprazole and Esomeprazole Exposure"
Wilcox, Gilbert M. MD*; Mattia, Anthony R. MD†
Journal of Clinical Gastroenterology 43(6):p 551-553, July 2009. | DOI: 10.1097/MCG.0b013e31817d3fa1
https://journals.lww.com/jcge/Abstract/2009/07000/Microscopic_Colitis_Associated_With_Omeprazole_and.8.aspx
Thank you for your time, Wordreader ( talk) 21:57, 17 June 2023 (UTC)