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Alternative lengthening of telomeres

However, a 10-15% fraction of tumors keeps on dividing without telomerase by making use of what is called the ALT-mechanism for "Alternative Lengthening of Telomeres". The hallmark of ALT cancer cells is a special type of complexes of promyelocytic leukemia (PML) protein at the telomeres that are termed ALT-associated PML nuclear bodies or APBs. ALT-tumors can be identified by the presence of APBs on fluorescence microscopy images since normal cells do not have these structures.

Are some or all of these Nuclear dots the APBs of ALT cancers ? - Rod57 ( talk) 00:57, 4 August 2015 (UTC) reply

We could use a PML nuclear body article to clarify. - Rod57 ( talk) 01:04, 4 August 2015 (UTC) reply