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Please see my discussion on the Category talk:Neurotoxins page. -- Chinasaur 01:47, 11 August 2004 (UTC)
why isn't neurotoxin and neurotoxicity the same article. I have no say in whether they are combined or not, but it seens they are kind of the same. jess523s
The merge proposal tag was removed today for no consensus. -- Scientizzle 03:06, 26 February 2007 (UTC)
I don't know whether the term "toxin" in english toxicology can be applied to all kinds of poisons; in german toxicology, for instance, "toxin" reffers only to a biogenic (i.e. produced by an organism) poison. It is not correct to label e.g. neurotoxic heavy metals or organophosphates as "neurotoxins", since they are of mineral or synthetic origin. A typical neurotoxin is tetrodotoxin or strychnine, but not lead, mercury or Sarin. Could some english-native-speaking toxicologist clarify, whether it is right to mark all neurotoxic substances as "neurotoxins", please?-- 84.163.95.165 18:26, 21 March 2007 (UTC)
"Toxins ingested from the environment are described as exogenous and include gases (such as carbon monoxide), metals (such as mercury), liquids (ethanol) and an endless list of solids. When exogenous toxins are ingested, the effect on neurons is largely dependent on dosage. Thus, ethanol (alcohol) is inebriating in low doses, only producing mild neurotoxicity. Prolonged exposure to "safe" alcohol levels slowly weakens and kills neurons."
and (maybe, with the exception of ethanol, as it can be of biogenic origin) to distinguish them from proper neurotoxins, which are discussed in the rest of the article.
Parallelly, an article dealing with neurotoxic substances should be created, or incorporated into the main article Poison, same goes for haemotoxic, cardiotoxic, cytotoxic and otherwise poisonous compounds. A lot of work, yes, but Wiki should be an encyclopedia...-- 84.163.109.68 23:10, 22 March 2007 (UTC)
Hello. There is a book about neurotoxins, which says in preface: "Neurotoxins are toxic substances with selective actions on the nervous system. By definition, toxins are of natural origin, but the term 'neurotoxin' has been widely applied to some synthetic chemicals that act selectively on neurones" ` a5b ( talk) 23:49, 25 May 2011 (UTC)
Anytime I see neurotoxin, I read it in GLaDOS's voice. — Preceding unsigned comment added by 96.24.179.52 ( talk) 19:11, 16 July 2011 (UTC)
Agreed Try searching it and go to images CodyM2001 ( talk) 05:19, 25 April 2014 (UTC)
I have made significant changes to the Neurotoxin article. I am relatively new to the process of editing Wikipedia articles and not sure about the policy of replacing existing material. I believe what I have written to be significantly improved over the existing article and so will be uploading it shortly for people to look at. I know the history function exists so nothing from the past will be deleted. In what I have written there are a few problems of which I am aware:
1) The clostridium tetani image is not linking properly (maybe because it is not in the english language section of wikipedia, I have no idea).
2) Some of my links to other articles are not working properly while the majority seem to work fine, and I am not sure what the problem is.
3) Additionally, when I uploaded what I had written, links to neurotoxin articles in other languages disappeared for some reason.
4) Lastly, my references are not in Wikipedia's preferred format, because I was unable to get it working. Hopefully everything is cited well enough that the article can be changed easily to the preferred format. I will work on this improvement as well in the near future.
I hope that this upload is appreciated, and I apologize in advance if this breaks any Wikipedia rules of which I am not aware.
-- Rysin ( talk) 14:22, 9 December 2011 (UTC)
An image used in this article, File:Clostridium tetani bacteria.jpg, has been nominated for speedy deletion for the following reason: All Wikipedia files with unknown copyright status
Don't panic; you should have time to contest the deletion (although please review deletion guidelines before doing so). The best way to contest this form of deletion is by posting on the image talk page.
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Reviewer: Pyrotec ( talk · contribs) 22:56, 3 December 2012 (UTC)
I've now done an initial quick read of the article and on balance it appears to be at or about GA-level, so "quick failing" this nomination is not appropriate and I will now review it against WP:WIAGA.
The article appears to be well referenced (I say "appears" because I've not checked them), comprehensive and well illustrated; however, the Lede (or WP:Lead) is a bit (well more than a bit) "indigestible", but I'll comeback to that later. I also see difficulties in determining the scope of the article from the lead, and that will make it difficult to assess the article against WP:WIAGA, clauses 3(a) & (b) although I suspect that the latter is OK. Pyrotec ( talk) 20:40, 13 December 2012 (UTC)
(Done) There is also a {{ citation needed}} flag present in the Background section which seems to date back to January 2012, some nine or ten month before this article was nominated at WP:GAN.
(Done) Also, a {{ clarification needed}} flag in the Inhibitors subsection going back to February 2102
(Done) as well as a {{ citation needed}} going back to April 2012. I did not spot these two flags earlier, or I might have invoked a "quick fail". Pyrotec ( talk) 22:24, 7 December 2012 (UTC)
I'm now going to work my way through the article, starting at the Background section and finishing with the Lead, and highlight any "problems" that I find. This is likely to take a few days. Pyrotec ( talk) 22:02, 7 December 2012 (UTC)
...stopping at this point. To be continued. Pyrotec ( talk) 23:01, 7 December 2012 (UTC)
At this point, I can see the end of the article and it just seems to stop. So I'm opening a new subsection on Scope & what is this article about?.
I would expect to be continuing this section after the conclusion of the following subsection. Pyrotec ( talk) 15:02, 9 December 2012 (UTC)
I normally do the WP:Lead last.
The lead has two main functions (see WP:Lead): (1) to introduce the topic of this article and (2) to summarise the main points in the article. It also has some constraints, for instance the Lead should not "tease" by discussions topics/subjects that don't appear in the body of the article and the "relative balance" of the lead should be similar to that of the body of the article. For these reasons, I find it easier to review the body of the article to find out what it is about and then go and review the Lead to see if it is "compliant".
Having got through the article to Mechanisms of activity/Inhibitors I think I need to step back and find out what this article is about. As I'll need to do this inorder to assess the article against WP:WIAGA, clauses 3(a) & (b) although I suspect that the latter is OK. Pyrotec ( talk) 20:40, 13 December 2012 (UTC)
I think this is what the article is about. If I've got it wrong, please say so.
My first impression is that the scope of the lead is broadly compatible with that of the body of the article with one exception. The Lead states: Support has been shown for a number of treatments aimed at attenuating neurotoxin-mediated injury, such as antioxidant,[9] antitoxin[19] and ethanol[20] administration. I think that this may be out of balance with the body of the article:
...Stopping for now. To be continued. Pyrotec ( talk) 23:09, 8 December 2012 (UTC)
I think this article is about Neurotoxins and in particular their use in the study of nervous systems thought their ability to specifically target neural components. There are quite a few examples of Neurotoxins and how they might interact with the body and some information on treatment(s). This includes some information on the problems associated with the use of lead, to show the antiquity" of the topic of neurotoxin/Neurotoxicity.
Pyrotec ( talk) 16:03, 9 December 2012 (UTC)
...stopping for now. To be continued. Pyrotec ( talk) 21:07, 20 December 2012 (UTC)
At this point I'm putting the review "On Hold". The article has many strong points in favour of it being made a GA, but the "problems" that I've raised above need to be consider and addressed first.
Pyrotec (
talk) 17:08, 23 December 2012 (UTC)
The alleged citation for 25i-NBOMe's neurotoxicity - Rutgrere 2012 - doesn't seem to exist?
Thoughts? — Preceding unsigned comment added by 24.121.115.108 ( talk) 05:47, 23 October 2014 (UTC)
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This excellent article appears to be addressed mainly to chemists and perhaps environmental scientists. A much larger audience that is not yet addressed consists of people who simply don't want their brains poisoned and who may also want to protect the unusually vulnerable brains of their children, including especially fetuses and infants. I wish I had time to be more constructive, but here are a few lay articles suggestive of what I would include: OOPS! I accidentally deleted most of the suggestions. Stay tuned. Page Notes ( talk) 01:51, 2 November 2019 (UTC)
Neurotoxins are toxins that are destructive to nerve tissue (causing neurotoxicity).[3] Neurotoxins are an extensive class of exogenous chemical neurological insults[4] that can adversely affect function in both developing and mature nervous tissue.[5] The term can also be used to classify endogenous compounds, which, when abnormally contacted, can prove neurologically toxic.[4] Though neurotoxins are often neurologically destructive, their ability to specifically target neural components is important in the study of nervous systems.[6] Common examples of neurotoxins include lead,[7] ethanol (drinking alcohol),[8] glutamate,[9] nitric oxide,[10] botulinum toxin (e.g. Botox),[11] tetanus toxin,[12] and tetrodotoxin.[6] Some substances such as nitric oxide and glutamate are in fact essential for proper function of the body and only exert neurotoxic effects at excessive concentrations. 2409:4063:4E8D:58C2:0:0:AA48:7506 ( talk) 16:45, 5 May 2022 (UTC)
Neurotoxins are toxins that are destructive to nerve tissue (causing neurotoxicity).[3] Neurotoxins are an extensive class of exogenous chemical neurological insults[4] that can adversely affect function in both developing and mature nervous tissue.[5] The term can also be used to classify endogenous compounds, which, when abnormally contacted, can prove neurologically toxic.[4] Though neurotoxins are often neurologically destructive, their ability to specifically target neural components is important in the study of nervous systems.[6] Common examples of neurotoxins include lead,[7] ethanol (drinking alcohol),[8] glutamate,[9] nitric oxide,[10] botulinum toxin (e.g. Botox),[11] tetanus toxin,[12] and tetrodotoxin.[6] Some substances such as nitric oxide and glutamate are in fact essential for proper function of the body and only exert neurotoxic effects at excessive concentrations. 2409:4063:4E8D:58C2:0:0:AA48:7506 ( talk) 16:45, 5 May 2022 (UTC)
This is the
talk page for discussing improvements to the
Neurotoxin article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL |
Neurotoxin was a Natural sciences good articles nominee, but did not meet the good article criteria at the time. There may be suggestions below for improving the article. Once these issues have been addressed, the article can be renominated. Editors may also seek a reassessment of the decision if they believe there was a mistake. | |||||||||||||
| |||||||||||||
A
fact from this article appeared on Wikipedia's
Main Page in the "
Did you know?" column on
December 20, 2011. The text of the entry was: Did you know ... that
cyanobacteria can be washed up on the
shore in a green scum, which may contain an acute
neurotoxin known as the
Very Fast Death Factor, which leads to fast death by paralysis? | |||||||||||||
Current status: Former good article nominee |
This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||||||||||||||||||||
|
Please see my discussion on the Category talk:Neurotoxins page. -- Chinasaur 01:47, 11 August 2004 (UTC)
why isn't neurotoxin and neurotoxicity the same article. I have no say in whether they are combined or not, but it seens they are kind of the same. jess523s
The merge proposal tag was removed today for no consensus. -- Scientizzle 03:06, 26 February 2007 (UTC)
I don't know whether the term "toxin" in english toxicology can be applied to all kinds of poisons; in german toxicology, for instance, "toxin" reffers only to a biogenic (i.e. produced by an organism) poison. It is not correct to label e.g. neurotoxic heavy metals or organophosphates as "neurotoxins", since they are of mineral or synthetic origin. A typical neurotoxin is tetrodotoxin or strychnine, but not lead, mercury or Sarin. Could some english-native-speaking toxicologist clarify, whether it is right to mark all neurotoxic substances as "neurotoxins", please?-- 84.163.95.165 18:26, 21 March 2007 (UTC)
"Toxins ingested from the environment are described as exogenous and include gases (such as carbon monoxide), metals (such as mercury), liquids (ethanol) and an endless list of solids. When exogenous toxins are ingested, the effect on neurons is largely dependent on dosage. Thus, ethanol (alcohol) is inebriating in low doses, only producing mild neurotoxicity. Prolonged exposure to "safe" alcohol levels slowly weakens and kills neurons."
and (maybe, with the exception of ethanol, as it can be of biogenic origin) to distinguish them from proper neurotoxins, which are discussed in the rest of the article.
Parallelly, an article dealing with neurotoxic substances should be created, or incorporated into the main article Poison, same goes for haemotoxic, cardiotoxic, cytotoxic and otherwise poisonous compounds. A lot of work, yes, but Wiki should be an encyclopedia...-- 84.163.109.68 23:10, 22 March 2007 (UTC)
Hello. There is a book about neurotoxins, which says in preface: "Neurotoxins are toxic substances with selective actions on the nervous system. By definition, toxins are of natural origin, but the term 'neurotoxin' has been widely applied to some synthetic chemicals that act selectively on neurones" ` a5b ( talk) 23:49, 25 May 2011 (UTC)
Anytime I see neurotoxin, I read it in GLaDOS's voice. — Preceding unsigned comment added by 96.24.179.52 ( talk) 19:11, 16 July 2011 (UTC)
Agreed Try searching it and go to images CodyM2001 ( talk) 05:19, 25 April 2014 (UTC)
I have made significant changes to the Neurotoxin article. I am relatively new to the process of editing Wikipedia articles and not sure about the policy of replacing existing material. I believe what I have written to be significantly improved over the existing article and so will be uploading it shortly for people to look at. I know the history function exists so nothing from the past will be deleted. In what I have written there are a few problems of which I am aware:
1) The clostridium tetani image is not linking properly (maybe because it is not in the english language section of wikipedia, I have no idea).
2) Some of my links to other articles are not working properly while the majority seem to work fine, and I am not sure what the problem is.
3) Additionally, when I uploaded what I had written, links to neurotoxin articles in other languages disappeared for some reason.
4) Lastly, my references are not in Wikipedia's preferred format, because I was unable to get it working. Hopefully everything is cited well enough that the article can be changed easily to the preferred format. I will work on this improvement as well in the near future.
I hope that this upload is appreciated, and I apologize in advance if this breaks any Wikipedia rules of which I am not aware.
-- Rysin ( talk) 14:22, 9 December 2011 (UTC)
An image used in this article, File:Clostridium tetani bacteria.jpg, has been nominated for speedy deletion for the following reason: All Wikipedia files with unknown copyright status
Don't panic; you should have time to contest the deletion (although please review deletion guidelines before doing so). The best way to contest this form of deletion is by posting on the image talk page.
This notification is provided by a Bot -- CommonsNotificationBot ( talk) 13:46, 14 December 2011 (UTC) |
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Reviewing |
Reviewer: Pyrotec ( talk · contribs) 22:56, 3 December 2012 (UTC)
I've now done an initial quick read of the article and on balance it appears to be at or about GA-level, so "quick failing" this nomination is not appropriate and I will now review it against WP:WIAGA.
The article appears to be well referenced (I say "appears" because I've not checked them), comprehensive and well illustrated; however, the Lede (or WP:Lead) is a bit (well more than a bit) "indigestible", but I'll comeback to that later. I also see difficulties in determining the scope of the article from the lead, and that will make it difficult to assess the article against WP:WIAGA, clauses 3(a) & (b) although I suspect that the latter is OK. Pyrotec ( talk) 20:40, 13 December 2012 (UTC)
(Done) There is also a {{ citation needed}} flag present in the Background section which seems to date back to January 2012, some nine or ten month before this article was nominated at WP:GAN.
(Done) Also, a {{ clarification needed}} flag in the Inhibitors subsection going back to February 2102
(Done) as well as a {{ citation needed}} going back to April 2012. I did not spot these two flags earlier, or I might have invoked a "quick fail". Pyrotec ( talk) 22:24, 7 December 2012 (UTC)
I'm now going to work my way through the article, starting at the Background section and finishing with the Lead, and highlight any "problems" that I find. This is likely to take a few days. Pyrotec ( talk) 22:02, 7 December 2012 (UTC)
...stopping at this point. To be continued. Pyrotec ( talk) 23:01, 7 December 2012 (UTC)
At this point, I can see the end of the article and it just seems to stop. So I'm opening a new subsection on Scope & what is this article about?.
I would expect to be continuing this section after the conclusion of the following subsection. Pyrotec ( talk) 15:02, 9 December 2012 (UTC)
I normally do the WP:Lead last.
The lead has two main functions (see WP:Lead): (1) to introduce the topic of this article and (2) to summarise the main points in the article. It also has some constraints, for instance the Lead should not "tease" by discussions topics/subjects that don't appear in the body of the article and the "relative balance" of the lead should be similar to that of the body of the article. For these reasons, I find it easier to review the body of the article to find out what it is about and then go and review the Lead to see if it is "compliant".
Having got through the article to Mechanisms of activity/Inhibitors I think I need to step back and find out what this article is about. As I'll need to do this inorder to assess the article against WP:WIAGA, clauses 3(a) & (b) although I suspect that the latter is OK. Pyrotec ( talk) 20:40, 13 December 2012 (UTC)
I think this is what the article is about. If I've got it wrong, please say so.
My first impression is that the scope of the lead is broadly compatible with that of the body of the article with one exception. The Lead states: Support has been shown for a number of treatments aimed at attenuating neurotoxin-mediated injury, such as antioxidant,[9] antitoxin[19] and ethanol[20] administration. I think that this may be out of balance with the body of the article:
...Stopping for now. To be continued. Pyrotec ( talk) 23:09, 8 December 2012 (UTC)
I think this article is about Neurotoxins and in particular their use in the study of nervous systems thought their ability to specifically target neural components. There are quite a few examples of Neurotoxins and how they might interact with the body and some information on treatment(s). This includes some information on the problems associated with the use of lead, to show the antiquity" of the topic of neurotoxin/Neurotoxicity.
Pyrotec ( talk) 16:03, 9 December 2012 (UTC)
...stopping for now. To be continued. Pyrotec ( talk) 21:07, 20 December 2012 (UTC)
At this point I'm putting the review "On Hold". The article has many strong points in favour of it being made a GA, but the "problems" that I've raised above need to be consider and addressed first.
Pyrotec (
talk) 17:08, 23 December 2012 (UTC)
The alleged citation for 25i-NBOMe's neurotoxicity - Rutgrere 2012 - doesn't seem to exist?
Thoughts? — Preceding unsigned comment added by 24.121.115.108 ( talk) 05:47, 23 October 2014 (UTC)
Hello fellow Wikipedians,
I have just modified 2 external links on Neurotoxin. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
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This excellent article appears to be addressed mainly to chemists and perhaps environmental scientists. A much larger audience that is not yet addressed consists of people who simply don't want their brains poisoned and who may also want to protect the unusually vulnerable brains of their children, including especially fetuses and infants. I wish I had time to be more constructive, but here are a few lay articles suggestive of what I would include: OOPS! I accidentally deleted most of the suggestions. Stay tuned. Page Notes ( talk) 01:51, 2 November 2019 (UTC)
Neurotoxins are toxins that are destructive to nerve tissue (causing neurotoxicity).[3] Neurotoxins are an extensive class of exogenous chemical neurological insults[4] that can adversely affect function in both developing and mature nervous tissue.[5] The term can also be used to classify endogenous compounds, which, when abnormally contacted, can prove neurologically toxic.[4] Though neurotoxins are often neurologically destructive, their ability to specifically target neural components is important in the study of nervous systems.[6] Common examples of neurotoxins include lead,[7] ethanol (drinking alcohol),[8] glutamate,[9] nitric oxide,[10] botulinum toxin (e.g. Botox),[11] tetanus toxin,[12] and tetrodotoxin.[6] Some substances such as nitric oxide and glutamate are in fact essential for proper function of the body and only exert neurotoxic effects at excessive concentrations. 2409:4063:4E8D:58C2:0:0:AA48:7506 ( talk) 16:45, 5 May 2022 (UTC)
Neurotoxins are toxins that are destructive to nerve tissue (causing neurotoxicity).[3] Neurotoxins are an extensive class of exogenous chemical neurological insults[4] that can adversely affect function in both developing and mature nervous tissue.[5] The term can also be used to classify endogenous compounds, which, when abnormally contacted, can prove neurologically toxic.[4] Though neurotoxins are often neurologically destructive, their ability to specifically target neural components is important in the study of nervous systems.[6] Common examples of neurotoxins include lead,[7] ethanol (drinking alcohol),[8] glutamate,[9] nitric oxide,[10] botulinum toxin (e.g. Botox),[11] tetanus toxin,[12] and tetrodotoxin.[6] Some substances such as nitric oxide and glutamate are in fact essential for proper function of the body and only exert neurotoxic effects at excessive concentrations. 2409:4063:4E8D:58C2:0:0:AA48:7506 ( talk) 16:45, 5 May 2022 (UTC)