![]() | This is an archive of past discussions. Do not edit the contents of this page. If you wish to start a new discussion or revive an old one, please do so on the current talk page. |
Archive 1 |
Does anyone have the technical details for mRNA-1273? There seems to be so little information available here and even in regulatory documents and on drug sites, but here's what our description of the Pfizer vaccine now looks like:
Seems like this would be of utmost importance considering the novelty of mRNA drugs and the wide variations across platforms. — C M B J 23:01, 31 December 2020 (UTC)
I suggest adding the following to the Design section, based on the references I've indicated:
Wikipedia doesn’t state which country has developed Moderna covid vaccine. It is an important information. — Preceding unsigned comment added by 49.192.4.27 ( talk) 22:53, 4 January 2021 (UTC)
The vaccine was codeveloped by researchers at the National Institute of Allergy and Infectious Diseases (NIAID, Bethesda, MD, USA) and at Moderna, Inc. (Cambridge, MA, USA).-- Jpmcgrath729 ( talk) 20:44, 18 January 2021 (UTC)
Per Pfizer-BioNTech COVID-19 vaccine, shouldn't this article be renamed to Moderna COVID-19 vaccine? I don't think this needs an RM (given the discussion at Talk:Pfizer-BioNTech COVID-19 vaccine#Requested move 16 December 2020, and pinging No such user who closed the RM), I think identical arguments apply? Britishfinance ( talk) 19:28, 16 January 2021 (UTC)
This document was released on Friday.
COVID-19 vaccine safety update for COVID-19 Vaccine Moderna: February 2021. [5]
References
{{
cite news}}
: CS1 maint: url-status (
link)
I don't think this is a controversy: "Pregnant and breastfeeding women were excluded from the initial trials used to obtain Emergency Use Authorization." There were probably no people from many other categories. If the company even tried to recruit pregnant women there'd be a media storm. No pregnant women would enroll anyway. This should be moved to the section that describes the trials. — Preceding unsigned comment added by 2601:646:8380:5020:C0F8:BBD7:13E6:648C ( talk) 20:49, 4 February 2021 (UTC)
"In February 2021, Moderna said that it was expecting $18.4 billion of its Covid-19 vaccine sales.[92] "
What, specifically, is the implied controversy here?
139.138.6.121 (
talk)
14:37, 11 March 2021 (UTC)
Given that this particular article subject was developed by an American company, shouldn't the date formatting on the article follow American standard? (e.g., "On December 18, 2020, mRNA-1273 was issued an Emergency Use Authorization...") Antoshi ☏ ★ 13:40, 1 April 2021 (UTC)
I write as a pro-vaccine person who enthusiastically received my first dose of the Moderna vaccine six days ago.
The article barely mentions side effects (two minor references). Wikipedia as a neutral and factual forum is a good place to provide factual and documented/sourced info about any side effects.
For example, this NEJM article that just appeared documents a significant effect for about 1% of patients: https://www.nejm.org/doi/10.1056/NEJMc2102131 .
72.174.46.173 ( talk) 05:00, 5 March 2021 (UTC)
Fact Sheet for Healthcare Providers Administering Vaccine
"Today, the U.S. Food and Drug Administration announced two revisions regarding the number of doses per vial available for the Moderna COVID-19 Vaccine. The first revision clarifies the number of doses per vial for the vials that are currently available, in that the maximum number of extractable doses is 11, with a range of 10-11 doses. The second revision authorizes the availability of an additional multi-dose vial in which each vial contains a maximum of 15 doses, with a range of 13-15 doses that can potentially be extracted."
2600:1000:B037:628E:54F0:F946:E988:7034 ( talk) 13:17, 2 April 2021 (UTC)
I was looking for information how the Moderna vaccinations are distributed worldwide (per country). Would be worth to add? -- Christianh ( talk) 08:40, 7 April 2021 (UTC)
EU is coloured blue on the Authorisation map, but is listed under Full Authorisation in the list below the map. Which one is correct? – 78.59.24.14 ( talk) 06:51, 16 April 2021 (UTC)
I've added a funding section to the article, similar to the one on the Pfizer–BioNTech COVID-19 vaccine article. I did my best to get a diversity of references and to imitate the style and tone from the other article, but I'm a fairly new editor so I'd appreciate if someone could take a look. -- Tufts2017 ( talk) 16:03, 25 April 2021 (UTC)
/info/en/?search=Pfizer%E2%80%93BioNTech_COVID-19_vaccine
"It is composed of nucleoside-modified mRNA (modRNA) encoding a mutated form of the full-length spike protein"
Has also the Moderna vaccine a full-length spike protein? If yes, it should be mentioned in Moderna Wikipedia page.
I suppose the Pfizer article is now a bit unaccurate, maybe it should be corrected to:
full‐length sequence of spike protein, so it is not about size of the protein, but lenght of the codon sequence?
--
ee1518 (
talk)
20:03, 16 May 2021 (UTC)
The result of the move request was: Not moved; consensus is that the article titles policy should take precedence over the manual of style on medicine-related articles.
These two requested moves pose the same question — whether the title of COVID-19 vaccine articles should be the international nonproprietary name (INN) (per the article titles section (MEDTITLE) of the manual of style on medicine-related articles) or the name of the company (or companies) which developed the vaccine concatenated with "COVID-19 vaccine" (which has been argued to be in accordance with the commonly recognisable names section (COMMONNAME) of the article titles policy). Both articles' title is currently the latter. The arguments made in each discussion were also very similar. Therefore, I am closing these discussions as one discussion.
There was not much question on what the manual of style or the article titles policy recommend — in this case, the INN or the company-name concatenation, respectively. Rather, much of the discussion was on which of these takes precedence. While the article titles policy is a policy and the manual of style is a guideline, the manual of style on medicine-related articles is much more specific (and there is no policy giving explicit advice on medical titles). Some opinions were that the manual of style takes precedence due to its specificity. Opposing opinions were varied; some argued that the INNs were not widely used enough in reliable medical sources; others made the point that the company-name concatenations were the common names in (non-medical) reliable sources by a large margin.
While medical guidelines are often stronger than other subject-specific guidelines because it is crucial that Wikipedia provides reliable information in this area (like those for biographies of living people), policies still override guidelines. In this case, the consensus appears to be that the article titles policy is stronger than the manual of style on medicine-related articles, so the company-name concatenations should be used instead of the INNs, and the pages should be not moved.
— ( closed by non-admin page mover) Tol | talk | contribs 22:32, 12 July 2021 (UTC)
Moderna COVID-19 vaccine → Elasomeran – Move to the drug's international nonproprietary name, naturally with a redirect in place and other common names mentioned in the lead section. Our WP:MEDTITLE guideline governs the naming of Wikipedia articles about drugs, and I find no convincing reason why this particular drug, however popular in 2021, should be an exception.
For clarity, MEDTITLE stypulates: The article title should be the scientific or recognised medical name that is most commonly used in recent, high-quality, English-language medical sources, rather than a lay term (unscientific or slang name).
—
kashmīrī
TALK
14:47, 3 July 2021 (UTC)
Most biologics, including vaccines, do not have INN or other generic names, so the brand name is used instead. I see no reason why the guideline should not apply to this vaccine. As for which guideline takes precedence, it must be the topic-specific one. The other way around makes absolutely no sense. ― Tartan357 Talk 07:45, 5 July 2021 (UTC)
scientific or recognised medical name that is most commonly used in recent, high-quality, English-language medical sources. In MEDRS, the name is mRNA-1273 not Elasomeran. But in any case, oppose both as per COMMONNAME. ProcrastinatingReader ( talk) 21:21, 6 July 2021 (UTC)
@
Gonnym: regarding your recent reverts (
first,
second), table footnotes using predefined groups next to the table are acceptable according to
WP:REFGROUP and
H:PREGROUP and you can see this in
good articles like
OPEC and
Windows XP, remaining unchanged in this usage for a long period of time. Therefore, it is incorrect to classify my edits as pushing
an agenda
. I admit that in my first edit it was not good practice to include footnotes in a table cell, though it is not uncommon, see
Philadelphia English, for example. But why do you consider the second edit to be bad practice? --
Fernando Trebien (
talk)
18:03, 30 July 2021 (UTC)
But since it's a note, it belongs in a note section.Like in Windows XP? -- Fernando Trebien ( talk) 19:25, 30 July 2021 (UTC)
Placing the notes in the middle of the page is just incorrect.So why do articles that meet good article criteria using this type of footnote remain unchallenged for so many years? Scientific articles often do this in tables. This saves the reader from having to jump to another location many times when parsing a table. -- Fernando Trebien ( talk) 19:25, 30 July 2021 (UTC)
If it was more important, the note should be replaced with prose text right under the table, explaining it.It can get complicated as more research is published filling different data points. Although it is not an issue at the moment for this particular vaccine. -- Fernando Trebien ( talk) 19:25, 30 July 2021 (UTC)
The table you gave as an example, isn't 100% correct. It is missing column and row scopes for example.It's true, but it's not part of the tutorial and it is also very rare, so I doubt there are any implications for the issue of table footnotes. -- Fernando Trebien ( talk) 19:25, 30 July 2021 (UTC)
For many months, table footnotes have also been used in the following articles, which are being actively edited and revised by many every day:
-- Fernando Trebien ( talk) 11:31, 8 August 2021 (UTC)
When appendix sections are used, they should appear at the bottom of an article. Gonnym ( talk) 12:04, 8 August 2021 (UTC)
Seriously, what's your point?
This saves the reader from having to jump to another location many times when parsing a table.So, precision and brevity. Perhaps some of the notes that apply to the entire table can be moved to prose (such as the notes in the table caption), but not all, as in the case of notes on studies that provide several (but not all) data points. It might be easier to see this in Novavax (same notes for multiple cells, but not all) and Janssen (some notes for rows, some for columns). -- Fernando Trebien ( talk) 13:57, 8 August 2021 (UTC)
Hi all, from 3rd Opinion here. I lean towards not placing the notes next to the table. I am not against adding notes next to the table as a rule, sometimes notes are important to comprehend data in a table, but this is not the case. Also, I would like to note that the argument "it happens in other articles" is pretty weak. Reason is that many errors happen in other articles. Had an argument like that survived, it would help spreading errors. Each article is build by the editors following firstly their common sense and secondly policies and guidelines of WP. Trying to mimic MoS or other patterns of other articles is not the way forward. Cinadon 36 21:03, 8 August 2021 (UTC)
Whywhenwhohow reverted
[3] my addition
[4] of a systematic meta-analysis of studies of serological neutralization to support the phrase: "a systematic meta-analysis of published results found that Moderna's mRNA-1273 vaccine is effective against the
Delta variant with a slightly reduced neutralizing effect.
" The editor asserted that the source was not a MEDRS.
I'd like to point out the assertion that this data cannot be used as evidence of effectiveness is inherently flawed. The study [5] is systematically analyzing studies which take serum from vaccinated patients, and test it against the delta variant. That's a clinical effectiveness study. As a guy who got his PhD doing these studies, and regularly reviews these studies, it is absolutely considered "supporting evidence of effectiveness" to have serum taken from the people who got the vaccine, and test it against live virus, evaluating "neutralization." This is exactly how the influenza vaccine is approved every year. A neutralization titer of a certain level is considered a "correlate of protection" in these established viruses (like flu) but is considered "suggestive" evidence of protection in novel viruses. I would be amenable to changing the text to "suggests that the vaccine may be effective" if that is the concern. My initial wording may have been too WP:BOLD. Because it does suggest that the vaccine is effective. Only observational cohort studies or RCTs can truly prove it definitively, and only then for a single point in time. You also don't need to trust me on all of this, you can trust these MEDRS sources:
The CDC: [6]
National regulatory authorities, such as the Food and Drug Administration (FDA) in the United States, require RCTs to be conducted and to demonstrate the protective benefits of a new vaccine before the vaccine is licensed for routine use. However, some vaccines are licensed based on RCTs that use antibody response to the vaccine as measured in the laboratory, rather than decreases in influenza disease among people who were vaccinated.
The WHO: [7]
For some types of vaccines the ICP may be the type and amount of immunological response that correlates with vaccine-induced protection against infection (e.g. hepatitis A and B vaccines). The ICP may be mechanistic (i.e. causative for protection, such as antibody that results in virus neutralization or serum bactericidal antibody) or it may be non-mechanistic (i.e. a non-causative immune response that is present in persons protected by vaccination but is not the cause of protection, such as serum immunoglobulin G [IgG] against varicella-zoster virus [VZV] in the context of prevention of herpes zoster).
These reviews which describe this method to measure/investigate effectiveness of viral vaccines (both routine and novel): [8] [9] [10] [11] [12] [13] [14] [15]
Should we should, therefore, include this systematic review
[16] in citing the following? a systematic meta-analysis of published results suggests that Moderna's mRNA-1273 vaccine may be effective against the
Delta variant with a slightly reduced neutralizing effect.
--
Shibbolethink (
♔
♕)
03:37, 9 August 2021 (UTC)
Fifty percent neutralization titre was decreased up to 8.4 fold as compared with the reference strainwhich the WHO considers similar to a change of −30% to −20% in efficacy, which in previous weekly reports was described as a "moderate reduction" by the WHO. But, the true efficacy may be outside this range. In addition, on Table 4, the study reports other serological assays with a smaller fold change. In WHO's epidemiological update 49, they also reported a smaller fold change for Moderna against Delta based on many studies, which helps support the claim that it is likely effective. -- Fernando Trebien ( talk) 14:39, 9 August 2021 (UTC)
![]() | This
edit request to
Moderna COVID-19 vaccine has been answered. Set the |answered= or |ans= parameter to no to reactivate your request. |
The genetic code of the vaccine has been reverse engineered by Stanford scientists and has been disclosed to the public with a silense consent by Moderna. The Stanford scientists saved drops of the COVID-19 vaccine destined for the garbage can, reverse engineered them, and have posted the mRNA sequence in Github for the scientific community to explore: https://github.com/NAalytics/Assemblies-of-putative-SARS-CoV2-spike-encoding-mRNA-sequences-for-vaccines-BNT-162b2-and-mRNA-1273. the vaccine is also posted in Pubmed: (https://pubmed.ncbi.nlm.nih.gov/32756549/) What is apparent when compared to the Pfizer genetic material which was also reverse engineered is that the two vaccines have a similar first part while the Moderna vaccine has extra 585 bases which encode the haemoglobin. Wikicontri-x ( talk) 15:43, 25 August 2021 (UTC)
It's fully approved in the US now for those 18 and older. Could someone please update (and the associated articles on the status of Covid vaccines)? https://www.usatoday.com/story/news/health/2022/01/31/covid-vaccine-mandate-cases-deaths/9278653002/ Difbobatl ( talk) 17:49, 31 January 2022 (UTC)
"In February 2021, the restrictions on the Pfizer vaccine were relaxed when the U.S. Food and Drug Administration (FDA) updated the emergency use authorization (EUA) to permit undiluted frozen vials of the vaccine to be transported and stored at between −25 and −15 °C (−13 and 5 °F) for up to two weeks before use.[42][50][51]"
Very interesting. But it's all about the Pfizer vaccine and seems to have no relevance to Moderna.— Preceding unsigned comment added by 80.94.115.69 ( talk) 04:17, 7 April 2021 (UTC)
ADD: Adverse effects: In early December 2021, the Japan Health Ministry recommended men Men aged 12-29 to choose Pfizer-Covid-19 Vaccine over Moderna due to a higher incident of myocarditis and pericarditis in men who received the Moderna vaccine. Health Ministry Ofifcials did not explain what could have caused this. However gealth officials debated, according to NHK, whether they should recommend the Pfizer vaccine for all young men. Conclusion reached that due to heart inflammation cases also linked to Pfizer, although much lower rate than Moderna COVID‑19 vaccine, they decided to let men aged 12-29 to choose either at their discretion. [1] Achezet ( talk) 13:55, 30 December 2021 (UTC)
![]() | This
edit request to
Moderna COVID-19 vaccine has been answered. Set the |answered= or |ans= parameter to no to reactivate your request. |
It is misinformation that the HEK 293 cell line was created from an elective abortion. Human embryonic kidney 293 cells, derived from a spontaneous miscarriage or a pregnancy that was terminated in order to save the life of the mother. This is undeniable because at the time of the fetus' death abortion was illegal in the Netherlands. [1] 2603:8000:4A06:A6D8:B8C7:7DF9:B23:1443 ( talk) 05:37, 13 February 2022 (UTC)
References
![]() | This
edit request to
Moderna COVID-19 vaccine has been answered. Set the |answered= or |ans= parameter to no to reactivate your request. |
Change:
A bivalent version of the vaccine containing elasomeran/elasomeran 0-omicron (Spikevax Bivalent Zero/Omicron)[46] is approved for use in Australia.[13]
to:
A bivalent version of the vaccine containing elasomeran/elasomeran 0-omicron (Spikevax Bivalent Zero/Omicron)[46] is approved for use in the UK[New citation], and pending approval in Australia.[13]
New citation: https://www.gov.uk/government/news/first-bivalent-covid-19-booster-vaccine-approved-by-uk-medicines-regulator 110.174.65.51 ( talk) 16:44, 16 August 2022 (UTC)
![]() | This is an archive of past discussions. Do not edit the contents of this page. If you wish to start a new discussion or revive an old one, please do so on the current talk page. |
Archive 1 |
Does anyone have the technical details for mRNA-1273? There seems to be so little information available here and even in regulatory documents and on drug sites, but here's what our description of the Pfizer vaccine now looks like:
Seems like this would be of utmost importance considering the novelty of mRNA drugs and the wide variations across platforms. — C M B J 23:01, 31 December 2020 (UTC)
I suggest adding the following to the Design section, based on the references I've indicated:
Wikipedia doesn’t state which country has developed Moderna covid vaccine. It is an important information. — Preceding unsigned comment added by 49.192.4.27 ( talk) 22:53, 4 January 2021 (UTC)
The vaccine was codeveloped by researchers at the National Institute of Allergy and Infectious Diseases (NIAID, Bethesda, MD, USA) and at Moderna, Inc. (Cambridge, MA, USA).-- Jpmcgrath729 ( talk) 20:44, 18 January 2021 (UTC)
Per Pfizer-BioNTech COVID-19 vaccine, shouldn't this article be renamed to Moderna COVID-19 vaccine? I don't think this needs an RM (given the discussion at Talk:Pfizer-BioNTech COVID-19 vaccine#Requested move 16 December 2020, and pinging No such user who closed the RM), I think identical arguments apply? Britishfinance ( talk) 19:28, 16 January 2021 (UTC)
This document was released on Friday.
COVID-19 vaccine safety update for COVID-19 Vaccine Moderna: February 2021. [5]
References
{{
cite news}}
: CS1 maint: url-status (
link)
I don't think this is a controversy: "Pregnant and breastfeeding women were excluded from the initial trials used to obtain Emergency Use Authorization." There were probably no people from many other categories. If the company even tried to recruit pregnant women there'd be a media storm. No pregnant women would enroll anyway. This should be moved to the section that describes the trials. — Preceding unsigned comment added by 2601:646:8380:5020:C0F8:BBD7:13E6:648C ( talk) 20:49, 4 February 2021 (UTC)
"In February 2021, Moderna said that it was expecting $18.4 billion of its Covid-19 vaccine sales.[92] "
What, specifically, is the implied controversy here?
139.138.6.121 (
talk)
14:37, 11 March 2021 (UTC)
Given that this particular article subject was developed by an American company, shouldn't the date formatting on the article follow American standard? (e.g., "On December 18, 2020, mRNA-1273 was issued an Emergency Use Authorization...") Antoshi ☏ ★ 13:40, 1 April 2021 (UTC)
I write as a pro-vaccine person who enthusiastically received my first dose of the Moderna vaccine six days ago.
The article barely mentions side effects (two minor references). Wikipedia as a neutral and factual forum is a good place to provide factual and documented/sourced info about any side effects.
For example, this NEJM article that just appeared documents a significant effect for about 1% of patients: https://www.nejm.org/doi/10.1056/NEJMc2102131 .
72.174.46.173 ( talk) 05:00, 5 March 2021 (UTC)
Fact Sheet for Healthcare Providers Administering Vaccine
"Today, the U.S. Food and Drug Administration announced two revisions regarding the number of doses per vial available for the Moderna COVID-19 Vaccine. The first revision clarifies the number of doses per vial for the vials that are currently available, in that the maximum number of extractable doses is 11, with a range of 10-11 doses. The second revision authorizes the availability of an additional multi-dose vial in which each vial contains a maximum of 15 doses, with a range of 13-15 doses that can potentially be extracted."
2600:1000:B037:628E:54F0:F946:E988:7034 ( talk) 13:17, 2 April 2021 (UTC)
I was looking for information how the Moderna vaccinations are distributed worldwide (per country). Would be worth to add? -- Christianh ( talk) 08:40, 7 April 2021 (UTC)
EU is coloured blue on the Authorisation map, but is listed under Full Authorisation in the list below the map. Which one is correct? – 78.59.24.14 ( talk) 06:51, 16 April 2021 (UTC)
I've added a funding section to the article, similar to the one on the Pfizer–BioNTech COVID-19 vaccine article. I did my best to get a diversity of references and to imitate the style and tone from the other article, but I'm a fairly new editor so I'd appreciate if someone could take a look. -- Tufts2017 ( talk) 16:03, 25 April 2021 (UTC)
/info/en/?search=Pfizer%E2%80%93BioNTech_COVID-19_vaccine
"It is composed of nucleoside-modified mRNA (modRNA) encoding a mutated form of the full-length spike protein"
Has also the Moderna vaccine a full-length spike protein? If yes, it should be mentioned in Moderna Wikipedia page.
I suppose the Pfizer article is now a bit unaccurate, maybe it should be corrected to:
full‐length sequence of spike protein, so it is not about size of the protein, but lenght of the codon sequence?
--
ee1518 (
talk)
20:03, 16 May 2021 (UTC)
The result of the move request was: Not moved; consensus is that the article titles policy should take precedence over the manual of style on medicine-related articles.
These two requested moves pose the same question — whether the title of COVID-19 vaccine articles should be the international nonproprietary name (INN) (per the article titles section (MEDTITLE) of the manual of style on medicine-related articles) or the name of the company (or companies) which developed the vaccine concatenated with "COVID-19 vaccine" (which has been argued to be in accordance with the commonly recognisable names section (COMMONNAME) of the article titles policy). Both articles' title is currently the latter. The arguments made in each discussion were also very similar. Therefore, I am closing these discussions as one discussion.
There was not much question on what the manual of style or the article titles policy recommend — in this case, the INN or the company-name concatenation, respectively. Rather, much of the discussion was on which of these takes precedence. While the article titles policy is a policy and the manual of style is a guideline, the manual of style on medicine-related articles is much more specific (and there is no policy giving explicit advice on medical titles). Some opinions were that the manual of style takes precedence due to its specificity. Opposing opinions were varied; some argued that the INNs were not widely used enough in reliable medical sources; others made the point that the company-name concatenations were the common names in (non-medical) reliable sources by a large margin.
While medical guidelines are often stronger than other subject-specific guidelines because it is crucial that Wikipedia provides reliable information in this area (like those for biographies of living people), policies still override guidelines. In this case, the consensus appears to be that the article titles policy is stronger than the manual of style on medicine-related articles, so the company-name concatenations should be used instead of the INNs, and the pages should be not moved.
— ( closed by non-admin page mover) Tol | talk | contribs 22:32, 12 July 2021 (UTC)
Moderna COVID-19 vaccine → Elasomeran – Move to the drug's international nonproprietary name, naturally with a redirect in place and other common names mentioned in the lead section. Our WP:MEDTITLE guideline governs the naming of Wikipedia articles about drugs, and I find no convincing reason why this particular drug, however popular in 2021, should be an exception.
For clarity, MEDTITLE stypulates: The article title should be the scientific or recognised medical name that is most commonly used in recent, high-quality, English-language medical sources, rather than a lay term (unscientific or slang name).
—
kashmīrī
TALK
14:47, 3 July 2021 (UTC)
Most biologics, including vaccines, do not have INN or other generic names, so the brand name is used instead. I see no reason why the guideline should not apply to this vaccine. As for which guideline takes precedence, it must be the topic-specific one. The other way around makes absolutely no sense. ― Tartan357 Talk 07:45, 5 July 2021 (UTC)
scientific or recognised medical name that is most commonly used in recent, high-quality, English-language medical sources. In MEDRS, the name is mRNA-1273 not Elasomeran. But in any case, oppose both as per COMMONNAME. ProcrastinatingReader ( talk) 21:21, 6 July 2021 (UTC)
@
Gonnym: regarding your recent reverts (
first,
second), table footnotes using predefined groups next to the table are acceptable according to
WP:REFGROUP and
H:PREGROUP and you can see this in
good articles like
OPEC and
Windows XP, remaining unchanged in this usage for a long period of time. Therefore, it is incorrect to classify my edits as pushing
an agenda
. I admit that in my first edit it was not good practice to include footnotes in a table cell, though it is not uncommon, see
Philadelphia English, for example. But why do you consider the second edit to be bad practice? --
Fernando Trebien (
talk)
18:03, 30 July 2021 (UTC)
But since it's a note, it belongs in a note section.Like in Windows XP? -- Fernando Trebien ( talk) 19:25, 30 July 2021 (UTC)
Placing the notes in the middle of the page is just incorrect.So why do articles that meet good article criteria using this type of footnote remain unchallenged for so many years? Scientific articles often do this in tables. This saves the reader from having to jump to another location many times when parsing a table. -- Fernando Trebien ( talk) 19:25, 30 July 2021 (UTC)
If it was more important, the note should be replaced with prose text right under the table, explaining it.It can get complicated as more research is published filling different data points. Although it is not an issue at the moment for this particular vaccine. -- Fernando Trebien ( talk) 19:25, 30 July 2021 (UTC)
The table you gave as an example, isn't 100% correct. It is missing column and row scopes for example.It's true, but it's not part of the tutorial and it is also very rare, so I doubt there are any implications for the issue of table footnotes. -- Fernando Trebien ( talk) 19:25, 30 July 2021 (UTC)
For many months, table footnotes have also been used in the following articles, which are being actively edited and revised by many every day:
-- Fernando Trebien ( talk) 11:31, 8 August 2021 (UTC)
When appendix sections are used, they should appear at the bottom of an article. Gonnym ( talk) 12:04, 8 August 2021 (UTC)
Seriously, what's your point?
This saves the reader from having to jump to another location many times when parsing a table.So, precision and brevity. Perhaps some of the notes that apply to the entire table can be moved to prose (such as the notes in the table caption), but not all, as in the case of notes on studies that provide several (but not all) data points. It might be easier to see this in Novavax (same notes for multiple cells, but not all) and Janssen (some notes for rows, some for columns). -- Fernando Trebien ( talk) 13:57, 8 August 2021 (UTC)
Hi all, from 3rd Opinion here. I lean towards not placing the notes next to the table. I am not against adding notes next to the table as a rule, sometimes notes are important to comprehend data in a table, but this is not the case. Also, I would like to note that the argument "it happens in other articles" is pretty weak. Reason is that many errors happen in other articles. Had an argument like that survived, it would help spreading errors. Each article is build by the editors following firstly their common sense and secondly policies and guidelines of WP. Trying to mimic MoS or other patterns of other articles is not the way forward. Cinadon 36 21:03, 8 August 2021 (UTC)
Whywhenwhohow reverted
[3] my addition
[4] of a systematic meta-analysis of studies of serological neutralization to support the phrase: "a systematic meta-analysis of published results found that Moderna's mRNA-1273 vaccine is effective against the
Delta variant with a slightly reduced neutralizing effect.
" The editor asserted that the source was not a MEDRS.
I'd like to point out the assertion that this data cannot be used as evidence of effectiveness is inherently flawed. The study [5] is systematically analyzing studies which take serum from vaccinated patients, and test it against the delta variant. That's a clinical effectiveness study. As a guy who got his PhD doing these studies, and regularly reviews these studies, it is absolutely considered "supporting evidence of effectiveness" to have serum taken from the people who got the vaccine, and test it against live virus, evaluating "neutralization." This is exactly how the influenza vaccine is approved every year. A neutralization titer of a certain level is considered a "correlate of protection" in these established viruses (like flu) but is considered "suggestive" evidence of protection in novel viruses. I would be amenable to changing the text to "suggests that the vaccine may be effective" if that is the concern. My initial wording may have been too WP:BOLD. Because it does suggest that the vaccine is effective. Only observational cohort studies or RCTs can truly prove it definitively, and only then for a single point in time. You also don't need to trust me on all of this, you can trust these MEDRS sources:
The CDC: [6]
National regulatory authorities, such as the Food and Drug Administration (FDA) in the United States, require RCTs to be conducted and to demonstrate the protective benefits of a new vaccine before the vaccine is licensed for routine use. However, some vaccines are licensed based on RCTs that use antibody response to the vaccine as measured in the laboratory, rather than decreases in influenza disease among people who were vaccinated.
The WHO: [7]
For some types of vaccines the ICP may be the type and amount of immunological response that correlates with vaccine-induced protection against infection (e.g. hepatitis A and B vaccines). The ICP may be mechanistic (i.e. causative for protection, such as antibody that results in virus neutralization or serum bactericidal antibody) or it may be non-mechanistic (i.e. a non-causative immune response that is present in persons protected by vaccination but is not the cause of protection, such as serum immunoglobulin G [IgG] against varicella-zoster virus [VZV] in the context of prevention of herpes zoster).
These reviews which describe this method to measure/investigate effectiveness of viral vaccines (both routine and novel): [8] [9] [10] [11] [12] [13] [14] [15]
Should we should, therefore, include this systematic review
[16] in citing the following? a systematic meta-analysis of published results suggests that Moderna's mRNA-1273 vaccine may be effective against the
Delta variant with a slightly reduced neutralizing effect.
--
Shibbolethink (
♔
♕)
03:37, 9 August 2021 (UTC)
Fifty percent neutralization titre was decreased up to 8.4 fold as compared with the reference strainwhich the WHO considers similar to a change of −30% to −20% in efficacy, which in previous weekly reports was described as a "moderate reduction" by the WHO. But, the true efficacy may be outside this range. In addition, on Table 4, the study reports other serological assays with a smaller fold change. In WHO's epidemiological update 49, they also reported a smaller fold change for Moderna against Delta based on many studies, which helps support the claim that it is likely effective. -- Fernando Trebien ( talk) 14:39, 9 August 2021 (UTC)
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The genetic code of the vaccine has been reverse engineered by Stanford scientists and has been disclosed to the public with a silense consent by Moderna. The Stanford scientists saved drops of the COVID-19 vaccine destined for the garbage can, reverse engineered them, and have posted the mRNA sequence in Github for the scientific community to explore: https://github.com/NAalytics/Assemblies-of-putative-SARS-CoV2-spike-encoding-mRNA-sequences-for-vaccines-BNT-162b2-and-mRNA-1273. the vaccine is also posted in Pubmed: (https://pubmed.ncbi.nlm.nih.gov/32756549/) What is apparent when compared to the Pfizer genetic material which was also reverse engineered is that the two vaccines have a similar first part while the Moderna vaccine has extra 585 bases which encode the haemoglobin. Wikicontri-x ( talk) 15:43, 25 August 2021 (UTC)
It's fully approved in the US now for those 18 and older. Could someone please update (and the associated articles on the status of Covid vaccines)? https://www.usatoday.com/story/news/health/2022/01/31/covid-vaccine-mandate-cases-deaths/9278653002/ Difbobatl ( talk) 17:49, 31 January 2022 (UTC)
"In February 2021, the restrictions on the Pfizer vaccine were relaxed when the U.S. Food and Drug Administration (FDA) updated the emergency use authorization (EUA) to permit undiluted frozen vials of the vaccine to be transported and stored at between −25 and −15 °C (−13 and 5 °F) for up to two weeks before use.[42][50][51]"
Very interesting. But it's all about the Pfizer vaccine and seems to have no relevance to Moderna.— Preceding unsigned comment added by 80.94.115.69 ( talk) 04:17, 7 April 2021 (UTC)
ADD: Adverse effects: In early December 2021, the Japan Health Ministry recommended men Men aged 12-29 to choose Pfizer-Covid-19 Vaccine over Moderna due to a higher incident of myocarditis and pericarditis in men who received the Moderna vaccine. Health Ministry Ofifcials did not explain what could have caused this. However gealth officials debated, according to NHK, whether they should recommend the Pfizer vaccine for all young men. Conclusion reached that due to heart inflammation cases also linked to Pfizer, although much lower rate than Moderna COVID‑19 vaccine, they decided to let men aged 12-29 to choose either at their discretion. [1] Achezet ( talk) 13:55, 30 December 2021 (UTC)
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It is misinformation that the HEK 293 cell line was created from an elective abortion. Human embryonic kidney 293 cells, derived from a spontaneous miscarriage or a pregnancy that was terminated in order to save the life of the mother. This is undeniable because at the time of the fetus' death abortion was illegal in the Netherlands. [1] 2603:8000:4A06:A6D8:B8C7:7DF9:B23:1443 ( talk) 05:37, 13 February 2022 (UTC)
References
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Change:
A bivalent version of the vaccine containing elasomeran/elasomeran 0-omicron (Spikevax Bivalent Zero/Omicron)[46] is approved for use in Australia.[13]
to:
A bivalent version of the vaccine containing elasomeran/elasomeran 0-omicron (Spikevax Bivalent Zero/Omicron)[46] is approved for use in the UK[New citation], and pending approval in Australia.[13]
New citation: https://www.gov.uk/government/news/first-bivalent-covid-19-booster-vaccine-approved-by-uk-medicines-regulator 110.174.65.51 ( talk) 16:44, 16 August 2022 (UTC)