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I second the prior call for additional information on its use as an antihypertensive. It's a third-line agent, but in refractory patients it is commonly considered. My particular interest is in knowing the incidence of pericardial effusions with minoxidil use. All the research appears to have been done in the late 70s and early 80s, and I'm having troubble accessing it. -- PCAndrew
Maybe someone asked this, but according to the line "known for its ability to slow or stop hair loss and promote hair regrowth" in the first paragraph, this implies a cure. So, is it? -- IdLoveOne ( talk) 05:22, 16 June 2008 (UTC)
the current entry says that it is unknown how minoxidil stimulates hair growth, but i don't believe that is accurate. my understanding is that it dialates blood vessels, increasing blood flow to the area. (that's why it was originally thought of as a heart attack/blood pressure medicine, because it would dialate blood vessels, increasing blood flow)
yes and...it's exat mechanism of action is not...known.
ok, well we're kind of splitting hairs -- The article says "It is unknown how the drug stimulates hair growth." Known is that it stimulates hair growth by dialating blood vessels which increases blood flow to the area. What is unknown is exactly how it dialates blood vessels.
it opens atp sensitive k+ channels causing hyperpolarisation which opens ca2+ channels and this causes vasodilation and falling TPR
It apparently directly opens ATP sensitive potassium channels and it is not through the cGMP-PKG pathway as the article hints. The Potassium hypothesis is supported by other potassium channel agonist ( pinacidil) increasing hair growth, so the effect may not be vascular but directly on the dermal papillae. GetAgrippa 01:52, 6 January 2007 (UTC)
Note that minoxidil's vasodilatory effect does not explain its ability to thicken hair. Other vasodilators have no effect on the hair.
Also - some in the hairloss community have started to use oral minoxidil tablets in an attempt to grow hair, although this is regarded as risky.
For citations, see for example: http://www.hairlosshelp.com/forums/messageview.cfm?catid=10&threadid=39415&FTVAR_MSGDBTABLE=
Or search for "loniten" on any hairloss forum.
81.179.103.232 21:03, 29 July 2007 (UTC)
This article really needs balance, as the drug was not originally for hair growth. 132.205.44.5 ( talk) 02:30, 22 November 2007 (UTC)
Is there any information on the combination of using this and Propecia?
the link is not spam.
Since Rogaine and Regaine are really nothing more than brand names for Minoxidil, I propose merging this article into the Minoxidil article. I suggest that Rogaine (drug) and Regaine should then redirect to the Minoxidil article. -- JHP 07:11, 24 July 2007 (UTC)
Merge completed - Draeco ( talk) 03:49, 4 March 2008 (UTC)
Currently links to " http://www.showcatsonline.com/x/minoxidil.htm" (404)
Should link to " http://www.showcatsonline.com/x/minoxidil.shtml"
Alsavage ( talk) 20:26, 23 August 2008 (UTC)
Just HOW toxic to cats is it? Obviously, you can't exactly go around spraying them with it... But is playing with or sharing a pillow with a minoxidil user dangerous to cats??? —Preceding unsigned comment added by Aadieu ( talk • contribs) 20:03, 17 March 2010 (UTC)
I've used it for about two years and my cat seems okay. The toxicity was discovered because ridiculous people actually used it ON show cats. Cats cannot metabolize minoxidil and it kills them, and I think the amount needed to become toxic is still unknown; on the other hand I think we would be able to turn up more information on the subject if it were EASY to kill cats with minoxidil accidentally.-- 98.216.50.36 ( talk) 05:27, 28 April 2011 (UTC)
Does Minoxidil has anything to do with Amenixil? It's referenced on de: Cogiati ( talk) 22:11, 21 April 2010 (UTC)
Isn't the picture of the regain a commercial, they invented the medicine but they are not the only producer.And this picture contribute anything to the article? —Preceding unsigned comment added by 94.159.211.57 ( talk) 19:24, 31 October 2010 (UTC)
Are there any studies that cover this topic? The link goes to a study which proves that minoxidil depletes collagen when applied in vitro for subconjunctival fibroblasts of Rabbits. Are there any studies regarding topical application and the documentation of this side effect? Scientifically I'm interested and personally I'm concerned :)
Dose0017 (
talk) 17:23, 3 February 2014 (UTC)
I am surprised this article makes no mention of one of this drug's inventors, Guinter Kahn. See this New York Times article. Best. 4meter4 ( talk) 16:49, 20 September 2014 (UTC)
81.135.37.186 you keep wanting to add content about hair loss but I have not found that in any source. You cited http://www.drugs.com/pro/minoxidil.html - would you please quote the part of that article where exacerbated hair loss is discussed? Please discuss. Thanks. Jytdog ( talk) 14:37, 19 January 2015 (UTC)
I don't see any discussion of side effects. I have yet to see *any* drug whichis actually effective which has *no* side effects, and the absence makes it look like nothing more than an ad. Critterkeeper ( talk) 05:25, 1 February 2016 (UTC)
The internet is full of attempts and reports about applying Minoxidil to trigger or improve beard growth in adult men. I myself have used it successfully that way. Would be interesting to find a source and add this. 2A02:8070:27B9:8BF0:29CB:2F8A:E1E2:5F10 ( talk) 03:43, 13 January 2019 (UTC)
It puzzles me why user Whywhenwhohow would completely delete the "See also" section in this article. According to WP:MEDMOS, the "See also" entries are relevant here, specially if they have no wikilinks in the main article or in navigation templates. I understand that user Whywhenwhohow quotes "Avoid the See also section when possible". However, a "See also" section here is a useful way to organize internal links to related or comparable articles and build the web, enabling readers to explore tangentially related topics (according to MOS:SEEALSO), where the corresponding wikilinks don't quite "fit", or need to be included within the text of the article. The "See also" section here enriches the whole article. What does Whywhenwhohow has to loose by preserving the "See also" section? I see the advantages mentioned above far surpass the disadvantage. I suggest preserving the "See also" section here, or perhaps editing its contents, if something in it can be mentioned within the text of the article instead. Thank you. 73.119.19.79 ( talk) 15:15, 5 March 2022 (UTC)
Rudolf.Fernandes Please get consensus before adding the text to the article. It doesn't meet the requirements for a reliable source for medical information. The information is based on a primary source and also a non-medical source. Please see WP:MEDRS and WP:MEDMOS. -- Whywhenwhohow ( talk) 07:02, 17 February 2023 (UTC)
When using low-dose minoxidil, it is important to let patients know that it is off label, but several published studies have shown safety and efficacy,”. This is definitely still in the "research" phase.
Rudolf.Fernandes It appears that your text about the study was copied from the conclusion in the abstract. Please see WP:NOABSTRACT and WP:COPY. The information about the low dose oral use belongs in the research section instead of the history section. See WP:PHARMMOS. -- Whywhenwhohow ( talk) 02:55, 24 February 2023 (UTC)
... an effective and well-tolerated treatment alternative for healthy patients having difficulty with topical formulations
... an effective and well-tolerated treatment alternative for healthy patients having difficulty with topical formulations.
Medical uses: This section should go into further detail regarding what the medication is used for (for each major indication). Take special care with regulatory terms; since drug approvals vary from country to country, so does the distinction between approved and off-label uses.
Research: Ongoing investigations into a medication that have not reached clinical usage
This is a phase II trial to determine the drug's effectiveness.
https://clinicaltrials.gov/study/NCT05272462
Quoting: "Laboratory results provide promising evidence that minoxidil could be used for the treatment of recurrent ovarian cancer." Scanon7 ( talk) 21:41, 1 January 2024 (UTC)
"...is generally reserved for use in severe hypertension patients who do not respond to at least two agents and a diuretic. [ref. 13]" I couldn't find this in ref. 13 70.55.197.56 ( talk) 23:13, 13 January 2024 (UTC)
![]() | This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||||||||||
|
![]() | Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Minoxidil.
|
I second the prior call for additional information on its use as an antihypertensive. It's a third-line agent, but in refractory patients it is commonly considered. My particular interest is in knowing the incidence of pericardial effusions with minoxidil use. All the research appears to have been done in the late 70s and early 80s, and I'm having troubble accessing it. -- PCAndrew
Maybe someone asked this, but according to the line "known for its ability to slow or stop hair loss and promote hair regrowth" in the first paragraph, this implies a cure. So, is it? -- IdLoveOne ( talk) 05:22, 16 June 2008 (UTC)
the current entry says that it is unknown how minoxidil stimulates hair growth, but i don't believe that is accurate. my understanding is that it dialates blood vessels, increasing blood flow to the area. (that's why it was originally thought of as a heart attack/blood pressure medicine, because it would dialate blood vessels, increasing blood flow)
yes and...it's exat mechanism of action is not...known.
ok, well we're kind of splitting hairs -- The article says "It is unknown how the drug stimulates hair growth." Known is that it stimulates hair growth by dialating blood vessels which increases blood flow to the area. What is unknown is exactly how it dialates blood vessels.
it opens atp sensitive k+ channels causing hyperpolarisation which opens ca2+ channels and this causes vasodilation and falling TPR
It apparently directly opens ATP sensitive potassium channels and it is not through the cGMP-PKG pathway as the article hints. The Potassium hypothesis is supported by other potassium channel agonist ( pinacidil) increasing hair growth, so the effect may not be vascular but directly on the dermal papillae. GetAgrippa 01:52, 6 January 2007 (UTC)
Note that minoxidil's vasodilatory effect does not explain its ability to thicken hair. Other vasodilators have no effect on the hair.
Also - some in the hairloss community have started to use oral minoxidil tablets in an attempt to grow hair, although this is regarded as risky.
For citations, see for example: http://www.hairlosshelp.com/forums/messageview.cfm?catid=10&threadid=39415&FTVAR_MSGDBTABLE=
Or search for "loniten" on any hairloss forum.
81.179.103.232 21:03, 29 July 2007 (UTC)
This article really needs balance, as the drug was not originally for hair growth. 132.205.44.5 ( talk) 02:30, 22 November 2007 (UTC)
Is there any information on the combination of using this and Propecia?
the link is not spam.
Since Rogaine and Regaine are really nothing more than brand names for Minoxidil, I propose merging this article into the Minoxidil article. I suggest that Rogaine (drug) and Regaine should then redirect to the Minoxidil article. -- JHP 07:11, 24 July 2007 (UTC)
Merge completed - Draeco ( talk) 03:49, 4 March 2008 (UTC)
Currently links to " http://www.showcatsonline.com/x/minoxidil.htm" (404)
Should link to " http://www.showcatsonline.com/x/minoxidil.shtml"
Alsavage ( talk) 20:26, 23 August 2008 (UTC)
Just HOW toxic to cats is it? Obviously, you can't exactly go around spraying them with it... But is playing with or sharing a pillow with a minoxidil user dangerous to cats??? —Preceding unsigned comment added by Aadieu ( talk • contribs) 20:03, 17 March 2010 (UTC)
I've used it for about two years and my cat seems okay. The toxicity was discovered because ridiculous people actually used it ON show cats. Cats cannot metabolize minoxidil and it kills them, and I think the amount needed to become toxic is still unknown; on the other hand I think we would be able to turn up more information on the subject if it were EASY to kill cats with minoxidil accidentally.-- 98.216.50.36 ( talk) 05:27, 28 April 2011 (UTC)
Does Minoxidil has anything to do with Amenixil? It's referenced on de: Cogiati ( talk) 22:11, 21 April 2010 (UTC)
Isn't the picture of the regain a commercial, they invented the medicine but they are not the only producer.And this picture contribute anything to the article? —Preceding unsigned comment added by 94.159.211.57 ( talk) 19:24, 31 October 2010 (UTC)
Are there any studies that cover this topic? The link goes to a study which proves that minoxidil depletes collagen when applied in vitro for subconjunctival fibroblasts of Rabbits. Are there any studies regarding topical application and the documentation of this side effect? Scientifically I'm interested and personally I'm concerned :)
Dose0017 (
talk) 17:23, 3 February 2014 (UTC)
I am surprised this article makes no mention of one of this drug's inventors, Guinter Kahn. See this New York Times article. Best. 4meter4 ( talk) 16:49, 20 September 2014 (UTC)
81.135.37.186 you keep wanting to add content about hair loss but I have not found that in any source. You cited http://www.drugs.com/pro/minoxidil.html - would you please quote the part of that article where exacerbated hair loss is discussed? Please discuss. Thanks. Jytdog ( talk) 14:37, 19 January 2015 (UTC)
I don't see any discussion of side effects. I have yet to see *any* drug whichis actually effective which has *no* side effects, and the absence makes it look like nothing more than an ad. Critterkeeper ( talk) 05:25, 1 February 2016 (UTC)
The internet is full of attempts and reports about applying Minoxidil to trigger or improve beard growth in adult men. I myself have used it successfully that way. Would be interesting to find a source and add this. 2A02:8070:27B9:8BF0:29CB:2F8A:E1E2:5F10 ( talk) 03:43, 13 January 2019 (UTC)
It puzzles me why user Whywhenwhohow would completely delete the "See also" section in this article. According to WP:MEDMOS, the "See also" entries are relevant here, specially if they have no wikilinks in the main article or in navigation templates. I understand that user Whywhenwhohow quotes "Avoid the See also section when possible". However, a "See also" section here is a useful way to organize internal links to related or comparable articles and build the web, enabling readers to explore tangentially related topics (according to MOS:SEEALSO), where the corresponding wikilinks don't quite "fit", or need to be included within the text of the article. The "See also" section here enriches the whole article. What does Whywhenwhohow has to loose by preserving the "See also" section? I see the advantages mentioned above far surpass the disadvantage. I suggest preserving the "See also" section here, or perhaps editing its contents, if something in it can be mentioned within the text of the article instead. Thank you. 73.119.19.79 ( talk) 15:15, 5 March 2022 (UTC)
Rudolf.Fernandes Please get consensus before adding the text to the article. It doesn't meet the requirements for a reliable source for medical information. The information is based on a primary source and also a non-medical source. Please see WP:MEDRS and WP:MEDMOS. -- Whywhenwhohow ( talk) 07:02, 17 February 2023 (UTC)
When using low-dose minoxidil, it is important to let patients know that it is off label, but several published studies have shown safety and efficacy,”. This is definitely still in the "research" phase.
Rudolf.Fernandes It appears that your text about the study was copied from the conclusion in the abstract. Please see WP:NOABSTRACT and WP:COPY. The information about the low dose oral use belongs in the research section instead of the history section. See WP:PHARMMOS. -- Whywhenwhohow ( talk) 02:55, 24 February 2023 (UTC)
... an effective and well-tolerated treatment alternative for healthy patients having difficulty with topical formulations
... an effective and well-tolerated treatment alternative for healthy patients having difficulty with topical formulations.
Medical uses: This section should go into further detail regarding what the medication is used for (for each major indication). Take special care with regulatory terms; since drug approvals vary from country to country, so does the distinction between approved and off-label uses.
Research: Ongoing investigations into a medication that have not reached clinical usage
This is a phase II trial to determine the drug's effectiveness.
https://clinicaltrials.gov/study/NCT05272462
Quoting: "Laboratory results provide promising evidence that minoxidil could be used for the treatment of recurrent ovarian cancer." Scanon7 ( talk) 21:41, 1 January 2024 (UTC)
"...is generally reserved for use in severe hypertension patients who do not respond to at least two agents and a diuretic. [ref. 13]" I couldn't find this in ref. 13 70.55.197.56 ( talk) 23:13, 13 January 2024 (UTC)