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Metabolomics is the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind" (This definition is ridiculous, I think these people have been watching too much CSI! Chemical fingerprint Horatio?) —Preceding unsigned comment added by 155.198.149.176 ( talk) 17:50, 29 July 2009 (UTC)
Hi -- I have taken the liberty to put down some of my thoughts on metabolomics. Any suggestions as to what else would be useful -- what about links to some metabolomics sites? Or what about citations to some of the more significant (peer-reviewed) scientific papers? thanks -- jake b 10:10, 16 Oct 2004 (UTC)
I've made a few changes: deleted one reference (seemed gratuitous, and more 'journalistic' than authoritative). Main thing I tried to do was rewrite the 'analytical technologies' section as it had got a bit confused, with reference to HPLC twice. comments? jake b 18:51, 24 Jun 2005 (UTC)
I'm not an expert in NMR, but I'm pretty sure some of the statements made on this page are incorrect. For example, it says "All kinds of small molecule metabolite can be measured simultaneously", but that's not true of any NMR techniques I know. For NMR you typically need to isolate your compound of interest in a very pure form for analysis. If significant impurities are present, you won't be able to properly characterize the analyte. This, along with lack of sensitivity, is among the major drawbacks of all NMR techniques. HPLC combined with mass spectrometry is popular in part because it eliminates the need to isolate pure compounds, as the separation is done on-line. Some scientists use HPLC combined with NMR, but this is a much more difficult set-up and I don't know if it's pratical for metabolomics. 146.6.144.113 19:29, 15 November 2005 (UTC)BDD
I have a couple of suggestions: 1. Implement a Metabobox similar to the Drugbox ( Template:Drugbox) to be used in constructing metabolite entries so that all entries have a consistent look and feel. 2. I know of a really great website, the Human Metabolome Database [2], that could be used as a source for some of the initial entries. -- Metabolite 17:15, 23 May 2007 (UTC)
Contrary to the statement on the main page, Arthur Robinson did NOT invent the field, and certainly did not author the first paper in the area of metabolic profiling. The 20-odd references to this author are mostly redundant, and do not represent the field. It's pretty clear that this is simply self-aggrandizing self-citation. —Preceding unsigned comment added by 74.87.29.154 ( talk) 00:17, 26 May 2008 (UTC) I have attempted to edit the numerous references to A. Robinson, by removing citations of conference proceedings, two other articles that were apparently not peer-reviewed, as well as a number of papers that do not relate to metabolomics, but rather to protein chemistry. The justification was provided above. These edits were immediately reverted, with no explanation. —Preceding unsigned comment added by 74.87.29.154 ( talk) 01:21, 26 May 2008 (UTC)
I cut these unlinked refs. Some could go back, but they should be justified.
http://lab.bcb.iastate.edu/projects/plantmetabolomics/
-- Kkmurray ( talk) 21:58, 28 November 2007 (UTC)
I've removed these refs which were collectively used as one citation. Most of them are very good papers but they tend to already have been cited elsewhere in the article (or, at least, other papers from these groups are represented)
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help)-- Amaher ( talk) 23:35, 18 January 2010 (UTC)
I don't want to stand on anyone's toes, but I think the section I've removed from the article and pasted below reads like an advert for one company's technologies and has no references so shouldn't be included. Otherwise the rest of the article seems quite informative. Terri G ( talk) 14:58, 21 November 2008 (UTC)
'Application of metabolomics to drug discovery and development' The use of biomarkers to improve drug discovery and development is a well established paradigm that, unfortunately, has yet to be achieved. While expectations have been set for biomarker discovery to be the engine for improved discovery and development, the mechanisms for achieving this remain unclear. In an attempt to clarify the approaches to help speed the development and approval of medical and pharmaceutical products, the US Food and Drug Administration developed the Critical Path initiatives in 2006. Within these guidelines, the importance of using qualified biomarkers is defined for the areas of: drug candidate safety testing, dose range identification, dose response evaluation, clinical trial subject selection, and using the biomarker as a surrogate endpoint to determine product efficacy. With these agency-defined objectives as a guideline, researchers are now beginning to fully leverage the benefits of biochemical biomarkers, by improving the prioritisation of drug candidates. Recently, Metabolon has developed a series of defined metabolomics-based solutions to address these needs. The first of these, mSelect, is designed to identify the leading drug candidate in early stage discovery. For example, in addition to interacting with the intended target, many drug candidates are likely to have unanticipated affects on other pathways. These effects can lead to safety issues that do not surface until late in the development process. With mSelect, metabolomics is used to isolate significantly altered biochemical biomarkers from dosed cell cultures. Through further analysis, the effected biochemical pathways are also identified so researchers can effectively assess the broad biological impact of each candidate drug. Using these data, the most promising lead compound(s) can continue to the next phase of development. Ideally, further evaluation of lead candidates throughout the discovery and development processes would be based on a consistent set of qualified biomarkers. Metabolomics offers a promising approach to achieve this objective because of the highly conserved nature of biochemical biomarkers across species. In addition, processing of biological samples from various sources can be examined on the same platforms, thus reducing variability introduced by differences in analytical equipment. Metabolon’s second solution, mVivo, is designed to evaluate the changes in drug-induced biochemical biomarkers during pre-clinical animal model testing. In many ways, this solution is similar to mSelect except that it is used in conjunction with routine animal studies and utilises various sample types such as plasma or biopsy material. mVivo can monitor the metabolism of the drug as well as measuring all of the other changes related to the action of the chemical. Finally, mProveClinical, the third solution, is designed to evaluate drug effects on biochemical biomarkers in first-in-human clinical studies. Currently, drug development companies make large investments to advance a compound to the point where the first tests in man can take place. However, since these studies are designed to test for drug safety, there is a relatively small amount of rich biomarker data derived from these studies. In addition to the traditional safety assessments performed at this stage of evaluation, with mProveClinical a preliminary read of the drug-induced effects on thepreviously identified biomarkers can be achieved. By applying these three solutions on a single metabolomics platform, researchers can leverage highly conserved biochemical biomarkers in a stepwise manner throughout the drug discovery and development process. Findings at each stage can be compared to the earlier results, whether in tissue culture, animals, or humans, to fully leverage biomarkers as a tool for rationale decisions ultimately leading to more reliable product development.
I have made a few edits to this page today - there were several instances where the article stated that metabolomics requires "extraction of metabolites" and "separation of analytes". This is a misleading generalisation since NMR-based methods do not require "separation" or "extraction" of any metabolites - just a spot of D2O and away you go. In general the article itself can do with a massive clean up. -- Amaher ( talk) 23:57, 7 January 2010 (UTC)
The history section of this article is mostly original research and as such does not belong in Wikipedia. This article is about Metabolomics, which means that the History section should detail the background to the field with respect to what people have published within the Metabolomics field. I'm going to clean this up very soon to align this section more closely with Wikipedia guidelines contained in WP:OR-- Amaher ( talk) 01:59, 11 January 2010 (UTC)
doi:10.1186/s13054-016-1222-8 JFW | T@lk 06:13, 30 March 2016 (UTC)
Hi - I think it makes sense to add a section for commercial labs. Knowledge of metabolomics is not limited to academia; there are many commercial organizations that provide an excellent source of research of the field, and many commercial labs run within academic institutions themselves. I've included as many as I could find, but please add any others you know of. DrJaneHarrison ( talk) 21:13, 8 January 2019 (UTC)Jane
![]() | This ![]() It is of interest to the following WikiProjects: | |||||||||||||||||||||||||||||
|
Metabolomics is the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind" (This definition is ridiculous, I think these people have been watching too much CSI! Chemical fingerprint Horatio?) —Preceding unsigned comment added by 155.198.149.176 ( talk) 17:50, 29 July 2009 (UTC)
Hi -- I have taken the liberty to put down some of my thoughts on metabolomics. Any suggestions as to what else would be useful -- what about links to some metabolomics sites? Or what about citations to some of the more significant (peer-reviewed) scientific papers? thanks -- jake b 10:10, 16 Oct 2004 (UTC)
I've made a few changes: deleted one reference (seemed gratuitous, and more 'journalistic' than authoritative). Main thing I tried to do was rewrite the 'analytical technologies' section as it had got a bit confused, with reference to HPLC twice. comments? jake b 18:51, 24 Jun 2005 (UTC)
I'm not an expert in NMR, but I'm pretty sure some of the statements made on this page are incorrect. For example, it says "All kinds of small molecule metabolite can be measured simultaneously", but that's not true of any NMR techniques I know. For NMR you typically need to isolate your compound of interest in a very pure form for analysis. If significant impurities are present, you won't be able to properly characterize the analyte. This, along with lack of sensitivity, is among the major drawbacks of all NMR techniques. HPLC combined with mass spectrometry is popular in part because it eliminates the need to isolate pure compounds, as the separation is done on-line. Some scientists use HPLC combined with NMR, but this is a much more difficult set-up and I don't know if it's pratical for metabolomics. 146.6.144.113 19:29, 15 November 2005 (UTC)BDD
I have a couple of suggestions: 1. Implement a Metabobox similar to the Drugbox ( Template:Drugbox) to be used in constructing metabolite entries so that all entries have a consistent look and feel. 2. I know of a really great website, the Human Metabolome Database [2], that could be used as a source for some of the initial entries. -- Metabolite 17:15, 23 May 2007 (UTC)
Contrary to the statement on the main page, Arthur Robinson did NOT invent the field, and certainly did not author the first paper in the area of metabolic profiling. The 20-odd references to this author are mostly redundant, and do not represent the field. It's pretty clear that this is simply self-aggrandizing self-citation. —Preceding unsigned comment added by 74.87.29.154 ( talk) 00:17, 26 May 2008 (UTC) I have attempted to edit the numerous references to A. Robinson, by removing citations of conference proceedings, two other articles that were apparently not peer-reviewed, as well as a number of papers that do not relate to metabolomics, but rather to protein chemistry. The justification was provided above. These edits were immediately reverted, with no explanation. —Preceding unsigned comment added by 74.87.29.154 ( talk) 01:21, 26 May 2008 (UTC)
I cut these unlinked refs. Some could go back, but they should be justified.
http://lab.bcb.iastate.edu/projects/plantmetabolomics/
-- Kkmurray ( talk) 21:58, 28 November 2007 (UTC)
I've removed these refs which were collectively used as one citation. Most of them are very good papers but they tend to already have been cited elsewhere in the article (or, at least, other papers from these groups are represented)
{{
cite book}}
: |author=
has generic name (
help)CS1 maint: multiple names: authors list (
link){{
cite journal}}
: Unknown parameter |month=
ignored (
help)CS1 maint: multiple names: authors list (
link){{
cite journal}}
: Unknown parameter |month=
ignored (
help)-- Amaher ( talk) 23:35, 18 January 2010 (UTC)
I don't want to stand on anyone's toes, but I think the section I've removed from the article and pasted below reads like an advert for one company's technologies and has no references so shouldn't be included. Otherwise the rest of the article seems quite informative. Terri G ( talk) 14:58, 21 November 2008 (UTC)
'Application of metabolomics to drug discovery and development' The use of biomarkers to improve drug discovery and development is a well established paradigm that, unfortunately, has yet to be achieved. While expectations have been set for biomarker discovery to be the engine for improved discovery and development, the mechanisms for achieving this remain unclear. In an attempt to clarify the approaches to help speed the development and approval of medical and pharmaceutical products, the US Food and Drug Administration developed the Critical Path initiatives in 2006. Within these guidelines, the importance of using qualified biomarkers is defined for the areas of: drug candidate safety testing, dose range identification, dose response evaluation, clinical trial subject selection, and using the biomarker as a surrogate endpoint to determine product efficacy. With these agency-defined objectives as a guideline, researchers are now beginning to fully leverage the benefits of biochemical biomarkers, by improving the prioritisation of drug candidates. Recently, Metabolon has developed a series of defined metabolomics-based solutions to address these needs. The first of these, mSelect, is designed to identify the leading drug candidate in early stage discovery. For example, in addition to interacting with the intended target, many drug candidates are likely to have unanticipated affects on other pathways. These effects can lead to safety issues that do not surface until late in the development process. With mSelect, metabolomics is used to isolate significantly altered biochemical biomarkers from dosed cell cultures. Through further analysis, the effected biochemical pathways are also identified so researchers can effectively assess the broad biological impact of each candidate drug. Using these data, the most promising lead compound(s) can continue to the next phase of development. Ideally, further evaluation of lead candidates throughout the discovery and development processes would be based on a consistent set of qualified biomarkers. Metabolomics offers a promising approach to achieve this objective because of the highly conserved nature of biochemical biomarkers across species. In addition, processing of biological samples from various sources can be examined on the same platforms, thus reducing variability introduced by differences in analytical equipment. Metabolon’s second solution, mVivo, is designed to evaluate the changes in drug-induced biochemical biomarkers during pre-clinical animal model testing. In many ways, this solution is similar to mSelect except that it is used in conjunction with routine animal studies and utilises various sample types such as plasma or biopsy material. mVivo can monitor the metabolism of the drug as well as measuring all of the other changes related to the action of the chemical. Finally, mProveClinical, the third solution, is designed to evaluate drug effects on biochemical biomarkers in first-in-human clinical studies. Currently, drug development companies make large investments to advance a compound to the point where the first tests in man can take place. However, since these studies are designed to test for drug safety, there is a relatively small amount of rich biomarker data derived from these studies. In addition to the traditional safety assessments performed at this stage of evaluation, with mProveClinical a preliminary read of the drug-induced effects on thepreviously identified biomarkers can be achieved. By applying these three solutions on a single metabolomics platform, researchers can leverage highly conserved biochemical biomarkers in a stepwise manner throughout the drug discovery and development process. Findings at each stage can be compared to the earlier results, whether in tissue culture, animals, or humans, to fully leverage biomarkers as a tool for rationale decisions ultimately leading to more reliable product development.
I have made a few edits to this page today - there were several instances where the article stated that metabolomics requires "extraction of metabolites" and "separation of analytes". This is a misleading generalisation since NMR-based methods do not require "separation" or "extraction" of any metabolites - just a spot of D2O and away you go. In general the article itself can do with a massive clean up. -- Amaher ( talk) 23:57, 7 January 2010 (UTC)
The history section of this article is mostly original research and as such does not belong in Wikipedia. This article is about Metabolomics, which means that the History section should detail the background to the field with respect to what people have published within the Metabolomics field. I'm going to clean this up very soon to align this section more closely with Wikipedia guidelines contained in WP:OR-- Amaher ( talk) 01:59, 11 January 2010 (UTC)
doi:10.1186/s13054-016-1222-8 JFW | T@lk 06:13, 30 March 2016 (UTC)
Hi - I think it makes sense to add a section for commercial labs. Knowledge of metabolomics is not limited to academia; there are many commercial organizations that provide an excellent source of research of the field, and many commercial labs run within academic institutions themselves. I've included as many as I could find, but please add any others you know of. DrJaneHarrison ( talk) 21:13, 8 January 2019 (UTC)Jane