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Hi mTOR editors, this is Bobby, a student in a Signal Transduction class at Saint Louis University. Each student is allowed to pick a topic that they found exciting as well as a topic they felt could expand the current wikipedia knowledge on. This article, along with mTOR and mTORC1 are going to be what I am going to be editing for the rest of the semester. If you have any help or input or advice, don't hesitate to leave a comment on my talk page. I am planning on, for the editing, reading upwards of twenty review articles (and perhaps a couple primary articles) about mTOR and its signaling within the cell and using that information to help (hopefully) add to the current knowledge about this protein (these proteins) already supplied on Wikipedia. This is just to help give a heads up that I am working on this.
This article was the subject of an educational assignment. Further details were available on the "Education Program:Saint Louis University/Signal Transduction (SP13)" page, which is now unavailable on the wiki. |
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Thanks, Flemingrjf ( talk) 03:22, 18 February 2013 (UTC)
Hey Bobby, here are my suggestions for your contribution to this article:
Great job so far! I've included my suggestions for improvement below as part of our Assignment 7. You'll notice that some are the same as for your main article (mTOR).
Lead section
Function section
Miscellaneous
Jnims ( talk) 01:18, 23 April 2013 (UTC)
BreCaitlin ( talk) 17:18, 1 May 2013 (UTC)
As a reader feedback, I found these articles generally readable, accessible, and very helpful. Thank you. (I utilise wikipedia articles like this to assist my understanding of biology re my advocacy role on the disease issue of Chronic Fatigue Syndrome (CFS), ME, CFIDS, FM.)
1 - Question: Should the word "lethal" re "mammalian lethal" be in the text, 2nd paragraph:
"mTOR Complex 1 (mTORC1) is composed of mTOR itself, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 ...."
This does not seem to read right, and the meaning to me is unclear. Should it perhaps read: ... lethal for mammalian cells with ... ???
2 - A point of some confusion as reader:
Reading several Wiki and non wiki articles concerning mTOR, I found some confusion if rapamycin = mTOR, or if rapamycin activates or suppresses mTOR. That is to say they are different entities.
For example in the Wikipedia article, /info/en/?search=Sirolimus, under Lupus,
" ... that inhibiting mTOR with rapamycin may be a disease-modifiying treatment.[54]".
This suggest rapamycin is a different entity that regulates mTOR. Yet other articles are clear rapamycin is another name for mTOR. (And also rapamycin=sirolimus.) Perhaps, rapamycin is mTOR, and rapamycin can be given, to regulate the level of mTORC1 and mTORC2 as derivative but different active entities?
Perhaps in any further review of this and other mTOR articles, the relationships can be made clearer for a reader not in this field.
Hope this comment helps the excellent work.
CitizenofEarth001 ( talk) 02:40, 9 December 2017 (UTC)
This article is rated Start-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||
|
Hi mTOR editors, this is Bobby, a student in a Signal Transduction class at Saint Louis University. Each student is allowed to pick a topic that they found exciting as well as a topic they felt could expand the current wikipedia knowledge on. This article, along with mTOR and mTORC1 are going to be what I am going to be editing for the rest of the semester. If you have any help or input or advice, don't hesitate to leave a comment on my talk page. I am planning on, for the editing, reading upwards of twenty review articles (and perhaps a couple primary articles) about mTOR and its signaling within the cell and using that information to help (hopefully) add to the current knowledge about this protein (these proteins) already supplied on Wikipedia. This is just to help give a heads up that I am working on this.
This article was the subject of an educational assignment. Further details were available on the "Education Program:Saint Louis University/Signal Transduction (SP13)" page, which is now unavailable on the wiki. |
or
Thanks, Flemingrjf ( talk) 03:22, 18 February 2013 (UTC)
Hey Bobby, here are my suggestions for your contribution to this article:
Great job so far! I've included my suggestions for improvement below as part of our Assignment 7. You'll notice that some are the same as for your main article (mTOR).
Lead section
Function section
Miscellaneous
Jnims ( talk) 01:18, 23 April 2013 (UTC)
BreCaitlin ( talk) 17:18, 1 May 2013 (UTC)
As a reader feedback, I found these articles generally readable, accessible, and very helpful. Thank you. (I utilise wikipedia articles like this to assist my understanding of biology re my advocacy role on the disease issue of Chronic Fatigue Syndrome (CFS), ME, CFIDS, FM.)
1 - Question: Should the word "lethal" re "mammalian lethal" be in the text, 2nd paragraph:
"mTOR Complex 1 (mTORC1) is composed of mTOR itself, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 ...."
This does not seem to read right, and the meaning to me is unclear. Should it perhaps read: ... lethal for mammalian cells with ... ???
2 - A point of some confusion as reader:
Reading several Wiki and non wiki articles concerning mTOR, I found some confusion if rapamycin = mTOR, or if rapamycin activates or suppresses mTOR. That is to say they are different entities.
For example in the Wikipedia article, /info/en/?search=Sirolimus, under Lupus,
" ... that inhibiting mTOR with rapamycin may be a disease-modifiying treatment.[54]".
This suggest rapamycin is a different entity that regulates mTOR. Yet other articles are clear rapamycin is another name for mTOR. (And also rapamycin=sirolimus.) Perhaps, rapamycin is mTOR, and rapamycin can be given, to regulate the level of mTORC1 and mTORC2 as derivative but different active entities?
Perhaps in any further review of this and other mTOR articles, the relationships can be made clearer for a reader not in this field.
Hope this comment helps the excellent work.
CitizenofEarth001 ( talk) 02:40, 9 December 2017 (UTC)