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This list starting the LQTS page would in my opinion be better suited in a separate article, especially since the list should be much longer when updated. In stead there should be an appropiate link to the list in the aquired LQTS section
Genetic testing was discussed in JAMA on 21 Dec 05 [1]. JFW | T@lk 21:55, 22 December 2005 (UTC)
Side effect of anti-psychotics based on PI sheets for Haldol and Geodon. John Elder 02:17, 28 March 2006 (UTC)
in the article http://en.wikipedia.org/wiki/Long_QT_syndrome, should the txt under LQT2, "are poised so drug binding to them will", be "drugs" or some gramatical change?
Left Cardiac Sympathetic Denervation is absent from the article. — C M B J 22:44, 17 December 2008 (UTC)
I have removed a long list (unsourced) with conditions and states in which the QTc interval may be prolonged. They don't belong in this article, because they are not "syndromal". They need to be discussed in another article, either about QTc prolongation or TDP.
More common than the various congenital causes of long QT syndrome are acquired causes. They can be divided into two main categories - those due to disturbances in blood electrolytes and those due to various drugs:
Just as with the congenital causes of the Long QT syndrome, the acquired causes may also lead to the potentially lethal arrythmia known as Torsade de Pointes. Treatment is straightforward - replace any deficient electrolytes if present and stop any culprit drugs if the patient is using one (or more).
Given its relatively high frequency of use, its tendency for drug-drug interaction, and its inherent ability to prolong the QT interval, the macrolide antibiotic erythromycin is probably the most prevalent cause of acquired long QT syndrome. Indeed, use of erythromycin is associated with a rate of death more than double that of use of other antibiotics [1]
In addition to the two major categories listed above, it should be noted that there are also some miscellaneous causes of QT prolongation such as anorexia nervosa, hypothyroidism, HIV infection, and myocardial infarction.
Hope this is OK.
References
{{
cite journal}}
: CS1 maint: multiple names: authors list (
link)
-- JFW | T@lk 14:59, 14 February 2010 (UTC)
NEJM covered this in 2008 doi: 10.1056/NEJMcp0706513 JFW | T@lk 12:53, 6 March 2011 (UTC)
could there be added a comparison picture of what a LQT looks like —Preceding unsigned comment added by 71.112.216.33 ( talk) 17:08, 23 March 2011 (UTC)
What about using primidone as a treatment. It is mentioned in the primidone article that it has been used for this purpose.
AriaNo11 ( talk) 18:11, 28 April 2011 (UTC)
It states that the use of potassium as a potential treatment is not evidence-based - I can understand this, but doesn't reference even an anecdotal reports of long QT going into remission after potassium supplementation, and/or in vitro studies of the effect of K supplementation on the functions of the various ion channels. I find it hard to believe there isn't *any* evidence whatsoever. — Preceding unsigned comment added by 98.223.232.121 ( talk) 18:16, 30 January 2012 (UTC)
Hi Editors,
Checked on citation #13, Challenges of Diagnosis of Long-QT Syndrome in Children, this article does not support the claim made, nor is the claim cited within the article, appears to be a mistaken citation. — Preceding unsigned comment added by 152.132.10.133 ( talk) 18:41, 4 September 2015 (UTC)
The language here is fairly technical and given without context, and I believe it should be marked. learnergenius ( talk) 03:58, 2 February 2017 (UTC)
The link in reference #2 is broken. Here's a link that works, but I don't know how to update it in the article. http://www.mdedge.com/ccjm/article/94949/cardiology/congenital-long-qt-syndrome-considerations-primary-care-physicians — Preceding unsigned comment added by Trogyssy ( talk • contribs) 16:21, 15 February 2017 (UTC)
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I have just modified one external link on Long QT syndrome. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
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A stat that says that 50% of untreated LQTS patients die within 10 years keeps getting republished. The citation keeps referring to an LQTS overview page from from the NIH. This page IS NOT original research. This stat has been floating around the Internet and is reposted often by hospitals, schools, and even the NIH. It is patently false without the word "symptomatic" or "of patients who have had an LQTS triggered cardiac episode".
This is as absurd as a claim that McDonalds hamburgers kill 50% of people within 10 years, because some study of morbidly obese people who died within 10 years found half ate McDonalds.
The original research is clear that this stat is for SYMPTOMATIC patients. Stop reposting this claim without context, even if the citation seems semi-reputable. Once a person has a cardiac episode and LQTS is discovered, if THOSE people are leaving untreated, they have the 50% odds of dying within 10 years. This is far different from the asymptomatic person who discovers it via genetic testing. There is absolutely no hard evidence or even plausible anecdotal evidence that this is the case.
Recent source correctly using context
BillySalon (
talk)
19:16, 4 February 2018 (UTC)BillySalon
There is a review on the topic and we summarize it already as "Mental stress or physical exertion may trigger arrhythmia in some people with LQTS. [1]"
No need for all the primary sources. Just to repeat what the review has said. Doc James ( talk · contribs · email) 10:54, 24 December 2018 (UTC)
References
Hi @ Doc James: I know you take a keen interest in this and many other medical articles so thought I'd flag up some proposed changes to see what you and others thought. I don't think the "Risk factors" section really belongs as it stands, there aren't risk factors for developing long QT syndrome per se, there are genetic and acquired causes which are dealt with in the preceding section. There are triggers for arrhythmias, but these are dealt with in part in the symptoms section, and this can be expanded in the pathophysiology section. I am therefore inclined to remove "Risk factors" but thought I'd bring it to the table first to see if anyone has a strong reason for it to stay. PeaBrainC ( talk) 06:21, 25 January 2019 (UTC)
Looking further, some comprehensive reviews such as Roden 2004 in NEJM have a list of risk factors for developing Torsades, perhaps it could be rephrased in this context? PeaBrainC ( talk) 06:56, 25 January 2019 (UTC)
The causes section as it stands is a bit of a mess. Causes is currently divided into Acquired and Genetics, with genetics being split into 16 subheadings of LQT1 through LQT16, all of which is pretty intimidating and difficult to read. Some of this could be condensed with "Main Article:" links to the relevant subtypes.
How about this for a proposed re-organisation:
If there are no dissenting views I'll aim to do this (at some point). PeaBrainC ( talk) 16:02, 16 June 2019 (UTC)
(Sorry for the ip edit; seems like mebbe the iPad 2 wp icon forgets after a few days that an admin logged me in, and only Google lets me log myself in. Or maybe my net provider changed too high-order a bit in my IP address.
Further Wonders of the
InterWebs!)
Anywhoo, the signs and symptoms and outcomes portion of the lead was dreadful, at least as a lead. Instead, I reworded to sort out the underlying mechanisms from the most relevant consequences, and avoided the false hint that drowning (though often fatal) is not a form of death, but rather an often remediable hazard. (I'll go back and be sure that I linked to
drowning.)
--
JerzyA (
talk)
02:38, 17 June 2019 (UTC)
Sorry, drowning is sometimes fatal and sometimes not; uses of double negatives are more often amusing than fatal.
--
JerzyA (
talk)
02:45, 17 June 2019 (UTC)
Long QT syndrome does not cause " Epileptic seizure"
Tester DJ, Schwartz PJ, Ackerman MJ (2013). "Congenital Long QT Syndrome". In Gussak I, Antzelevitch C (eds.). Electrical Diseases of the Heart. London: Springer. pp. = 39–46.
doi:
10.1007/978-1-4471-4881-4_27.
ISBN
978-1-4471-4881-4.{{
cite book}}
: CS1 maint: extra punctuation (
link)
Despite the source saying "With an incidence as high as 1 in 2,000–2,500 live births, long QT syndrome (LQTS) is often characterized clinically by prolongation of the heart rate corrected QT interval (QTc) on a 12-lead surface electrocardiogram (ECG) and is associated with syncope, seizures, and sudden cardiac death due to ventricular arrhythmias usually following a precipitating event such as exertion, extreme emotion, or auditory stimulation."
Doc James ( talk · contribs · email) 22:23, 18 December 2019 (UTC)
User:PeaBrainC have split the sentence into one on convulsive syncope and one on the increased risk of epilepsy in LQT2. Clarified that seizure like activity is also known as non epileptic seizures. Doc James ( talk · contribs · email) 00:24, 21 December 2019 (UTC)
This is the
talk page for discussing improvements to the
Long QT syndrome article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL |
![]() | This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||
|
See WP:MEDMOS for suggestions on layout and style |
![]() | Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Long QT syndrome.
|
This list starting the LQTS page would in my opinion be better suited in a separate article, especially since the list should be much longer when updated. In stead there should be an appropiate link to the list in the aquired LQTS section
Genetic testing was discussed in JAMA on 21 Dec 05 [1]. JFW | T@lk 21:55, 22 December 2005 (UTC)
Side effect of anti-psychotics based on PI sheets for Haldol and Geodon. John Elder 02:17, 28 March 2006 (UTC)
in the article http://en.wikipedia.org/wiki/Long_QT_syndrome, should the txt under LQT2, "are poised so drug binding to them will", be "drugs" or some gramatical change?
Left Cardiac Sympathetic Denervation is absent from the article. — C M B J 22:44, 17 December 2008 (UTC)
I have removed a long list (unsourced) with conditions and states in which the QTc interval may be prolonged. They don't belong in this article, because they are not "syndromal". They need to be discussed in another article, either about QTc prolongation or TDP.
More common than the various congenital causes of long QT syndrome are acquired causes. They can be divided into two main categories - those due to disturbances in blood electrolytes and those due to various drugs:
Just as with the congenital causes of the Long QT syndrome, the acquired causes may also lead to the potentially lethal arrythmia known as Torsade de Pointes. Treatment is straightforward - replace any deficient electrolytes if present and stop any culprit drugs if the patient is using one (or more).
Given its relatively high frequency of use, its tendency for drug-drug interaction, and its inherent ability to prolong the QT interval, the macrolide antibiotic erythromycin is probably the most prevalent cause of acquired long QT syndrome. Indeed, use of erythromycin is associated with a rate of death more than double that of use of other antibiotics [1]
In addition to the two major categories listed above, it should be noted that there are also some miscellaneous causes of QT prolongation such as anorexia nervosa, hypothyroidism, HIV infection, and myocardial infarction.
Hope this is OK.
References
{{
cite journal}}
: CS1 maint: multiple names: authors list (
link)
-- JFW | T@lk 14:59, 14 February 2010 (UTC)
NEJM covered this in 2008 doi: 10.1056/NEJMcp0706513 JFW | T@lk 12:53, 6 March 2011 (UTC)
could there be added a comparison picture of what a LQT looks like —Preceding unsigned comment added by 71.112.216.33 ( talk) 17:08, 23 March 2011 (UTC)
What about using primidone as a treatment. It is mentioned in the primidone article that it has been used for this purpose.
AriaNo11 ( talk) 18:11, 28 April 2011 (UTC)
It states that the use of potassium as a potential treatment is not evidence-based - I can understand this, but doesn't reference even an anecdotal reports of long QT going into remission after potassium supplementation, and/or in vitro studies of the effect of K supplementation on the functions of the various ion channels. I find it hard to believe there isn't *any* evidence whatsoever. — Preceding unsigned comment added by 98.223.232.121 ( talk) 18:16, 30 January 2012 (UTC)
Hi Editors,
Checked on citation #13, Challenges of Diagnosis of Long-QT Syndrome in Children, this article does not support the claim made, nor is the claim cited within the article, appears to be a mistaken citation. — Preceding unsigned comment added by 152.132.10.133 ( talk) 18:41, 4 September 2015 (UTC)
The language here is fairly technical and given without context, and I believe it should be marked. learnergenius ( talk) 03:58, 2 February 2017 (UTC)
The link in reference #2 is broken. Here's a link that works, but I don't know how to update it in the article. http://www.mdedge.com/ccjm/article/94949/cardiology/congenital-long-qt-syndrome-considerations-primary-care-physicians — Preceding unsigned comment added by Trogyssy ( talk • contribs) 16:21, 15 February 2017 (UTC)
Hello fellow Wikipedians,
I have just modified one external link on Long QT syndrome. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
This message was posted before February 2018.
After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than
regular verification using the archive tool instructions below. Editors
have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the
RfC before doing mass systematic removals. This message is updated dynamically through the template {{
source check}}
(last update: 5 June 2024).
Cheers.— InternetArchiveBot ( Report bug) 21:02, 5 January 2018 (UTC)
A stat that says that 50% of untreated LQTS patients die within 10 years keeps getting republished. The citation keeps referring to an LQTS overview page from from the NIH. This page IS NOT original research. This stat has been floating around the Internet and is reposted often by hospitals, schools, and even the NIH. It is patently false without the word "symptomatic" or "of patients who have had an LQTS triggered cardiac episode".
This is as absurd as a claim that McDonalds hamburgers kill 50% of people within 10 years, because some study of morbidly obese people who died within 10 years found half ate McDonalds.
The original research is clear that this stat is for SYMPTOMATIC patients. Stop reposting this claim without context, even if the citation seems semi-reputable. Once a person has a cardiac episode and LQTS is discovered, if THOSE people are leaving untreated, they have the 50% odds of dying within 10 years. This is far different from the asymptomatic person who discovers it via genetic testing. There is absolutely no hard evidence or even plausible anecdotal evidence that this is the case.
Recent source correctly using context
BillySalon (
talk)
19:16, 4 February 2018 (UTC)BillySalon
There is a review on the topic and we summarize it already as "Mental stress or physical exertion may trigger arrhythmia in some people with LQTS. [1]"
No need for all the primary sources. Just to repeat what the review has said. Doc James ( talk · contribs · email) 10:54, 24 December 2018 (UTC)
References
Hi @ Doc James: I know you take a keen interest in this and many other medical articles so thought I'd flag up some proposed changes to see what you and others thought. I don't think the "Risk factors" section really belongs as it stands, there aren't risk factors for developing long QT syndrome per se, there are genetic and acquired causes which are dealt with in the preceding section. There are triggers for arrhythmias, but these are dealt with in part in the symptoms section, and this can be expanded in the pathophysiology section. I am therefore inclined to remove "Risk factors" but thought I'd bring it to the table first to see if anyone has a strong reason for it to stay. PeaBrainC ( talk) 06:21, 25 January 2019 (UTC)
Looking further, some comprehensive reviews such as Roden 2004 in NEJM have a list of risk factors for developing Torsades, perhaps it could be rephrased in this context? PeaBrainC ( talk) 06:56, 25 January 2019 (UTC)
The causes section as it stands is a bit of a mess. Causes is currently divided into Acquired and Genetics, with genetics being split into 16 subheadings of LQT1 through LQT16, all of which is pretty intimidating and difficult to read. Some of this could be condensed with "Main Article:" links to the relevant subtypes.
How about this for a proposed re-organisation:
If there are no dissenting views I'll aim to do this (at some point). PeaBrainC ( talk) 16:02, 16 June 2019 (UTC)
(Sorry for the ip edit; seems like mebbe the iPad 2 wp icon forgets after a few days that an admin logged me in, and only Google lets me log myself in. Or maybe my net provider changed too high-order a bit in my IP address.
Further Wonders of the
InterWebs!)
Anywhoo, the signs and symptoms and outcomes portion of the lead was dreadful, at least as a lead. Instead, I reworded to sort out the underlying mechanisms from the most relevant consequences, and avoided the false hint that drowning (though often fatal) is not a form of death, but rather an often remediable hazard. (I'll go back and be sure that I linked to
drowning.)
--
JerzyA (
talk)
02:38, 17 June 2019 (UTC)
Sorry, drowning is sometimes fatal and sometimes not; uses of double negatives are more often amusing than fatal.
--
JerzyA (
talk)
02:45, 17 June 2019 (UTC)
Long QT syndrome does not cause " Epileptic seizure"
Tester DJ, Schwartz PJ, Ackerman MJ (2013). "Congenital Long QT Syndrome". In Gussak I, Antzelevitch C (eds.). Electrical Diseases of the Heart. London: Springer. pp. = 39–46.
doi:
10.1007/978-1-4471-4881-4_27.
ISBN
978-1-4471-4881-4.{{
cite book}}
: CS1 maint: extra punctuation (
link)
Despite the source saying "With an incidence as high as 1 in 2,000–2,500 live births, long QT syndrome (LQTS) is often characterized clinically by prolongation of the heart rate corrected QT interval (QTc) on a 12-lead surface electrocardiogram (ECG) and is associated with syncope, seizures, and sudden cardiac death due to ventricular arrhythmias usually following a precipitating event such as exertion, extreme emotion, or auditory stimulation."
Doc James ( talk · contribs · email) 22:23, 18 December 2019 (UTC)
User:PeaBrainC have split the sentence into one on convulsive syncope and one on the increased risk of epilepsy in LQT2. Clarified that seizure like activity is also known as non epileptic seizures. Doc James ( talk · contribs · email) 00:24, 21 December 2019 (UTC)