This disorder should be listed in the Common Disorders box, as it is the second most common genetic syndrome after Down. The incidence is though to be somewhere between 1:2000 and 1:4000.
The list looks nice but I think it'd be better if we list them in categories as shown here;
I. Autosomal
(a). Dominant (b). Recessive
II.Sex-linked
(a). Dominant (b). Recessive
Such a list would be more interesting form an academic point of view especially for we physicians. Joram Beda 08:37, 1 October 2006 (UTC)
Dear administrator Read Harrison's Principles of Internal Medicine, 15th Edition . Your list contains genetic diseases that are almost theory because their occurances are so rare, one might have to live a century to see one hopefully. Joram Beda 08:44, 1 October 2006 (UTC)
I have a better list but i am having difficulty in uploading the file to wiki. Joram Beda 12:49, 1 October 2006 (UTC)
I am pasting a section here that I cut from dominance relationship in case it can be incorporated here. Dr d12 20:44, 2 December 2006 (UTC)dr_d12
![]() | This list is
incomplete; you can help by
adding missing items. |
Disease | Gene is... |
Polydactylism | dominant |
Marfan syndrome | dominant |
Some types of Dwarfism | recessive |
Tay-Sachs disease | recessive |
![]() | This list is
incomplete; you can help by
adding missing items. |
Celiac is now recognized as the most common genetic disorder (this is a change.) Ignorance of this is extremely costly, as most physicians have seen hundreds of cases but never diagnosed a single one!
Inheritance is complex, but there is nothing unique about that. Environmental factors affect it's expression, but there's nothing unique about that either.
Celiac wasn't listed anywhere here (Marach 2007) so I've added it.
Some sources:
CD is one of the most common inherited diseases http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16091925
NIH Consensus Development Conference on Celiac Disease
National Institutes of Health Consensus Development Conference Statement June 28–30, 2004
Celiac disease has been considered until recently to be a rare disease in the United States. Studies, primarily in Europe but also in the United States, now suggest that its prevalence is much greater than previous estimates, possibly affecting as many as 3 million Americans (roughly 1 percent of the U.S. population), indicating that the disease is widely underrecognized. http://consensus.nih.gov/2004/2004CeliacDisease118html.htm
only 35% of primary care physicians had ever diagnosed celiac disease. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16050861
“Celiac disease not limited to young” from the column Your Good Health by Dr. Paul Donahue Not so long ago, celiac was believed to be a rare bird. Today it is diagnosed with 100 times the frequency it was diagnosed 50 years ago.
http://www.sun-herald.com/NewsArchive2/092305/hn1.htm?date=092305&story=hn1.htm Ndaniels 19:46, 10 March 2007 (UTC)
Note for future addition of Huntington's Disease-like conditions referenced in Schneider SA, Walker RH, Bhatia KP (2007).
"The Huntington's disease-like syndromes: what to consider in patients with a negative Huntington's disease gene test". Nat Clin Pract Neurol. 3 (9): 517–25.
doi:
10.1038/ncpneuro0606.
PMID
17805246. {{
cite journal}}
: Unknown parameter |month=
ignored (
help)CS1 maint: multiple names: authors list (
link)
LeeVJ (
talk)
16:25, 1 May 2008 (UTC)
I know little about the topic, but it seems to me that at least Familial advanced sleep phase syndrome (FASPS) should be included here and possible some of the other Circadian rhythm sleep disorders. Thanks. -- Hordaland ( talk) 20:32, 20 August 2008 (UTC)
Have just removed wikilinks on entries that are synonyms /covered by article - i.e. any with 'see so-an-so'. This means hopefully that each variant is linked once as the main entry in the list and any synonyms only have a 'see also' link. It was a first step in removing redundancy - I was contemplating only having the chromosone and mutation info for each main entry rather than for every synonym ..in order to reduce efforts to keep them accurate, which is a tricky task - how do we check them all! LeeVJ ( talk) 19:06, 4 December 2008 (UTC)
Should we dedicate a section to this function of genetics? I'd like your opinions.
This disorder should be listed in the Common Disorders box, as it is the second most common genetic syndrome after Down. The incidence is though to be somewhere between 1:2000 and 1:4000.
The list looks nice but I think it'd be better if we list them in categories as shown here;
I. Autosomal
(a). Dominant (b). Recessive
II.Sex-linked
(a). Dominant (b). Recessive
Such a list would be more interesting form an academic point of view especially for we physicians. Joram Beda 08:37, 1 October 2006 (UTC)
Dear administrator Read Harrison's Principles of Internal Medicine, 15th Edition . Your list contains genetic diseases that are almost theory because their occurances are so rare, one might have to live a century to see one hopefully. Joram Beda 08:44, 1 October 2006 (UTC)
I have a better list but i am having difficulty in uploading the file to wiki. Joram Beda 12:49, 1 October 2006 (UTC)
I am pasting a section here that I cut from dominance relationship in case it can be incorporated here. Dr d12 20:44, 2 December 2006 (UTC)dr_d12
![]() | This list is
incomplete; you can help by
adding missing items. |
Disease | Gene is... |
Polydactylism | dominant |
Marfan syndrome | dominant |
Some types of Dwarfism | recessive |
Tay-Sachs disease | recessive |
![]() | This list is
incomplete; you can help by
adding missing items. |
Celiac is now recognized as the most common genetic disorder (this is a change.) Ignorance of this is extremely costly, as most physicians have seen hundreds of cases but never diagnosed a single one!
Inheritance is complex, but there is nothing unique about that. Environmental factors affect it's expression, but there's nothing unique about that either.
Celiac wasn't listed anywhere here (Marach 2007) so I've added it.
Some sources:
CD is one of the most common inherited diseases http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16091925
NIH Consensus Development Conference on Celiac Disease
National Institutes of Health Consensus Development Conference Statement June 28–30, 2004
Celiac disease has been considered until recently to be a rare disease in the United States. Studies, primarily in Europe but also in the United States, now suggest that its prevalence is much greater than previous estimates, possibly affecting as many as 3 million Americans (roughly 1 percent of the U.S. population), indicating that the disease is widely underrecognized. http://consensus.nih.gov/2004/2004CeliacDisease118html.htm
only 35% of primary care physicians had ever diagnosed celiac disease. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16050861
“Celiac disease not limited to young” from the column Your Good Health by Dr. Paul Donahue Not so long ago, celiac was believed to be a rare bird. Today it is diagnosed with 100 times the frequency it was diagnosed 50 years ago.
http://www.sun-herald.com/NewsArchive2/092305/hn1.htm?date=092305&story=hn1.htm Ndaniels 19:46, 10 March 2007 (UTC)
Note for future addition of Huntington's Disease-like conditions referenced in Schneider SA, Walker RH, Bhatia KP (2007).
"The Huntington's disease-like syndromes: what to consider in patients with a negative Huntington's disease gene test". Nat Clin Pract Neurol. 3 (9): 517–25.
doi:
10.1038/ncpneuro0606.
PMID
17805246. {{
cite journal}}
: Unknown parameter |month=
ignored (
help)CS1 maint: multiple names: authors list (
link)
LeeVJ (
talk)
16:25, 1 May 2008 (UTC)
I know little about the topic, but it seems to me that at least Familial advanced sleep phase syndrome (FASPS) should be included here and possible some of the other Circadian rhythm sleep disorders. Thanks. -- Hordaland ( talk) 20:32, 20 August 2008 (UTC)
Have just removed wikilinks on entries that are synonyms /covered by article - i.e. any with 'see so-an-so'. This means hopefully that each variant is linked once as the main entry in the list and any synonyms only have a 'see also' link. It was a first step in removing redundancy - I was contemplating only having the chromosone and mutation info for each main entry rather than for every synonym ..in order to reduce efforts to keep them accurate, which is a tricky task - how do we check them all! LeeVJ ( talk) 19:06, 4 December 2008 (UTC)
Should we dedicate a section to this function of genetics? I'd like your opinions.