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This list only contains the alternate and business routes for the U.S. highways. There are also other bannered routes that are missing (italics denoting former routes; actual links may not exist or may need to be revamped):

Bypass

• U.S. Route 17 Bypass (Myrtle Beach, South Carolina)
• U.S. Route 21 Bypass (Orangeburg, South Carolina)
• U.S. Route 76 Bypass (Newberry, South Carolina)
• U.S. Route 76 Bypass (Sumter, South Carolina)
• U.S. Route 178 Bypass (Greenwood, South Carolina)
• U.S. Route 178 Bypass (Orangeburg, South Carolina)
• U.S. Route 221 Bypass (Greenwood, South Carolina)
• U.S. Route 276 Bypass (Greenville, South Carolina)
• U.S. Route 378 Bypass (Lake City, South Carolina)

Connector

• U.S. Route 178 Connector (Orangeburg, South Carolina)

Spur

• U.S. Route 21 Spur (Orangeburg, South Carolina)
• U.S. Route 21 Spur (Columbia, South Carolina)

Truck

• U.S. Route 25 Truck (North Augusta, South Carolina)
• U.S. Route 301 Truck (Florence, South Carolina) Charlotte Allison (Allen/Morriswa) ( talk) 02:23, 30 January 2016 (UTC) reply

I just started a little work on one of the two truck routes in Florence. --------- User:DanTD ( talk) 03:46, 17 September 2016 (UTC) reply