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User:A Real Journalist, about this (which had edit note "updated scientific data") and then this which had edit note "correct citation".
Over the last 15 years, ketamine has been found to be very effective as an antidepressant when administered intravenously in sub-anaesthetic doses. Over 100 independent clinical trials at leading institutions such as The National Institute of Mental Health, The Cleveland Clinic, Mt. Sinai Hospital, Yale University, Stanford University, UCLA, USC, and NYU, have been conducted. Average response rate to Ketamine Infusion Therapy among participants across all the studies is about 70%. In the last 5 years, there has been a significant increase in the number of ketamine clinics in the United States offering the treatment to the general public. [1]
However advancements over the last 15 years show that ketamine has been found to be very effective as an antidepressant when administered intravenously in sub-anaesthetic doses. Over 100 independent clinical trials at leading institutions such as The National Institute of Mental Health, The Cleveland Clinic, Mt. Sinai Hospital, Yale University, Stanford University, UCLA, USC, and NYU, have been conducted. Average response rate to Ketamine Infusion Therapy among participants across all the studies is about 70%. In the last 5 years, there has been a significant increase in the number of ketamine clinics in the United States offering the treatment to the general public. [2]
References
The section of the article where you put this content is "medical use". Content that goes into this section needs to describe medical use, and be sourced per WP:MEDRS, which briefly means a fairly recent literature review published in the biomedical literature, or a statement by a major medical medical or scientific body. The content in that section already describes medical use and the evidence for it, and is sourced to a fairly recent review.
The first source is an interview in NY Magazine and is not MEDRS. The second source is a news piece by the NIH, which is also not a MEDRS source.
The content is also very promotional, and obviously so, and really importantly, not supported by either source. Jytdog ( talk) 00:14, 25 March 2017 (UTC)
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User:Irapliss, you are making changes only to the WP:LEAD and are using poor refs. Please see the note on your talk page at User_talk:Irapliss#Welcome and the other messages there as well. Jytdog ( talk) 19:50, 4 March 2018 (UTC)
These could be used as references potentially? Doc James ( talk · contribs · email) 05:00, 22 March 2018 (UTC)
Ketamine is not approved for this. Wired is not a good source to support Velasquez-Manoff, Moises (2018-05-08). "Ketamine Stirs Up Hope—and Controversy—as a Depression Drug". Wired. ISSN 1059-1028. Retrieved 2019-04-03.
We have a whole section in the body Ketamine#Depression Doc James ( talk · contribs · email) 20:50, 3 April 2019 (UTC)
This article is a little messy and could do with some rearranging. The medicinal uses part needs some subsections, and some thought might be given to partial merge with the medical research section. — Preceding unsigned comment added by Testem ( talk • contribs) 10:28, 15 January 2014
In the structure subsection of the chemistry section, there is a table which includes axial and equatorial forms of ketamine, equating them to the salt and the free base forms. While chemically this may be true, the ball and stick structures do not show the nitrogen atom with the correct number of hydrogen atoms in covalent linkage. 24.12.7.29 ( talk) 00:37, 9 May 2019 (UTC)
The media (Washington Post, Cosmopolitan, et al) have delivered glowing reviews (repeatedly in the case of the Washington Post) of this drug for depression. These are anecdotal stories of one or more individuals who have a story of remarkable success apparently related to their use of the drug.
However, the following link shows flimsy evidence was used by the FDA to approve this drug for depression:
Moncrieff, J., & Horowitz, M. (2019). Esketamine for treatment-resistant depression. BMJ, 366. DOI: https://doi.org/10.1136/bmj.l5572 (Link)
Also Ketamine is known to be addictive. Here's this:
https://www.independent.co.uk/topic/ketamine
Side effects seem to include depression itself:
Short, B., Fong, J., Galvez, V., Shelker, W., & Loo, C. K. (2017). Side-effects associated with ketamine use in depression: A systematic review. Lancet Psychiatry. http://dx.doi.org/10.1016/ S2215-0366(17)30272-9 — Preceding unsigned comment added by 173.153.152.32 ( talk) 23:40, 29 November 2019 (UTC)
Ref says "The resulting trancelike cataleptic state of “sensory isolation" not dream like. Propofol gives one the nice dreams. Doc James ( talk · contribs · email) 21:50, 11 April 2020 (UTC)
I suggest removing all targets with Ki > 10 mkM from the table. These targets are too weak to lead to any noticeable biological effect, and they make the Table confusing. The same goes about the text on the left from the Table: what is your opinion about removing all references to the targets inhibited with K more that 10 μM ?
The Sceptical Chymist ( talk) 18:12, 26 November 2020 (UTC)
The "Recreational use" section is now duplicated in Ketamine in society and culture, so it should be just summarized here with a "main article" link. MB 01:37, 13 December 2020 (UTC)
Done. The Sceptical Chymist ( talk) 12:58, 13 December 2020 (UTC)
It is an incorrect term. It's not "use", it's recreational "abuse" as is misuse of all Rx medications, especially Scheduled ones. 2603:6000:D70A:BC00:1C69:20E9:6115:D11D ( talk) 14:52, 19 July 2022 (UTC)
More info on ketamine’s use as a date rape drug would be useful, and it likely shouldn’t be included under Recreational Use? 69.42.137.164 ( talk) 00:24, 19 November 2021 (UTC)
A novel trimodal system on a paper-based microfluidic device for on-site detection of the date rape drug “ketamine”
https://doi.org/10.1016/J.ACA.2020.01.002 2603:6000:D70A:BC00:1C69:20E9:6115:D11D ( talk) 16:15, 19 July 2022 (UTC)
![]() | This is an archive of past discussions. Do not edit the contents of this page. If you wish to start a new discussion or revive an old one, please do so on the current talk page. |
Archive 1 | Archive 2 | Archive 3 |
User:A Real Journalist, about this (which had edit note "updated scientific data") and then this which had edit note "correct citation".
Over the last 15 years, ketamine has been found to be very effective as an antidepressant when administered intravenously in sub-anaesthetic doses. Over 100 independent clinical trials at leading institutions such as The National Institute of Mental Health, The Cleveland Clinic, Mt. Sinai Hospital, Yale University, Stanford University, UCLA, USC, and NYU, have been conducted. Average response rate to Ketamine Infusion Therapy among participants across all the studies is about 70%. In the last 5 years, there has been a significant increase in the number of ketamine clinics in the United States offering the treatment to the general public. [1]
However advancements over the last 15 years show that ketamine has been found to be very effective as an antidepressant when administered intravenously in sub-anaesthetic doses. Over 100 independent clinical trials at leading institutions such as The National Institute of Mental Health, The Cleveland Clinic, Mt. Sinai Hospital, Yale University, Stanford University, UCLA, USC, and NYU, have been conducted. Average response rate to Ketamine Infusion Therapy among participants across all the studies is about 70%. In the last 5 years, there has been a significant increase in the number of ketamine clinics in the United States offering the treatment to the general public. [2]
References
The section of the article where you put this content is "medical use". Content that goes into this section needs to describe medical use, and be sourced per WP:MEDRS, which briefly means a fairly recent literature review published in the biomedical literature, or a statement by a major medical medical or scientific body. The content in that section already describes medical use and the evidence for it, and is sourced to a fairly recent review.
The first source is an interview in NY Magazine and is not MEDRS. The second source is a news piece by the NIH, which is also not a MEDRS source.
The content is also very promotional, and obviously so, and really importantly, not supported by either source. Jytdog ( talk) 00:14, 25 March 2017 (UTC)
Hello fellow Wikipedians,
I have just modified one external link on Ketamine. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
This message was posted before February 2018.
After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than
regular verification using the archive tool instructions below. Editors
have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the
RfC before doing mass systematic removals. This message is updated dynamically through the template {{
source check}}
(last update: 5 June 2024).
Cheers.— InternetArchiveBot ( Report bug) 05:51, 9 December 2017 (UTC)
User:Irapliss, you are making changes only to the WP:LEAD and are using poor refs. Please see the note on your talk page at User_talk:Irapliss#Welcome and the other messages there as well. Jytdog ( talk) 19:50, 4 March 2018 (UTC)
These could be used as references potentially? Doc James ( talk · contribs · email) 05:00, 22 March 2018 (UTC)
Ketamine is not approved for this. Wired is not a good source to support Velasquez-Manoff, Moises (2018-05-08). "Ketamine Stirs Up Hope—and Controversy—as a Depression Drug". Wired. ISSN 1059-1028. Retrieved 2019-04-03.
We have a whole section in the body Ketamine#Depression Doc James ( talk · contribs · email) 20:50, 3 April 2019 (UTC)
This article is a little messy and could do with some rearranging. The medicinal uses part needs some subsections, and some thought might be given to partial merge with the medical research section. — Preceding unsigned comment added by Testem ( talk • contribs) 10:28, 15 January 2014
In the structure subsection of the chemistry section, there is a table which includes axial and equatorial forms of ketamine, equating them to the salt and the free base forms. While chemically this may be true, the ball and stick structures do not show the nitrogen atom with the correct number of hydrogen atoms in covalent linkage. 24.12.7.29 ( talk) 00:37, 9 May 2019 (UTC)
The media (Washington Post, Cosmopolitan, et al) have delivered glowing reviews (repeatedly in the case of the Washington Post) of this drug for depression. These are anecdotal stories of one or more individuals who have a story of remarkable success apparently related to their use of the drug.
However, the following link shows flimsy evidence was used by the FDA to approve this drug for depression:
Moncrieff, J., & Horowitz, M. (2019). Esketamine for treatment-resistant depression. BMJ, 366. DOI: https://doi.org/10.1136/bmj.l5572 (Link)
Also Ketamine is known to be addictive. Here's this:
https://www.independent.co.uk/topic/ketamine
Side effects seem to include depression itself:
Short, B., Fong, J., Galvez, V., Shelker, W., & Loo, C. K. (2017). Side-effects associated with ketamine use in depression: A systematic review. Lancet Psychiatry. http://dx.doi.org/10.1016/ S2215-0366(17)30272-9 — Preceding unsigned comment added by 173.153.152.32 ( talk) 23:40, 29 November 2019 (UTC)
Ref says "The resulting trancelike cataleptic state of “sensory isolation" not dream like. Propofol gives one the nice dreams. Doc James ( talk · contribs · email) 21:50, 11 April 2020 (UTC)
I suggest removing all targets with Ki > 10 mkM from the table. These targets are too weak to lead to any noticeable biological effect, and they make the Table confusing. The same goes about the text on the left from the Table: what is your opinion about removing all references to the targets inhibited with K more that 10 μM ?
The Sceptical Chymist ( talk) 18:12, 26 November 2020 (UTC)
The "Recreational use" section is now duplicated in Ketamine in society and culture, so it should be just summarized here with a "main article" link. MB 01:37, 13 December 2020 (UTC)
Done. The Sceptical Chymist ( talk) 12:58, 13 December 2020 (UTC)
It is an incorrect term. It's not "use", it's recreational "abuse" as is misuse of all Rx medications, especially Scheduled ones. 2603:6000:D70A:BC00:1C69:20E9:6115:D11D ( talk) 14:52, 19 July 2022 (UTC)
More info on ketamine’s use as a date rape drug would be useful, and it likely shouldn’t be included under Recreational Use? 69.42.137.164 ( talk) 00:24, 19 November 2021 (UTC)
A novel trimodal system on a paper-based microfluidic device for on-site detection of the date rape drug “ketamine”
https://doi.org/10.1016/J.ACA.2020.01.002 2603:6000:D70A:BC00:1C69:20E9:6115:D11D ( talk) 16:15, 19 July 2022 (UTC)