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Perhaps having the word YET used more frequently, as well as having as a second point if not the first, a clarification clarifying / a differentiation differentiating between,..
.
1 matched-with-others-in-surpassed-evolutionary-progressions-and-so-redundant(true junk) DNA,
2 assumed-no-function junk from genetic processes (high confidence - temporary retentions kept longer than needed if needing to be kept at all), and
3 theorised to have no function but of more compatible DNA-chemistry -combinations ... junk (ones that have still matching after-activation matching chemistry with organelles or functional materials in plasma/interstitial spaces, but are without 'context' in nearby genes along the chains, and so seem pointless, despite chemical-compatibility. Compared to things like say, immune system instructions or embryonic stages, ones with clear-purpose) (less-confidence / more reasonable uncertainty - the chemistry suggests a high likelyhood if not outright proof, of past usefullness) ...
.
... could help to introduce the concept FIRST?
Rather than finding the contrast or inferred-problems with the single concept or inferred consistency, further down the page, and the static tense (scientific conclusion-ary) avoiding the still-new problems of the field? i.e. using YET, adds necessary cautionary relativity to a solid concept, but a phenomenon that is sometimes irreversibly presumed static.
---
i.e. when something THOUGHT junk, is 'let-back-in', at the PREVIOUS time of it being labelled junk, the static nature was less correct, than saying "YET", so,.. yet-confirmed as junk, or yet-re-included back into unknown status rather than confirmed-junk or certified-junk, etc. A big part of that problem is WHO certifies, but that might end up making the page much larger than it should be if that kind of debate/issue should be on a separate page or is not subjectively purposed - i.e. at least the 'YET' nature of both corrective processes, reveals just HOW-new, this science is. Sort of like if you re-wrote it entirely, and re-wrote it with constant inferred STATUS inferences, to keep reminding the reader, that DNAs classification can rapidly CHANGE, that DNA is only sometimes statically clearly-purposed, nature's IMperfections, compared to imaginary ideals, etc. That's not opinion, that's hard-science. Human DNA for tails, for example, are recent, but HAD function. Tense with it as an example, would be an easy example to demonstrate the principle of CAUTION with DNA's classification as junk or not-junk. 120.21.106.152 ( talk) 15:13, 30 June 2023 (UTC)
Junk DNA is DNA that does not have a function so the entire debate hinges on determining which part of the genome is functional. You can't do that unless you can define function in some meaningful way. The debate over the proper meaning of function is called the "function wars" and since 2012 it has almost exclusively been about the best way to describe a selected effect function. I think the "maintenance" function definition is the best one.
This is 2024. There are no other definitions of function that are actively defended in the scientific literature. The causal role function (biochemical activity) was thoroughly debunked a decade ago and I'm not aware of any serious publication that defends biochemical activity as a viable definition of function. In order for biochemical activity to be a serious contender, there would have to be numerous examples of genuine functional regions of the genome that exhibit biochemical activity but are not under purifying selection. In the absence of such examples, the maintenance function definition covers all examples of genuine biochemical activity plus functional regions that don't exhibit traditional biochemical activity.
Ramos1990 insists on inserting a reference to the ENCODE 2014 paper that casts doubt on the maintenance function by claiming that there are "diverse understandings of 'function' in different fields." The three diverse understandings are genetic, evolutionary, and biochemical.
This is not helpful since we have highlighted the serious shortcomings of biochemical activity as a definition of function and provided references to 10 papers that discuss these shortcomings. There's no good explanation of "genetic" function in this article. (The section under "Genetic function" is useless and should be deleted.) Readers will be left wondering why there are still "diverse understandings" of function when the only one supported by data and logic is the one based on conservation and purifying selection.
The only reason for bringing up biochemical function in this article is to alert readers to the false claim made by the ENCODE researchers in 2012. That claim received such massive coverage in the popular press that there are still many readers (and many scientists) who think that the idea of junk DNA has been abandoned by the experts in the field. By putting undue emphasis on the excuses and rationalizations made by the ENCODE workers in 2014 we are contributing to the misconceptions that they promoted in 2012. Genome42 ( talk) 14:42, 2 May 2024 (UTC)
This section of the article serves no purpose since the important material is covered in the rest of the article. I will delete it in a few days unless there are objections from other editors. Genome42 ( talk) 16:52, 21 May 2024 (UTC)
This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||
|
This page has archives. Sections older than 60 days may be automatically archived by Lowercase sigmabot III when more than 3 sections are present. |
Perhaps having the word YET used more frequently, as well as having as a second point if not the first, a clarification clarifying / a differentiation differentiating between,..
.
1 matched-with-others-in-surpassed-evolutionary-progressions-and-so-redundant(true junk) DNA,
2 assumed-no-function junk from genetic processes (high confidence - temporary retentions kept longer than needed if needing to be kept at all), and
3 theorised to have no function but of more compatible DNA-chemistry -combinations ... junk (ones that have still matching after-activation matching chemistry with organelles or functional materials in plasma/interstitial spaces, but are without 'context' in nearby genes along the chains, and so seem pointless, despite chemical-compatibility. Compared to things like say, immune system instructions or embryonic stages, ones with clear-purpose) (less-confidence / more reasonable uncertainty - the chemistry suggests a high likelyhood if not outright proof, of past usefullness) ...
.
... could help to introduce the concept FIRST?
Rather than finding the contrast or inferred-problems with the single concept or inferred consistency, further down the page, and the static tense (scientific conclusion-ary) avoiding the still-new problems of the field? i.e. using YET, adds necessary cautionary relativity to a solid concept, but a phenomenon that is sometimes irreversibly presumed static.
---
i.e. when something THOUGHT junk, is 'let-back-in', at the PREVIOUS time of it being labelled junk, the static nature was less correct, than saying "YET", so,.. yet-confirmed as junk, or yet-re-included back into unknown status rather than confirmed-junk or certified-junk, etc. A big part of that problem is WHO certifies, but that might end up making the page much larger than it should be if that kind of debate/issue should be on a separate page or is not subjectively purposed - i.e. at least the 'YET' nature of both corrective processes, reveals just HOW-new, this science is. Sort of like if you re-wrote it entirely, and re-wrote it with constant inferred STATUS inferences, to keep reminding the reader, that DNAs classification can rapidly CHANGE, that DNA is only sometimes statically clearly-purposed, nature's IMperfections, compared to imaginary ideals, etc. That's not opinion, that's hard-science. Human DNA for tails, for example, are recent, but HAD function. Tense with it as an example, would be an easy example to demonstrate the principle of CAUTION with DNA's classification as junk or not-junk. 120.21.106.152 ( talk) 15:13, 30 June 2023 (UTC)
Junk DNA is DNA that does not have a function so the entire debate hinges on determining which part of the genome is functional. You can't do that unless you can define function in some meaningful way. The debate over the proper meaning of function is called the "function wars" and since 2012 it has almost exclusively been about the best way to describe a selected effect function. I think the "maintenance" function definition is the best one.
This is 2024. There are no other definitions of function that are actively defended in the scientific literature. The causal role function (biochemical activity) was thoroughly debunked a decade ago and I'm not aware of any serious publication that defends biochemical activity as a viable definition of function. In order for biochemical activity to be a serious contender, there would have to be numerous examples of genuine functional regions of the genome that exhibit biochemical activity but are not under purifying selection. In the absence of such examples, the maintenance function definition covers all examples of genuine biochemical activity plus functional regions that don't exhibit traditional biochemical activity.
Ramos1990 insists on inserting a reference to the ENCODE 2014 paper that casts doubt on the maintenance function by claiming that there are "diverse understandings of 'function' in different fields." The three diverse understandings are genetic, evolutionary, and biochemical.
This is not helpful since we have highlighted the serious shortcomings of biochemical activity as a definition of function and provided references to 10 papers that discuss these shortcomings. There's no good explanation of "genetic" function in this article. (The section under "Genetic function" is useless and should be deleted.) Readers will be left wondering why there are still "diverse understandings" of function when the only one supported by data and logic is the one based on conservation and purifying selection.
The only reason for bringing up biochemical function in this article is to alert readers to the false claim made by the ENCODE researchers in 2012. That claim received such massive coverage in the popular press that there are still many readers (and many scientists) who think that the idea of junk DNA has been abandoned by the experts in the field. By putting undue emphasis on the excuses and rationalizations made by the ENCODE workers in 2014 we are contributing to the misconceptions that they promoted in 2012. Genome42 ( talk) 14:42, 2 May 2024 (UTC)
This section of the article serves no purpose since the important material is covered in the rest of the article. I will delete it in a few days unless there are objections from other editors. Genome42 ( talk) 16:52, 21 May 2024 (UTC)