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This article was the subject of a Wiki Education Foundation-supported course assignment, between 10 September 2020 and 15 December 2020. Further details are available
on the course page. Student editor(s):
Smazuera. Peer reviewers:
Ncneurowiki.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 21:01, 17 January 2022 (UTC)
I did a search on PGC1 and found PPARGC1A which it says is also called PGC-1alpha. However, as that article is about genetics, and not being an expert in this area, I would appreciate someone else taking a look and seeing if it would be an appropriate link. Thanks. Derek Andrews ( talk) 14:31, 16 January 2012 (UTC)
It seems hard to believe that somebody came up with an exercise pill a full year ago, and no further research has happened since (January 2012). — Darxus ( talk) 19:31, 2 January 2013 (UTC)
This article is based heavily off one source and surrounding press articles and this paper in Nature casts doubt on the original research. Until someone can update the article to include this, the article needs a {{ disputed}} tag. SmartSE ( talk) 17:21, 4 April 2013 (UTC)
Additional critique of the experimental basis of the irisin story is published in the journal Adipocyte, volume 2 issue 4 (Aug. 19, 2013) https://www.landesbioscience.com/journals/adipocyte/article/26082/ “Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor?” by Harold P Erickson HPErickson ( talk) 21:08, 21 August 2013 (UTC)
The irisin story is continuing its downward flight. A recent paper pursued the "unusual start codon" of human FNDC5, the parent of irisin (it starts with ATA instead of the ATG that starts almost all proteins). Raschke et al (1) report that mRNA starting with the ATA is hardly translated at all. That means that humans essentially don't make FNDC5 protein, and don't have any irisin. 1. Raschke S, Elsen M, Gassenhuber H, Sommerfeld M, Schwahn U, Brockmann B, Jung R, Wisloff U, Tjonna AE, Raastad T, Hallen J, Norheim F, Drevon CA, Romacho T, Eckardt K, Eckel J. Evidence against a Beneficial Effect of Irisin in Humans. PLoS One 2013;8:e73680 — Preceding unsigned comment added by HPErickson ( talk • contribs) 20:42, 8 November 2013 (UTC)
Was reading this August 2014 article about Cold Therapy and it mentions:
Does anyone know of any studies confirming these claims? Ranze ( talk) 01:49, 23 August 2014 (UTC)
Given the controversial nature of this topic, it is inappropriate for researchers to be citing their own publications per WP:SELFCITE. Unfortunately it appears that HPErickson ( talk · contribs) has already done so, although it is a review article that is highly cited so not overly problematic. Recently, Mjedrych1 ( talk · contribs) added a piece of primary research which has only just been published and after it was removed then seemingly edited as an IP instead: [1]. I will be reverting this addition and would ask that anybody involved in research on FNDC5 requests review of any additions from uninvolved editors such as myself before editing the article. SmartSE ( talk) 17:36, 25 August 2015 (UTC)
![]() | This article is rated Start-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||
|
This article was the subject of a Wiki Education Foundation-supported course assignment, between 10 September 2020 and 15 December 2020. Further details are available
on the course page. Student editor(s):
Smazuera. Peer reviewers:
Ncneurowiki.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 21:01, 17 January 2022 (UTC)
I did a search on PGC1 and found PPARGC1A which it says is also called PGC-1alpha. However, as that article is about genetics, and not being an expert in this area, I would appreciate someone else taking a look and seeing if it would be an appropriate link. Thanks. Derek Andrews ( talk) 14:31, 16 January 2012 (UTC)
It seems hard to believe that somebody came up with an exercise pill a full year ago, and no further research has happened since (January 2012). — Darxus ( talk) 19:31, 2 January 2013 (UTC)
This article is based heavily off one source and surrounding press articles and this paper in Nature casts doubt on the original research. Until someone can update the article to include this, the article needs a {{ disputed}} tag. SmartSE ( talk) 17:21, 4 April 2013 (UTC)
Additional critique of the experimental basis of the irisin story is published in the journal Adipocyte, volume 2 issue 4 (Aug. 19, 2013) https://www.landesbioscience.com/journals/adipocyte/article/26082/ “Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor?” by Harold P Erickson HPErickson ( talk) 21:08, 21 August 2013 (UTC)
The irisin story is continuing its downward flight. A recent paper pursued the "unusual start codon" of human FNDC5, the parent of irisin (it starts with ATA instead of the ATG that starts almost all proteins). Raschke et al (1) report that mRNA starting with the ATA is hardly translated at all. That means that humans essentially don't make FNDC5 protein, and don't have any irisin. 1. Raschke S, Elsen M, Gassenhuber H, Sommerfeld M, Schwahn U, Brockmann B, Jung R, Wisloff U, Tjonna AE, Raastad T, Hallen J, Norheim F, Drevon CA, Romacho T, Eckardt K, Eckel J. Evidence against a Beneficial Effect of Irisin in Humans. PLoS One 2013;8:e73680 — Preceding unsigned comment added by HPErickson ( talk • contribs) 20:42, 8 November 2013 (UTC)
Was reading this August 2014 article about Cold Therapy and it mentions:
Does anyone know of any studies confirming these claims? Ranze ( talk) 01:49, 23 August 2014 (UTC)
Given the controversial nature of this topic, it is inappropriate for researchers to be citing their own publications per WP:SELFCITE. Unfortunately it appears that HPErickson ( talk · contribs) has already done so, although it is a review article that is highly cited so not overly problematic. Recently, Mjedrych1 ( talk · contribs) added a piece of primary research which has only just been published and after it was removed then seemingly edited as an IP instead: [1]. I will be reverting this addition and would ask that anybody involved in research on FNDC5 requests review of any additions from uninvolved editors such as myself before editing the article. SmartSE ( talk) 17:36, 25 August 2015 (UTC)