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(the first few posts of this thread were originally on A.Z.'s talk page, but he thought it was better that the discussion continue here)
Hi A.Z., Thanks for your recent edits to the opening paragraph of the integrin article. I noticed you reverted the article straight back to your version when someone undid your changes. I'm sorry and I don't mean to upset you in any way but the version before you made changes was better. Someone (i.e. myself) could spend time improving on your edits, but I think the result would be an opening paragraph similar to the original, which you were not happy with. In the interest of heading of an editing war before it starts, how can we resolve this? Maybe switch back to the original opening paragraph (before your edits) and any points you think need clarifying we'll discuss either here or on the integrin talk page. cheers K.murphy 08:09, 14 August 2007 (UTC)
I agree with A.Z. that intros should be written for a general audience, and not assume that readers are already familiar with the terms and concepts used. If a simple explanation (say one line) of each term can be included directly in the article, it should be (with the link still retained for those who want the full details). The problem with clicking on links for explanations is that those articles may in turn require clicking on links to understand them, and those subsequent articles may require the same, etc. Thus, the poor reader is sent down an infinite chain due to the lack of a simple explanation for each term. Also, there are the concerns of those going off printed copies, and those with slow computers who won't want to load dozens of other pages in an attempt to understand this article. Some of A.Z.'s edits needed a few English fixes, and some removal of duplication, which I've now made. Hopefully, we now have a reasonable compromise between brevity and comprehension by a general audience.
One other comment, intros are intended for a general audience, so technical concepts which will not be understood by the average reader should be moved from the intro to the body of the article. We may want to do some of that here. StuRat 08:25, 16 August 2007 (UTC)
Dear enwiki collegues, a group of us is translating this article in Italian language for itwiki, but we cannot understand this phrase: Experimental evidence indicates that integrins can be released from attaching the cell to the substrate near the back of the cell . Please, could you explain what the back of the cell mean, and write the entire concept in other words? Alternatively (or in addition) could you link us to a site were this interesting process is graphically showed? Thank you, sorry for my bad English -- Corneliae 15:40, 6 September 2007 (UTC)
During cell migration, cells have a front and a back, like a boat. Part of the process of movement is to detach the back from the substrate so that the cell can move forward. Since it is integrins which anchor the cell to the substrate, they need to be released here. A useful analogy is a caterpillar track, with the vehicle being like the cell, and the plates of the track being like integrin molecules: the vehicle moves forward by putting down new plates at the front, pulling itself over them (while the plates remain stationary), and then lifting them up at the back (and then sending them back to the front to be put down again). As i understand it, the release happens by switching off the signals which promote adhesion complex formation, and then applying tension generated by actin-myosin contraction to literally pull the adhesions off the substrate. There's then endocytosis to recover the integrins and other molecules from the plasma membrane, ready for reuse. There is also some cleavage of integrins by calpain, but i think that's for signalling rather than degradation. -- Tom Anderson 2008-01-02 14:09 +0000 —Preceding unsigned comment added by 128.40.81.141 ( talk)
doi:10.1182/blood-2011-04-29212 - in Blood JFW | T@lk 19:45, 5 January 2012 (UTC)
Font on table of human integrins is too large is the reason it looks folded over on itself. WikiHelpChat says post problem here.
IiKkEe ( talk) 15:50, 9 May 2014 (UTC)
I came here to learn something - and I did - but I noticed no Talk in 6 years and no editing in a long time. I also found the page in need of improvements, and took about 30 minutes to clean up the first few paragraphs, but I need to move on for now. Here's a to do list for me later, or anyone who agrees to tackle:
Will flag "needs improvement"
IiKkEe ( talk) 18:06, 9 May 2014 (UTC)
Hello fellow Wikipedians,
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The PDF for this page doesn't have the right layout and format. Rnaactivation ( talk) 06:51, 17 April 2023 (UTC)
This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||||
|
(the first few posts of this thread were originally on A.Z.'s talk page, but he thought it was better that the discussion continue here)
Hi A.Z., Thanks for your recent edits to the opening paragraph of the integrin article. I noticed you reverted the article straight back to your version when someone undid your changes. I'm sorry and I don't mean to upset you in any way but the version before you made changes was better. Someone (i.e. myself) could spend time improving on your edits, but I think the result would be an opening paragraph similar to the original, which you were not happy with. In the interest of heading of an editing war before it starts, how can we resolve this? Maybe switch back to the original opening paragraph (before your edits) and any points you think need clarifying we'll discuss either here or on the integrin talk page. cheers K.murphy 08:09, 14 August 2007 (UTC)
I agree with A.Z. that intros should be written for a general audience, and not assume that readers are already familiar with the terms and concepts used. If a simple explanation (say one line) of each term can be included directly in the article, it should be (with the link still retained for those who want the full details). The problem with clicking on links for explanations is that those articles may in turn require clicking on links to understand them, and those subsequent articles may require the same, etc. Thus, the poor reader is sent down an infinite chain due to the lack of a simple explanation for each term. Also, there are the concerns of those going off printed copies, and those with slow computers who won't want to load dozens of other pages in an attempt to understand this article. Some of A.Z.'s edits needed a few English fixes, and some removal of duplication, which I've now made. Hopefully, we now have a reasonable compromise between brevity and comprehension by a general audience.
One other comment, intros are intended for a general audience, so technical concepts which will not be understood by the average reader should be moved from the intro to the body of the article. We may want to do some of that here. StuRat 08:25, 16 August 2007 (UTC)
Dear enwiki collegues, a group of us is translating this article in Italian language for itwiki, but we cannot understand this phrase: Experimental evidence indicates that integrins can be released from attaching the cell to the substrate near the back of the cell . Please, could you explain what the back of the cell mean, and write the entire concept in other words? Alternatively (or in addition) could you link us to a site were this interesting process is graphically showed? Thank you, sorry for my bad English -- Corneliae 15:40, 6 September 2007 (UTC)
During cell migration, cells have a front and a back, like a boat. Part of the process of movement is to detach the back from the substrate so that the cell can move forward. Since it is integrins which anchor the cell to the substrate, they need to be released here. A useful analogy is a caterpillar track, with the vehicle being like the cell, and the plates of the track being like integrin molecules: the vehicle moves forward by putting down new plates at the front, pulling itself over them (while the plates remain stationary), and then lifting them up at the back (and then sending them back to the front to be put down again). As i understand it, the release happens by switching off the signals which promote adhesion complex formation, and then applying tension generated by actin-myosin contraction to literally pull the adhesions off the substrate. There's then endocytosis to recover the integrins and other molecules from the plasma membrane, ready for reuse. There is also some cleavage of integrins by calpain, but i think that's for signalling rather than degradation. -- Tom Anderson 2008-01-02 14:09 +0000 —Preceding unsigned comment added by 128.40.81.141 ( talk)
doi:10.1182/blood-2011-04-29212 - in Blood JFW | T@lk 19:45, 5 January 2012 (UTC)
Font on table of human integrins is too large is the reason it looks folded over on itself. WikiHelpChat says post problem here.
IiKkEe ( talk) 15:50, 9 May 2014 (UTC)
I came here to learn something - and I did - but I noticed no Talk in 6 years and no editing in a long time. I also found the page in need of improvements, and took about 30 minutes to clean up the first few paragraphs, but I need to move on for now. Here's a to do list for me later, or anyone who agrees to tackle:
Will flag "needs improvement"
IiKkEe ( talk) 18:06, 9 May 2014 (UTC)
Hello fellow Wikipedians,
I have just modified one external link on Integrin. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
This message was posted before February 2018.
After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than
regular verification using the archive tool instructions below. Editors
have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the
RfC before doing mass systematic removals. This message is updated dynamically through the template {{
source check}}
(last update: 5 June 2024).
Cheers.— InternetArchiveBot ( Report bug) 14:50, 14 November 2017 (UTC)
The PDF for this page doesn't have the right layout and format. Rnaactivation ( talk) 06:51, 17 April 2023 (UTC)