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A function section would be appreciated. 216.75.114.13 ( talk) 14:40, 13 December 2022 (UTC) reply

I think some better sources are required for this. In the "Synthesis and circulation" section it states there are 6 IGF-1 binding proteins (the source cited nearby talks about something else though, so this specific claim appears to be unsourced), and in the "Mechanism of action" section it states there are 7 binding proteins (this claim has a tag saying a medical citation is needed). I haven't got time at the moment to do a deep dive into the literature to find a source that confirms what the actual number is (nothing on the first search pages on PubMed or Google Scholar) so hopefully someone has a reliable source handy. Lumberjane Lilly ( talk) 18:57, 18 December 2023 (UTC) reply

@ Bendegúz Ács: why do we mention the association in the lead as it's not causal per this paper (already cited)? a455bcd9 (Antoine) ( talk) 19:37, 20 May 2024 (UTC) reply

The lead is summary of the contents of the article (see MOS:LEAD). The sentence in question is a summary of the Health effects section, which states that low levels are associated with an increased risk of CVD. This content is based on this reference [1], which is fully WP:MEDRS-compliant. Now the paper you linked is just a primary study, so it should not have the same weight as this systematic review and meta-analysis, i.e. a fully WP:MEDRS-compliant source. See WP:MEDASSESS for more information on the distinction and how to use studies representing different quality of evidence. The Mendelian randomisation study does not contradict any claim regarding the health effects of low IGF-1 levels:

Another shortcoming is that we could not investigate whether there is a U- or J-shaped relationship between IGF-1 levels and cardiometabolic diseases and insulin resistance, as suggested by a few observational studies

Bendegúz Ács ( talk) 19:56, 20 May 2024 (UTC) reply

Got it, thanks. a455bcd9 (Antoine) ( talk) 20:14, 20 May 2024 (UTC) reply