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Beginning with "Although IgE is typically the ..." This whole paragraph is a single sentence packed with a broad variety of punctuation. As a reader who is not formally skilled in Immunology, it makes comprehension between difficult and onward to impossible.
Someone has greatly expanded the article, but it is now almost exclusively about allergy. Scientific articles in this field should really follow the form (1) Physiology (normal function), (2) Genetics/molecular biology (ultrastructure and DNA), (3) Role in disease (allergy, in this case), (4) Therapeutic role (e.g. cromoglycate or omalizumab).
In its present form, the article is off-balance. Could the new contributor kindly do some tidying up and avoid speculation as much as possible? JFW | T@lk 21:26, 8 October 2005 (UTC)
The source quoting Lichtenstein and Norman is not about the IgE discovery, but a type of myeloma. All sources indicate 2 teams: Johansson & Bennich and Ishizaka's team. I took the liberty to edit the portion on the discovery. Cheers, BatteryIncluded ( talk) 01:48, 27 February 2016 (UTC)
References
Can someone, not necessarily an expert, please rewrite this run on sentence;
"IgE that can specifically recognise an "allergen" (typically this is a protein, such as dust mite DerP1, cat FelD1, grass or ragweed pollen, etc.) has a unique long-lived interaction with its high-affinity receptor FcεRI so that basophils and mast cells, capable of mediating inflammatory reactions, become "primed", ready to release chemicals like histamine, leukotrienes, and certain interleukins, which cause many of the symptoms we associate with allergy, such as airway constriction in asthma, local inflammation in eczema, increased mucus secretion in allergic rhinitis, and increased vascular permeability, it is presumed, to allow other immune cells to gain access to tissues, but which can lead to a potentially fatal drop in blood pressure as in anaphylaxis."
Thanks very much
220.101.92.34 (
talk). —Preceding
undated comment added 07:50, 11 May 2011 (UTC).
i added a citation needed label to the value that's already in the article.
i spent a long time googling and haven't found any quotes of "normal" levels (neither with nor without a description of how many standard deviations "normal" actually means!).
If somebody can find this, then we could add one or both of the following refs and also give the value in IU/mL (or kIU/L, which is the same thing). The conversion according to these two references is: 1 IU/mL = 1kIU/L = 2.44 ng/mL. The polish reference gives 2.44, the US one 2.4, so presumably the polish one just goes to higher precision and the US one is a rougher approximation.
These would put 75 ng/mL = 30.7 kIU/L or 31 kIU/L to keep about the same level of precision.
However, until we get a reference, i don't see much point in adding the kIU/L value.
Boud ( talk) 19:32, 7 August 2008 (UTC)
This hardly seems relevant - when its there with out further introduction?
"In 1975, Robert N. Hamburger, M.D. published "Peptide Inhibition of the P-K Reaction" based on blocking up to 89% of the IgE receptors on mast cells by the pentapeptide representing amino acids 320 to 324 on the epsilon chain of IgE.[13] Confirming the IgE binding site, in 1979 he published in Immunology "Inhibition of IgE binding to tissue culture cells and leucocytes by pentapeptide" (ref).
I'll remove unless someone objects? — Preceding unsigned comment added by Radicularia ( talk • contribs) 21:25, 4 March 2012 (UTC)
This article is full of technical terms, explained only by links to other pages, which themselves are full of other technical terms. This page may (?) be well written for biologists and doctors. Someone please make it accessible by the average parent who is looking up information for their hyperallergic children. I do *NOT* mean to "dum it down". Make it as comprehensive as possible. Just leave some of it within reach of non-experts. 69.247.14.176 17:17, 5 February 2015 (UTC)
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I don't see in the article any meaningful explanation of the production of IgEs. There's a graphic and a few allusions to the fact that they are specific to specific antigens, and I'd be curious to have more information about how that comes to be. Unfortunately I don't have the knowledge to add this myself, but if someone else would be able to add it would be appreciated! zplizzi ( talk) 16:30, 14 September 2022 (UTC)
This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||
|
Beginning with "Although IgE is typically the ..." This whole paragraph is a single sentence packed with a broad variety of punctuation. As a reader who is not formally skilled in Immunology, it makes comprehension between difficult and onward to impossible.
Someone has greatly expanded the article, but it is now almost exclusively about allergy. Scientific articles in this field should really follow the form (1) Physiology (normal function), (2) Genetics/molecular biology (ultrastructure and DNA), (3) Role in disease (allergy, in this case), (4) Therapeutic role (e.g. cromoglycate or omalizumab).
In its present form, the article is off-balance. Could the new contributor kindly do some tidying up and avoid speculation as much as possible? JFW | T@lk 21:26, 8 October 2005 (UTC)
The source quoting Lichtenstein and Norman is not about the IgE discovery, but a type of myeloma. All sources indicate 2 teams: Johansson & Bennich and Ishizaka's team. I took the liberty to edit the portion on the discovery. Cheers, BatteryIncluded ( talk) 01:48, 27 February 2016 (UTC)
References
Can someone, not necessarily an expert, please rewrite this run on sentence;
"IgE that can specifically recognise an "allergen" (typically this is a protein, such as dust mite DerP1, cat FelD1, grass or ragweed pollen, etc.) has a unique long-lived interaction with its high-affinity receptor FcεRI so that basophils and mast cells, capable of mediating inflammatory reactions, become "primed", ready to release chemicals like histamine, leukotrienes, and certain interleukins, which cause many of the symptoms we associate with allergy, such as airway constriction in asthma, local inflammation in eczema, increased mucus secretion in allergic rhinitis, and increased vascular permeability, it is presumed, to allow other immune cells to gain access to tissues, but which can lead to a potentially fatal drop in blood pressure as in anaphylaxis."
Thanks very much
220.101.92.34 (
talk). —Preceding
undated comment added 07:50, 11 May 2011 (UTC).
i added a citation needed label to the value that's already in the article.
i spent a long time googling and haven't found any quotes of "normal" levels (neither with nor without a description of how many standard deviations "normal" actually means!).
If somebody can find this, then we could add one or both of the following refs and also give the value in IU/mL (or kIU/L, which is the same thing). The conversion according to these two references is: 1 IU/mL = 1kIU/L = 2.44 ng/mL. The polish reference gives 2.44, the US one 2.4, so presumably the polish one just goes to higher precision and the US one is a rougher approximation.
These would put 75 ng/mL = 30.7 kIU/L or 31 kIU/L to keep about the same level of precision.
However, until we get a reference, i don't see much point in adding the kIU/L value.
Boud ( talk) 19:32, 7 August 2008 (UTC)
This hardly seems relevant - when its there with out further introduction?
"In 1975, Robert N. Hamburger, M.D. published "Peptide Inhibition of the P-K Reaction" based on blocking up to 89% of the IgE receptors on mast cells by the pentapeptide representing amino acids 320 to 324 on the epsilon chain of IgE.[13] Confirming the IgE binding site, in 1979 he published in Immunology "Inhibition of IgE binding to tissue culture cells and leucocytes by pentapeptide" (ref).
I'll remove unless someone objects? — Preceding unsigned comment added by Radicularia ( talk • contribs) 21:25, 4 March 2012 (UTC)
This article is full of technical terms, explained only by links to other pages, which themselves are full of other technical terms. This page may (?) be well written for biologists and doctors. Someone please make it accessible by the average parent who is looking up information for their hyperallergic children. I do *NOT* mean to "dum it down". Make it as comprehensive as possible. Just leave some of it within reach of non-experts. 69.247.14.176 17:17, 5 February 2015 (UTC)
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Immunoglobulin E. Please take a moment to review
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Cheers. — cyberbot II Talk to my owner:Online 12:37, 19 October 2015 (UTC)
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Cheers.— InternetArchiveBot ( Report bug) 18:02, 9 April 2017 (UTC)
I don't see in the article any meaningful explanation of the production of IgEs. There's a graphic and a few allusions to the fact that they are specific to specific antigens, and I'd be curious to have more information about how that comes to be. Unfortunately I don't have the knowledge to add this myself, but if someone else would be able to add it would be appreciated! zplizzi ( talk) 16:30, 14 September 2022 (UTC)