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This article was the subject of a Wiki Education Foundation-supported course assignment, between 10 January 2022 and 27 April 2022. Further details are available
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Suggested template for Orthopaedic Conditions (see
Talk:Orthopedic surgery) is
Name
Definition
Synonyms
Incidence
Pathogenesis
Pathology
Stages
Classification
Natural History/Untreated Prognosis
Clinical Features
Investigation
Non-Operative Treatment
Risks of Non-Operative Treatment
Prognosis following Non-Operative Treatment
Operative Treatment (Note that each operations should have its own wiki entry)
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Complications
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--
Mylesclough
05:38, 8 October 2005 (UTC)
This site says 2,500 have been reported (1 in 2,000,000) to date. The most recent date is April 23, 2006.
http://www.usbjd.org/projects/project_op.cfm?dirID=142
Stovetopcookies 08:35, 16 May 2006 (UTC)
Site is incorrect. Number is based on projection based on world population. Registry maintained by IFOPA is considerably less. —Preceding unsigned comment added by 70.123.135.58 ( talk) 05:58, 21 July 2008 (UTC)
This disease was features in today's Qwantz would it be appropriate to create a Popular Culture section and mention it?
No. I came here because of the mention in Qwantz as well, but I don't think that nearly relevant Njerseyguy 20:20, 14 January 2007 (UTC).
The article on myositis ossificans says that the ossification in the progressiva type of myositis ossificans (which this article refers to as fibrodysplasia ossificans progressiva) does not require injury, and develops in a predictable pattern, which seems to contradict this article. Can anyone help clear this up? Dancter 22:55, 9 June 2006 (UTC)
A quick but much better source to check out on emedicie.medscape.com re fibrodysplasia ossificans progressiva or the hereditary form of myositis ossificans : http://emedicine.medscape.com/article/1007104-overview. —Preceding unsigned comment added by Kristalywiki ( talk • contribs) 06:22, 13 March 2009 (UTC)
Note that the info from Discovery disagrees with the 'Statistics' above. Until someone finds a published source, please stop reverting unconfirmable information you saw on cable. Cable show are not good sources for an encyclopedia. —The preceding unsigned comment was added by Lord Kelvin ( talk • contribs) 01:17, 22 June 2006 (UTC)
In the study by Gannon (entitled "Mast Cell involvment in fibrodysplasia ossificans progressiva") formation of lesions in this disease are linked to activation of inflammitory mast cells. This means any injury resulting in inflammation and therefore activation of mast cells can trigger the formation of bone. This disease is not however caused by injury and has usually been found to follow a classical endochondral ossification pathway found in developing embryo. For more info read the article "Transgenic Mice Overexpressing BMP4 Develop a Fibrodysplasia Ossificans Progressiva-Like Phenotype" by Lixin Kan. —Preceding
unsigned comment added by
134.50.25.59 (
talk)
23:46, 26 September 2007 (UTC)
i have seen this spelled fibrodysplasia ossificans progessiva,
progessiva instead of progressiva. can anyone verify this?
Jbpanther20 00:00, 29 August 2006 (UTC)jbpanther20
Sounds to me like it's simply a misspelling. WizardofOskemen 22:24, 19 October 2006 (UTC)
Yea, "progressiva" refers to the progressive nature of the disease. See the International Fibrodysplasia Ossificans Progressiva Association webpage. Njerseyguy 20:23, 14 January 2007 (UTC)
A haunting picture of Harry Eastwick appears side by side with his skeleton (post mortem) is available here (google image frame. The original page is here. Anyone with some time might want to add the photo or at least link to it. Njerseyguy
On a side note, I can't spell worth a damn Njerseyguy 20:27, 14 January 2007 (UTC)
Spelling corrected and noted that the first shot is not a cadever
70.123.129.246 ( talk) 22:34, 20 January 2008 (UTC)Steve Eichner 70.123.129.246 ( talk) 22:34, 20 January 2008 (UTC)
It can be seen full size here. Captain Gamma ( talk) 18:44, 16 April 2009 (UTC)
^ ^^ ^^^ ^^^^^ NEVER MIND. all the image links above are dead. there, i saved you 5 minutes of life. Cramyourspam ( talk) 21:17, 22 July 2020 (UTC)
The "cases" section of this article starts talking about someone named "Mr. Eastlack." The second paragraph starts referring to someone who can only move their lips, but never says their name. The third paragraph mentions a "Mr. Eastlack." Is Mr. Eastlack the person from the second paragraph? Does Mr. Eastlack have a full name? Is he worth mentioning? Please, REWRITE THIS SECTION.
(No, I'm not a real doctor)
Dr. Mordecai 01:48, 23 March 2007 (UTC)
Harry Eastlack is the individual's name. The current Wiki entry inidicates this
70.123.129.246 ( talk) 22:35, 20 January 2008 (UTC)Steve Eichner 70.123.129.246 ( talk) 22:35, 20 January 2008 (UTC)
Discovery Health Channel ran a documentary on FOP a few years ago, titled "Skeleton Key". It opened with video of Eastlack's deformed skeleton.
The entire "Cases" section doesn't have any referrences. I would suggest citing the Mutter museum website, which has a brief description of the specimen and an image, but as I am inexperienced in Wiki formatting I'll leave that to someone else. The part about accounts in the 1800s might need to be removed--there's accounts of human petrification in the Bible, for one thing, and for another without any sources at all this seems irrelevant. —Preceding unsigned comment added by 66.245.93.148 ( talk) 22:02, 29 January 2008 (UTC)
"Injuries from falling can provoke the bone growth and should be avoided." Is this really necessary? I think 10 out of 10 doctors recommend not falling, even for those not affected by FOP. -- MacAddct 1984 ( talk • contribs) 15:15, 5 May 2008 (UTC)
I don't understand why doctors can't just take some recombinant rat BMP4, mix it up in an adjuvant, and inject it into these people until they develop an autoimmune response. Is anyone working on this? Wnt ( talk) 01:36, 7 May 2009 (UTC)
{{editsemiprotected}}
Please change the following sentence in the "Symptoms" paragraph: "The gene that causes ossification is normally deactivated after a fetus' bones are formed in the nutsack, but in patients with FOP, the gene keeps working." The word "nutsack" should be changed to "uterus."
Cchen91765 ( talk) 16:01, 28 March 2010 (UTC)
Done Welcome and thanks for pointing this out. I returned the text to 'womb', since that was the text prior to the vandalism. If you would prefer 'uterus', let me know and I will change it.
Celestra (
talk)
16:33, 28 March 2010 (UTC)
What happened to the picture of Harry Eastlack's skeleton? 71.192.108.214 ( talk) 00:40, 23 June 2011 (UTC)
Can someone find a better figure to use under genetics. To someone unfamiliar with that type of spectra like myself I found it very confusing that the peak colors didn’t match their assigned nucleotide and the most important base just looks like noise or a null peak. There are much more elegant and intuitive ways to visualize a point mutation and as a common phenomenon a more appropriate visual probably either already exists or would just take editing a couple letters.
In the "Skeleton Key" documentary it was stated that the white blood cells deposit BMP4 into sites of injury, which promotes conversion of tissue to bone. Seems to me the obvious treatment is to "nuke and pave" by destroying the source of the malfunctioning lymphocytes and replacing it, same as is done for other disorders caused by bad bone marrow. As has been done with leukemia, a method of sorting and culturing marrow cells without the defect would allow an autograft and no need for anti rejection drugs. Once the progression is stopped it woul be possible to do surgery to remove the bone growths. 174.145.244.98 ( talk) 11:54, 4 March 2012 (UTC)
This article has severe sourcing issues. News articles etc are not suitable. All medical content on wikipedia should be sourced per WP:MEDRS. I will tag the sources that need to go for now. Lesion ( talk) 10:58, 26 August 2013 (UTC)
The IFOPA website has a problem, and I have removed all links to it from Wikipedia until the issue is resolved. See Wikipedia talk:WikiProject Spam/2013 Archive Jan 1#International Fibrodysplasia Ossificans Progressiva Association for details. -- Guy Macon ( talk) 08:14, 8 November 2015 (UTC)
The ifopa’s website issue has long been resolved Eichners ( talk) 06:06, 8 July 2021 (UTC)
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![]() | This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||
|
![]() | Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Fibrodysplasia ossificans progressiva.
|
![]() | This article has been viewed enough times in a single week to appear in the
Top 25 Report. The week in which this happened:
|
This article was the subject of a Wiki Education Foundation-supported course assignment, between 10 January 2022 and 27 April 2022. Further details are available
on the course page. Student editor(s):
MaherJankiss (
article contribs).
Suggested template for Orthopaedic Conditions (see
Talk:Orthopedic surgery) is
Name
Definition
Synonyms
Incidence
Pathogenesis
Pathology
Stages
Classification
Natural History/Untreated Prognosis
Clinical Features
Investigation
Non-Operative Treatment
Risks of Non-Operative Treatment
Prognosis following Non-Operative Treatment
Operative Treatment (Note that each operations should have its own wiki entry)
Risks of Operative Treatment
Prognosis Post Operation
Complications
Management
Prevention
History
--
Mylesclough
05:38, 8 October 2005 (UTC)
This site says 2,500 have been reported (1 in 2,000,000) to date. The most recent date is April 23, 2006.
http://www.usbjd.org/projects/project_op.cfm?dirID=142
Stovetopcookies 08:35, 16 May 2006 (UTC)
Site is incorrect. Number is based on projection based on world population. Registry maintained by IFOPA is considerably less. —Preceding unsigned comment added by 70.123.135.58 ( talk) 05:58, 21 July 2008 (UTC)
This disease was features in today's Qwantz would it be appropriate to create a Popular Culture section and mention it?
No. I came here because of the mention in Qwantz as well, but I don't think that nearly relevant Njerseyguy 20:20, 14 January 2007 (UTC).
The article on myositis ossificans says that the ossification in the progressiva type of myositis ossificans (which this article refers to as fibrodysplasia ossificans progressiva) does not require injury, and develops in a predictable pattern, which seems to contradict this article. Can anyone help clear this up? Dancter 22:55, 9 June 2006 (UTC)
A quick but much better source to check out on emedicie.medscape.com re fibrodysplasia ossificans progressiva or the hereditary form of myositis ossificans : http://emedicine.medscape.com/article/1007104-overview. —Preceding unsigned comment added by Kristalywiki ( talk • contribs) 06:22, 13 March 2009 (UTC)
Note that the info from Discovery disagrees with the 'Statistics' above. Until someone finds a published source, please stop reverting unconfirmable information you saw on cable. Cable show are not good sources for an encyclopedia. —The preceding unsigned comment was added by Lord Kelvin ( talk • contribs) 01:17, 22 June 2006 (UTC)
In the study by Gannon (entitled "Mast Cell involvment in fibrodysplasia ossificans progressiva") formation of lesions in this disease are linked to activation of inflammitory mast cells. This means any injury resulting in inflammation and therefore activation of mast cells can trigger the formation of bone. This disease is not however caused by injury and has usually been found to follow a classical endochondral ossification pathway found in developing embryo. For more info read the article "Transgenic Mice Overexpressing BMP4 Develop a Fibrodysplasia Ossificans Progressiva-Like Phenotype" by Lixin Kan. —Preceding
unsigned comment added by
134.50.25.59 (
talk)
23:46, 26 September 2007 (UTC)
i have seen this spelled fibrodysplasia ossificans progessiva,
progessiva instead of progressiva. can anyone verify this?
Jbpanther20 00:00, 29 August 2006 (UTC)jbpanther20
Sounds to me like it's simply a misspelling. WizardofOskemen 22:24, 19 October 2006 (UTC)
Yea, "progressiva" refers to the progressive nature of the disease. See the International Fibrodysplasia Ossificans Progressiva Association webpage. Njerseyguy 20:23, 14 January 2007 (UTC)
A haunting picture of Harry Eastwick appears side by side with his skeleton (post mortem) is available here (google image frame. The original page is here. Anyone with some time might want to add the photo or at least link to it. Njerseyguy
On a side note, I can't spell worth a damn Njerseyguy 20:27, 14 January 2007 (UTC)
Spelling corrected and noted that the first shot is not a cadever
70.123.129.246 ( talk) 22:34, 20 January 2008 (UTC)Steve Eichner 70.123.129.246 ( talk) 22:34, 20 January 2008 (UTC)
It can be seen full size here. Captain Gamma ( talk) 18:44, 16 April 2009 (UTC)
^ ^^ ^^^ ^^^^^ NEVER MIND. all the image links above are dead. there, i saved you 5 minutes of life. Cramyourspam ( talk) 21:17, 22 July 2020 (UTC)
The "cases" section of this article starts talking about someone named "Mr. Eastlack." The second paragraph starts referring to someone who can only move their lips, but never says their name. The third paragraph mentions a "Mr. Eastlack." Is Mr. Eastlack the person from the second paragraph? Does Mr. Eastlack have a full name? Is he worth mentioning? Please, REWRITE THIS SECTION.
(No, I'm not a real doctor)
Dr. Mordecai 01:48, 23 March 2007 (UTC)
Harry Eastlack is the individual's name. The current Wiki entry inidicates this
70.123.129.246 ( talk) 22:35, 20 January 2008 (UTC)Steve Eichner 70.123.129.246 ( talk) 22:35, 20 January 2008 (UTC)
Discovery Health Channel ran a documentary on FOP a few years ago, titled "Skeleton Key". It opened with video of Eastlack's deformed skeleton.
The entire "Cases" section doesn't have any referrences. I would suggest citing the Mutter museum website, which has a brief description of the specimen and an image, but as I am inexperienced in Wiki formatting I'll leave that to someone else. The part about accounts in the 1800s might need to be removed--there's accounts of human petrification in the Bible, for one thing, and for another without any sources at all this seems irrelevant. —Preceding unsigned comment added by 66.245.93.148 ( talk) 22:02, 29 January 2008 (UTC)
"Injuries from falling can provoke the bone growth and should be avoided." Is this really necessary? I think 10 out of 10 doctors recommend not falling, even for those not affected by FOP. -- MacAddct 1984 ( talk • contribs) 15:15, 5 May 2008 (UTC)
I don't understand why doctors can't just take some recombinant rat BMP4, mix it up in an adjuvant, and inject it into these people until they develop an autoimmune response. Is anyone working on this? Wnt ( talk) 01:36, 7 May 2009 (UTC)
{{editsemiprotected}}
Please change the following sentence in the "Symptoms" paragraph: "The gene that causes ossification is normally deactivated after a fetus' bones are formed in the nutsack, but in patients with FOP, the gene keeps working." The word "nutsack" should be changed to "uterus."
Cchen91765 ( talk) 16:01, 28 March 2010 (UTC)
Done Welcome and thanks for pointing this out. I returned the text to 'womb', since that was the text prior to the vandalism. If you would prefer 'uterus', let me know and I will change it.
Celestra (
talk)
16:33, 28 March 2010 (UTC)
What happened to the picture of Harry Eastlack's skeleton? 71.192.108.214 ( talk) 00:40, 23 June 2011 (UTC)
Can someone find a better figure to use under genetics. To someone unfamiliar with that type of spectra like myself I found it very confusing that the peak colors didn’t match their assigned nucleotide and the most important base just looks like noise or a null peak. There are much more elegant and intuitive ways to visualize a point mutation and as a common phenomenon a more appropriate visual probably either already exists or would just take editing a couple letters.
In the "Skeleton Key" documentary it was stated that the white blood cells deposit BMP4 into sites of injury, which promotes conversion of tissue to bone. Seems to me the obvious treatment is to "nuke and pave" by destroying the source of the malfunctioning lymphocytes and replacing it, same as is done for other disorders caused by bad bone marrow. As has been done with leukemia, a method of sorting and culturing marrow cells without the defect would allow an autograft and no need for anti rejection drugs. Once the progression is stopped it woul be possible to do surgery to remove the bone growths. 174.145.244.98 ( talk) 11:54, 4 March 2012 (UTC)
This article has severe sourcing issues. News articles etc are not suitable. All medical content on wikipedia should be sourced per WP:MEDRS. I will tag the sources that need to go for now. Lesion ( talk) 10:58, 26 August 2013 (UTC)
The IFOPA website has a problem, and I have removed all links to it from Wikipedia until the issue is resolved. See Wikipedia talk:WikiProject Spam/2013 Archive Jan 1#International Fibrodysplasia Ossificans Progressiva Association for details. -- Guy Macon ( talk) 08:14, 8 November 2015 (UTC)
The ifopa’s website issue has long been resolved Eichners ( talk) 06:06, 8 July 2021 (UTC)
Hello fellow Wikipedians,
I have just modified one external link on Fibrodysplasia ossificans progressiva. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
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Cheers.— InternetArchiveBot ( Report bug) 07:57, 31 December 2016 (UTC)
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Cheers.— InternetArchiveBot ( Report bug) 09:21, 30 September 2017 (UTC)