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Sorry if this sounds stupid, but couldn’t a person help to cure fatal familial insomnia by getting nightly injections of a sedative?- EKN
Thanks Dan. This is very peculiar. So there is no way of "putting them to sleep"?- EKN 19 March 2006
What about inducing a coma? - moon octopus
I'm wondering about that too. EKN 14:26, 5 April 2006 (UTC)EKN
The phrase "death is inevitable" seems highly unencyclopedic to me--this is a tautology! Death is inevitable with or without this condition. Perhaps this should be rephrase to reflect the intended meaning. 128.237.245.71 12:05, 13 May 2006 (UTC)
Wouldn't putting them in a coma every night at least relieve the tiredness even if it doesn't stop the disease? —Preceding unsigned comment added by 69.180.75.74 ( talk) 07:21, 7 October 2007 (UTC)
Systemic enzymes could be a possible answer. TwoHotMinutes ( talk) 18:15, 21 September 2008 (UTC)
The first time I heard of this disease was on a news show (either 20/20 or 60 minutes). On the show, they said that when doctors tried to sedate the patients or give them sleeping pills, it only made matter worse, and the disease progressed more rapidly. I don't know the exact source of this information, but it's worth looking into, I guess Shu ster ( talk) 22:12, 16 January 2009 (UTC)
The main article said "The gene responsible is carried in just 28 families worldwide". I moved this statement here so we could talk about it. At first glance, it sounds like an impossible claim to support, as no one has analyzed the genes for all families worldwide, nor is there any statement about how the families are counted. I suspect the statement is a misinterpretation of something much more nuanced from the medical literature, but I was unable to find the original. I would like to hear what other peopel think. -- Zippy 05:58, 5 June 2006 (UTC)
Agreed. Perhaps: "The gene responisble has been identified in only 28 families worldwide."
I just heard on NPR today that it has been documented in 40 families worldwide, and estimates based on genetics put the total number somewhere about 200. However, I am hesitant to put this in because I am not sure that 40 was an exact number ('though I believe it was). -- Azsymkamen 19:40, 18 November 2006
An unfounded speculative remedy might be meditation which I'm told reduces ther meditator's need for sleep.
Think of a prion as a tightly coiled spring. What happens is the disease causes the "coil" to unravel. There is no way to reverse the uncoiling/straightening out of the protein. Once the protein is "uncoiled" there is no way to fix it. As the condition progresses, more and more unraveling occurs, and eventually causes death. Since this is not a virus or a bacteria, is difficult next to impossible to destroy. In the prion disease that causes mad cow, the brain matter of an infected animal, even if incinerated, can still cause infection if circulated back into the food source. I hope this helps explain why this disease is not treatable. —Preceding unsigned comment added by 68.104.188.59 ( talk) 22:53, 28 May 2010 (UTC)
There are families in Canada with this illness. Canada is not mentioned above. — Preceding unsigned comment added by 207.61.86.5 ( talk) 19:29, 13 April 2017 (UTC)
The msnbc report ( http://www.msnbc.msn.com/id/6822468/) says that-"The Roiters’ extended family has formed an association to help find a cure, and raise the money for research."-is there any other information about this association as i can't find anything, anywhere.
-- Frills 04:51, 15 August 2006 (UTC)
The official website is http://www.afiff.net It is also the only website involving the FATAL FAMILIAL INSOMNIA FAMILIES ASSOCIATION - PRION DISEASES, that I can find. I'll get back to you if I find anymore.
"There are other diseases hello involving the mammalian prion."
- This sentence is nonsensical -- there is no such thing as "the mammalian prion." -- 201.51.236.252 11:59, 7 November 2006 (UTC)
"Some are transmissible (TSEs) such as kuru, bovine spongiform encephalopathy (BSE, also known as "mad cow disease") in cows, and chronic wasting disease in American deer and American elk (in some areas of the Rocky Mountains). Some forms of congestive heart failure are also believed to be caused by variant prion, as well as Creutzfeldt-Jakob disease (CJD). These are generally not considered to be transmissible, except by direct contact with infected tissue, such as cannibalism, transfusion or transplantation."
- This is irrelevant to sleep deprivation and should be deleted. -- 201.51.236.252 11:59, 7 November 2006 (UTC)
If this is a dominent trait couldn't the possibility be there for 100% inheritance. Look at this. Say someone had parents each with one of the dominant genes (Pp and Pp) and their child had two of the genes (PP). All of their gammetes would contain the dominant gene thus making it impossible for the offspring not to inherit the gene.
The chances of both parents having the defective alleles are astronomical and even then there would only be a 25% chance of having offspring with a PP genotype. If this person went on to breed then yes there would be 100% inheritance but I presume that the onset would be far earlier and more rapid than in the heterozygous individual reducing their chances of having children. Those are my thoughts anyway. -- Meridius 23:25, 5 February 2007 (UTC)
This one - http://www.afiff.net
I went there just now, and it has a "Hacked by / y@kışıkLı® / CAPRAZ ATES TEAM" message. If this is not reversed, then the external link to it will be useless, and should be removed. 81.153.110.46 ( talk) 16:02, 20 January 2008 (UTC)
What a shame, I really wanted to do some research on the disease. Whomever is maintaining that website should wake up. —Preceding unsigned comment added by 71.59.140.95 ( talk) 04:20, 25 February 2008 (UTC)
CJD is a TCE, so this should be edited to reflect that. Snellios ( talk) 19:23, 13 April 2008 (UTC)
"Some forms of congestive heart failure are also believed to be caused by variant prion" - really? I don't think I've ever come across this in any of the literature. If it doesn't get a citation I'm going to remove it. Snellios ( talk) 18:28, 4 May 2008 (UTC)
I think this comes from the history of one of the families with this disease. A lot of them died of what was thought to be congestive heart failure, but was probably/could have been FFI instead. That would have to be confirmed... i heard it somewhere a while ago... 58.108.18.123 ( talk) 13:51, 7 May 2008 (UTC)
"These are generally not considered to be transmissible, except by direct contact with infected tissue, such as from eating infected tissue, transfusion or transplantation."
By the same "Turkish hackers" at yakisikli@caprazAtes.org
Take off the link and it won't be targeted.
Lu na ke et 14:32, 19 May 2008 (UTC)
in the presentation section the following appear,separated by 2 sentences: 'death usually occurs between 7 and 36 months of onset.' and 'the disease has 4 stages, taking from 7 to 18 months to run its course.'seems to me it's gotta be one or the other or something else, but not both. Toyokuni3 ( talk) 02:48, 4 June 2008 (UTC)
Complete inability to sleep is followed by rapid loss of weight. This lasts for about three months.
I am not familiar with this condition, and I suppose the number of people who truly are could be counted on three hands. I am, however, familiar with how much sleep deprivation a person can undergo before they die, and it's far less than three months. So I'm guessing that when this says "complete inability to sleep" it means complete inability to fall asleep normally, but with periods of passing out for short time intervals all throughout the day. The current world record for sleep deprivation is on the order of 280 hours, and much more than that is potentially fatal. -- 68.252.213.218 ( talk) 05:50, 24 July 2008 (UTC)
Under the symptoms it said people with this syndrome crave Taco Bell. This is obviously a joke, so I removed it.
-- 68.44.13.238 ( talk) 12:05, 4 February 2010 (UTC)Quba Osman
How rare is this disease? Because I am scared of it. —Preceding unsigned comment added by 203.96.2.2 ( talk) 12:06, 21 December 2010 (UTC)
I was trying to find something about FFI & sleeping pills or sedatives but no luck.-- RicHard-59 ( talk) 04:44, 28 December 2010 (UTC)
Sleeping pills only put you into a coma and accelerate (Spelling)your path towards death. :/ —Preceding unsigned comment added by 203.96.12.235 ( talk) 08:55, 4 January 2011 (UTC)
The existence of this disease must have been disporven because the doctor in Fight Club said you couldnt die from insomnia. — Preceding unsigned comment added by 86.148.50.141 ( talk) 01:44, 21 September 2011 (UTC)
Well, if the doctor in fight club said it, it must be right, right? Perhaps the film was...WRONG, because this disease certainly exists;) 92.41.4.193 ( talk) 16:38, 24 July 2012 (UTC)
The article states multiple times that prolonged lack of sleep is eventually followed by death, but as a layman I feel like it's unclear on what specifically causes the afflicted to die. "Lack of sleep" is very vague as a description of the cause - precisely what physiological process occurs (or fails to occur) in the body or brain or a person who does not sleep that results in death? — Preceding unsigned comment added by 58.84.237.200 ( talk) 13:57, 19 January 2012 (UTC)
This is not true at all. NREM is the most important for health, and avoiding REM sleep has been linked to improvement of health. You treat depression by avoiding REM sleep. Polyphasic sleep is based on avoiding REM sleep. Melatonin supplementation promotes NREM sleep and reduces REM sleep. During REM phase, stress hormones are released, they are more of a shock for the body. That's why by practicing polyphasic sleep, people can avoid REM phase, nightmares (vivid dreams) and stay healthier.
Grammar And Sentence Structure
Some of the sentences in this article are slightly lengthy, and could be broken down making the article easier to understand for the reader. Specifically the opening statement. Wilson0624 ( talk) 18:48, 4 March 2014 (UTC)
Is there any more information available on SFI?
"Gene therapy has been unsuccessful thus far"
An overall lack of sleep is the cause of death? Or the exact reasons are... We need to find more information on this interesting topic!! Doing this for a class has been difficult, but I want to find more information!
76.84.119.31 ( talk) 04:46, 5 March 2014 (UTC)
As someone reading this article without special knowledge of biological functions, I found it quite difficult to follow along with some of the terminology. After reading the page I understand that simplifying information about prions and chromosomes and their role in FFI is not easy, but it would make the page much more interesting and beneficial to an average reader!
Csmith2017 ( talk) 07:56, 2 May 2014 (UTC)
I want to applaud the edits that have been made to this article since I read it last. As a student studying sleeping and dreaming, I understand a lot of these terms, but somebody who may not know the terms could become confused, especially by the scientific sections such as the prion and the sleep stage sections. I am not by any means saying that it needs to be dumbed down, but maybe we could go back through and explain some of that in a more simplistic way, that could really make this article more accessible and understandable to the public.
Also, I think it would be helpful for more to be added into the Epidemiology section. The sentence structures look fantastic, but as mentioned before, more simplified detail could be helpful.
Sam.kazda04 ( talk) 16:37, 9 May 2014 (UTC)
The initial summary of the article dated the first documented case in 1765, found in an Italian man. The source seems iffy.
Later, under the Onset section, there's this line:
>The first case was reported in the Netherlands of a 57 year old man of Egyptian descent.
The source for that only says "scientific correspondence".
It may well be that the first definite case was the case in the Netherlands and the former is simply a suspicion, but either way, clarification needed!
This article appears to include two claims regarding first presentation:
Several problems exist here. The key one is that the "Scientific Correspondence" references go nowhere, and therefore are uselessly unverifiable unless someone can expand them. Another is that the two claims appear to contradict each other on first reading; however, the second one might be implying, not that the Netherlands case was the first recorded case of FFI, but that this subject was the first case to be recorded in the Netherlands. If someone can confirm the latter to be true (I don't have access to the cited journal), then this can be clarified by changing the opening of the sentence in the Presentation section to something like, "The first case of FFI to be reported in the Netherlands was a 57-year-old man of Egyptian descent." — KGF0 ( T | C ) 22:07, 22 June 2015 (UTC)
This is also the first thing I've noticed..if as Kgf0 says the Egyptian man was just the first case in the Netherlands, then I don't even know that it would be worth even mentioning in the article. If there are two competing claims about the first case, then this is something which needs to be resolved. — Preceding unsigned comment added by Chilltherevolutionist ( talk • contribs) 07:44, 28 June 2015 (UTC)
Can someone expand/explain what source 5 is? Using page version 678814086. Thanks, 15zulu ( talk) 00:54, 8 October 2015 (UTC)
<ref>Scientific Correspondence</ref>
refers to <ref>Jansen, C. C., Parchi ...</ref>
. Doing a google search, got me
the article, which happens to be in a section titled "Scientific Correspondence". Wilson0624 does two more unique short cites: <ref>Journal of Sleep Research</ref>
and <ref>Gambetti and Lugaresi 1998</ref>
. I assume the "Journal of Sleep Research" refers to <ref>Cortelli, Gambetti, Montagna, ...</ref>
but that doesn't make sense for "Gambetti and Lugaresi 1998" since that's only the second & fourth author and a different year. Joyful mess. Cheers,
15zulu (
talk)
08:59, 10 October 2015 (UTC)
The 'cause' section only says that the disease is caused by a certain mutation. It doesn't say how that mutation causes the symptoms. I think that information should be added. — Preceding unsigned comment added by ChengduTeacher ( talk • contribs) 11:43, 23 September 2018 (UTC)
-- James Az. H ( talk) 00:21, 2 November 2019 (UTC)
“Fatal familial insomnia (FFI) is a prion disease of the brain.[1] It is usually caused by a mutation to the gene encoding protein PrPC.[2] It has two forms: fatal familial insomnia (FFI), which is autosomal dominant and sporadic fatal insomnia (sFI) which is due to a noninherited mutation.”
These sentences are confused. Per the Merck citation in [2], FFI is genetic, whereas sFI is a non-genetic prion disease. But these sentences seem to be saying that FFI and sFI are two forms of…FFI? And that FFI is always a prion disease, whereas sFI is apparently the prion-caused syndrome and FFI is genetic but not prion. Foijsdf ( talk) 13:15, 8 March 2022 (UTC)
This article was the subject of a Wiki Education Foundation-supported course assignment, between 16 August 2022 and 9 December 2022. Further details are available on the course page. Student editor(s): MeadorBriannaM ( article contribs).
— Assignment last updated by MeadorBriannaM ( talk) 18:52, 6 October 2022 (UTC)
This is the
talk page for discussing improvements to the
Fatal insomnia article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL |
This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||
|
Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Fatal insomnia.
|
Sorry if this sounds stupid, but couldn’t a person help to cure fatal familial insomnia by getting nightly injections of a sedative?- EKN
Thanks Dan. This is very peculiar. So there is no way of "putting them to sleep"?- EKN 19 March 2006
What about inducing a coma? - moon octopus
I'm wondering about that too. EKN 14:26, 5 April 2006 (UTC)EKN
The phrase "death is inevitable" seems highly unencyclopedic to me--this is a tautology! Death is inevitable with or without this condition. Perhaps this should be rephrase to reflect the intended meaning. 128.237.245.71 12:05, 13 May 2006 (UTC)
Wouldn't putting them in a coma every night at least relieve the tiredness even if it doesn't stop the disease? —Preceding unsigned comment added by 69.180.75.74 ( talk) 07:21, 7 October 2007 (UTC)
Systemic enzymes could be a possible answer. TwoHotMinutes ( talk) 18:15, 21 September 2008 (UTC)
The first time I heard of this disease was on a news show (either 20/20 or 60 minutes). On the show, they said that when doctors tried to sedate the patients or give them sleeping pills, it only made matter worse, and the disease progressed more rapidly. I don't know the exact source of this information, but it's worth looking into, I guess Shu ster ( talk) 22:12, 16 January 2009 (UTC)
The main article said "The gene responsible is carried in just 28 families worldwide". I moved this statement here so we could talk about it. At first glance, it sounds like an impossible claim to support, as no one has analyzed the genes for all families worldwide, nor is there any statement about how the families are counted. I suspect the statement is a misinterpretation of something much more nuanced from the medical literature, but I was unable to find the original. I would like to hear what other peopel think. -- Zippy 05:58, 5 June 2006 (UTC)
Agreed. Perhaps: "The gene responisble has been identified in only 28 families worldwide."
I just heard on NPR today that it has been documented in 40 families worldwide, and estimates based on genetics put the total number somewhere about 200. However, I am hesitant to put this in because I am not sure that 40 was an exact number ('though I believe it was). -- Azsymkamen 19:40, 18 November 2006
An unfounded speculative remedy might be meditation which I'm told reduces ther meditator's need for sleep.
Think of a prion as a tightly coiled spring. What happens is the disease causes the "coil" to unravel. There is no way to reverse the uncoiling/straightening out of the protein. Once the protein is "uncoiled" there is no way to fix it. As the condition progresses, more and more unraveling occurs, and eventually causes death. Since this is not a virus or a bacteria, is difficult next to impossible to destroy. In the prion disease that causes mad cow, the brain matter of an infected animal, even if incinerated, can still cause infection if circulated back into the food source. I hope this helps explain why this disease is not treatable. —Preceding unsigned comment added by 68.104.188.59 ( talk) 22:53, 28 May 2010 (UTC)
There are families in Canada with this illness. Canada is not mentioned above. — Preceding unsigned comment added by 207.61.86.5 ( talk) 19:29, 13 April 2017 (UTC)
The msnbc report ( http://www.msnbc.msn.com/id/6822468/) says that-"The Roiters’ extended family has formed an association to help find a cure, and raise the money for research."-is there any other information about this association as i can't find anything, anywhere.
-- Frills 04:51, 15 August 2006 (UTC)
The official website is http://www.afiff.net It is also the only website involving the FATAL FAMILIAL INSOMNIA FAMILIES ASSOCIATION - PRION DISEASES, that I can find. I'll get back to you if I find anymore.
"There are other diseases hello involving the mammalian prion."
- This sentence is nonsensical -- there is no such thing as "the mammalian prion." -- 201.51.236.252 11:59, 7 November 2006 (UTC)
"Some are transmissible (TSEs) such as kuru, bovine spongiform encephalopathy (BSE, also known as "mad cow disease") in cows, and chronic wasting disease in American deer and American elk (in some areas of the Rocky Mountains). Some forms of congestive heart failure are also believed to be caused by variant prion, as well as Creutzfeldt-Jakob disease (CJD). These are generally not considered to be transmissible, except by direct contact with infected tissue, such as cannibalism, transfusion or transplantation."
- This is irrelevant to sleep deprivation and should be deleted. -- 201.51.236.252 11:59, 7 November 2006 (UTC)
If this is a dominent trait couldn't the possibility be there for 100% inheritance. Look at this. Say someone had parents each with one of the dominant genes (Pp and Pp) and their child had two of the genes (PP). All of their gammetes would contain the dominant gene thus making it impossible for the offspring not to inherit the gene.
The chances of both parents having the defective alleles are astronomical and even then there would only be a 25% chance of having offspring with a PP genotype. If this person went on to breed then yes there would be 100% inheritance but I presume that the onset would be far earlier and more rapid than in the heterozygous individual reducing their chances of having children. Those are my thoughts anyway. -- Meridius 23:25, 5 February 2007 (UTC)
This one - http://www.afiff.net
I went there just now, and it has a "Hacked by / y@kışıkLı® / CAPRAZ ATES TEAM" message. If this is not reversed, then the external link to it will be useless, and should be removed. 81.153.110.46 ( talk) 16:02, 20 January 2008 (UTC)
What a shame, I really wanted to do some research on the disease. Whomever is maintaining that website should wake up. —Preceding unsigned comment added by 71.59.140.95 ( talk) 04:20, 25 February 2008 (UTC)
CJD is a TCE, so this should be edited to reflect that. Snellios ( talk) 19:23, 13 April 2008 (UTC)
"Some forms of congestive heart failure are also believed to be caused by variant prion" - really? I don't think I've ever come across this in any of the literature. If it doesn't get a citation I'm going to remove it. Snellios ( talk) 18:28, 4 May 2008 (UTC)
I think this comes from the history of one of the families with this disease. A lot of them died of what was thought to be congestive heart failure, but was probably/could have been FFI instead. That would have to be confirmed... i heard it somewhere a while ago... 58.108.18.123 ( talk) 13:51, 7 May 2008 (UTC)
"These are generally not considered to be transmissible, except by direct contact with infected tissue, such as from eating infected tissue, transfusion or transplantation."
By the same "Turkish hackers" at yakisikli@caprazAtes.org
Take off the link and it won't be targeted.
Lu na ke et 14:32, 19 May 2008 (UTC)
in the presentation section the following appear,separated by 2 sentences: 'death usually occurs between 7 and 36 months of onset.' and 'the disease has 4 stages, taking from 7 to 18 months to run its course.'seems to me it's gotta be one or the other or something else, but not both. Toyokuni3 ( talk) 02:48, 4 June 2008 (UTC)
Complete inability to sleep is followed by rapid loss of weight. This lasts for about three months.
I am not familiar with this condition, and I suppose the number of people who truly are could be counted on three hands. I am, however, familiar with how much sleep deprivation a person can undergo before they die, and it's far less than three months. So I'm guessing that when this says "complete inability to sleep" it means complete inability to fall asleep normally, but with periods of passing out for short time intervals all throughout the day. The current world record for sleep deprivation is on the order of 280 hours, and much more than that is potentially fatal. -- 68.252.213.218 ( talk) 05:50, 24 July 2008 (UTC)
Under the symptoms it said people with this syndrome crave Taco Bell. This is obviously a joke, so I removed it.
-- 68.44.13.238 ( talk) 12:05, 4 February 2010 (UTC)Quba Osman
How rare is this disease? Because I am scared of it. —Preceding unsigned comment added by 203.96.2.2 ( talk) 12:06, 21 December 2010 (UTC)
I was trying to find something about FFI & sleeping pills or sedatives but no luck.-- RicHard-59 ( talk) 04:44, 28 December 2010 (UTC)
Sleeping pills only put you into a coma and accelerate (Spelling)your path towards death. :/ —Preceding unsigned comment added by 203.96.12.235 ( talk) 08:55, 4 January 2011 (UTC)
The existence of this disease must have been disporven because the doctor in Fight Club said you couldnt die from insomnia. — Preceding unsigned comment added by 86.148.50.141 ( talk) 01:44, 21 September 2011 (UTC)
Well, if the doctor in fight club said it, it must be right, right? Perhaps the film was...WRONG, because this disease certainly exists;) 92.41.4.193 ( talk) 16:38, 24 July 2012 (UTC)
The article states multiple times that prolonged lack of sleep is eventually followed by death, but as a layman I feel like it's unclear on what specifically causes the afflicted to die. "Lack of sleep" is very vague as a description of the cause - precisely what physiological process occurs (or fails to occur) in the body or brain or a person who does not sleep that results in death? — Preceding unsigned comment added by 58.84.237.200 ( talk) 13:57, 19 January 2012 (UTC)
This is not true at all. NREM is the most important for health, and avoiding REM sleep has been linked to improvement of health. You treat depression by avoiding REM sleep. Polyphasic sleep is based on avoiding REM sleep. Melatonin supplementation promotes NREM sleep and reduces REM sleep. During REM phase, stress hormones are released, they are more of a shock for the body. That's why by practicing polyphasic sleep, people can avoid REM phase, nightmares (vivid dreams) and stay healthier.
Grammar And Sentence Structure
Some of the sentences in this article are slightly lengthy, and could be broken down making the article easier to understand for the reader. Specifically the opening statement. Wilson0624 ( talk) 18:48, 4 March 2014 (UTC)
Is there any more information available on SFI?
"Gene therapy has been unsuccessful thus far"
An overall lack of sleep is the cause of death? Or the exact reasons are... We need to find more information on this interesting topic!! Doing this for a class has been difficult, but I want to find more information!
76.84.119.31 ( talk) 04:46, 5 March 2014 (UTC)
As someone reading this article without special knowledge of biological functions, I found it quite difficult to follow along with some of the terminology. After reading the page I understand that simplifying information about prions and chromosomes and their role in FFI is not easy, but it would make the page much more interesting and beneficial to an average reader!
Csmith2017 ( talk) 07:56, 2 May 2014 (UTC)
I want to applaud the edits that have been made to this article since I read it last. As a student studying sleeping and dreaming, I understand a lot of these terms, but somebody who may not know the terms could become confused, especially by the scientific sections such as the prion and the sleep stage sections. I am not by any means saying that it needs to be dumbed down, but maybe we could go back through and explain some of that in a more simplistic way, that could really make this article more accessible and understandable to the public.
Also, I think it would be helpful for more to be added into the Epidemiology section. The sentence structures look fantastic, but as mentioned before, more simplified detail could be helpful.
Sam.kazda04 ( talk) 16:37, 9 May 2014 (UTC)
The initial summary of the article dated the first documented case in 1765, found in an Italian man. The source seems iffy.
Later, under the Onset section, there's this line:
>The first case was reported in the Netherlands of a 57 year old man of Egyptian descent.
The source for that only says "scientific correspondence".
It may well be that the first definite case was the case in the Netherlands and the former is simply a suspicion, but either way, clarification needed!
This article appears to include two claims regarding first presentation:
Several problems exist here. The key one is that the "Scientific Correspondence" references go nowhere, and therefore are uselessly unverifiable unless someone can expand them. Another is that the two claims appear to contradict each other on first reading; however, the second one might be implying, not that the Netherlands case was the first recorded case of FFI, but that this subject was the first case to be recorded in the Netherlands. If someone can confirm the latter to be true (I don't have access to the cited journal), then this can be clarified by changing the opening of the sentence in the Presentation section to something like, "The first case of FFI to be reported in the Netherlands was a 57-year-old man of Egyptian descent." — KGF0 ( T | C ) 22:07, 22 June 2015 (UTC)
This is also the first thing I've noticed..if as Kgf0 says the Egyptian man was just the first case in the Netherlands, then I don't even know that it would be worth even mentioning in the article. If there are two competing claims about the first case, then this is something which needs to be resolved. — Preceding unsigned comment added by Chilltherevolutionist ( talk • contribs) 07:44, 28 June 2015 (UTC)
Can someone expand/explain what source 5 is? Using page version 678814086. Thanks, 15zulu ( talk) 00:54, 8 October 2015 (UTC)
<ref>Scientific Correspondence</ref>
refers to <ref>Jansen, C. C., Parchi ...</ref>
. Doing a google search, got me
the article, which happens to be in a section titled "Scientific Correspondence". Wilson0624 does two more unique short cites: <ref>Journal of Sleep Research</ref>
and <ref>Gambetti and Lugaresi 1998</ref>
. I assume the "Journal of Sleep Research" refers to <ref>Cortelli, Gambetti, Montagna, ...</ref>
but that doesn't make sense for "Gambetti and Lugaresi 1998" since that's only the second & fourth author and a different year. Joyful mess. Cheers,
15zulu (
talk)
08:59, 10 October 2015 (UTC)
The 'cause' section only says that the disease is caused by a certain mutation. It doesn't say how that mutation causes the symptoms. I think that information should be added. — Preceding unsigned comment added by ChengduTeacher ( talk • contribs) 11:43, 23 September 2018 (UTC)
-- James Az. H ( talk) 00:21, 2 November 2019 (UTC)
“Fatal familial insomnia (FFI) is a prion disease of the brain.[1] It is usually caused by a mutation to the gene encoding protein PrPC.[2] It has two forms: fatal familial insomnia (FFI), which is autosomal dominant and sporadic fatal insomnia (sFI) which is due to a noninherited mutation.”
These sentences are confused. Per the Merck citation in [2], FFI is genetic, whereas sFI is a non-genetic prion disease. But these sentences seem to be saying that FFI and sFI are two forms of…FFI? And that FFI is always a prion disease, whereas sFI is apparently the prion-caused syndrome and FFI is genetic but not prion. Foijsdf ( talk) 13:15, 8 March 2022 (UTC)
This article was the subject of a Wiki Education Foundation-supported course assignment, between 16 August 2022 and 9 December 2022. Further details are available on the course page. Student editor(s): MeadorBriannaM ( article contribs).
— Assignment last updated by MeadorBriannaM ( talk) 18:52, 6 October 2022 (UTC)