This page is an archive of past discussions. Do not edit the contents of this page. If you wish to start a new discussion or revive an old one, please do so on the current talk page. |
I suffer with this condition and was wondering what medication people are given? — Preceding unsigned comment added by 82.42.182.127 ( talk) 00:56, 30 December 2005 (UTC)
My mother suffers this disorder. The doctors told her that it is very unlike to have a female child, and in case of having female child, it would be very probable that it would not be "normal" healthy child. How much of it is true? True is, that she has two children, two boys. They found that my brother is carrier as well. Is it possible that the mutation is sex chromosom linked? Because the doctors say that it won't have any effect on my brother or his children anymore. I would love to know ANY more information about this mutation. Thanks Alllfff — Preceding unsigned comment added by Alllfff ( talk • contribs) 08:43, 11 February 2006 (UTC)
I'm not sure what is the different between Factor V and Leiden Mutation, but the doctors said Leiden Mutation. Btw, thank you so much for the information writen here so far!-- Alllfff 11:45, 1 April 2006 (UTC)
Hey, Leiden is not in Sweden, thank you very much! :-) JFW | T@lk 22:48, 2 April 2006 (UTC)
I have Factor V Leiden and successfully carried and gave birth to two healthy children - a boy and a girl. Within 4 weeks of falling pregnant I was prescribed Heparin injections which i needed daily in order to lower the risk of any complications. Once I had given birth I was then prescribed wafarin for 6 weeks. As yet my children (aged 9 and 7) havent been screened for Factor V Leiden but I will ensure my daughter is screened before she reaches an age where she needs to choose a method of birth control.(The combined pill is not an option for women with FVL.) Nelbusy ( talk) 21:29, 6 October 2011 (UTC)
A casual search of PubMed shows that the overwhelming majority of references to "factor V Ledien" have "factor V" in lower case. This should be reflected in the article. Andrew73 02:48, 15 May 2006 (UTC)
I have Factor V Leiden - 37 yr old female. My first pregnancy at age 30 was riddled with problems including preeclampsia w/bedrest. Our baby boy was stillborn at 38 wks. Genetic testing showed the Factor V Leiden mutation. Since, on the recommendation of my doctor, I have taken Folbee Plus (high dose folic acid w/B Vitamins) and had a successful pregnancy - also a boy. I would be interested to hear more about the mutation causing women to bear mostly boys or a possibility of having an "abnormal" girl.
I have the mutation as well and fortunately for me have had no problems getting or staying pregnant I have two healthy 'normal' girls in 2007 and 2010. They both developmentally hitting all miles stones and have no problems in school or otherwise. — Preceding unsigned comment added by 86.142.126.20 ( talk) 19:39, 13 August 2014 (UTC)
Is the V in Factor V Leiden a V or a roman 5 (therefore would be pronounced Factor Five Leiden)? 90.129.0.158 20:34, 9 May 2007 (UTC)
PMID 14996674 shows the 3x increased thrombosis risk and 18x in homozygotes. JFW | T@lk 19:54, 3 July 2007 (UTC)
My half sister recently found out she has factor 5 Leiden. She has had difficulty with blood clots for most of her adult life. We had the same father, but not the same mother. My brother,(full brother, we share the same mother and father) recently had himself tested before surgery and his test came back negative. Does this mean I would be negative also? Or is there a chance that I would have the abnormality? We do not know which parent my half sister received this from, or if she received it from both for that matter. My father has passed and therefore cannot be tested. Any info in laymans terms would be very helpful. Thank you. [REMOVED E-MAIL ADDRESS] — Preceding unsigned comment added by 72.73.90.148 ( talk) 06:21, 14 July 2007 (UTC)
What is the rate of recurring clotting episodes for FVL+ patients? Are there any other ways to reduce the risk other than taking warfarin or heperin? Thank you. — Preceding unsigned comment added by 136.237.60.105 ( talk) 14:46, 12 October 2007 (UTC)
my doctor told me iam unable to have children ever again! can anyone tell me different? have factor V leiden and lupus anticoagulant? because i would really like to have another child my son is 5 and i did have problems during my pregancy{i.e hemorage,low birth wieght and 18 days early Please i relly need some answers? CDW 11-01-07 —Preceding unsigned comment added by 68.189.202.57 ( talk) 01:47, 2 November 2007 (UTC)
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1538-7836.2007.02883.x - I can't get the fulltext but it seems FVL is more likely to cause distal as opposed to proximal DVTs. JFW | T@lk 14:44, 24 February 2008 (UTC)
My husband recently found out that he has Factor V Leiden after being diagnosed with a DVT. I read above, if I'm interpreting what was said correctly, that aspirin therapy has not been succuessful in preventing more clots? What is the usual treatment for this disease? He is on coumadin now for the DVT, but told he'd take that for about 6 months and then probably be on aspirin therapy the rest of his life. He is heterozygous for this condition. We have since tested both of our daughters for this condition (they are ages 3 1/2 and 6) and found that they are both also heterozygous for Factor V. What is the treatment if any for children? Are there precautions I should take for them? I found out after a couple miscarriages trying to have our second daughter that I have antiphospholipid anticardiolipin clotting disorder. I've been told this is not hereditary. Do you know if that is true? I'd hate for my daughters to have an even greater risk. Thanks in advance for any help. 72.75.220.87 ( talk) 19:55, 11 March 2008 (UTC)momfits
This article definitely needs more references. "Studies show..." Great, which studies? Neoprote ( talk) 11:34, 20 May 2008 (UTC)
There is now a standard nomenclature for describing DNA mutations, although the old reports wont use it and some of the new ones wont either. Pathology reports should be using the standard HGVS nomenclature. The nomenclature standards are here: www.hgvs.org
This link uses standard names and the colloquial ones too. http://www.ncbi.nlm.nih.gov/books/NBK1368/#factor-v-leiden.Molecular_Genetics see table 2. eg of standard nomenclature: NM_000130.4: c.4125A>G, p.His1327Arg — Preceding unsigned comment added by 121.44.105.201 ( talk) 07:53, 2 November 2011 (UTC)
This page is an archive of past discussions. Do not edit the contents of this page. If you wish to start a new discussion or revive an old one, please do so on the current talk page. |
I suffer with this condition and was wondering what medication people are given? — Preceding unsigned comment added by 82.42.182.127 ( talk) 00:56, 30 December 2005 (UTC)
My mother suffers this disorder. The doctors told her that it is very unlike to have a female child, and in case of having female child, it would be very probable that it would not be "normal" healthy child. How much of it is true? True is, that she has two children, two boys. They found that my brother is carrier as well. Is it possible that the mutation is sex chromosom linked? Because the doctors say that it won't have any effect on my brother or his children anymore. I would love to know ANY more information about this mutation. Thanks Alllfff — Preceding unsigned comment added by Alllfff ( talk • contribs) 08:43, 11 February 2006 (UTC)
I'm not sure what is the different between Factor V and Leiden Mutation, but the doctors said Leiden Mutation. Btw, thank you so much for the information writen here so far!-- Alllfff 11:45, 1 April 2006 (UTC)
Hey, Leiden is not in Sweden, thank you very much! :-) JFW | T@lk 22:48, 2 April 2006 (UTC)
I have Factor V Leiden and successfully carried and gave birth to two healthy children - a boy and a girl. Within 4 weeks of falling pregnant I was prescribed Heparin injections which i needed daily in order to lower the risk of any complications. Once I had given birth I was then prescribed wafarin for 6 weeks. As yet my children (aged 9 and 7) havent been screened for Factor V Leiden but I will ensure my daughter is screened before she reaches an age where she needs to choose a method of birth control.(The combined pill is not an option for women with FVL.) Nelbusy ( talk) 21:29, 6 October 2011 (UTC)
A casual search of PubMed shows that the overwhelming majority of references to "factor V Ledien" have "factor V" in lower case. This should be reflected in the article. Andrew73 02:48, 15 May 2006 (UTC)
I have Factor V Leiden - 37 yr old female. My first pregnancy at age 30 was riddled with problems including preeclampsia w/bedrest. Our baby boy was stillborn at 38 wks. Genetic testing showed the Factor V Leiden mutation. Since, on the recommendation of my doctor, I have taken Folbee Plus (high dose folic acid w/B Vitamins) and had a successful pregnancy - also a boy. I would be interested to hear more about the mutation causing women to bear mostly boys or a possibility of having an "abnormal" girl.
I have the mutation as well and fortunately for me have had no problems getting or staying pregnant I have two healthy 'normal' girls in 2007 and 2010. They both developmentally hitting all miles stones and have no problems in school or otherwise. — Preceding unsigned comment added by 86.142.126.20 ( talk) 19:39, 13 August 2014 (UTC)
Is the V in Factor V Leiden a V or a roman 5 (therefore would be pronounced Factor Five Leiden)? 90.129.0.158 20:34, 9 May 2007 (UTC)
PMID 14996674 shows the 3x increased thrombosis risk and 18x in homozygotes. JFW | T@lk 19:54, 3 July 2007 (UTC)
My half sister recently found out she has factor 5 Leiden. She has had difficulty with blood clots for most of her adult life. We had the same father, but not the same mother. My brother,(full brother, we share the same mother and father) recently had himself tested before surgery and his test came back negative. Does this mean I would be negative also? Or is there a chance that I would have the abnormality? We do not know which parent my half sister received this from, or if she received it from both for that matter. My father has passed and therefore cannot be tested. Any info in laymans terms would be very helpful. Thank you. [REMOVED E-MAIL ADDRESS] — Preceding unsigned comment added by 72.73.90.148 ( talk) 06:21, 14 July 2007 (UTC)
What is the rate of recurring clotting episodes for FVL+ patients? Are there any other ways to reduce the risk other than taking warfarin or heperin? Thank you. — Preceding unsigned comment added by 136.237.60.105 ( talk) 14:46, 12 October 2007 (UTC)
my doctor told me iam unable to have children ever again! can anyone tell me different? have factor V leiden and lupus anticoagulant? because i would really like to have another child my son is 5 and i did have problems during my pregancy{i.e hemorage,low birth wieght and 18 days early Please i relly need some answers? CDW 11-01-07 —Preceding unsigned comment added by 68.189.202.57 ( talk) 01:47, 2 November 2007 (UTC)
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1538-7836.2007.02883.x - I can't get the fulltext but it seems FVL is more likely to cause distal as opposed to proximal DVTs. JFW | T@lk 14:44, 24 February 2008 (UTC)
My husband recently found out that he has Factor V Leiden after being diagnosed with a DVT. I read above, if I'm interpreting what was said correctly, that aspirin therapy has not been succuessful in preventing more clots? What is the usual treatment for this disease? He is on coumadin now for the DVT, but told he'd take that for about 6 months and then probably be on aspirin therapy the rest of his life. He is heterozygous for this condition. We have since tested both of our daughters for this condition (they are ages 3 1/2 and 6) and found that they are both also heterozygous for Factor V. What is the treatment if any for children? Are there precautions I should take for them? I found out after a couple miscarriages trying to have our second daughter that I have antiphospholipid anticardiolipin clotting disorder. I've been told this is not hereditary. Do you know if that is true? I'd hate for my daughters to have an even greater risk. Thanks in advance for any help. 72.75.220.87 ( talk) 19:55, 11 March 2008 (UTC)momfits
This article definitely needs more references. "Studies show..." Great, which studies? Neoprote ( talk) 11:34, 20 May 2008 (UTC)
There is now a standard nomenclature for describing DNA mutations, although the old reports wont use it and some of the new ones wont either. Pathology reports should be using the standard HGVS nomenclature. The nomenclature standards are here: www.hgvs.org
This link uses standard names and the colloquial ones too. http://www.ncbi.nlm.nih.gov/books/NBK1368/#factor-v-leiden.Molecular_Genetics see table 2. eg of standard nomenclature: NM_000130.4: c.4125A>G, p.His1327Arg — Preceding unsigned comment added by 121.44.105.201 ( talk) 07:53, 2 November 2011 (UTC)