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Please add a section on contraindications Leningrad ( talk) —Preceding undated comment added 16:55, 17 November 2018 (UTC)
What I have drawn is, actually, the correct structure of S-omeprazole. The S designation of this molecule is with respect to its structure in vivo - where the sulfinyl moiety is ionised, and there is an additional hydrogen substituent off the chiral sulfur. Under these circumstances the stereochemistry is clearly S. So whilst, technically, this drawing may be R, it actually does represent the structure of S-omeprazole. Techelf 11:14, 21 Oct 2004 (UTC)
The following information from the DrugBank should be incorporated (not copied!) into this article:
"Esomeprazole is a compound that inhibits gastric acid secretion and is indicated in the treatment of gastroesophageal reflux disease (GERD), the healing of erosive esophagitis, and H. pylori eradication to reduce the risk of duodenal ulcer recurrence. Esomeprazole belongs to a new class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or H2 histamine antagonistic properties, but that suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the gastric mucosa, Esomeprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus."
[1]
I'll probably do it myself eventually, if no one else does. Fuzzform 02:13, 22 February 2006 (UTC)
With all of the citations that I provided -- please provide a rationale as to why you keep reverting text which enhances this information? —Preceding unsigned comment added by Chrisgaffneymd ( talk • contribs)
I have noticed that Esomeprazole shares metabolic mechanisms with other drugs such as Clonazepam, and SSRIs like Escitalopram and Citalopram. Can someone look up if there is expected to be heightened serum levels of these drugs while on Esomeprazole due to their shared hepatic clearance mechanisms? If so, I think this should be included in this article. Please include with a source. -- 1000Faces ( talk) 16:16, 1 December 2009 (UTC)
The Interactions section includes a paragraph on omeprazole. Esomeprazole is a newer generation, therefore the omeprazole paragraph should either be substatiated for relevance or deleted.
Parzivalamfortas 11:10, 9 June 2020 (UTC) — Preceding unsigned comment added by Parzivalamfortas ( talk • contribs)
Is there any literature which cites the dosage equivalency of omeprazole to Esomeprazole? For example, if someone were to switch from 40mg of Esomeprazole, should they switch to 10, 20, 40, or 80mg of omeprazole? If there is data in the literature on this, I think it should be mentioned here. It is touched upon during the Controversy segment, but lacks conclusive statements. -- 1000Faces ( talk) 04:25, 2 December 2009 (UTC)
The Prilosec article states that: "In theory, by using pure esomeprazole the effect on the proton pump will be equal in all patients, eliminating the poor metabolizer effect." Can this be explained here with citations? It has been mentioned in this article that overcoming individual differences was a reason for developing this drug, but is this what is meant? More clarity is needed. -- 1000Faces ( talk) 15:20, 24 December 2009 (UTC)
i found the paper here http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2005.02418.x/full Qwh ( talk) 11:45, 9 June 2013 (UTC)
If someone can find a source that points this out, it would be useful to have in the article. As it stands now however it's not cited. hbdragon88 ( talk) 01:37, 5 January 2010 (UTC)
Hey All,
Sorry I am in a rush and am unwell so cannot make the amendment myself but the structural diagram for Esomeprazole is clearly wrong. The fact that the molecule has 3 oxygen atoms but only two are present in the figure is a stark example of just one of the couple of mistakes I witnessed. If someone with more knowledge and experience than myself could please rectify the issue that would be great.
Thanks, Cyn — Preceding unsigned comment added by Cynicle ( talk • contribs) 10:34, 12 May 2012 (UTC)
BaeyerDrewson ( talk) 01:05, 19 October 2012 (UTC)
This article seems largely duplicative of the PPI article. The bulk of the redundant info should be removed. There also seems to be little mention of the mainstream view of Nexium (Nexium = Prilosec + deceptive marketing), as exemplified by the comments of Robert Bazell, NBC's chief science and health correspondent:
The website this citation links to appears to use material from the Wikipedia article (it acknowledges this). Isn't this circular referencing? What is the original data from www.news-medical.net that is incorporated into the Wiki page? Bonza9683 16:57, 18 October 2012 (UTC)
The Intro part reads to a large part like an advertisement of the two producing companies, let's put the relevant stuff here, let's have the pharma industry make their own ads and pay for them, okay? If nobody disagrees until the next week, I'll just do the edit in the intro...-- Triple5 ( talk) 09:46, 18 February 2013 (UTC)
Hi, I am confused about the USFDA Pregnancy Category of Esomeprazole. Some places state it as Category C while others are stating it as Category B ( [1], [2]). I think that a section on this topic would be helpful to many. However, I would prefer not to edit myself as I may not be most suited to edit. I hope editors of this page will consider adding a section on this.
Thank you.
References
-- — Preceding unsigned comment added by 180.211.215.248 ( talk) 16:19, 16 July 2016 (UTC)
the following is unsourced - moved here per PRESERVE
The granules are manufactured in a fluidized bed system with small sugar spheres as the starting material. The sugar spheres are sequentially spray-coated with a suspension containing esomeprazole, a protective layer to prevent degradation of the drug in manufacturing, an enteric coating, and an outer layer to reduce granule aggregation. The granules are mixed with other inactive excipients and compressed into tablets. Finally, the tablets are film-coated to improve the stability and appearance of the preparation. -- Jytdog ( talk) 16:16, 2 January 2017 (UTC)
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User:Acyclic please explain your objection to the hatnote. Jytdog ( talk) 21:24, 22 April 2018 (UTC)
This line from the second paragraph of the intro:
"Esomeprazole is the (S)-(−)-enantiomer (or less specifically the S-isomer) of omeprazole."
Has the following footnote:
"The name thus is an onomatopoeia, as it can also be read as Es + omeprazole"
It doesn't really make any sense. Neither omeprazole nor esomeprazole are describing a sound, regardless of the latter's prefix. 70.20.28.112 ( talk) 16:54, 8 July 2024 (UTC)
![]() | This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||
|
![]() | Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Esomeprazole.
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Please add a section on contraindications Leningrad ( talk) —Preceding undated comment added 16:55, 17 November 2018 (UTC)
What I have drawn is, actually, the correct structure of S-omeprazole. The S designation of this molecule is with respect to its structure in vivo - where the sulfinyl moiety is ionised, and there is an additional hydrogen substituent off the chiral sulfur. Under these circumstances the stereochemistry is clearly S. So whilst, technically, this drawing may be R, it actually does represent the structure of S-omeprazole. Techelf 11:14, 21 Oct 2004 (UTC)
The following information from the DrugBank should be incorporated (not copied!) into this article:
"Esomeprazole is a compound that inhibits gastric acid secretion and is indicated in the treatment of gastroesophageal reflux disease (GERD), the healing of erosive esophagitis, and H. pylori eradication to reduce the risk of duodenal ulcer recurrence. Esomeprazole belongs to a new class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or H2 histamine antagonistic properties, but that suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the gastric mucosa, Esomeprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus."
[1]
I'll probably do it myself eventually, if no one else does. Fuzzform 02:13, 22 February 2006 (UTC)
With all of the citations that I provided -- please provide a rationale as to why you keep reverting text which enhances this information? —Preceding unsigned comment added by Chrisgaffneymd ( talk • contribs)
I have noticed that Esomeprazole shares metabolic mechanisms with other drugs such as Clonazepam, and SSRIs like Escitalopram and Citalopram. Can someone look up if there is expected to be heightened serum levels of these drugs while on Esomeprazole due to their shared hepatic clearance mechanisms? If so, I think this should be included in this article. Please include with a source. -- 1000Faces ( talk) 16:16, 1 December 2009 (UTC)
The Interactions section includes a paragraph on omeprazole. Esomeprazole is a newer generation, therefore the omeprazole paragraph should either be substatiated for relevance or deleted.
Parzivalamfortas 11:10, 9 June 2020 (UTC) — Preceding unsigned comment added by Parzivalamfortas ( talk • contribs)
Is there any literature which cites the dosage equivalency of omeprazole to Esomeprazole? For example, if someone were to switch from 40mg of Esomeprazole, should they switch to 10, 20, 40, or 80mg of omeprazole? If there is data in the literature on this, I think it should be mentioned here. It is touched upon during the Controversy segment, but lacks conclusive statements. -- 1000Faces ( talk) 04:25, 2 December 2009 (UTC)
The Prilosec article states that: "In theory, by using pure esomeprazole the effect on the proton pump will be equal in all patients, eliminating the poor metabolizer effect." Can this be explained here with citations? It has been mentioned in this article that overcoming individual differences was a reason for developing this drug, but is this what is meant? More clarity is needed. -- 1000Faces ( talk) 15:20, 24 December 2009 (UTC)
i found the paper here http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2005.02418.x/full Qwh ( talk) 11:45, 9 June 2013 (UTC)
If someone can find a source that points this out, it would be useful to have in the article. As it stands now however it's not cited. hbdragon88 ( talk) 01:37, 5 January 2010 (UTC)
Hey All,
Sorry I am in a rush and am unwell so cannot make the amendment myself but the structural diagram for Esomeprazole is clearly wrong. The fact that the molecule has 3 oxygen atoms but only two are present in the figure is a stark example of just one of the couple of mistakes I witnessed. If someone with more knowledge and experience than myself could please rectify the issue that would be great.
Thanks, Cyn — Preceding unsigned comment added by Cynicle ( talk • contribs) 10:34, 12 May 2012 (UTC)
BaeyerDrewson ( talk) 01:05, 19 October 2012 (UTC)
This article seems largely duplicative of the PPI article. The bulk of the redundant info should be removed. There also seems to be little mention of the mainstream view of Nexium (Nexium = Prilosec + deceptive marketing), as exemplified by the comments of Robert Bazell, NBC's chief science and health correspondent:
The website this citation links to appears to use material from the Wikipedia article (it acknowledges this). Isn't this circular referencing? What is the original data from www.news-medical.net that is incorporated into the Wiki page? Bonza9683 16:57, 18 October 2012 (UTC)
The Intro part reads to a large part like an advertisement of the two producing companies, let's put the relevant stuff here, let's have the pharma industry make their own ads and pay for them, okay? If nobody disagrees until the next week, I'll just do the edit in the intro...-- Triple5 ( talk) 09:46, 18 February 2013 (UTC)
Hi, I am confused about the USFDA Pregnancy Category of Esomeprazole. Some places state it as Category C while others are stating it as Category B ( [1], [2]). I think that a section on this topic would be helpful to many. However, I would prefer not to edit myself as I may not be most suited to edit. I hope editors of this page will consider adding a section on this.
Thank you.
References
-- — Preceding unsigned comment added by 180.211.215.248 ( talk) 16:19, 16 July 2016 (UTC)
the following is unsourced - moved here per PRESERVE
The granules are manufactured in a fluidized bed system with small sugar spheres as the starting material. The sugar spheres are sequentially spray-coated with a suspension containing esomeprazole, a protective layer to prevent degradation of the drug in manufacturing, an enteric coating, and an outer layer to reduce granule aggregation. The granules are mixed with other inactive excipients and compressed into tablets. Finally, the tablets are film-coated to improve the stability and appearance of the preparation. -- Jytdog ( talk) 16:16, 2 January 2017 (UTC)
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User:Acyclic please explain your objection to the hatnote. Jytdog ( talk) 21:24, 22 April 2018 (UTC)
This line from the second paragraph of the intro:
"Esomeprazole is the (S)-(−)-enantiomer (or less specifically the S-isomer) of omeprazole."
Has the following footnote:
"The name thus is an onomatopoeia, as it can also be read as Es + omeprazole"
It doesn't really make any sense. Neither omeprazole nor esomeprazole are describing a sound, regardless of the latter's prefix. 70.20.28.112 ( talk) 16:54, 8 July 2024 (UTC)