This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||||||||||||||||||||||||||
|
As a class of drug EPO is an Erythropoietin Stimulating Agent (ESA).
Does anybody else see a problem with this statement? lol Leondegrance ( talk) 20:48, 11 July 2008 (UTC)
could increased haemoglobin (as a result of lung disease i.e increased producfion of 'erythropoietin' by bone marrow, be a cause of high blood pressure?.
No. GiollaUidir 11:23, 23 March 2006 (UTC)
Article in french newspaper announced that Lance armstrong might have used EPO. Keep an eye on this?
Recent big article is showing that Erythropoietin could have big role in protecting neurons in CNS:
http://www.clinsci.org/cs/103/0275/cs1030275.htm
Note NYT obituary of Dr. Margot Kruskall, who was one of the early researchers of EPO in the 1980s, and helped to develop the blood test for it. Possibly some of this material could be used (but of course not copied) in the article. -- Blainster 22:04, 8 September 2005 (UTC)
Medical books (e.g. Junqueira's Functional Histology) and dictionaries ( [1]) spell it 'poe', not 'poie'. I changed the title to match this spelling. MrTroy 13:02, 12 April 2006 (UTC)
References
I'm really not sure about the pronunciation given here - although it may be the US form. I'm adding a British version. Wee Jimmy ( talk) 12:15, 26 September 2014 (UTC)
The pronunciation as I added was exactly according to Wikipedia's style guide. The current revision isn't. Your statement that it's "more common IPA representation style" may be correct, but let's follow Wikipedia's style guide, OK? MrTroy 11:28, 15 April 2006 (UTC)
I'm not Italic textevenItalic text qualified to edit this page, however I think somebody more qualified might want to mention that erythropoietin is also used (semi-experimentally) in domestic animals.
Basesurge 06:09, 23 February 2007 (UTC)
could increased haemoglobin (as a result of lung disease i.e increased production of 'erythropoietin' by bone marrow, be a cause of high blood pressure?.
No. GiollaUidir 11:23, 23 March 2006 (UTC)
Article in french newspaper announced that Lance Armstrong might have used EPO. Keep an eye on this?
Recent big article is showing that Erythropoietin could have big role in protecting neurons in CNS:
http://www.clinsci.org/cs/103/0275/cs1030275.htm
Note NYT obituary of Dr. Margot Kruskall, who was one of the early researchers of EPO in the 1980s, and helped to develop the blood test for it. Possibly some of this material could be used (but of course not copied) in the article. -- Blaster 22:04, 8 September 2005 (UTC)
Medical books (e.g. Junqueira Functional Histology) and dictionaries ( [2]) spell it 'Poe', not 'poie'. I changed the title to match this spelling. MrTroy 13:02, 12 April 2006 (UTC)
The pronunciation as I added was exactly according to Wikipedia style guide. The current revision isn't. Your statement that it's "more common IPA representation style" may be correct, but let's follow Wikipedia style guide, OK? MrTroy 11:28, 15 April 2006 (UTC)
There should also be a pronunciation for people in the United States. I'm a freaking novelist and I can't make heads or tails out of that silly pronunciation method, even after reading the so-called explanation. That "International Phonetic Alphabet" isn't really used or widely known in the United States. Especially since this is the first I've ever seen or heard of it, I'd say there should be another entry for American English speakers. As it stands, I have no clue how to pronounce this word.
-- 12.201.55.10 ( talk) 05:20, 17 December 2007 (UTC)Brandon Harwell
I'm not Italic textevenItalic text qualified to edit this page, however I think somebody more qualified might want to mention that erythropoietin is also used (semi-experimentally) in domestic animals.
Basesurge 06:09, 23 February 2007 (UTC)
13.0 g/ml seems to low a number here. I don't have full text access to the article, but the abstract would seem to indicate normal is 13.0 - 15.0 g/dl. Anyone care to expand or correct?
Ganesha 04:42, 11 April 2007 (UTC)
How long does a change in altitude take to cause EPO to restore oxygen availability?
I am not scientifically qualified to make edits on this page, but I am knowledgeable enough to know that EPO and recombinant EPO are not the same. The main EPO page discusses blood doping as if the natural hormone EPO is what's being abused, when in reality, it is the artificial hormone found in drugs such as epogen. I think people use the term "EPO" too generically and confuse naturally occuring EPO with the rEPO drugs which are widely abused by endurance athletes. The page should refer people interested in the topic of blood doping to a page on recombinant EPO.
I think the article is very poorly written, and uses nomenclature in a very simplistic way. —Preceding unsigned comment added by 205.241.11.6 ( talk) 20:36, 15 August 2008 (UTC)
An EPO masking agent was detected in a billiards player. The article conveys this fact as if it is popular to use EPO to enhance billiards play. [3] MM962 ( talk) 23:22, 7 March 2009 (UTC)
The article didn't really go into the process of how EPO is made and used in the lab. I'm trying to find some sites, but nothing seems to be coming up. 99.230.7.159 ( talk) 17:58, 2 April 2009 (UTC)
First paragraph: "...it is produced by the peritubular capillary endothelial cells in the kidney..." Several USMLE review books that I've seen say this same thing, but it looks like they're actually produced by fibroblasts in the cortical interstitium. See http://www.ncbi.nlm.nih.gov/pubmed/9402140 and http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18575881 Can anyone find evidence to dispute this? Sirmky ( talk) 06:46, 28 September 2009 (UTC)
This article currently is very confusing because it mixes information about the endogenously produced erythropoietin hormone and recombinantly manufactured erythropoetin that is administered as a drug. Hence I propose that this article focus on the erythropoietin gene/protein and the drug specific parts be move to Epoetin alfa (analogous to the insulin and insulin therapy articles). Furthermore this article should conform to WP:MCBMOS while the drug specific article should conform to WP:PHARMMOS. Boghog ( talk) 05:45, 12 April 2012 (UTC)
"The report contained affidavits from numerous riders on the team including Frankie Andreu, Tyler Hamilton, George Hincapie, Floyd Landis, Levi Leipheimer, and several others describing wide spread EPO use during the Tour de France and other bicycling races around the turn of the century. They also implicated Lance Armstrong."
USADAs report is not focused on widespread EPO use in the peleton. Its primary focus is this: that Lance Armstrong: (i) cheated, and (ii) the necessary corollary: that Lance Armstrong is a liar. They did not "implicate" Armstrong. USADA and USADAs witnesses, who have testified on pain of perjury state openly and clearly that Armstrong is a drug cheat. No "implication". No innuendo. it's not as if his name was mentioned in passing and he was 'implicated' in the event, but he's clearly innocent. no no no. Given the evidence and Armstrong's lack of testimony, he has effectively entered a guilty plea as far as USADA and the UCI are concerned.
It is patently obvious that Armstrong's PR machine (guys you can't win the editing war - you are paid whereas wiki users are not. we'll be here forever reverting the changes) or the few supporters he has are making these pro-armstrong edits despite the overwhelming evidence to the contrary. nearly the whole US Postal and Discovery channel have admitted to using performance enhancing substances - lance armstrong is the only one, according to his story, who is clean.
guys, USADA is very clear on this point: Armstrong is a cheat. Fact. Period.
Captainandrewwiggins ( talk) 22:48, 7 November 2012 (UTC) Captainandrewwiggins ( talk) 23:05, 7 November 2012 (UTC)
...suggests that EPO may not work as a performance-enhancing drug: http://www.eurekalert.org/pub_releases/2012-12/w-edi120412.php
Probably worth mentioning on this page? ed g2s • talk 17:21, 16 January 2013 (UTC)
Seems to me not much doubt that it increases hematocrit, and that is performance enhancing in endurance sports that depend on getting oxygen to muscles. Might be much less useful for other sports. Gah4 ( talk) 02:07, 14 April 2014 (UTC)
There really needs to be actual chemical structure or name, including the specific amino acid sequence, the genes involved, and the types/locations of glycoslyations (the terms alfa, beta, etc. are virtually meaningless, with no explanations given even on their respective pages). The synthesis and regulation section only talks about regulation, not the actual synthesis or process for different glycosylations. The PDB structure is colorized but does not indicate the various atoms or even which parts are protein and which are glycans. Lakshwadeep ( talk) 21:58, 23 April 2013 (UTC)
The statement When exogenous EPO is used as a performance-enhancing drug,[dubious – discuss] it is classified as an erythropoiesis-stimulating agent (ESA). needs clarification.
By search, I find that :
Request some-one who knows more on this issue to:
@ FeatherPluma: may please see!
AshLin ( talk) 10:49, 17 June 2014 (UTC)
There seem to have been no objections to merge a page for an EPO brand (Dynepo) into this generic page since it was proposed in June 2014. It seems like a good idea to me, as there is little specific on that page. Klbrain ( talk) 19:27, 31 August 2015 (UTC)
Article merged: See old talk-page here
The contents of the Dynepo page were merged into Erythropoietin on 31 August 2015. For the contribution history and old versions of the redirected page, please see its history; for the discussion at that location, see its talk page. |
The article currently states
'Synthetic EPO is believed to have come into use in cycling about 1990'
In the book 'Het laatste geel', former professional Mathieu Hermans admits to using EPO during the 1989 Tour de France. He adds that he did nothing illegal, as it was not yet on the banned substances list yet. — Preceding unsigned comment added by 195.22.11.246 ( talk) 13:05, 2 October 2015 (UTC)
Hello fellow Wikipedians,
I have just added archive links to one external link on
Erythropoietin. Please take a moment to review
my edit. If necessary, add {{
cbignore}}
after the link to keep me from modifying it. Alternatively, you can add {{
nobots|deny=InternetArchiveBot}}
to keep me off the page altogether. I made the following changes:
When you have finished reviewing my changes, please set the checked parameter below to true to let others know.
This message was posted before February 2018.
After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than
regular verification using the archive tool instructions below. Editors
have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the
RfC before doing mass systematic removals. This message is updated dynamically through the template {{
source check}}
(last update: 5 June 2024).
Cheers. — cyberbot II Talk to my owner:Online 09:56, 17 October 2015 (UTC)
This link "Safety Labeling Changes: Epogen/Procrit (epoetin alfa) and Aranesp (darbepoetin alfa)" goes to a 404 now.
Juliansteinb (
talk) 18:36, 26 April 2019 (UTC)
Not everyone is going to like my attempt to detach the physiological role of erythropoietin and its pharmacological use, but I think it is needed. The content about pharmacological use and misuse is now on Erythropoiesis-stimulating agent (taken from this version). Happy to be shot down, but I think it is helpful. JFW | T@lk 11:41, 17 February 2016 (UTC)
User:IiKkEe this article should follow WP:MCBMOS in its structure. Jytdog ( talk) 20:37, 8 September 2017 (UTC)
I fail to see any need for this unrelated LINK to Jehovah's Witness and Blood Transfusions — Preceding unsigned comment added by 137.118.161.59 ( talk) 14:33, 20 February 2022 (UTC)
This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||||||||||||||||||||||||||
|
As a class of drug EPO is an Erythropoietin Stimulating Agent (ESA).
Does anybody else see a problem with this statement? lol Leondegrance ( talk) 20:48, 11 July 2008 (UTC)
could increased haemoglobin (as a result of lung disease i.e increased producfion of 'erythropoietin' by bone marrow, be a cause of high blood pressure?.
No. GiollaUidir 11:23, 23 March 2006 (UTC)
Article in french newspaper announced that Lance armstrong might have used EPO. Keep an eye on this?
Recent big article is showing that Erythropoietin could have big role in protecting neurons in CNS:
http://www.clinsci.org/cs/103/0275/cs1030275.htm
Note NYT obituary of Dr. Margot Kruskall, who was one of the early researchers of EPO in the 1980s, and helped to develop the blood test for it. Possibly some of this material could be used (but of course not copied) in the article. -- Blainster 22:04, 8 September 2005 (UTC)
Medical books (e.g. Junqueira's Functional Histology) and dictionaries ( [1]) spell it 'poe', not 'poie'. I changed the title to match this spelling. MrTroy 13:02, 12 April 2006 (UTC)
References
I'm really not sure about the pronunciation given here - although it may be the US form. I'm adding a British version. Wee Jimmy ( talk) 12:15, 26 September 2014 (UTC)
The pronunciation as I added was exactly according to Wikipedia's style guide. The current revision isn't. Your statement that it's "more common IPA representation style" may be correct, but let's follow Wikipedia's style guide, OK? MrTroy 11:28, 15 April 2006 (UTC)
I'm not Italic textevenItalic text qualified to edit this page, however I think somebody more qualified might want to mention that erythropoietin is also used (semi-experimentally) in domestic animals.
Basesurge 06:09, 23 February 2007 (UTC)
could increased haemoglobin (as a result of lung disease i.e increased production of 'erythropoietin' by bone marrow, be a cause of high blood pressure?.
No. GiollaUidir 11:23, 23 March 2006 (UTC)
Article in french newspaper announced that Lance Armstrong might have used EPO. Keep an eye on this?
Recent big article is showing that Erythropoietin could have big role in protecting neurons in CNS:
http://www.clinsci.org/cs/103/0275/cs1030275.htm
Note NYT obituary of Dr. Margot Kruskall, who was one of the early researchers of EPO in the 1980s, and helped to develop the blood test for it. Possibly some of this material could be used (but of course not copied) in the article. -- Blaster 22:04, 8 September 2005 (UTC)
Medical books (e.g. Junqueira Functional Histology) and dictionaries ( [2]) spell it 'Poe', not 'poie'. I changed the title to match this spelling. MrTroy 13:02, 12 April 2006 (UTC)
The pronunciation as I added was exactly according to Wikipedia style guide. The current revision isn't. Your statement that it's "more common IPA representation style" may be correct, but let's follow Wikipedia style guide, OK? MrTroy 11:28, 15 April 2006 (UTC)
There should also be a pronunciation for people in the United States. I'm a freaking novelist and I can't make heads or tails out of that silly pronunciation method, even after reading the so-called explanation. That "International Phonetic Alphabet" isn't really used or widely known in the United States. Especially since this is the first I've ever seen or heard of it, I'd say there should be another entry for American English speakers. As it stands, I have no clue how to pronounce this word.
-- 12.201.55.10 ( talk) 05:20, 17 December 2007 (UTC)Brandon Harwell
I'm not Italic textevenItalic text qualified to edit this page, however I think somebody more qualified might want to mention that erythropoietin is also used (semi-experimentally) in domestic animals.
Basesurge 06:09, 23 February 2007 (UTC)
13.0 g/ml seems to low a number here. I don't have full text access to the article, but the abstract would seem to indicate normal is 13.0 - 15.0 g/dl. Anyone care to expand or correct?
Ganesha 04:42, 11 April 2007 (UTC)
How long does a change in altitude take to cause EPO to restore oxygen availability?
I am not scientifically qualified to make edits on this page, but I am knowledgeable enough to know that EPO and recombinant EPO are not the same. The main EPO page discusses blood doping as if the natural hormone EPO is what's being abused, when in reality, it is the artificial hormone found in drugs such as epogen. I think people use the term "EPO" too generically and confuse naturally occuring EPO with the rEPO drugs which are widely abused by endurance athletes. The page should refer people interested in the topic of blood doping to a page on recombinant EPO.
I think the article is very poorly written, and uses nomenclature in a very simplistic way. —Preceding unsigned comment added by 205.241.11.6 ( talk) 20:36, 15 August 2008 (UTC)
An EPO masking agent was detected in a billiards player. The article conveys this fact as if it is popular to use EPO to enhance billiards play. [3] MM962 ( talk) 23:22, 7 March 2009 (UTC)
The article didn't really go into the process of how EPO is made and used in the lab. I'm trying to find some sites, but nothing seems to be coming up. 99.230.7.159 ( talk) 17:58, 2 April 2009 (UTC)
First paragraph: "...it is produced by the peritubular capillary endothelial cells in the kidney..." Several USMLE review books that I've seen say this same thing, but it looks like they're actually produced by fibroblasts in the cortical interstitium. See http://www.ncbi.nlm.nih.gov/pubmed/9402140 and http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18575881 Can anyone find evidence to dispute this? Sirmky ( talk) 06:46, 28 September 2009 (UTC)
This article currently is very confusing because it mixes information about the endogenously produced erythropoietin hormone and recombinantly manufactured erythropoetin that is administered as a drug. Hence I propose that this article focus on the erythropoietin gene/protein and the drug specific parts be move to Epoetin alfa (analogous to the insulin and insulin therapy articles). Furthermore this article should conform to WP:MCBMOS while the drug specific article should conform to WP:PHARMMOS. Boghog ( talk) 05:45, 12 April 2012 (UTC)
"The report contained affidavits from numerous riders on the team including Frankie Andreu, Tyler Hamilton, George Hincapie, Floyd Landis, Levi Leipheimer, and several others describing wide spread EPO use during the Tour de France and other bicycling races around the turn of the century. They also implicated Lance Armstrong."
USADAs report is not focused on widespread EPO use in the peleton. Its primary focus is this: that Lance Armstrong: (i) cheated, and (ii) the necessary corollary: that Lance Armstrong is a liar. They did not "implicate" Armstrong. USADA and USADAs witnesses, who have testified on pain of perjury state openly and clearly that Armstrong is a drug cheat. No "implication". No innuendo. it's not as if his name was mentioned in passing and he was 'implicated' in the event, but he's clearly innocent. no no no. Given the evidence and Armstrong's lack of testimony, he has effectively entered a guilty plea as far as USADA and the UCI are concerned.
It is patently obvious that Armstrong's PR machine (guys you can't win the editing war - you are paid whereas wiki users are not. we'll be here forever reverting the changes) or the few supporters he has are making these pro-armstrong edits despite the overwhelming evidence to the contrary. nearly the whole US Postal and Discovery channel have admitted to using performance enhancing substances - lance armstrong is the only one, according to his story, who is clean.
guys, USADA is very clear on this point: Armstrong is a cheat. Fact. Period.
Captainandrewwiggins ( talk) 22:48, 7 November 2012 (UTC) Captainandrewwiggins ( talk) 23:05, 7 November 2012 (UTC)
...suggests that EPO may not work as a performance-enhancing drug: http://www.eurekalert.org/pub_releases/2012-12/w-edi120412.php
Probably worth mentioning on this page? ed g2s • talk 17:21, 16 January 2013 (UTC)
Seems to me not much doubt that it increases hematocrit, and that is performance enhancing in endurance sports that depend on getting oxygen to muscles. Might be much less useful for other sports. Gah4 ( talk) 02:07, 14 April 2014 (UTC)
There really needs to be actual chemical structure or name, including the specific amino acid sequence, the genes involved, and the types/locations of glycoslyations (the terms alfa, beta, etc. are virtually meaningless, with no explanations given even on their respective pages). The synthesis and regulation section only talks about regulation, not the actual synthesis or process for different glycosylations. The PDB structure is colorized but does not indicate the various atoms or even which parts are protein and which are glycans. Lakshwadeep ( talk) 21:58, 23 April 2013 (UTC)
The statement When exogenous EPO is used as a performance-enhancing drug,[dubious – discuss] it is classified as an erythropoiesis-stimulating agent (ESA). needs clarification.
By search, I find that :
Request some-one who knows more on this issue to:
@ FeatherPluma: may please see!
AshLin ( talk) 10:49, 17 June 2014 (UTC)
There seem to have been no objections to merge a page for an EPO brand (Dynepo) into this generic page since it was proposed in June 2014. It seems like a good idea to me, as there is little specific on that page. Klbrain ( talk) 19:27, 31 August 2015 (UTC)
Article merged: See old talk-page here
The contents of the Dynepo page were merged into Erythropoietin on 31 August 2015. For the contribution history and old versions of the redirected page, please see its history; for the discussion at that location, see its talk page. |
The article currently states
'Synthetic EPO is believed to have come into use in cycling about 1990'
In the book 'Het laatste geel', former professional Mathieu Hermans admits to using EPO during the 1989 Tour de France. He adds that he did nothing illegal, as it was not yet on the banned substances list yet. — Preceding unsigned comment added by 195.22.11.246 ( talk) 13:05, 2 October 2015 (UTC)
Hello fellow Wikipedians,
I have just added archive links to one external link on
Erythropoietin. Please take a moment to review
my edit. If necessary, add {{
cbignore}}
after the link to keep me from modifying it. Alternatively, you can add {{
nobots|deny=InternetArchiveBot}}
to keep me off the page altogether. I made the following changes:
When you have finished reviewing my changes, please set the checked parameter below to true to let others know.
This message was posted before February 2018.
After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than
regular verification using the archive tool instructions below. Editors
have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the
RfC before doing mass systematic removals. This message is updated dynamically through the template {{
source check}}
(last update: 5 June 2024).
Cheers. — cyberbot II Talk to my owner:Online 09:56, 17 October 2015 (UTC)
This link "Safety Labeling Changes: Epogen/Procrit (epoetin alfa) and Aranesp (darbepoetin alfa)" goes to a 404 now.
Juliansteinb (
talk) 18:36, 26 April 2019 (UTC)
Not everyone is going to like my attempt to detach the physiological role of erythropoietin and its pharmacological use, but I think it is needed. The content about pharmacological use and misuse is now on Erythropoiesis-stimulating agent (taken from this version). Happy to be shot down, but I think it is helpful. JFW | T@lk 11:41, 17 February 2016 (UTC)
User:IiKkEe this article should follow WP:MCBMOS in its structure. Jytdog ( talk) 20:37, 8 September 2017 (UTC)
I fail to see any need for this unrelated LINK to Jehovah's Witness and Blood Transfusions — Preceding unsigned comment added by 137.118.161.59 ( talk) 14:33, 20 February 2022 (UTC)